TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.464 | Formula: C23H23FN6O5
H donors: 4 H acceptors: 8 LogP: -0.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@@H](O)[C@@H]([C@H]([C@@H]1O)O)n1nnc(c1)c1nc(c(n1C)c1ccncc1)c1ccc(cc1)F
InChi: 1S/C23H23FN6O5/c1-29-18(13-6-8-25-9-7-13)17(12-2-4-14(24)5-3-12)26-22(29)15-10-30(28-27-15)19-21(33)20(32)16(11-31)35-23(19)34/h2-10,16,19-21,23,31-34H,11H2,1H3/t16-,19-,20-,21-,23-/m1/s1
InChiKey: OXLSSSLDAPCKMJ-DSKKVCCRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 1, delta	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	casein kinase I, isoform 2	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	casein kinase, delta isoform, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Plasmodium knowlesi	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	Casein kinase I isoform delta, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Cryptosporidium hominis	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Entamoeba histolytica	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania mexicana	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma brucei gambiense	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Candida albicans	Casein kinase I: DNA repair, meiosis	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Giardia lamblia	Kinase, CK1 Casein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Trichomonas vaginalis	CK1 family protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania braziliensis	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Theileria parva	casein kinase I, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, delta isoform, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Plasmodium berghei	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma congolense	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Neospora caninum	AFL091Wp, related	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K02218 casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma japonicum	ko:K08959 casein kinase 1, delta, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Toxoplasma gondii	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania major	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	Casein kinase I: DNA repair, meiosis	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania infantum	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Brugia malayi	casein kinase 1, delta	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium falciparum	casein kinase 1	Get druggable targets OG5_126780	All targets in OG5_126780
Onchocerca volvulus		Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	casein kinase I delta	Get druggable targets OG5_126780	All targets in OG5_126780
Cryptosporidium parvum	casein kinase I	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium yoelii	casein kinase i	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Onchocerca volvulus		Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma congolense	casein kinase I, isoform 2	Get druggable targets OG5_126780	All targets in OG5_126780
Babesia bovis	casein kinase I, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Trypanosoma cruzi	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Plasmodium vivax	casein kinase 1, putative	Get druggable targets OG5_126780	All targets in OG5_126780
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Echinococcus granulosus	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	Get druggable targets OG5_126780	All targets in OG5_126780
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	casein kinase I alpha	Get druggable targets OG5_126780	All targets in OG5_126780
Leishmania donovani	casein kinase, putative	Get druggable targets OG5_126780	All targets in OG5_126780

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0157	0.0177	0.0975
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0157	0.0177	0.0975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0157	0.0177	1
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0157	0.0177	0.0975
Onchocerca volvulus	4.1 G protein, putative homolog	0.0157	0.0177	0.0192
Schistosoma mansoni	protein tyrosine phosphatase	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Trichomonas vaginalis	pten, drome, putative	0.0157	0.0177	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0278	0.0769	0.4239
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0157	0.0177	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0157	0.0177	0.0975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0157	0.0177	0.0975
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Brugia malayi	Protein-tyrosine phosphatase	0.0157	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.1875	0.8633	0.9176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.1875	0.8633	0.9176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0278	0.0769	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0278	0.0769	0.4239
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0153	0.0154	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0157	0.0177	0.0188
Brugia malayi	hypothetical protein	0.0157	0.0177	0.0177
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0153	0.0154	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Brugia malayi	hypothetical protein	0.0157	0.0177	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0278	0.0769	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	hypothetical protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Leishmania major	tyrosine specific protein phosphatase, putative	0.0157	0.0177	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0278	0.0769	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Onchocerca volvulus		0.0157	0.0177	0.0192
Onchocerca volvulus		0.0157	0.0177	0.0192
Onchocerca volvulus		0.0157	0.0177	0.0192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Onchocerca volvulus		0.0157	0.0177	0.0192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0278	0.0769	0.4239
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0157	0.0177	1
Onchocerca volvulus		0.1995	0.9225	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.049	0.1815	0.1929
Brugia malayi	hypothetical protein	0.0157	0.0177	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0157	0.0177	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0278	0.0769	0.4239
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0157	0.0177	0.0975
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0157	0.0177	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0157	0.0177	0.0975
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0157	0.0177	0.0975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0157	0.0177	0.0975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0278	0.0769	0.4239
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.049	0.1815	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Echinococcus multilocularis		0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0157	0.0177	0.0975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0153	0.0154	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Giardia lamblia	Protein tyrosine phosphatase	0.0157	0.0177	0.5
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0153	0.0154	0.0846
Onchocerca volvulus		0.0157	0.0177	0.0192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	P38 map kinase family protein 2	0.0153	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0157	0.0177	0.0188
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0157	0.0177	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0278	0.0769	0.4239
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Schistosoma mansoni	protein tyrosine phosphatase	0.0157	0.0177	0.0975
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0278	0.0769	0.4239
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0157	0.0177	0.0975
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0278	0.0769	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0278	0.0769	0.0818
Onchocerca volvulus		0.0157	0.0177	0.0192
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0157	0.0177	0.0188
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0153	0.0154	0.0846
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Schistosoma mansoni	pcd6 interacting protein-related	0.0157	0.0177	0.0975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0278	0.0769	0.4239
Onchocerca volvulus		0.0157	0.0177	0.0192
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0157	0.0177	0.0975
Onchocerca volvulus		0.0157	0.0177	0.0192
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0157	0.0177	0.0177
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0278	0.0769	0.4239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Onchocerca volvulus		0.0157	0.0177	0.0192
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0278	0.0769	0.4239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0157	0.0177	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.0177	0.0975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Schistosoma mansoni	protein tyrosine phosphatase	0.0278	0.0769	0.4239
Onchocerca volvulus		0.0157	0.0177	0.0192
Echinococcus multilocularis	hypothetical protein	0.0157	0.0177	0.0975
Echinococcus granulosus	mitogen activated protein kinase 11	0.0153	0.0154	0.0846
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.049	0.1815	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0157	0.0177	0.0177
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0157	0.0177	0.0188
Brugia malayi	hypothetical protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Echinococcus granulosus	mitogen activated protein kinase 14	0.0153	0.0154	0.0846
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.049	0.1815	0.1815
Brugia malayi	Protein-tyrosine phosphatase 1	0.0157	0.0177	0.0177
Onchocerca volvulus		0.0157	0.0177	0.0192
Loa Loa (eye worm)	hypothetical protein	0.2032	0.9408	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.1875	0.8633	0.9176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.049	0.1815	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0278	0.0769	0.4239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0157	0.0177	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0177	0.0188
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.0177	0.0177
Onchocerca volvulus		0.0157	0.0177	0.0192
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0157	0.0177	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.439 uM	Inhibition of CK1-delta (unknown origin) by radiometric assay	ChEMBL.	24930833
IC50 (binding)	= 1.02 uM	Inhibition of p38alpha MAPK (unknown origin) by radiometric assay	ChEMBL.	24930833
IC50 (binding)	> 100 uM	Inhibition of JAK1 (unknown origin) by radiometric assay	ChEMBL.	24930833
IC50 (binding)	> 100 uM	Inhibition of JAK2 (unknown origin) by radiometric assay	ChEMBL.	24930833
IC50 (binding)	> 100 uM	Inhibition of JAK3 (unknown origin) by radiometric assay	ChEMBL.	24930833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3314270

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 919578