TDR Targets

Basic information

Technical information

TDR Targets ID: 882755
Name: 7-fluoro-1-(3-fluorophenyl)-2-pyridin-2-yl-1H -chromeno[2,3-c]pyrrole-3,9-dione
MW: 390.339 | Formula: C22H12F2N2O3
H donors: 0 H acceptors: 3 LogP: 3.51 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)C1N(c2ccccn2)C(=O)c2c1c(=O)c1c(o2)ccc(c1)F
InChi: 1S/C22H12F2N2O3/c23-13-5-3-4-12(10-13)19-18-20(27)15-11-14(24)7-8-16(15)29-21(18)22(28)26(19)17-6-1-2-9-25-17/h1-11,19H
InChiKey: UTIGRYXBTFWSFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-fluoro-1-(3-fluorophenyl)-2-(2-pyridyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
7-fluoro-1-(3-fluorophenyl)-2-(2-pyridyl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone
STOCK5S-73888

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis		0.0041	0.0137	0.0137
Onchocerca volvulus		0.0041	0.0137	0.2975
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0408	0.2863	1
Brugia malayi	ATPase, AAA family protein	0.0041	0.0137	0.0111
Brugia malayi	Hexokinase family protein	0.0053	0.0227	0.0201
Echinococcus multilocularis	hexokinase	0.0085	0.0461	0.0461
Brugia malayi	polybromodomain protein	0.0041	0.0137	0.0111
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0408	0.2863	1
Schistosoma mansoni	polybromo-1	0.0041	0.0137	0.0137
Schistosoma mansoni	hexokinase	0.0085	0.0461	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Schistosoma mansoni	hypothetical protein	0.0041	0.0137	0.0137
Echinococcus multilocularis	protein kinase C binding protein 1	0.0041	0.0137	0.0137
Echinococcus multilocularis	CREB binding protein	0.0072	0.0368	0.0368
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Brugia malayi	bromodomain containing protein	0.0041	0.0137	0.0111
Loa Loa (eye worm)	hexokinase	0.0026	0.0027	0.0027
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Leishmania major	hexokinase, putative	0.0085	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Echinococcus granulosus	CREB binding protein	0.0072	0.0368	0.038
Echinococcus multilocularis	hexokinase	0.0085	0.0461	0.0461
Echinococcus multilocularis	PH interacting protein	0.0041	0.0137	0.0137
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0408	0.2863	1
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0041	0.0137	0.0137
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Echinococcus granulosus	PH interacting protein	0.0041	0.0137	0.0142
Echinococcus granulosus	ATPase family AAA domain containing protein 2B	0.0041	0.0137	0.0142
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0408	0.2863	1
Trypanosoma cruzi	hexokinase, putative	0.0085	0.0461	1
Schistosoma mansoni	zinc finger protein	0.0041	0.0137	0.0137
Brugia malayi	PHD-finger family protein	0.0041	0.0137	0.0111
Onchocerca volvulus	Brd8 homolog	0.0041	0.0137	0.2975
Treponema pallidum	hexokinase (hxk)	0.0085	0.0461	0.5
Echinococcus multilocularis	bromodomain containing protein 8	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Onchocerca volvulus		0.0041	0.0137	0.2975
Echinococcus granulosus	CREB binding protein	0.0072	0.0368	0.038
Brugia malayi	Hexokinase family protein	0.0085	0.0461	0.0436
Entamoeba histolytica	acetyltransferase, GNAT family	0.0367	0.2558	1
Schistosoma mansoni	transcription initiation factor tfiid	0.0041	0.0137	0.0137
Schistosoma mansoni	hypothetical protein	0.0041	0.0137	0.0137
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0472	0.3344	0.3344
Echinococcus multilocularis	CREB binding protein	0.0072	0.0368	0.0368
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Echinococcus multilocularis	Bromodomain containing protein	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Onchocerca volvulus		0.0085	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Echinococcus granulosus	Bromodomain containing protein	0.0041	0.0137	0.0142
Echinococcus granulosus	peregrin	0.0041	0.0137	0.0142
Echinococcus multilocularis	zinc finger protein	0.0041	0.0137	0.0137
Brugia malayi	BRM protein	0.0041	0.0137	0.0111
Brugia malayi	hexokinase type II	0.0027	0.0032	0.0005
Echinococcus multilocularis	bromodomain containing 2	0.0041	0.0137	0.0137
Leishmania major	hexokinase, putative	0.0085	0.0461	1
Toxoplasma gondii	hexokinase	0.0085	0.0461	0.1189
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Plasmodium falciparum	histone acetyltransferase GCN5	0.0367	0.2558	1
Echinococcus granulosus	zinc finger protein	0.0041	0.0137	0.0142
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Echinococcus multilocularis	hexokinase type 2	0.0085	0.0461	0.0461
Echinococcus multilocularis	CREB binding protein	0.0072	0.0368	0.0368
Loa Loa (eye worm)	bromodomain containing protein	0.0041	0.0137	0.0137
Schistosoma mansoni	bromodomain containing protein	0.0041	0.0137	0.0137
Echinococcus granulosus	transcription initiation factor TFIID subunit 1	0.0041	0.0137	0.0142
Echinococcus granulosus	hexokinase	0.0085	0.0461	0.0478
Onchocerca volvulus	Bromodomain adjacent to zinc finger domain protein 1A homolog	0.0041	0.0137	0.2975
Echinococcus multilocularis	ATPase family AAA domain containing protein 2B	0.0041	0.0137	0.0137
Echinococcus granulosus	bromodomain containing protein 8	0.0041	0.0137	0.0142
Schistosoma mansoni	bromodomain containing protein	0.0041	0.0137	0.0137
Trypanosoma brucei	hexokinase	0.0085	0.0461	1
Schistosoma mansoni	phd finger protein	0.0041	0.0137	0.0137
Echinococcus multilocularis	polybromo 1	0.0041	0.0137	0.0137
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Brugia malayi	polybromodomain protein	0.0041	0.0137	0.0111
Echinococcus granulosus	hexokinase type 2	0.0085	0.0461	0.0478
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0137	0.0137
Onchocerca volvulus		0.0053	0.0227	0.4919
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.1368	1	1
Trypanosoma cruzi	hexokinase, putative	0.0085	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Trypanosoma brucei	hexokinase, putative	0.0085	0.0461	1
Onchocerca volvulus		0.0085	0.0461	1
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1365	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0032	0.0032
Onchocerca volvulus		0.0041	0.0137	0.2975
Loa Loa (eye worm)	bromodomain containing protein	0.0041	0.0137	0.0137
Entamoeba histolytica	hexokinase 1	0.0085	0.0461	0.1339
Onchocerca volvulus		0.0085	0.0461	1
Echinococcus granulosus	hexokinase	0.0085	0.0461	0.0478
Echinococcus multilocularis	CREB binding protein	0.0334	0.2319	0.2319
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0137	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hexokinase	0.0053	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0261	0.0261
Echinococcus granulosus	polybromo 1	0.0041	0.0137	0.0142
Loa Loa (eye worm)	BRM protein	0.0041	0.0137	0.0137
Echinococcus granulosus	CREB binding protein	0.0472	0.3344	0.3462
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0114	0.0114
Schistosoma mansoni	helicase	0.0041	0.0137	0.0137
Echinococcus granulosus	protein kinase C binding protein 1	0.0041	0.0137	0.0142
Plasmodium vivax	hexokinase, putative	0.0085	0.0461	0.1189
Loa Loa (eye worm)	hexokinase type II	0.0085	0.0461	0.0461
Brugia malayi	Bromodomain containing protein	0.0041	0.0137	0.0111
Echinococcus granulosus	global transcription activator snf2l2	0.0041	0.0137	0.0142
Entamoeba histolytica	hexokinase 2	0.0085	0.0461	0.1339
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0408	0.2863	1
Loa Loa (eye worm)	CBP-B	0.0338	0.2347	0.2347
Echinococcus multilocularis	peregrin	0.0041	0.0137	0.0137
Echinococcus granulosus	CREB binding protein	0.0304	0.2093	0.2167
Brugia malayi	hexokinase	0.0085	0.0461	0.0436
Echinococcus multilocularis	global transcription activator snf2l2	0.0041	0.0137	0.0137
Schistosoma mansoni	bromodomain containing	0.0041	0.0137	0.0137
Onchocerca volvulus	Hexokinase homolog	0.0053	0.0227	0.4919
Echinococcus granulosus	hexokinase	0.0085	0.0461	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.1368	1	1
Echinococcus multilocularis	Bromodomain containing protein	0.0041	0.0137	0.0137
Loa Loa (eye worm)	hexokinase	0.0085	0.0461	0.0461
Loa Loa (eye worm)	hexokinase	0.0085	0.0461	0.0461
Trypanosoma brucei	hexokinase	0.0085	0.0461	1
Schistosoma mansoni	CREB-binding protein 2	0.0472	0.3344	0.3344
Echinococcus multilocularis	hexokinase	0.0085	0.0461	0.0461
Plasmodium falciparum	hexokinase	0.0085	0.0461	0.1339
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0137	0.0137
Schistosoma mansoni	hypothetical protein	0.0041	0.0137	0.0137
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0046	0.0173	0.0131
Echinococcus granulosus	Bromodomain containing protein	0.0041	0.0137	0.0142
Echinococcus granulosus	bromodomain containing 2	0.0041	0.0137	0.0142
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0408	0.2863	0.2964
Schistosoma mansoni	hypothetical protein	0.0041	0.0137	0.0137
Giardia lamblia	Histone acetyltransferase GCN5	0.0367	0.2558	1
Brugia malayi	TAZ zinc finger family protein	0.0472	0.3344	0.3326
Loa Loa (eye worm)	acetyltransferase	0.1368	1	1
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0046	0.0173	0.0131
Echinococcus granulosus	histone acetyltransferase KAT2B	0.1322	0.9659	1
Schistosoma mansoni	bromodomain containing protein	0.0041	0.0137	0.0137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 882755