TDR Targets

Basic information

Technical information

TDR Targets ID: 889147
Name: 2-ethylhexyl 4-[2-[(2,4-difluorophenyl)amino] -2-oxoethyl]-1,4-diazepane-1-carboxylate
MW: 425.513 | Formula: C22H33F2N3O3
H donors: 1 H acceptors: 2 LogP: 4.53 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(COC(=O)N1CCCN(CC1)CC(=O)Nc1ccc(cc1F)F)CC
InChi: 1S/C22H33F2N3O3/c1-3-5-7-17(4-2)16-30-22(29)27-11-6-10-26(12-13-27)15-21(28)25-20-9-8-18(23)14-19(20)24/h8-9,14,17H,3-7,10-13,15-16H2,1-2H3,(H,25,28)
InChiKey: XGMNCOQHFMGMHL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-ethylhexyl 4-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]-1,4-diazepane-1-carboxylate
4-[2-[(2,4-difluorophenyl)amino]-2-oxoethyl]-1,4-diazepane-1-carboxylic acid 2-ethylhexyl ester
4-[2-[(2,4-difluorophenyl)amino]-2-keto-ethyl]-1,4-diazepane-1-carboxylic acid 2-ethylhexyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	catabolite gene activator (Crp)	0.0037	0.0102	0.5
Schistosoma mansoni	hypothetical protein	0.0544	0.2765	0.5741
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0037	0.0102	1
Treponema pallidum	cyclic nucleotide binding protein	0.0037	0.0102	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0031	0.307
Onchocerca volvulus		0.0024	0.0031	0.1263
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0059	0.0216	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0384	0.0363
Trypanosoma cruzi	cAMP response protein 1	0.0037	0.0102	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0102	0.2017
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0037	0.0102	0.2238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0384	0.0363
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0366	0.1829	0.3782
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0037	0.0102	0.2017
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0037	0.0102	0.0081
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0059	0.0216	0.0195
Trypanosoma brucei	Flagellar Member 6	0.0037	0.0102	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0031	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0031	0.307
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0031	0.307
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Leishmania major	hypothetical protein, conserved	0.0037	0.0102	1
Plasmodium falciparum	cGMP-dependent protein kinase	0.0037	0.0102	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0031	0.5
Schistosoma mansoni	transient receptor potential channel	0.0082	0.0337	0.066
Onchocerca volvulus		0.0037	0.0102	1
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0037	0.0102	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0037	0.0102	1
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0037	0.0102	1
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0037	0.0102	1
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0037	0.0102	0.0081
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0384	0.0363
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0037	0.0102	0.017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Mycobacterium leprae	Conserved hypothetical protein	0.0037	0.0102	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0059	0.0216	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0619
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0031	0.307
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0102	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0037	0.0102	0.017
Brugia malayi	N-terminal motif family protein	0.0037	0.0102	0.2238
Mycobacterium ulcerans	transmembrane transport protein	0.0037	0.0102	1
Trypanosoma brucei	cAMP response protein 1, putative	0.0037	0.0102	1
Echinococcus multilocularis	hypothetical protein	0.0544	0.2765	0.275
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0031	0.307
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0387	0.1943	1
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0037	0.0102	0.2238
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0031	0.0283
Loa Loa (eye worm)	hypothetical protein	0.006	0.0223	0.4396
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0037	0.0102	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0037	0.0102	0.0081
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0037	0.0102	0.0081
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0037	0.0102	1
Mycobacterium ulcerans	regulatory protein	0.0037	0.0102	1
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0037	0.0102	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0037	0.0102	0.0081
Loa Loa (eye worm)	voltage-gated calcium channel	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Echinococcus granulosus	cGMP dependent protein kinase	0.0037	0.0102	0.0081
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0384	0.0758
Loa Loa (eye worm)	ryanodine receptor	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0059	0.0216	0.0195
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0059	0.0216	0.0195
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0054	0.0191	0.017
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0931	0.48	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0102	0.2017
Loa Loa (eye worm)	calcium channel	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Treponema pallidum	cyclic nucleotide binding protein	0.0037	0.0102	0.5
Echinococcus granulosus	geminin	0.0169	0.0795	0.0775
Leishmania major	protein kinase, putative	0.0037	0.0102	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0031	0.1263
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0059	0.0216	0.4265
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0037	0.0102	1
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0102	1
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0102	0.017
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0037	0.0102	0.0081
Echinococcus multilocularis	expressed conserved protein	0.0037	0.0102	0.0081
Echinococcus granulosus	short transient receptor potential channel 6	0.0082	0.0337	0.0316
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0031	0.307
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0191	0.3774
Leishmania major	protein kinase A regulatory subunit, putative	0.0037	0.0102	1
Leishmania major	hypothetical protein, unknown function	0.0037	0.0102	1
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0037	0.0102	1
Echinococcus granulosus	TRP transient receptor potential channel	0.0054	0.0191	0.017
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0619
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0102	1
Trypanosoma brucei	protein kinase A regulatory subunit	0.0037	0.0102	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0037	0.0102	0.0081
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0022	0.0021	0.0417
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0102	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0082	0.0337	0.0316
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0037	0.0102	0.017
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0031	0.307
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0037	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0169	0.0795	0.1618
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0059	0.0216	0.0619
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0037	0.0102	1
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0037	0.0102	0.017
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0384	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Mycobacterium ulcerans	transcriptional regulatory protein	0.0037	0.0102	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0031	0.0283
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0059	0.0216	0.0195
Leishmania major	hypothetical protein, conserved	0.0037	0.0102	1
Brugia malayi	Transient-receptor-potential like protein	0.0054	0.0191	0.4694
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0077	0.1526
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0037	0.0102	1
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0102	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0384	0.0758
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0037	0.0102	0.017
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0037	0.0102	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0059	0.0216	0.0195
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0037	0.0102	0.0081
Leishmania major	hypothetical protein, conserved	0.0037	0.0102	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0216	0.4265
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0031	0.0283
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0031	0.307
Onchocerca volvulus		0.0037	0.0102	1
Treponema pallidum	catabolite gene activator	0.0037	0.0102	0.5
Trypanosoma cruzi	cAMP binding protein, putative	0.0037	0.0102	1
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0037	0.0102	0.0081
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0031	0.1263
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0384	0.0758
Trypanosoma cruzi	Flagellar Member 6	0.0037	0.0102	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1921	1	1
Trypanosoma brucei	cAMP binding protein, putative	0.0037	0.0102	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0059	0.0216	0.0195
Echinococcus granulosus	transient receptor potential gamma protein	0.0114	0.0507	0.0487
Schistosoma mansoni	transient receptor potential channel 4	0.0114	0.0507	0.1016
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0059	0.0216	0.4265
Loa Loa (eye worm)	voltage-gated potassium channel	0.0022	0.0021	0.0417
Leishmania major	protein kinase, putative	0.0037	0.0102	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0059	0.0216	0.5381
Schistosoma mansoni	transient receptor potential channel	0.0082	0.0337	0.066
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0059	0.0216	0.5381
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0507	1
Loa Loa (eye worm)	ion channel NompC	0.0022	0.0021	0.0417
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0102	0.017
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0216	0.0408
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0037	0.0102	0.017
Schistosoma mansoni	transient receptor potential channel	0.0114	0.0507	0.1016
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0216	0.0408
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0059	0.0216	0.5381
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0216	0.0408
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0037	0.0102	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0059	0.0216	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0216	0.0408
Schistosoma mansoni	voltage-gated potassium channel	0.0059	0.0216	0.0408
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0931	0.48	1
Brugia malayi	Egg laying defective protein 4	0.0037	0.0102	0.2238
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0102	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0031	0.5
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0037	0.0102	1
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0037	0.0102	0.017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0031	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0037	0.0102	0.2238
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0037	0.0102	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0037	0.0102	0.0081
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0031	0.307
Echinococcus multilocularis	transient receptor potential ion channel A	0.0092	0.0393	0.0373
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0102	0.017
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0037	0.0102	0.017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0216	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0037	0.0102	0.5
Echinococcus granulosus	Ion_trans_N domain containing protein	0.0544	0.2765	0.275
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0384	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0037	0.0102	1
Echinococcus multilocularis	geminin	0.0169	0.0795	0.0775
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0037	0.0102	0.0081
Echinococcus multilocularis	transient receptor potential gamma protein	0.0114	0.0507	0.0487
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0037	0.0102	0.0081
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0037	0.0102	0.017
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0037	0.0102	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0037	0.0102	0.0081
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0216	0.0408
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0037	0.0102	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0037	0.0102	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0384	0.7567
Echinococcus granulosus	voltage gated potassium channel	0.0059	0.0216	0.0195
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0037	0.0102	0.017
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0216	0.0408
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0037	0.0102	0.017
Echinococcus granulosus	transient receptor potential ion channel A	0.0092	0.0393	0.0373
Echinococcus granulosus	short transient receptor potential channel 6	0.0082	0.0337	0.0316
Echinococcus granulosus	hyperpolarization activated cyclic	0.0931	0.48	0.4789
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0037	0.0102	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0931	0.48	0.4789
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0059	0.0216	0.4265
Echinococcus multilocularis	short transient receptor potential channel 6	0.0082	0.0337	0.0316
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0059	0.0216	0.0408
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0037	0.0102	0.2017
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0031	0.307
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0037	0.0102	0.0081
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0931	0.48	0.4789
Trypanosoma cruzi	cAMP response protein 1, putative	0.0037	0.0102	1
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0037	0.0102	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0037	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0169	0.0795	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0037	0.0102	0.0081
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0931	0.48	0.4789
Echinococcus multilocularis	voltage gated potassium channel	0.0059	0.0216	0.0195
Echinococcus granulosus	hyperpolarization activated cyclic	0.0931	0.48	0.4789
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0931	0.48	1
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0037	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0102	0.017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 889147