Detailed information for compound 903555

Basic information

Technical information
  • TDR Targets ID: 903555
  • Name: N-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]-3 -(4-fluorophenyl)sulfonylpropanamide
  • MW: 418.505 | Formula: C20H19FN2O3S2
  • H donors: 1 H acceptors: 4 LogP: 3.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1scc(n1)c1cc(C)ccc1C)CCS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C20H19FN2O3S2/c1-13-3-4-14(2)17(11-13)18-12-27-20(22-18)23-19(24)9-10-28(25,26)16-7-5-15(21)6-8-16/h3-8,11-12H,9-10H2,1-2H3,(H,22,23,24)
  • InChiKey: CUQIEFXTAUUINV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(2,5-dimethylphenyl)thiazol-2-yl]-3-(4-fluorophenyl)sulfonyl-propanamide
  • N-[4-(2,5-dimethylphenyl)-2-thiazolyl]-3-(4-fluorophenyl)sulfonylpropanamide
  • N-[4-(2,5-dimethylphenyl)thiazol-2-yl]-3-(4-fluorophenyl)sulfonyl-propionamide
  • N-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]-3-(4-fluorophenyl)sulfonyl-propanamide
  • ZINC04496268

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) endoplasmin 0.0045 0.0169 0.0098
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0127 0.18
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0095 0.0023
Brugia malayi hypothetical protein 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 0.9998
Schistosoma mansoni heat shock protein 0.0045 0.0169 0.0098
Onchocerca volvulus 0.004 0.0135 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.01 0.0316
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0151 0.0278
Echinococcus granulosus heat shock protein 90 0.0045 0.0169 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Onchocerca volvulus 0.004 0.0135 1
Onchocerca volvulus 0.004 0.0135 1
Onchocerca volvulus 0.004 0.0135 1
Plasmodium falciparum heat shock protein 90, putative 0.017 0.0981 1
Echinococcus granulosus geminin 0.0166 0.0954 0.0889
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Schistosoma mansoni endoplasmin 0.0045 0.0169 0.0098
Echinococcus multilocularis endoplasmin 0.0042 0.0151 0.008
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0169 0.1074
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Plasmodium vivax heat shock protein, putative 0.017 0.0981 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.01 0.0316
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Schistosoma mansoni transcription factor btf3 0.0034 0.01 0.0029
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Brugia malayi beta-NAC-like protein 0.0034 0.01 0.0029
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 1
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 0.9998
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0151 0.817
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Onchocerca volvulus 0.004 0.0135 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0169 0.2396
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0127 0.0214
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0151 0.5
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0169 0.0326
Entamoeba histolytica hypothetical protein 0.0034 0.01 0.294
Trichomonas vaginalis Sialidase-1 precursor, putative 0.0603 0.3781 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.0135 0.191
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.0135 0.6487
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Plasmodium vivax endoplasmin, putative 0.0045 0.0169 0.1074
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.01 0.0142
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Echinococcus granulosus protein tyrosine phosphatase n9 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Leishmania major basic transcription factor 3a, putative 0.0034 0.01 0.294
Schistosoma mansoni protein-tyrosine phosphatase n9 0.004 0.0135 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0151 0.0278
Onchocerca volvulus 0.004 0.0135 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0636 0.0569
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 0.9998
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0169 0.2396
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Trypanosoma brucei trans-sialidase, putative 0.0128 0.0706 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Brugia malayi hypothetical protein 0.004 0.0135 0.0064
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0135 0.0064
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Echinococcus granulosus transcription factor btf3 0.0034 0.01 0.0029
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0135 0.0064
Brugia malayi Dual specificity protein phosphatase CDC14B 0.004 0.0135 0.0064
Trypanosoma brucei trans-sialidase 0.0128 0.0706 1
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Echinococcus granulosus heat shock protein 0.0045 0.0169 0.0098
Treponema pallidum heat shock protein 90 0.0042 0.0151 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0169 0.2396
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0089 0.0113
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Plasmodium falciparum endoplasmin, putative 0.0033 0.0089 0.045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Schistosoma mansoni hypothetical protein 0.0166 0.0954 0.0889
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0089 0.0113
Schistosoma mansoni hypothetical protein 0.0033 0.0095 0.0023
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0127 0.18
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus multilocularis heat shock protein 0.0045 0.0169 0.0098
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 0.9998
Brugia malayi Endoplasmin precursor 0.0045 0.0169 0.0098
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0127 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0023
Onchocerca volvulus 0.004 0.0135 1
Trichomonas vaginalis conserved hypothetical protein 0.0375 0.2305 0.6048
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0169 1
Brugia malayi hypothetical protein 0.004 0.0135 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.01 0.294
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.01 0.1419
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.01 0.1419
Leishmania major protein-tyrosine phosphatase 1-like protein 0.004 0.0135 0.6487
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0151 0.5
Onchocerca volvulus 0.004 0.0135 1
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.004 0.0135 0.6487
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.01 0.0142
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0195 0.0124
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis geminin 0.0166 0.0954 0.0889
Trypanosoma cruzi heat shock protein, putative 0.003 0.0071 0.1012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.004 0.0135 0.0064
Giardia lamblia Protein tyrosine phosphatase 0.004 0.0135 0.1837
Trypanosoma brucei trans-sialidase, putative 0.0128 0.0706 1
Brugia malayi hypothetical protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Brugia malayi heat shock protein 90 0.0045 0.0169 0.0098
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0151 0.5
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.0135 0.6487
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0195 0.0124
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Leishmania major tyrosine specific protein phosphatase, putative 0.004 0.0135 0.6487
Schistosoma mansoni endoplasmin 0.0045 0.0169 0.0098
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Schistosoma mansoni rgs-gaip interacting protein gipc 0.004 0.0135 0.0064
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis transcription factor btf3 0.0034 0.01 0.0029
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0169 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.004 0.0135 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1565 1 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Loa Loa (eye worm) hypothetical protein 0.0049 0.0195 0.0124
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0135 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.004 0.0135 0.0064
Echinococcus multilocularis heat shock protein 90 0.0038 0.0127 0.0056
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1565 1 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0169 0.1539
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.004 0.0135 0.0064
Loa Loa (eye worm) protein tyrosine phosphatase 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Loa Loa (eye worm) ICD-1 protein 0.0034 0.01 0.0029
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.004 0.0135 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.01 0.0453
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.0135 0.191
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Echinococcus multilocularis 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Brugia malayi hypothetical protein 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Plasmodium falciparum heat shock protein 90 0.0045 0.0169 0.1305
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0169 0.1074
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0169 0.1539
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Onchocerca volvulus 0.004 0.0135 1
Schistosoma mansoni heat shock protein 0.0045 0.0169 0.0098
Brugia malayi Protein-tyrosine phosphatase 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1565 1 1
Onchocerca volvulus 0.004 0.0135 1
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.0981 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.0135 0.0064
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1565 1 1
Onchocerca volvulus 0.004 0.0135 1
Trypanosoma brucei trans-sialidase, putative 0.0128 0.0706 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.004 0.0135 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0636 0.0569
Schistosoma mansoni pcd6 interacting protein-related 0.004 0.0135 0.0064
Trypanosoma brucei trans-sialidase, putative 0.0128 0.0706 1
Trypanosoma brucei protein tyrosine phosphatase 1 0.004 0.0135 0.0998
Echinococcus granulosus endoplasmin 0.0042 0.0151 0.008
Trichomonas vaginalis pten, drome, putative 0.004 0.0135 0.0234
Trypanosoma cruzi trans-sialidase, putative 0.0128 0.0706 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0169 0.1539
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0128 0.0706 1
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.004 0.0135 0.0064
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.0135 0.0064
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0135 0.0064
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0169 0.2396
Leishmania major heat shock protein 83-1 0.0045 0.0169 1
Brugia malayi Protein-tyrosine phosphatase 1 0.004 0.0135 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0135 0.0064
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.01 0.0566
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Brugia malayi Protein-tyrosine phosphatase 0.004 0.0135 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0169 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0603 0.3781 1
Echinococcus granulosus heat shock protein 90 0.0038 0.0127 0.0056
Onchocerca volvulus 0.004 0.0135 1
Onchocerca volvulus 4.1 G protein, putative homolog 0.004 0.0135 1
Echinococcus multilocularis protein tyrosine phosphatase n9 0.004 0.0135 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Onchocerca volvulus 0.004 0.0135 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0195 0.0124
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0169 0.2396
Onchocerca volvulus 0.004 0.0135 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.0135 0.191
Onchocerca volvulus 0.004 0.0135 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.004 0.0135 0.0064
Giardia lamblia Grp94/Hsp90 0.0042 0.0151 0.5748
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0169 0.1539
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0151 0.5
Onchocerca volvulus 0.004 0.0135 1
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.004 0.0135 0.0064
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.004 0.0135 0.0064
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.004 0.0135 0.0064
Trypanosoma brucei trans-sialidase, putative 0.0128 0.0706 1
Onchocerca volvulus 0.004 0.0135 1
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0169 0.1074
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0135 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0135 0.0064
Schistosoma mansoni hypothetical protein 0.0166 0.0954 0.0889
Echinococcus multilocularis hypothetical protein 0.004 0.0135 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.01 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0064
Brugia malayi MH2 domain containing protein 0.0117 0.0636 0.0569
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0135 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064
Echinococcus multilocularis heat shock protein 90 0.0045 0.0169 0.0098
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0135 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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