Detailed information for compound 894510

Basic information

Technical information
  • TDR Targets ID: 894510
  • Name: 1-(4-methoxyphenyl)-3-(4-methylpiperidin-1-yl )pyrrolidine-2,5-dione
  • MW: 302.368 | Formula: C17H22N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1C(=O)CC(C1=O)N1CCC(CC1)C
  • InChi: 1S/C17H22N2O3/c1-12-7-9-18(10-8-12)15-11-16(20)19(17(15)21)13-3-5-14(22-2)6-4-13/h3-6,12,15H,7-11H2,1-2H3
  • InChiKey: WUFYPVNMKFIBPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methoxyphenyl)-3-(4-methyl-1-piperidyl)pyrrolidine-2,5-dione
  • 1-(4-methoxyphenyl)-3-(4-methyl-1-piperidinyl)pyrrolidine-2,5-dione
  • 1-(4-methoxyphenyl)-3-(4-methyl-1-piperidyl)pyrrolidine-2,5-quinone
  • BAS 00345441
  • ST5224661
  • EU-0037453
  • CBMicro_013777
  • BIM-0013762.P001
  • 1-(4-Methoxyphenyl)-3-(4-methyl-1-piperidinyl)-2,5-pyrrolidinedione
  • 1-(4-Methoxyphenyl)-3-(4-methylpiperidino)pyrrolidine-2,5-dione
  • 1-(4-Methoxy-phenyl)-3-(4-methyl-piperidin-1-yl)-pyrrolidine-2,5-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0115 0.0526
Echinococcus multilocularis snurportin 1 0.0323 0.078 0.3251
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0012 0.0074
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0135 0.0279 0.116
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0096 0.0174 0.0801
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0014 0.0051
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0047 0.0212
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0011 0.5
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0343 0.0834 0.3866
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0115 0.0473
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0258 0.1144
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0094 0.0171 0.0786
Onchocerca volvulus Matrix metalloproteinase homolog 0.0209 0.0477 0.2926
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0115 0.0478
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0258 1
Schistosoma mansoni hypothetical protein 0.0198 0.0447 0.2068
Brugia malayi 6-phosphofructokinase 0.0127 0.0258 0.0256
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2142 0.9941
Loa Loa (eye worm) hypothetical protein 0.0838 0.2155 0.2155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0014 0.0012
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0115 0.0226 0.0224
Onchocerca volvulus Bile acid receptor homolog 0.0229 0.0531 0.3259
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0736 0.1882 0.1882
Schistosoma mansoni hypothetical protein 0.0077 0.0123 0.0566
Toxoplasma gondii ABC1 family protein 0.0035 0.0012 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0258 1
Loa Loa (eye worm) hypothetical protein 0.0736 0.1882 0.1882
Schistosoma mansoni hypothetical protein 0.0134 0.0276 0.1274
Brugia malayi Hemopexin family protein 0.0134 0.0276 0.0274
Loa Loa (eye worm) peptidase family M13 containing protein 0.0736 0.1882 0.1882
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0123 0.0122
Schistosoma mansoni lipoxygenase 0.0135 0.0279 0.1291
Schistosoma mansoni hypothetical protein 0.0323 0.078 0.3617
Brugia malayi RNA, U transporter 1 0.0086 0.0148 0.0147
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0115 0.0526
Echinococcus granulosus muscleblind protein 0.0174 0.0384 0.1777
Echinococcus granulosus GPCR family 2 0.0035 0.0014 0.0057
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0011 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0012 0.0074
Echinococcus multilocularis muscleblind protein 1 0.0174 0.0384 0.1598
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0115 0.0478
Brugia malayi phosphofructokinase 0.0127 0.0258 0.0256
Brugia malayi 6-phosphofructokinase 0.0127 0.0258 0.0256
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0014 0.0012
Onchocerca volvulus 0.0035 0.0012 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0047 0.0212
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2142 0.8936
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0012 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0012 1
Brugia malayi Cytochrome P450 family protein 0.0051 0.0055 0.0053
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.078 0.078
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0838 0.2155 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0258 0.0258
Echinococcus granulosus snurportin 1 0.0323 0.078 0.3617
Loa Loa (eye worm) matrix metalloproteinase 0.0094 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0736 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.0115 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Brugia malayi Matrixin family protein 0.0094 0.0171 0.0169
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0198 0.0447 0.2069
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.0736 0.1882 0.1882
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0218 0.0218
Brugia malayi beta-lactamase 0.0035 0.0012 0.0011
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0078 0.0127 0.0583
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0135 0.0279 0.1291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0014 0.0057
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Schistosoma mansoni neprilysin 0.0102 0.0192 0.0885
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0218 0.0217
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Onchocerca volvulus Matrilysin homolog 0.0094 0.0171 0.1041
Brugia malayi hypothetical protein 0.0467 0.1164 0.1162
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0115 0.0478
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0012 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0115 0.0526
Echinococcus granulosus geminin 0.0198 0.0447 0.2068
Brugia malayi Matrixin family protein 0.0094 0.0171 0.0169
Brugia malayi peptidase family M13 containing protein 0.0096 0.0174 0.0172
Brugia malayi Matrixin family protein 0.0094 0.0171 0.0169
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0258 1
Onchocerca volvulus 0.0094 0.0171 0.1041
Brugia malayi Matrixin family protein 0.0094 0.0171 0.0169
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0012 0.0074
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0057
Schistosoma mansoni hypothetical protein 0.0095 0.0173 0.0796
Brugia malayi Peptidase family M13 containing protein 0.0838 0.2155 0.2153
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0515 0.2346
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3779 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0047 0.0212
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0838 0.2155 0.2155
Loa Loa (eye worm) matrixin family protein 0.0228 0.0527 0.0527
Echinococcus multilocularis endothelin converting enzyme 1 0.0838 0.2155 0.8989
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0173 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0047 0.0212
Schistosoma mansoni polycystin 1-related 0.0121 0.0242 0.1117
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0258 0.1189
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) peptidase family M13 containing protein 0.0736 0.1882 0.1882
Echinococcus multilocularis muscleblind protein 0.0174 0.0384 0.1598
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0014 0.0051
Onchocerca volvulus 0.0035 0.0012 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0055 0.0055
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0258 0.1144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0115 0.4174
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0258 1
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Onchocerca volvulus 0.0035 0.0012 0.0067
Schistosoma mansoni survival motor neuron protein 0.0095 0.0173 0.0796
Loa Loa (eye worm) hypothetical protein 0.0174 0.0384 0.0384
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0115 0.0226 0.0995
Brugia malayi Muscleblind-like protein 0.0174 0.0384 0.0383
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0838 0.2155 0.2153
Loa Loa (eye worm) hypothetical protein 0.064 0.1627 0.1627
Brugia malayi ecdysteroid receptor 0.0229 0.0531 0.053
Schistosoma mansoni hypothetical protein 0.0198 0.0447 0.2068
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0115 0.0486
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.1164 0.5397
Loa Loa (eye worm) matrixin family protein 0.0209 0.0477 0.0477
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0011 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0929 0.2397 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0012 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.1164 0.4852
Echinococcus multilocularis geminin 0.0198 0.0447 0.1859
Loa Loa (eye worm) hypothetical protein 0.0077 0.0123 0.0123
Mycobacterium ulcerans zinc metalloprotease 0.0838 0.2155 1
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0258 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0047 0.0212
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0047 0.0046
Onchocerca volvulus 0.064 0.1627 1
Mycobacterium leprae probable zinc metalloprotease 0.0838 0.2155 1
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0258 0.1189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0012 0.0045
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0174 0.0801
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0014 0.0057
Loa Loa (eye worm) beta-lactamase 0.0035 0.0012 0.0012
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0258 1
Schistosoma mansoni lipoxygenase 0.0094 0.0171 0.0787
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0174 0.0801
Schistosoma mansoni hypothetical protein 0.0102 0.0192 0.0885
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0218 0.0217
Loa Loa (eye worm) hypothetical protein 0.0094 0.0171 0.0171
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0258 0.1069
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0047 0.019
Loa Loa (eye worm) hypothetical protein 0.0174 0.0384 0.0384
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0047 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0012 0.005
Loa Loa (eye worm) hypothetical protein 0.0112 0.0218 0.0218
Trichomonas vaginalis esterase, putative 0.0035 0.0012 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0047 0.019
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0096 0.0174 0.0801
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0012 0.0074
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2142 0.9941
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0012 0.005
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0102 0.0192 0.0885
Schistosoma mansoni neprilysin-2 (M13 family) 0.0198 0.0447 0.2069
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0198 0.0447 0.2069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0838 0.2155 0.2155
Loa Loa (eye worm) hypothetical protein 0.0094 0.0171 0.0171
Brugia malayi Matrixin family protein 0.0228 0.0527 0.0526
Mycobacterium ulcerans hydrolase 0.0115 0.0226 0.0995
Loa Loa (eye worm) hypothetical protein 0.0229 0.0531 0.0531
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0258 1
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0258 1
Echinococcus granulosus endothelin converting enzyme 1 0.0838 0.2155 1
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0258 0.0258
Loa Loa (eye worm) zinc metallopeptidase 4 0.0096 0.0174 0.0174
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0012 0.0074
Schistosoma mansoni endothelin-converting enzyme-related 0.0096 0.0174 0.0801
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0198 0.0447 0.2069
Brugia malayi beta-lactamase family protein 0.0035 0.0012 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0258 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0115 0.0478
Echinococcus multilocularis GPCR, family 2 0.0035 0.0014 0.0051
Brugia malayi beta-lactamase family protein 0.0035 0.0012 0.0011
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0838 0.2155 1
Onchocerca volvulus 0.0095 0.0173 0.1055
Toxoplasma gondii peptidase family M13 protein 0.0838 0.2155 1
Loa Loa (eye worm) hypothetical protein 0.0467 0.1164 0.1164
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0198 0.0447 0.2069
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0258 1
Onchocerca volvulus 0.0134 0.0276 0.1688
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0258 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0258 0.0258
Mycobacterium leprae PROBABLE HYDROLASE 0.0115 0.0226 0.0995
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0258 0.1144
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0343 0.0834 0.3475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0014 0.0014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0174 0.0801
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0057
Onchocerca volvulus Matrilysin homolog 0.0209 0.0477 0.2926
Loa Loa (eye worm) hypothetical protein 0.0094 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0743 0.19 0.19
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.112 0.2908 0.5
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0258 0.1189

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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