Detailed information for compound 904582

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.58 | Formula: C25H27N5S
  • H donors: 0 H acceptors: 3 LogP: 4.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1nnc(n1C)SCc1ccncc1)Cc1cccc(c1)c1ccccc1C
  • InChi: 1S/C25H27N5S/c1-19-7-4-5-10-23(19)22-9-6-8-21(15-22)16-29(2)17-24-27-28-25(30(24)3)31-18-20-11-13-26-14-12-20/h4-15H,16-18H2,1-3H3
  • InChiKey: SIOKBKIVMVHEGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit epsilon 0.0086 0.0256 0.1363
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0163
Plasmodium vivax tubulin alpha chain, putative 0.016 0.0645 0.249
Giardia lamblia Gamma tubulin 0.0086 0.0256 0.099
Echinococcus granulosus tar DNA binding protein 0.0068 0.0159 0.0846
Trichomonas vaginalis tubulin, putative 0.0049 0.006 0.0924
Trypanosoma brucei beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus peroxisome assembly protein 26 0.016 0.0645 0.3429
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.0402 0.2139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.006 0.0083
Mycobacterium ulcerans lipase LipD 0.0114 0.0402 0.5672
Plasmodium falciparum tubulin beta chain 0.0086 0.0256 0.099
Echinococcus multilocularis tubulin alpha chain 0.016 0.0645 0.149
Mycobacterium tuberculosis Conserved protein 0.0114 0.0402 0.1108
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.0402 0.1108
Echinococcus granulosus tubulin gamma 1 chain 0.0086 0.0256 0.1363
Trypanosoma cruzi tubulin gamma chain 0.0086 0.0256 0.099
Echinococcus multilocularis tubulin subunit beta 0.0086 0.0256 0.0592
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.1523 0.5882
Loa Loa (eye worm) tubulin beta chain 0.0086 0.0256 0.3974
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.006 0.0933
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Leishmania major beta tubulin 0.0086 0.0256 0.099
Brugia malayi tubulin alpha chain - mouse 0.016 0.0645 0.0893
Echinococcus granulosus expressed conserved protein 0.0098 0.0319 0.1698
Toxoplasma gondii hypothetical protein 0.0053 0.0081 0.0312
Leishmania major beta tubulin 0.0086 0.0256 0.099
Trypanosoma brucei epsilon tubulin 0.0086 0.0256 0.099
Echinococcus granulosus tubulin alpha 1C chain 0.016 0.0645 0.3429
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0039 0.0208
Echinococcus multilocularis Tubulin alpha 1 chain 0.016 0.0645 0.149
Echinococcus granulosus tubulin alpha chain 0.016 0.0645 0.3429
Trypanosoma cruzi beta tubulin, putative 0.0086 0.0256 0.099
Loa Loa (eye worm) tubulin alpha 2 0.0074 0.0192 0.2977
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.0402 0.5672
Leishmania major beta tubulin 0.0086 0.0256 0.099
Trypanosoma brucei beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus tubulin alpha chain 0.016 0.0645 0.3429
Schistosoma mansoni hypothetical protein 0.0395 0.188 1
Trypanosoma brucei tubulin gamma chain 0.0086 0.0256 0.099
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.0402 0.1108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.006 0.032
Brugia malayi Tubulin beta-1 chain 0.0086 0.0256 0.0355
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.0402 0.5672
Brugia malayi alpha-tubulin 0.016 0.0645 0.0893
Trypanosoma cruzi alpha tubulin, putative 0.016 0.0645 0.249
Echinococcus granulosus beta tubulin 0.0086 0.0256 0.1363
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Echinococcus granulosus tubulin alpha 3 chain 0.016 0.0645 0.3429
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0045 0.0174
Leishmania major alpha tubulin 0.016 0.0645 0.249
Mycobacterium ulcerans hypothetical protein 0.0172 0.0709 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Echinococcus granulosus tubulin epsilon chain 0.0086 0.0256 0.1363
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0727 0.3628 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.053 0.2589 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.006 0.032
Toxoplasma gondii ABC1 family protein 0.0114 0.0402 0.1553
Leishmania major alpha tubulin 0.016 0.0645 0.249
Trichomonas vaginalis tubulin, putative 0.0049 0.006 0.0924
Onchocerca volvulus 0.0114 0.0402 0.0345
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0045 0.0174
Giardia lamblia Alpha-tubulin 0.016 0.0645 0.249
Trichomonas vaginalis tubulin gamma chain, putative 0.0086 0.0256 0.3974
Loa Loa (eye worm) hypothetical protein 0.016 0.0645 1
Echinococcus multilocularis protein patched 0.0045 0.0039 0.009
Leishmania major beta tubulin 0.0086 0.0256 0.099
Trypanosoma brucei beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus Tubulin alpha 1 chain 0.016 0.0645 0.3429
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0361 0.192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0402 0.2139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.006 0.0139
Brugia malayi beta-lactamase family protein 0.0114 0.0402 0.0557
Schistosoma mansoni tubulin subunit gamma 0.0086 0.0256 0.1363
Loa Loa (eye worm) alpha-tubulin 0.016 0.0645 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0588 0.136
Leishmania major alpha tubulin 0.016 0.0645 0.249
Entamoeba histolytica tubulin family protein 0.0086 0.0256 0.3936
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0098 0.0379
Leishmania major epsilon tubulin, putative 0.0086 0.0256 0.099
Plasmodium falciparum tubulin gamma chain 0.0086 0.0256 0.099
Trypanosoma cruzi epsilon tubulin, putative 0.0086 0.0256 0.099
Brugia malayi Tubulin gamma chain 0.0086 0.0256 0.0355
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0045 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0159 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0402 0.1553
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0352 0.0489
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.0402 0.1108
Mycobacterium ulcerans hypothetical protein 0.0114 0.0402 0.5672
Echinococcus multilocularis geminin 0.0395 0.188 0.4345
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0402 0.6237
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus tubulin alpha chain 0.016 0.0645 0.3429
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0123 0.0448 0.6951
Brugia malayi Tubulin beta chain 0.0049 0.006 0.0083
Leishmania major beta tubulin 0.0086 0.0256 0.099
Trichomonas vaginalis tubulin alpha chain, putative 0.0049 0.006 0.0924
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0039 0.0208
Schistosoma mansoni tubulin subunit alpha 0.016 0.0645 0.3429
Leishmania major beta tubulin 0.0086 0.0256 0.099
Leishmania major hypothetical protein, conserved 0.0114 0.0402 0.1553
Echinococcus granulosus Tubulin beta 2C chain 0.0086 0.0256 0.1363
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Echinococcus multilocularis tubulin subunit TubB 0.016 0.0645 0.149
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.0402 0.1108
Leishmania major alpha tubulin 0.016 0.0645 0.249
Plasmodium falciparum telomerase reverse transcriptase 0.053 0.2589 1
Entamoeba histolytica tubulin alpha-1 chain 0.016 0.0645 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0123 0.0448 0.6951
Toxoplasma gondii alpha-tubulin I, putative 0.016 0.0645 0.249
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0004 0.0022
Echinococcus granulosus tubulin alpha 1C chain 0.016 0.0645 0.3429
Echinococcus multilocularis tubulin gamma 1 chain 0.0086 0.0256 0.0592
Echinococcus multilocularis tubulin alpha chain 0.016 0.0645 0.149
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0402 0.1553
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.0402 0.6237
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0045 0.0174
Echinococcus granulosus tubulin alpha chain 0.016 0.0645 0.3429
Plasmodium vivax tubulin beta chain, putative 0.0086 0.0256 0.099
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.0402 0.1553
Echinococcus granulosus alpha tubulin 0.016 0.0645 0.3429
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0037 0 0.5
Giardia lamblia Telomerase catalytic subunit 0.053 0.2589 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0004 0.0009
Trichomonas vaginalis tubulin alpha chain, putative 0.0049 0.006 0.0924
Echinococcus granulosus Tubulin beta 2C chain 0.0086 0.0256 0.1363
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0159 0.022
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0086 0.0256 0.099
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus tubulin subunit beta 0.0086 0.0256 0.1363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.032
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0617 0.2384
Trypanosoma brucei alpha tubulin 0.016 0.0645 0.249
Loa Loa (eye worm) hypothetical protein 0.0123 0.0448 0.6951
Leishmania major beta tubulin 0.0086 0.0256 0.099
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Brugia malayi Tubulin alpha chain 0.016 0.0645 0.0893
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0039 0.0606
Trypanosoma brucei beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus Tubulin beta 2C chain 0.0086 0.0256 0.1363
Trypanosoma cruzi epsilon tubulin, putative 0.0086 0.0256 0.099
Toxoplasma gondii beta tubulin 0.0086 0.0256 0.099
Trypanosoma brucei alpha tubulin, putative 0.0049 0.006 0.023
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Plasmodium falciparum tubulin epsilon chain, putative 0.0086 0.0256 0.099
Echinococcus granulosus tubulin subunit TubB 0.016 0.0645 0.3429
Echinococcus granulosus tubulin beta 1 chain 0.0086 0.0256 0.1363
Echinococcus multilocularis tubulin alpha 1C chain 0.016 0.0645 0.149
Leishmania major beta tubulin 0.0086 0.0256 0.099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0402 0.2139
Brugia malayi TAR-binding protein 0.0068 0.0159 0.022
Onchocerca volvulus 0.0114 0.0402 0.0345
Loa Loa (eye worm) tubulin alpha-2 chain 0.016 0.0645 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0086 0.0256 0.3974
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.032
Echinococcus granulosus tubulin beta 4A class IVa 0.0086 0.0256 0.1363
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus multilocularis protein dispatched 1 0.0051 0.0072 0.0167
Echinococcus multilocularis tubulin alpha chain 0.016 0.0645 0.149
Echinococcus granulosus tubulin alpha 0.0086 0.0256 0.1363
Brugia malayi Tubulin alpha-2 chain 0.016 0.0645 0.0893
Trichomonas vaginalis tubulin epsilon chain, putative 0.0086 0.0256 0.3974
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Giardia lamblia Alpha-tubulin 0.016 0.0645 0.249
Echinococcus multilocularis beta tubulin 0.0086 0.0256 0.0592
Loa Loa (eye worm) tubulin alpha chain 0.016 0.0645 1
Echinococcus granulosus tubulin alpha 3 chain 0.016 0.0645 0.3429
Plasmodium falciparum alpha tubulin 1 0.016 0.0645 0.249
Trypanosoma brucei epsilon tubulin 0.0086 0.0256 0.099
Echinococcus multilocularis Tubulin alpha 1 chain 0.016 0.0645 0.149
Trichomonas vaginalis tubulin gamma chain, putative 0.0086 0.0256 0.3974
Echinococcus granulosus tubulin alpha chain 0.016 0.0645 0.3429
Echinococcus multilocularis tubulin alpha chain 0.016 0.0645 0.149
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0352 0.1875
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.0402 0.1108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0004 0.0022
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.016 0.0645 1
Leishmania major gamma-tubulin 0.0086 0.0256 0.099
Echinococcus multilocularis tubulin epsilon chain 0.0086 0.0256 0.0592
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.0256 0.3974
Brugia malayi Tubulin alpha-2 chain 0.016 0.0645 0.0893
Loa Loa (eye worm) tubulin alpha 2 0.0123 0.0448 0.6951
Trichomonas vaginalis tubulin beta chain, putative 0.0086 0.0256 0.3974
Echinococcus multilocularis Tubulin beta 2C chain 0.0086 0.0256 0.0592
Mycobacterium tuberculosis Conserved protein 0.0114 0.0402 0.1108
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0402 0.6237
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0159 0.0846
Leishmania major beta tubulin 0.0086 0.0256 0.099
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus geminin 0.0395 0.188 1
Leishmania major alpha tubulin 0.016 0.0645 0.249
Brugia malayi tubulin alpha-2 chain 0.016 0.0645 0.0893
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0617 0.2384
Echinococcus multilocularis peroxisome assembly protein 26 0.016 0.0645 0.149
Leishmania major alpha tubulin 0.016 0.0645 0.249
Brugia malayi Telomerase reverse transcriptase 0.1409 0.7215 1
Schistosoma mansoni tubulin subunit alpha 0.016 0.0645 0.3429
Leishmania major beta tubulin 0.0086 0.0256 0.099
Schistosoma mansoni hypothetical protein 0.0038 0.0004 0.0022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.4326 1
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0159 0.2466
Giardia lamblia Beta tubulin 0.0086 0.0256 0.099
Loa Loa (eye worm) tubulin beta-1 chain 0.0086 0.0256 0.3974
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0352 0.0815
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0159 0.0846
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0402 0.6237
Brugia malayi beta-lactamase 0.0114 0.0402 0.0557
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0402 0.1553
Loa Loa (eye worm) hypothetical protein 0.0111 0.0388 0.6026
Trichomonas vaginalis tubulin, putative 0.0086 0.0256 0.3974
Trichomonas vaginalis tubulin gamma chain, putative 0.0086 0.0256 0.3974
Brugia malayi hypothetical protein 0.0038 0.0004 0.0006
Plasmodium vivax tubulin epsilon chain, putative 0.0086 0.0256 0.099
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Loa Loa (eye worm) BEN-1 protein 0.0086 0.0256 0.3974
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.0402 0.0557
Onchocerca volvulus 0.0114 0.0402 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.1523 0.5882
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.0402 0.0929
Leishmania major alpha tubulin 0.016 0.0645 0.249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.006 0.0139
Treponema pallidum cell division protein FtsZ 0.0037 0 0.5
Trypanosoma brucei beta tubulin 0.0086 0.0256 0.099
Trichomonas vaginalis tubulin epsilon chain, putative 0.016 0.0645 1
Trypanosoma brucei alpha tubulin 0.016 0.0645 0.249
Echinococcus multilocularis Tubulin beta 2C chain 0.0086 0.0256 0.0592
Schistosoma mansoni hypothetical protein 0.0395 0.188 1
Schistosoma mansoni alpha tubulin 0.016 0.0645 0.3429
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0111 0.0388 0.6026
Loa Loa (eye worm) RNA binding protein 0.0068 0.0159 0.2466
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.0709 0.1954
Leishmania major alpha tubulin 0.016 0.0645 0.249
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0086 0.0256 0.0592
Toxoplasma gondii alpha tubulin TUBA1 0.016 0.0645 0.249
Entamoeba histolytica tubulin gamma chain 0.0086 0.0256 0.3936
Loa Loa (eye worm) BEN-1 protein 0.0086 0.0256 0.3974
Trichomonas vaginalis esterase, putative 0.0114 0.0402 0.6237
Schistosoma mansoni tubulin subunit beta 0.0086 0.0256 0.1363
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0617 0.2384
Plasmodium falciparum alpha tubulin 2 0.016 0.0645 0.249
Echinococcus multilocularis tubulin alpha 0.0086 0.0256 0.0592
Brugia malayi RNA binding protein 0.0068 0.0159 0.022
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0588 0.3129
Schistosoma mansoni patched 1 0.0045 0.0039 0.0208
Brugia malayi beta-tubulin, identical 0.0086 0.0256 0.0355
Echinococcus multilocularis tubulin alpha 3 chain 0.016 0.0645 0.149
Leishmania major beta tubulin 0.0086 0.0256 0.099
Echinococcus granulosus beta tubulin 0.0086 0.0256 0.1363
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0049 0.006 0.0924
Trypanosoma brucei alpha tubulin 0.016 0.0645 0.249
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.0402 0.1108
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.1523 0.5882
Mycobacterium leprae Probable lipase LipE 0.0114 0.0402 1
Trypanosoma brucei epsilon tubulin 0.0086 0.0256 0.099
Loa Loa (eye worm) tubulin alpha 2 0.0123 0.0448 0.6951
Echinococcus granulosus Tubulin beta 2C chain 0.0086 0.0256 0.1363
Mycobacterium tuberculosis Conserved protein 0.0114 0.0402 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0159 0.0846
Echinococcus multilocularis tubulin alpha 3 chain 0.016 0.0645 0.149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0352 0.5468
Plasmodium vivax tubulin gamma chain, putative 0.0086 0.0256 0.099
Leishmania major alpha tubulin 0.016 0.0645 0.249
Trichomonas vaginalis tubulin epsilon chain, putative 0.0086 0.0256 0.3974
Entamoeba histolytica tubulin alpha chain, putative 0.016 0.0645 1
Echinococcus multilocularis hypothetical protein 0.016 0.0645 0.149
Echinococcus granulosus Tubulin alpha 1 chain 0.016 0.0645 0.3429
Echinococcus multilocularis Tubulin beta 2C chain 0.0086 0.0256 0.0592
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0159 0.0368
Loa Loa (eye worm) alpha-tubulin 0.016 0.0645 1
Plasmodium vivax tubulin alpha chain, putative 0.016 0.0645 0.249
Toxoplasma gondii beta-tubulin, putative 0.0086 0.0256 0.099
Plasmodium vivax telomerase reverse transcriptase, putative 0.053 0.2589 1
Mycobacterium leprae conserved hypothetical protein 0.0114 0.0402 1
Leishmania major alpha tubulin 0.016 0.0645 0.249
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0402 0.6237
Echinococcus multilocularis Tubulin beta 2C chain 0.0086 0.0256 0.0592
Echinococcus multilocularis expressed conserved protein 0.0098 0.0319 0.0738
Toxoplasma gondii RNA-directed DNA polymerase 0.053 0.2589 1
Mycobacterium ulcerans beta-lactamase 0.0114 0.0402 0.5672
Loa Loa (eye worm) hypothetical protein 0.0055 0.0092 0.1428
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0163
Leishmania major beta tubulin 0.0086 0.0256 0.099
Leishmania major alpha tubulin 0.016 0.0645 0.249
Loa Loa (eye worm) hypothetical protein 0.0114 0.0402 0.6237
Toxoplasma gondii beta-1 tubulin, putative 0.0086 0.0256 0.099
Trypanosoma brucei alpha tubulin 0.016 0.0645 0.249
Giardia lamblia Beta tubulin 0.0086 0.0256 0.099
Trichomonas vaginalis tubulin epsilon chain, putative 0.016 0.0645 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0352 0.5439
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0163
Echinococcus granulosus Tubulin beta 2C chain 0.0086 0.0256 0.1363
Loa Loa (eye worm) tubulin beta-2A chain 0.0086 0.0256 0.3974
Loa Loa (eye worm) beta-tubulin 0.0086 0.0256 0.3974
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.053 0.2589 1
Echinococcus multilocularis beta tubulin 0.0086 0.0256 0.0592
Loa Loa (eye worm) beta-lactamase 0.0114 0.0402 0.6237
Trypanosoma brucei telomerase reverse transcriptase 0.053 0.2589 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.016 0.0645 0.149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.032
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0039 0.009
Trichomonas vaginalis tubulin alpha chain, putative 0.0049 0.006 0.0924
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0159 0.0846
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.0402 0.1108
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.0256 0.3974
Schistosoma mansoni alpha tubulin 0.016 0.0645 0.3429
Echinococcus multilocularis tubulin alpha 1C chain 0.016 0.0645 0.149
Loa Loa (eye worm) tubulin alpha-3 chain 0.0111 0.0388 0.6026
Loa Loa (eye worm) tubulin alpha chain 0.016 0.0645 1
Trichomonas vaginalis tubulin beta chain, putative 0.0049 0.006 0.0924
Echinococcus multilocularis tubulin alpha chain 0.016 0.0645 0.149
Giardia lamblia Beta tubulin 0.0086 0.0256 0.099
Entamoeba histolytica tubulin family protein 0.0086 0.0256 0.3936
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0402 0.6237
Leishmania major beta tubulin 0.0086 0.0256 0.099
Loa Loa (eye worm) tubulin gamma chain 0.0086 0.0256 0.3974
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.1523 0.5882
Echinococcus multilocularis Tubulin beta 2C chain 0.0086 0.0256 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0039 0.0606
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.0645 1
Schistosoma mansoni tubulin subunit alpha 0.016 0.0645 0.3429
Schistosoma mansoni alpha tubulin 0.016 0.0645 0.3429
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0606
Leishmania major telomerase reverse transcriptase, putative 0.053 0.2589 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0159 0.2466
Brugia malayi beta-lactamase family protein 0.0114 0.0402 0.0557
Echinococcus granulosus Tubulin alpha 1 chain 0.016 0.0645 0.3429
Brugia malayi CHE-14 protein 0.0045 0.0039 0.0054
Leishmania major alpha tubulin 0.016 0.0645 0.249
Echinococcus multilocularis tubulin beta 1 chain 0.0086 0.0256 0.0592

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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