TDR Targets

Basic information

Technical information

TDR Targets ID: 909400
Name: ethyl 2-[(4-chlorophenyl)sulfonylamino]benzoa te
MW: 339.794 | Formula: C15H14ClNO4S
H donors: 1 H acceptors: 3 LogP: 3.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccccc1NS(=O)(=O)c1ccc(cc1)Cl
InChi: 1S/C15H14ClNO4S/c1-2-21-15(18)13-5-3-4-6-14(13)17-22(19,20)12-9-7-11(16)8-10-12/h3-10,17H,2H2,1H3
InChiKey: JTRAEMIESZUYMS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-chlorophenyl)sulfonylamino]benzoic acid ethyl ester
BIM-0011776.P001
AK-968/11635432
ZINC00123179
ST012648
CBMicro_011552

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0102	0.5
Brugia malayi	beta-lactamase	0.0035	0.0556	0.0645
Trypanosoma brucei	trypanothione reductase	0.0046	0.0826	0.0851
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0826	0.0851
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0456	0.053
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0102	0.0118
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Brugia malayi	GnHR receptor homolog	0.0012	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2051	0.2047
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0556	0.0645
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.2245	0.857
Brugia malayi	sulfakinin receptor protein	0.0012	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0031	0.0456	0.1229
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.5069	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0556	0.0913
Leishmania major	C-14 sterol reductase, putative	0.0088	0.1829	0.2031
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Leishmania major	trypanothione reductase	0.0046	0.0826	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1313	0.1308
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0005	0.0006
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0088	0.1829	0.4969
Echinococcus multilocularis	lamin b receptor	0.0088	0.1829	0.4969
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0046	0.0815	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.2245	0.4315
Brugia malayi	Serotonin receptor	0.0012	0.0005	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0556	0.0533
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0102	0.5
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0102	0.0264
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0005	0.0006
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0088	0.1829	0.2031
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0556	1
Echinococcus granulosus	geminin	0.0165	0.3677	1
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0266	0.6106	0.706
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0556	1
Onchocerca volvulus		0.0035	0.0556	0.0902
Onchocerca volvulus		0.0035	0.0556	0.0902
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0005	0.0006
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0556	1
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0005	0.0006
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0102	0.0264
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0826	0.0821
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.189	0.5135
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0556	0.15
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0088	0.1829	0.2031
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0556	1
Brugia malayi	G-protein coupled receptor	0.0012	0.0005	0.0006
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Brugia malayi	MH2 domain containing protein	0.0116	0.2507	0.2913
Brugia malayi	Serotonin receptor	0.0012	0.0005	0.0006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.2051	0.2047
Treponema pallidum	NADH oxidase	0.0016	0.0102	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0556	0.0533
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0456	0.1229
Brugia malayi	beta-lactamase family protein	0.0035	0.0556	0.0645
Schistosoma mansoni	hypothetical protein	0.0031	0.0456	0.1229
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0266	0.6106	0.706
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0556	0.0913
Brugia malayi	beta-lactamase family protein	0.0035	0.0556	0.0645
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.189	0.5135
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0556	0.0913
Brugia malayi	RE15519p	0.0012	0.0005	0.0006
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0456	0.1229
Trypanosoma brucei	Emopamil binding protein, putative	0.0266	0.6106	0.706
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0556	0.0913
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0556	0.0913
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0826	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0556	0.15
Brugia malayi	putative neuropeptide receptor	0.0012	0.0005	0.0006
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0556	0.0551
Leishmania major	hypothetical protein, conserved	0.0266	0.6106	0.706
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2507	0.2503
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0556	0.0551
Onchocerca volvulus		0.0266	0.6106	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0456	0.0451
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0556	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0556	0.0533
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.2245	0.4315
Brugia malayi	AKH receptor	0.0012	0.0005	0.0006
Brugia malayi	Dopamine receptor	0.0012	0.0005	0.0006
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0066	0.1313	0.3561
Leishmania major	sterol C-24 reductase, putative	0.0046	0.0815	0.0838
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0005	0.0006
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0102	0.5
Leishmania major	hypothetical protein, conserved	0.0035	0.0556	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.2051	0.2382
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.2527	0.4883
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0371	0.8607	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.189	0.1886
Brugia malayi	glutathione reductase	0.0046	0.0826	0.096
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0556	0.0913
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.2245	0.4315
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0826	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0556	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.189	0.5135
Loa Loa (eye worm)	hypothetical protein	0.0371	0.8607	0.8606
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.2051	0.2382
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0556	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.4261	0.4258
Brugia malayi	larval opioid receptor	0.0012	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0031	0.0456	0.1229
Toxoplasma gondii	ABC1 family protein	0.0035	0.0556	0.6266
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0266	0.6106	0.706
Mycobacterium ulcerans	lipase LipD	0.0035	0.0556	1
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0556	0.15
Leishmania major	C-8 sterol isomerase-like protein	0.0371	0.8607	1
Trypanosoma cruzi	Emopamil binding protein, putative	0.0266	0.6106	0.706
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0005	0.0006
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0371	0.8607	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0826	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0456	0.053
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0556	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Brugia malayi	G protein-coupled receptor	0.0012	0.0005	0.0006
Echinococcus granulosus	lamin b receptor	0.0088	0.1829	0.4969
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2507	0.2503
Schistosoma mansoni	hypothetical protein	0.0165	0.3677	1
Brugia malayi	neuropeptide F receptor	0.0012	0.0005	0.0006
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0456	0.1229
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.2245	0.4315
Trypanosoma cruzi	Emopamil binding protein, putative	0.0266	0.6106	0.706
Schistosoma mansoni	hypothetical protein	0.0031	0.0456	0.1229
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0556	0.0913
Trypanosoma brucei	C-14 sterol reductase, putative	0.0088	0.1829	0.2031
Echinococcus multilocularis	geminin	0.0165	0.3677	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0556	0.0551
Plasmodium falciparum	glutathione reductase	0.0046	0.0826	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.189	0.5135
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0102	0.5
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.2527	0.4883
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.189	0.5135
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.2527	1
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0826	1
Loa Loa (eye worm)	hypothetical protein	0.0429	1	1
Brugia malayi	hypothetical protein	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.2527	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0815	0.081
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.189	0.5135
Schistosoma mansoni	hypothetical protein	0.0165	0.3677	1
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0005	0.0006
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0005	0.0006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.189	0.5135
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0826	0.1458
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0826	0.2236
Brugia malayi	Thioredoxin reductase	0.0046	0.0826	0.096
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.1313	0.1525
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0456	0.0451
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0826	0.0821
Brugia malayi	G-protein coupled receptor	0.0012	0.0005	0.0006
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0005	0.0006
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0102	0.0264
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0456	0.1229
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0456	0.1229
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0371	0.8607	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.2245	0.4315
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0556	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0556	0.6266
Echinococcus granulosus	GPCR family 2	0.0031	0.0456	0.1229
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0826	0.2236
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0556	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0556	0.0913
Trichomonas vaginalis	esterase, putative	0.0035	0.0556	1
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0046	0.0815	0.0838
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.189	0.2196
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0556	0.0913
Brugia malayi	neuropeptide F receptor	0.0012	0.0005	0.0006
Mycobacterium tuberculosis	Probable reductase	0.0105	0.2245	0.4315
Onchocerca volvulus		0.0035	0.0556	0.0902
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0556	0.15

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 909400