Detailed information for compound 886922

Basic information

Technical information
  • TDR Targets ID: 886922
  • Name: N-(2,4-dibromophenyl)-1,5-dioxa-9-azaspiro[5. 5]undecane-9-carboxamide
  • MW: 434.123 | Formula: C15H18Br2N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)Br)NC(=O)N1CCC2(CC1)OCCCO2
  • InChi: 1S/C15H18Br2N2O3/c16-11-2-3-13(12(17)10-11)18-14(20)19-6-4-15(5-7-19)21-8-1-9-22-15/h2-3,10H,1,4-9H2,(H,18,20)
  • InChiKey: WEUYIEPYLATEMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_419031

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0175 0.2954
Plasmodium vivax aspartyl protease, putative 0.0017 0.0194 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0374 0.1674
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0557 0.2494
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0572 0.1927
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0572 0.256
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0572 0.0404
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0373 0.0201
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0194 0.0029
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0572 0.0617
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0785
Echinococcus granulosus lamin dm0 0.0026 0.0374 0.1674
Plasmodium vivax plasmepsin V, putative 0.0017 0.0194 0.0019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Plasmodium falciparum plasmepsin V 0.0017 0.0194 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0828 0.3708
Brugia malayi intermediate filament protein 0.0026 0.0374 0.1674
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0676 0.051
Echinococcus granulosus General substrate transporter 0.01 0.1896 0.8492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0422 0.1891
Brugia malayi MH2 domain containing protein 0.0116 0.2208 0.9889
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0175 0.2954
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.039
Plasmodium falciparum plasmepsin VII 0.0017 0.0194 0.0019
Entamoeba histolytica protein kinase, putative 0.0036 0.0572 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0373 0.0201
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0152 0.0679
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0017 0.0194 0.0867
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0581 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Trypanosoma brucei glucose transporter 2A 0.0036 0.0581 0.8107
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0175 0.2954
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0572 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0017 0.0194 0.0867
Brugia malayi Sugar transporter family protein 0.0117 0.2233 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0097 0.0434
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0572 0.0404
Schistosoma mansoni protein kinase 0.0036 0.0572 0.256
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0175 0.0785
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0373 0.3046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Onchocerca volvulus 0.0026 0.0374 1
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0785
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.3707 0.3595
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0373 0.167
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0373 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0557 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0581 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0152 0.0679
Brugia malayi hypothetical protein 0.0017 0.0194 0.0867
Schistosoma mansoni hypothetical protein 0.0015 0.0152 0.0679
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Onchocerca volvulus 0.0017 0.0194 0.093
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2208 0.9889
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0676 1
Echinococcus multilocularis General substrate transporter 0.01 0.1896 0.8492
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0194 0.0867
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0785
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0292 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0496 1 1
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0785
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0785
Entamoeba histolytica protein kinase, putative 0.0036 0.0572 1
Schistosoma mansoni hypothetical protein 0.0015 0.0152 0.0679
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0073 0.1341 0.6004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.039
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0373 0.0308
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0785
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0373 0.167
Plasmodium falciparum plasmepsin I 0.0073 0.1341 0.1186
Schistosoma mansoni protein kinase 0.0036 0.0572 0.256
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0526 0.2357
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.6004
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0557 0.2494
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0557 0.2494
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0434
Schistosoma mansoni hypothetical protein 0.0015 0.0152 0.0679
Brugia malayi hypothetical protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0572 0.256
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0125 0.0561
Schistosoma mansoni glucose transport protein 0.0117 0.2233 1
Echinococcus multilocularis lamin dm0 0.0026 0.0374 0.1674
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.3707 0.3595
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0676 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Plasmodium falciparum plasmepsin VI 0.0073 0.1341 0.1186
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0785
Echinococcus granulosus lamin 0.0026 0.0374 0.1674
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0581 0.1973
Schistosoma mansoni lamin 0.0026 0.0374 0.1674
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0152 0.0679
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0307 0.0641
Loa Loa (eye worm) hypothetical protein 0.0036 0.0572 0.256
Plasmodium falciparum protein kinase 7 0.033 0.6603 0.6542
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0073 0.1341 0.6004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0175 0.0785
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0373 0.167
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0194 0.0019
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0373 1
Schistosoma mansoni lamin 0.0026 0.0374 0.1674
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2208 0.9889
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0194 0.0867
Schistosoma mansoni glucose transport protein 0.0117 0.2233 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.3707 0.5495
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0581 0.1973
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0073 0.1341 0.6004
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0572 0.0404
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0194 0.0867
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0152 0.0679
Onchocerca volvulus 0.0026 0.0374 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0035 0.0557 0.2494
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0373 0.0961
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0557 1
Brugia malayi hypothetical protein 0.0017 0.0194 0.0867
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0572 0.0404
Toxoplasma gondii aspartyl protease 0.0017 0.0194 0.0029
Echinococcus granulosus intermediate filament protein 0.0026 0.0374 0.1674
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0785
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0374 0.1674
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Mycobacterium ulcerans sugar transporter 0.0016 0.0175 0.2954
Loa Loa (eye worm) hypothetical protein 0.0026 0.0364 0.163
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.2233 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0581 0.1973
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0785
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0581 0.8107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0373 0.167
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0785
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0373 0.167
Plasmodium vivax aspartyl proteinase, putative 0.0073 0.1341 0.1186
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0785
Plasmodium falciparum plasmepsin III 0.0017 0.0194 0.0019
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0572 0.0617
Echinococcus granulosus GPCR family 2 0.0015 0.0152 0.0679
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0515 0.2306
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0557 0.2494
Schistosoma mansoni hypothetical protein 0.0033 0.0515 0.2306
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0572 0.7919
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0175 0.0785
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0373 0.5182
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0572 0.0404
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0572 0.0404
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0581 0.8107
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0194 0.0867
Schistosoma mansoni intermediate filament proteins 0.0026 0.0374 0.1674
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0373 0.167
Schistosoma mansoni glucose transporter 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0033 0.0515 0.2306
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0373 0.395
Brugia malayi hypothetical protein 0.0016 0.0175 0.0785
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0073 0.1341 0.1813
Schistosoma mansoni hypothetical protein 0.0117 0.2233 1
Plasmodium vivax aspartyl protease, putative 0.0017 0.0194 0.0019
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0676 1
Leishmania major glucose transporter, lmgt2 0.0036 0.0581 0.8107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0676 0.0779
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0676 1
Loa Loa (eye worm) sugar transporter 0.0016 0.0175 0.0785
Trypanosoma cruzi hexose transporter, putative 0.002 0.0244 0.1383
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0152 0.0679
Brugia malayi Pepsin A precursor 0.0017 0.0194 0.0867
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0175 0.0785
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0557 0.2494
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0152 0.0679
Onchocerca volvulus 0.0017 0.0194 0.093
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0785
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0676 0.051
Brugia malayi hypothetical protein 0.0016 0.0175 0.0785
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0557 0.2494
Schistosoma mansoni hypothetical protein 0.0015 0.0152 0.0679
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0557 0.9253
Echinococcus multilocularis GPCR, family 2 0.0015 0.0152 0.0679
Plasmodium falciparum plasmepsin II 0.0073 0.1341 0.1186
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) hypothetical protein 0.0035 0.0557 0.2494
Plasmodium vivax plasmepsin IV, putative 0.0073 0.1341 0.1186
Plasmodium vivax aspartyl protease, putative 0.0017 0.0194 0.0019
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0194 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0125 0.0561
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0572 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0581 0.1973
Plasmodium falciparum plasmepsin IX 0.0017 0.0194 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Toxoplasma gondii aspartyl protease ASP1 0.0073 0.1341 0.1813
Echinococcus multilocularis musashi 0.0026 0.0374 0.1674
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0581 0.1973
Plasmodium falciparum hexose transporter 0.0117 0.2233 0.2094
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0572 0.0617
Brugia malayi Cam kinase protein 1 0.0036 0.0572 0.256
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0572 0.256
Leishmania major protein kinase, putative 0.0036 0.0572 0.7919
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0581 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0572 0.256
Schistosoma mansoni protein kinase 0.0036 0.0572 0.256
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.1341 0.6004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0292 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0097 0.0434
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Schistosoma mansoni cathepsin D (A01 family) 0.0073 0.1341 0.6004
Leishmania major glucose transporter, lmgt1 0.0036 0.0581 0.8107
Schistosoma mansoni sugar transporter 0.0016 0.0175 0.0785
Schistosoma mansoni glucose transport protein 0.0117 0.2233 1
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0092 0.5
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.2233 0.3201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0828 0.3708
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0373 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0581 0.8107
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0557 0.1855
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0679
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Echinococcus multilocularis lamin 0.0026 0.0374 0.1674
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0526 0.2357
Brugia malayi major facilitator superfamily protein 0.0016 0.0175 0.0785
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0581 0.1973
Plasmodium falciparum plasmepsin X 0.0017 0.0194 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0572 0.256
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0581 0.8107
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0374 0.1674
Trypanosoma brucei glucose transporter, putative 0.0036 0.0581 0.8107
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0581 0.1973
Plasmodium vivax hexose transporter 0.0117 0.2233 0.2094
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0572 0.256
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0373 0.395
Echinococcus granulosus solute carrier family 22 0.0016 0.0175 0.0785
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0374 0.1674
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0175 0.0785
Brugia malayi Sugar transporter family protein 0.0016 0.0175 0.0785
Leishmania major glucose transporter, lmgt3 0.0036 0.0581 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Trypanosoma brucei glucose transporter 1E 0.0036 0.0581 0.8107
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0073 0.1341 0.5664
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Loa Loa (eye worm) sugar transporter 0.0117 0.2233 1
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0194 0.0029
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0175 0.0785
Plasmodium falciparum plasmepsin IV 0.0073 0.1341 0.1186
Schistosoma mansoni memapsin-2 (A01 family) 0.0017 0.0194 0.0867
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0194 0.0867
Toxoplasma gondii protein kinase, putative 0.033 0.6603 1
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2233 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0828 0.3708
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0828 0.3708
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0785
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0572 0.0404
Trypanosoma cruzi hexose transporter 0.0036 0.0581 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2233 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0152 0.0679
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0194 0.0867
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0373 0.395
Schistosoma mansoni cathepsin D (A01 family) 0.0073 0.1341 0.6004
Echinococcus multilocularis solute carrier family 22 0.0016 0.0175 0.0785
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0133 0.0597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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