Detailed information for compound 921585

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.529 | Formula: C25H29N5O4
  • H donors: 5 H acceptors: 4 LogP: 1.68 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N)Cc1ccccc1)Cc1c(C)[nH]c2c1cccc2
  • InChi: 1S/C25H29N5O4/c1-15-19(18-10-6-7-11-20(18)28-15)13-22(29-16(2)31)25(34)30-21(24(33)27-14-23(26)32)12-17-8-4-3-5-9-17/h3-11,21-22,28H,12-14H2,1-2H3,(H2,26,32)(H,27,33)(H,29,31)(H,30,34)/t21-,22+/m0/s1
  • InChiKey: DIZHOMBRKQIQQB-FCHUYYIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus somatostatin receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) matrixin family protein 0.0058 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0459 0.0458
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0219 0.1292 0.1291
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0004 0.0004
Brugia malayi CD36 family protein 0.0051 0.0148 0.0148
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0004 0.0002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0623 0.4037 0.4036
Loa Loa (eye worm) fibroinase 0.0029 0.0001 0.0001
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0284 0.173 0.1729
Echinococcus multilocularis CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0097 0.0459 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.5308 0.5307
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0158 0.0873 0.0872
Loa Loa (eye worm) hypothetical protein 0.0219 0.1292 0.1292
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0004 0.0002
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0097 0.0459 1
Schistosoma mansoni hypothetical protein 0.0034 0.0033 0.0032
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0158 0.0873 0.0872
Echinococcus granulosus serotonin receptor 0.003 0.0004 0.0002
Echinococcus multilocularis cathepsin b 0.0158 0.0873 0.0872
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0097 0.0459 0.062
Trypanosoma brucei cysteine peptidase C (CPC) 0.0055 0.0175 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0459 0.0459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0004 0.0002
Schistosoma mansoni CD36-like class B scavenger receptor 0.0051 0.0148 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.5835 0.5834
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0004 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0004 0.0002
Echinococcus granulosus sex peptide receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.173 0.173
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1499 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.3221 0.322
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0097 0.0459 0.0458
Loa Loa (eye worm) phosphatidylinositol kinase 0.0097 0.0459 0.0459
Echinococcus multilocularis g protein coupled receptor 0.003 0.0004 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0004 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0004 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptide receptor 0.003 0.0004 0.0002
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0097 0.0459 0.0458
Schistosoma mansoni biogenic amine receptor 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptide receptor 0.003 0.0004 0.0002
Brugia malayi Melatonin receptor type 1A 0.003 0.0004 0.0004
Onchocerca volvulus 0.003 0.0004 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0109 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.3221 0.322
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0896 0.5895 0.5895
Brugia malayi larval opioid receptor 0.003 0.0004 0.0004
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0219 0.1292 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0097 0.0459 0.0459
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma brucei unspecified product 0.0038 0.006 0.0058
Loa Loa (eye worm) matrixin family protein 0.0053 0.0164 0.0164
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus hypothetical protein 0.003 0.0004 0.0002
Brugia malayi polk-prov protein 0.0034 0.0034 0.0034
Brugia malayi Matrixin family protein 0.0058 0.0196 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0097 0.0459 0.0458
Leishmania major hypothetical protein, conserved 0.0097 0.0459 0.0458
Onchocerca volvulus 0.0097 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0503 0.3221 0.322
Brugia malayi G-protein coupled receptor 0.003 0.0004 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1499 1 1
Schistosoma mansoni CD36-like class B scavenger receptor 0.0051 0.0148 0.0147
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0097 0.0459 0.0458
Loa Loa (eye worm) phosphatidylinositol 3 0.0503 0.3221 0.3221
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0097 0.0459 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0004 0.0002
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0097 0.0459 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0459 0.0459
Toxoplasma gondii FATC domain-containing protein 0.0284 0.173 0.2341
Loa Loa (eye worm) ctsf protein 0.0029 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.1072 0.1071
Echinococcus multilocularis g protein coupled receptor 0.003 0.0004 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0004 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0004 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0459 0.0459
Brugia malayi cathepsin B-like cysteine proteinase 0.0158 0.0873 0.0873
Echinococcus granulosus dna polymerase kappa 0.0045 0.0109 0.0108
Entamoeba histolytica hypothetical protein 0.0097 0.0459 0.0458
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0004 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0004 0.0051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0097 0.0459 0.062
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1194 0.7922 0.7921
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0414 0.0414
Schistosoma mansoni histamine h1 receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0284 0.173 0.1729
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1499 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0001 0.0001
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Brugia malayi Dopamine receptor protein 1 0.003 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0097 0.0459 0.0458
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0004 0.0004
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0097 0.0459 0.0458
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0097 0.0459 0.0458
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0109 0.0108
Echinococcus granulosus g protein coupled receptor 0.003 0.0004 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0097 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni opsin-like receptor 0.003 0.0004 0.0002
Schistosoma mansoni opsin-like receptor 0.003 0.0004 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0414 0.0414
Trypanosoma cruzi target of rapamycin kinase 3 0.1194 0.7922 0.7921
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0004 0.0002
Echinococcus multilocularis 0.0097 0.0459 0.0458
Onchocerca volvulus 0.003 0.0004 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0004 0.0002
Brugia malayi putative neuropeptide receptor 0.003 0.0004 0.0004
Brugia malayi GnHR receptor homolog 0.003 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0097 0.0459 0.0458
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.0459 0.0458
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1499 1 1
Loa Loa (eye worm) cysteine protease 0.0029 0.0001 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0284 0.173 0.1729
Echinococcus granulosus orexin receptor type 2 0.003 0.0004 0.0002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0503 0.3221 0.322
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.7913 0.7913
Brugia malayi G protein-coupled receptor 0.003 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0503 0.3221 0.322
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0097 0.0459 0.0458
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0097 0.0459 0.0458
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0503 0.3221 0.3221
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.0051 0.0148 0.0148
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0503 0.3221 0.322
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0004 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Brugia malayi Dopamine receptor protein 2 0.003 0.0004 0.0004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1194 0.7922 0.7921
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0004 0.0004
Entamoeba histolytica protein kinase rad3, putative 0.0284 0.173 0.1729
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0284 0.173 0.1729
Echinococcus granulosus CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Leishmania major phosphatidylinositol kinase related protein, putative 0.0097 0.0459 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0414 0.0413
Schistosoma mansoni fkbp-rapamycin associated protein 0.0284 0.173 0.1729
Brugia malayi Serotonin receptor 0.003 0.0004 0.0004
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0097 0.0459 1
Brugia malayi sulfakinin receptor protein 0.003 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0097 0.0459 0.0458
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0097 0.0459 0.0458
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0097 0.0459 0.0458
Echinococcus granulosus CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0284 0.173 0.1729
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.5308 0.5307
Schistosoma mansoni hypothetical protein 0.003 0.0004 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0109 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0808 0.53 0.5299
Echinococcus granulosus CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0004 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0503 0.3221 0.322
Echinococcus granulosus CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Giardia lamblia GTOR 0.1499 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Onchocerca volvulus 0.003 0.0004 0.0051
Echinococcus granulosus allatostatin A receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0973 0.6422 0.6421
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0097 0.0459 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.3221 0.322
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0109 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Giardia lamblia Hypothetical protein 0.0097 0.0459 0.0288
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0004 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus neuropeptide receptor 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0004 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0004 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0097 0.0459 0.0458
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.1292 0.1291
Echinococcus multilocularis somatostatin receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0004 0.0002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0004 0.0002
Echinococcus multilocularis lysosome membrane protein 2 0.0051 0.0148 0.0147
Echinococcus multilocularis allatostatin A receptor 0.003 0.0004 0.0002
Echinococcus multilocularis fmrfamide receptor 0.003 0.0004 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0004 0.0002
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0097 0.0459 0.0458
Echinococcus granulosus g protein coupled receptor 0.003 0.0004 0.0002
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.7913 0.7913
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.173 0.173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0459 0.0458
Leishmania major phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Onchocerca volvulus Matrilysin homolog 0.0053 0.0164 0.3549
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0097 0.0459 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0284 0.173 0.1729
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0097 0.0459 0.0458
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0004 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0097 0.0459 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.1006 0.6642 0.6642
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0097 0.0459 0.0458
Schistosoma mansoni biogenic amine receptor 0.003 0.0004 0.0002
Brugia malayi neuropeptide F receptor 0.003 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0402 0.2537 0.2536
Echinococcus granulosus serine protein kinase ATM 0.0284 0.173 0.1729
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Plasmodium vivax hypothetical protein 0.0097 0.0459 1
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus cathepsin b 0.0158 0.0873 0.0872
Loa Loa (eye worm) hypothetical protein 0.0306 0.1879 0.1879
Schistosoma mansoni biogenic amine receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1499 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Echinococcus multilocularis CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0004 0.0002
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0087 0.0396 0.0394
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0503 0.3221 0.322
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Schistosoma mansoni cd36 antigen 0.0051 0.0148 0.0147
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0459 0.0459
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0097 0.0459 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0004 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0004 0.0002
Onchocerca volvulus 0.0097 0.0459 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Onchocerca volvulus 0.003 0.0004 0.0051
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1499 1 1
Onchocerca volvulus 0.003 0.0004 0.0051
Loa Loa (eye worm) hypothetical protein 0.0284 0.173 0.173
Leishmania major phosphatidylinositol 3-kinase, putative 0.0503 0.3221 0.322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0284 0.173 0.1729
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0109 0.0108
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0004 0.0051
Onchocerca volvulus 0.0034 0.0033 0.069
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0051 0.0148 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0175 0.0174
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0097 0.0459 0.0458
Leishmania major phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Onchocerca volvulus 0.003 0.0004 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0316 0.195 0.195
Echinococcus multilocularis g protein coupled receptor 0.003 0.0004 0.0002
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0087 0.0396 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.3221 0.322
Schistosoma mansoni amine GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0896 0.5895 0.5895
Entamoeba histolytica hypothetical protein 0.0097 0.0459 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0414 0.0413
Schistosoma mansoni myosin xvIII 0.003 0.0004 0.0002
Brugia malayi Serotonin receptor 0.003 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0414 0.0413
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0097 0.0459 0.0458
Onchocerca volvulus 0.003 0.0004 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0896 0.5895 0.5895
Schistosoma mansoni hypothetical protein 0.0219 0.1292 0.1291
Brugia malayi follicle stimulating hormone receptor 0.003 0.0004 0.0004
Onchocerca volvulus 0.003 0.0004 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0459 1
Schistosoma mansoni opsin-like receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0284 0.173 0.1729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0158 0.0873 0.0872
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1499 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0055 0.0175 0.0174
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0004 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0097 0.0459 0.062
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0284 0.173 0.1729
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.5835 0.5834
Loa Loa (eye worm) hypothetical protein 0.0187 0.1072 0.1072
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0097 0.0459 0.062
Onchocerca volvulus 0.003 0.0004 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.7913 0.7913
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Echinococcus multilocularis serotonin receptor 0.003 0.0004 0.0002
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0097 0.0459 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Brugia malayi Dopamine receptor 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.128 0.8509 0.8508
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0097 0.0459 0.0458
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0414 0.0413
Onchocerca volvulus 0.003 0.0004 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0097 0.0459 0.0458
Loa Loa (eye worm) hypothetical protein 0.0158 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Giardia lamblia Phosphatidylinositol 4-kinase 0.0097 0.0459 0.0288
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Onchocerca volvulus 0.003 0.0004 0.0051
Entamoeba histolytica hypothetical protein 0.0284 0.173 0.1729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0097 0.0459 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Echinococcus granulosus cathepsin b 0.0158 0.0873 0.0872
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0316 0.195 0.2639
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0004 0.0004
Echinococcus granulosus lysosome membrane protein 2 0.0051 0.0148 0.0147
Leishmania major phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.1072 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.1499 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0503 0.3221 0.322
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Onchocerca volvulus 0.003 0.0004 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0004 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0808 0.53 0.5299
Echinococcus multilocularis CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.0459 0.0458
Echinococcus granulosus g protein coupled receptor 0.003 0.0004 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0004 0.0002
Echinococcus multilocularis serotonin receptor 0.003 0.0004 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus neuropeptide s receptor 0.003 0.0004 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1499 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0097 0.0459 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0004 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0004 0.0004
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0004 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0097 0.0459 0.0458
Echinococcus multilocularis fmrfamide receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0097 0.0459 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Schistosoma mansoni amine GPCR 0.003 0.0004 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0097 0.0459 0.0458
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Brugia malayi hypothetical protein 0.0051 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0097 0.0459 0.0458
Echinococcus multilocularis orexin receptor type 2 0.003 0.0004 0.0002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0004 0.0002
Onchocerca volvulus 0.003 0.0004 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Echinococcus multilocularis CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Schistosoma mansoni neuropeptide receptor 0.003 0.0004 0.0002
Schistosoma mansoni amine GPCR 0.003 0.0004 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1499 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0284 0.173 0.1729
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0187 0.1072 0.1071
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0004 0.0004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0004 0.0002
Onchocerca volvulus Matrix metalloproteinase homolog 0.0053 0.0164 0.3549
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0004 0.0004
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0004 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0004 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0932 0.6142 0.6142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0808 0.53 0.5299
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0004 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0709 0.4624 0.4624
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0097 0.0459 1
Loa Loa (eye worm) cathepsin B 0.0055 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0004 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Leishmania major hypothetical protein, unknown function 0.0097 0.0459 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.1499 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0097 0.0459 0.0458
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0055 0.0175 0.0174
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0004 0.0002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0932 0.6142 0.6142
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0004 0.0002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1499 1 1
Schistosoma mansoni neuropeptide receptor 0.003 0.0004 0.0002
Schistosoma mansoni adenoreceptor 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0004 0.0002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0097 0.0459 0.0458
Echinococcus granulosus g-protein coupled receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Brugia malayi RE15519p 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0097 0.0459 0.0459
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0097 0.0459 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.7913 0.7913
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0004 0.0004
Echinococcus multilocularis Zinc finger, PHD finger 0.0097 0.0459 0.0458
Mycobacterium leprae conserved hypothetical protein 0.0097 0.0459 1
Schistosoma mansoni hypothetical protein 0.003 0.0004 0.0002
Schistosoma mansoni amine GPCR 0.003 0.0004 0.0002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1499 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0503 0.3221 0.322
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0004 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0109 0.0108
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Echinococcus granulosus fmrfamide receptor 0.003 0.0004 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0004 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0004 0.0002
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0097 0.0459 0.0458
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.7913 0.7913
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0097 0.0459 0.0458
Echinococcus multilocularis CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0097 0.0459 0.0458
Schistosoma mansoni neuropeptide receptor 0.003 0.0004 0.0002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1499 1 1
Brugia malayi G-protein coupled receptor 0.003 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0051 0.0148 0.3207
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0004 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0097 0.0459 0.0458
Brugia malayi ORL1-like opioid receptor 0.003 0.0004 0.0004
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0097 0.0459 0.0458
Brugia malayi Hemopexin family protein 0.0034 0.0033 0.0033
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.0459 0.0458
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0097 0.0459 0.0458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0175 0.0174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0004 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0004 0.0002
Brugia malayi neuropeptide F receptor 0.003 0.0004 0.0004
Echinococcus granulosus CD36 class B scavenger receptor 0.0051 0.0148 0.0147
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0109 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0004 0.0002
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0109 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0414 0.0413
Echinococcus multilocularis sex peptide receptor 0.003 0.0004 0.0002
Brugia malayi hypothetical protein 0.003 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.195 0.1949
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0097 0.0459 0.0458
Echinococcus granulosus neuropeptide receptor 0.003 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0029 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.3221 0.322
Echinococcus multilocularis serine protein kinase ATM 0.0284 0.173 0.1729
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.5308 0.5307
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.5308 0.5307
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.0459 0.0458
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.0459 0.0459
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0004 0.0002
Onchocerca volvulus 0.003 0.0004 0.0051
Schistosoma mansoni neuropeptide receptor 0.003 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.7386 0.7386
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0158 0.0873 0.0872
Onchocerca volvulus 0.003 0.0004 0.0051
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0004 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0004 0.0002
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0097 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0004 0.0002
Brugia malayi FAT domain containing protein 0.0219 0.1292 0.1292
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0004 0.0002
Onchocerca volvulus 0.003 0.0004 0.0051
Schistosoma mansoni hypothetical protein 0.003 0.0004 0.0002
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0097 0.0459 0.0458
Entamoeba histolytica hypothetical protein 0.0097 0.0459 0.0458
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0004 0.0004
Brugia malayi AKH receptor 0.003 0.0004 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0004 0.0004
Onchocerca volvulus 0.003 0.0004 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0414 0.0413
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0004 0.0002
Echinococcus multilocularis cathepsin b 0.0158 0.0873 0.0872
Schistosoma mansoni hypothetical protein 0.003 0.0004 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0158 0.0873 0.0872
Toxoplasma gondii cathepsin B 0.0055 0.0175 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0004 0.0002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1499 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Toxoplasma gondii target of rapamycin (TOR), putative 0.1115 0.7386 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0004 0.0002
Schistosoma mansoni amine GPCR 0.003 0.0004 0.0002

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 314 nM Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cells by scintillation counting ChEMBL. 25051243
Ki (binding) > 100000 nM Displacement of [3H]diprenorphine from human delta opioid receptor expressed in HEK293 cells by scintillation counting ChEMBL. 25051243
Ki (binding) > 100000 nM Displacement of [3H]U69593 from human kappa opioid receptor expressed in HEK293 cells by scintillation counting ChEMBL. 25051243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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