Detailed information for compound 890996

Basic information

Technical information
  • TDR Targets ID: 890996
  • Name: 1-acetyl-N-(3-chlorophenyl)piperidine-4-carbo xamide
  • MW: 280.75 | Formula: C14H17ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)C(=O)C)Nc1cccc(c1)Cl
  • InChi: 1S/C14H17ClN2O2/c1-10(18)17-7-5-11(6-8-17)14(19)16-13-4-2-3-12(15)9-13/h2-4,9,11H,5-8H2,1H3,(H,16,19)
  • InChiKey: SVLCTHUEWPCMEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-acetyl-N-(3-chlorophenyl)-4-piperidinecarboxamide
  • 1-acetyl-N-(3-chlorophenyl)isonipecotamide
  • N-(3-chlorophenyl)-1-ethanoyl-piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0581 0.0663
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0793 0.1096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0205 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0793 0.0905
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0069 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1058 0.1586
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0793 0.6646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1646 0.1879
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0205 0.0308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0581 0.0775
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0363 0.0544
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0793 0.6646
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0069 0.0581
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0205 0.0308
Loa Loa (eye worm) hypothetical protein 0.0008 0.0069 0.0079
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0069 0.0359
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0793 0.6567
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0581 0.475
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0581 0.0871
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0112
Onchocerca volvulus 0.0008 0.0069 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0363 0.0544
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0182 0.667 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0205 0.0234
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0205 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0205 0.0234
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0793 0.6646
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0363 0.0414
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0069 0.0581
Schistosoma mansoni coup transcription factor 0.0012 0.0205 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0205 0.0234
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0581 0.5
Treponema pallidum hypothetical protein 0.0038 0.1193 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0581 0.0871
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0793 0.6646
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0205 0.0234
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0581 0.4871
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0075 0.0112
Toxoplasma gondii CAAX amino terminal protease family protein 0.0038 0.1193 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0069 0.0359
Toxoplasma gondii hypothetical protein 0.0038 0.1193 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0534 0.4135
Echinococcus granulosus Smad4 0.0008 0.0075 0.0112
Brugia malayi steroid hormone receptor 0.0012 0.0205 0.0234
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.1058 0.1586
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0793 0.1096
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0069 0.0359
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0205 0.0234
Brugia malayi MH2 domain containing protein 0.0118 0.4259 0.4863
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0182 0.667 1
Echinococcus multilocularis Smad4 0.0008 0.0075 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Brugia malayi MH2 domain containing protein 0.0008 0.0075 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0205 0.0308
Plasmodium vivax SET domain protein, putative 0.0034 0.1058 0.8801
Echinococcus granulosus GPCR family 2 0.0016 0.0363 0.0544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0793 0.0905
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.1058 0.1586
Loa Loa (eye worm) hypothetical protein 0.0034 0.1058 0.1208
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0182 0.667 0.6647
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0069 0.0359
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0069 0.0359
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0205 0.0234
Onchocerca volvulus 0.0034 0.1058 0.1058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0793 0.6567
Plasmodium falciparum protease, putative 0.0038 0.1193 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0205 0.0234
Mycobacterium ulcerans hypothetical protein 0.0038 0.1193 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.3317 0.4974
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0793 0.6646
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.4259 0.4863
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0205 0.0234
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0075 0.0112
Loa Loa (eye worm) Smad1 0.0008 0.0075 0.0085
Mycobacterium ulcerans hypothetical protein 0.0038 0.1193 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0205 0.0205
Toxoplasma gondii exonuclease III APE 0.0021 0.0581 0.4555
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0205 0.0308
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0069 0.0079
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0205 0.0308
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1646 0.1879
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0581 0.4555
Entamoeba histolytica CAAX amino terminal protease family 0.0038 0.1193 0.1702
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Brugia malayi MH1 domain containing protein 0.0008 0.0075 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0363 0.0544
Entamoeba histolytica CAAX prenyl protease family 0.0182 0.667 1
Schistosoma mansoni smad 0.0008 0.0075 0.0112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0581 0.0775
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Echinococcus multilocularis CAAX prenyl protease 2 0.0182 0.667 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0205 0.0234
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.8758 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0069 0.0581
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0182 0.667 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0069 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.1011 0.1515
Trypanosoma brucei CAAX amino terminal protease, putative 0.0182 0.667 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0205 0.0234
Mycobacterium tuberculosis Probable integral membrane protein 0.0038 0.1193 1
Chlamydia trachomatis hypothetical protein 0.0038 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.3317 0.3788
Brugia malayi Pre-SET motif family protein 0.0237 0.8758 1
Mycobacterium ulcerans integral membrane protein 0.0038 0.1193 1
Entamoeba histolytica CAAX amino terminal protease family 0.0038 0.1193 0.1702
Loa Loa (eye worm) hypothetical protein 0.0182 0.667 0.7616
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0038 0.1193 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0793 0.0905
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0069 0.0104
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Loa Loa (eye worm) hypothetical protein 0.005 0.1646 0.1879
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0069 0.0359
Brugia malayi nuclear receptor NHR-88 0.0012 0.0205 0.0234
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0581 0.0515
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0205 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Mycobacterium ulcerans hypothetical protein 0.0027 0.0793 0.6646
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0075 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0363 0.0414
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0205 0.0308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0492 0.3987
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0069 0.0359
Brugia malayi Smad1 0.0008 0.0075 0.0085
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0069 0.0079
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0069 0.0581
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0205 0.0308
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0205 0.0308
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0544
Echinococcus granulosus CAAX prenyl protease 2 0.0182 0.667 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Toxoplasma gondii hypothetical protein 0.0038 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0534 0.061
Plasmodium vivax protease, putative 0.0038 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0534 0.061
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0363 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0205 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0205 0.0234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0534 0.4476
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0205 0.0308
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0069 0.0104
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0182 0.667 1
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0205 0.0234
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0069 0.0359
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0075 0.0112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0205 0.0308
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0205 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0205 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.1058 0.1586
Loa Loa (eye worm) hypothetical protein 0.002 0.0534 0.061
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0205 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0205 0.0234
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0205 0.0308
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0182 0.667 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1052 0.1201
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0534 0.061
Onchocerca volvulus 0.0088 0.3086 0.3086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0581 0.0775
Brugia malayi CAAX amino terminal protease family protein 0.0182 0.667 0.7616
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0581 0.4555
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0534 0.4135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1058 0.1586
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0534 0.4345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1646 0.1879
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0205 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0205 0.0308
Schistosoma mansoni hypothetical protein 0.0034 0.1052 0.1577
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0205 0.0308
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0069 0.0581
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0793 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0205 0.0234
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0069 0.0104
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0581 0.0775
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0793 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0069 0.0581
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0205 0.0234
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0205 0.0308
Echinococcus granulosus smad 0.0008 0.0075 0.0112
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0205 0.0308
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0793 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0205 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0793 0.0905
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0069 0.0581
Echinococcus multilocularis smad 0.0008 0.0075 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Brugia malayi Pre-SET motif family protein 0.0034 0.1058 0.1208
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0069 0.0581
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0112
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0581 0.0515
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0075 0.0085
Schistosoma mansoni ap endonuclease 0.0021 0.0581 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0793 0.0905
Onchocerca volvulus 0.0008 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0544
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0205 0.0234
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0205 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Trichomonas vaginalis set domain proteins, putative 0.027 1 1
Onchocerca volvulus 0.0012 0.0205 0.0205
Loa Loa (eye worm) oxidoreductase 0.0008 0.0069 0.0079
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0069 0.0359
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.3317 0.4974
Schistosoma mansoni Smad4 0.0008 0.0075 0.0112
Onchocerca volvulus 0.0094 0.3317 0.3317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1058 0.1586
Onchocerca volvulus 0.0027 0.0793 0.0793
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0038 0.1193 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0205 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0793 0.6646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0492 0.3987
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0534 0.061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0793 0.0905
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0363 0.0544
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0069 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0793 0.1096
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0069 0.0079
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0793 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0205 0.0205
Echinococcus multilocularis GPCR, family 2 0.0016 0.0363 0.0544
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0363 0.0414
Brugia malayi MH2 domain containing protein 0.0008 0.0075 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0205 0.0308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0492 0.3987
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0069 0.0581
Onchocerca volvulus 0.0008 0.0069 0.0069
Brugia malayi nuclear hormone receptor 0.0012 0.0205 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0205 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0492 0.3987
Loa Loa (eye worm) hypothetical protein 0.0034 0.1052 0.1201
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0793 0.6646
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0205 0.0308
Schistosoma mansoni ap endonuclease 0.0021 0.0581 0.0871
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0069 0.0581
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0205 0.0308
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0793 0.1096
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0581 0.0663
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0205 0.0308
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0205 0.0308
Brugia malayi MH1 domain containing protein 0.0008 0.0075 0.0085
Giardia lamblia Hypothetical protein 0.0182 0.667 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.4259 0.4863
Brugia malayi Trypsin family protein 0.0094 0.3317 0.3788
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0075 0.0085
Schistosoma mansoni hypothetical protein 0.0016 0.0363 0.0544
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.1058 0.1586
Onchocerca volvulus 0.0008 0.0069 0.0069
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0205 0.0308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0205 0.0308
Brugia malayi ecdysteroid receptor 0.0012 0.0205 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0205 0.0234
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.1058 0.8801
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0075 0.0112
Loa Loa (eye worm) hypothetical protein 0.0094 0.3317 0.3788
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0205 0.0308
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0581 0.0775

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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