Detailed information for compound 92181

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.389 | Formula: C19H21N3O2
  • H donors: 3 H acceptors: 1 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(COc1cccc(c1O)c1cc2c([nH]1)ccc(c2)C(=N)N)C
  • InChi: 1S/C19H21N3O2/c1-11(2)10-24-17-5-3-4-14(18(17)23)16-9-13-8-12(19(20)21)6-7-15(13)22-16/h3-9,11,22-23H,10H2,1-2H3,(H3,20,21)
  • InChiKey: UTYMFQPKWLTXJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens plasminogen activator, tissue Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens plasminogen Starlite/ChEMBL References
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0176 0.0804
Plasmodium vivax hypothetical protein, conserved 0.004 0.0176 0.1031
Schistosoma mansoni cpg binding protein 0.0062 0.04 0.1418
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0511 0.1814
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0174 0.0174
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.2373 0.8416
Mycobacterium ulcerans beta-lactamase 0.004 0.0176 0.0176
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0887 0.3145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0732 0.2595
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.2373 0.8416
Mycobacterium leprae conserved hypothetical protein 0.004 0.0176 0.0824
Mycobacterium ulcerans hypothetical protein 0.004 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0418
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.1828 0.6483
Loa Loa (eye worm) hypothetical protein 0.011 0.0887 0.3145
Toxoplasma gondii kringle domain-containing protein 0.0105 0.0834 0.9318
Leishmania major hypothetical protein, conserved 0.0239 0.219 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Echinococcus granulosus expressed conserved protein 0.0091 0.0699 0.3823
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0176 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0176 0.0804
Loa Loa (eye worm) hypothetical protein 0.0047 0.025 0.0886
Brugia malayi Cytochrome P450 family protein 0.0041 0.0186 0.0659
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0732 0.2595
Onchocerca volvulus 0.0058 0.0366 0.1158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0732 0.2595
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0511 0.0344
Brugia malayi Protein kinase domain containing protein 0.0105 0.0834 0.2958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0732 0.2595
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0176 0.0185
Leishmania major hypothetical protein, conserved 0.0105 0.0834 0.3809
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0197 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0176 0.0185
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0118 0.0418
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0239 0.219 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0511 0.0344
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.025 0.0886
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1727 0.9447
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0887 0.3145
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0511 0.2336
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0511 0.5775
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.01 0.1121
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0176 0.0185
Trichomonas vaginalis glutaminase, putative 0.0301 0.282 0.2693
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1105 0.3918
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Mycobacterium ulcerans integral membrane transporter 0.0032 0.01 0.01
Echinococcus granulosus tissue type plasminogen activator 0.0105 0.0834 0.4562
Schistosoma mansoni cpg binding protein 0.0062 0.04 0.1418
Echinococcus multilocularis carbonic anhydrase 0.011 0.0887 0.4851
Schistosoma mansoni hypothetical protein 0.0293 0.2743 0.9726
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0176 0.0002
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.025 0.1367
Trichomonas vaginalis esterase, putative 0.004 0.0176 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Schistosoma mansoni carbonic anhydrase 0.011 0.0887 0.3145
Onchocerca volvulus 0.0047 0.025 0.045
Loa Loa (eye worm) hypothetical protein 0.011 0.0887 0.3145
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0186 0.0659
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0197 0.0699
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0049 0.0268 0.1255
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0645
Echinococcus multilocularis carbonic anhydrase II 0.0203 0.1828 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0176 0.0624
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0176 0.0624
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0645
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.0185
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.01 0.0458
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0859 0.3044
Mycobacterium leprae Probable transmembrane transport protein 0.0233 0.2135 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0887 0.3145
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0186 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0511 0.2336
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0316 0.1726
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0176 0.0185
Echinococcus granulosus carbonic anhydrase 0.011 0.0887 0.4851
Brugia malayi glutaminase DH11.1 0.0301 0.282 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0186 0.0186
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0511 0.2798
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0176 0.0176
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0174 0.0616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0176 0.0624
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0186 0.0848
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.148 0.794
Loa Loa (eye worm) carbonic anhydrase 3 0.0203 0.1828 0.6483
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0174 0.0932
Echinococcus multilocularis tissue type plasminogen activator 0.0105 0.0834 0.4562
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0203 0.1828 0.6483
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0174 0.0616
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0118 0.0644
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0511 0.0344
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1181 0.6459
Schistosoma mansoni hypothetical protein 0.011 0.0887 0.3145
Chlamydia trachomatis sulfate transporter 0.0032 0.01 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0176 0.0624
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0887 0.3145
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0197 0.1078
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0316 0.1726
Echinococcus multilocularis GPCR, family 2 0.0034 0.0118 0.0644
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0233 0.2135 0.2246
Plasmodium falciparum cysteine repeat modular protein 1 0.0105 0.0834 0.9329
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.1828 0.8348
Mycobacterium ulcerans glutaminase 0.0301 0.282 0.282
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2337 0.2459
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.025 0.0886
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0732 0.4003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0176 0.0624
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0002
Onchocerca volvulus Putative sulfate transporter 0.0202 0.1818 1
Brugia malayi beta-lactamase family protein 0.004 0.0176 0.0624
Schistosoma mansoni ap endonuclease 0.0039 0.0174 0.0616
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.01 0.01
Brugia malayi beta-lactamase family protein 0.004 0.0176 0.0624
Schistosoma mansoni lipoxygenase 0.0054 0.0319 0.1131
Trypanosoma brucei carbonic anhydrase-like protein 0.0203 0.1828 0.8348
Loa Loa (eye worm) glutaminase 2 0.0301 0.282 1
Brugia malayi Kringle domain containing protein 0.0105 0.0834 0.2958
Entamoeba histolytica carbonic anhydrase, putative 0.0049 0.0268 0.1613
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0239 0.219 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0887 0.3145
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0203 0.1828 0.6483
Brugia malayi MH2 domain containing protein 0.0131 0.1105 0.3918
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Onchocerca volvulus 0.0105 0.0834 0.4008
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0834 0.3809
Trichomonas vaginalis conserved hypothetical protein 0.101 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.011 0.0887 0.3145
Plasmodium falciparum carbonic anhydrase 0.011 0.0887 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0118 0.0644
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0319 0.1745
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.025 0.1367
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.01 0.0458
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0732 0.4003
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0511 0.1814
Brugia malayi Cytochrome P450 family protein 0.0041 0.0186 0.0659
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0732 0.4003
Loa Loa (eye worm) TK/ROR protein kinase 0.0105 0.0834 0.2958
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0174 0.0793
Echinococcus multilocularis protein dispatched 1 0.0048 0.0257 0.1404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0732 0.4003
Schistosoma mansoni carbonic anhydrase-related 0.011 0.0887 0.3145
Schistosoma mansoni glutaminase 0.0301 0.282 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0174 0.5
Echinococcus multilocularis cpg binding protein 0.0062 0.04 0.2187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0418
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0511 0.2798
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1105 0.3918
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1572 0.1423
Echinococcus multilocularis carbonic anhydrase 0.011 0.0887 0.4851
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0176 0.0185
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0174 0.095
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0174 0.5
Leishmania major carbonic anhydrase-like protein 0.0203 0.1828 0.8348
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0859 0.3044
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.0185
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.025 0.1367
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0511 0.2798
Loa Loa (eye worm) hypothetical protein 0.0105 0.0834 0.2958
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0774 0.2744
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0366 0.1298
Schistosoma mansoni hypothetical protein 0.0105 0.0834 0.2958
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0105 0.0834 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0002
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0645
Schistosoma mansoni cpg binding protein 0.0058 0.0366 0.1298
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0405 0.1434
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0118 0.0418
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0174 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0186 0.0848
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0759 0.269
Echinococcus granulosus cpg binding protein 0.0062 0.04 0.2187
Mycobacterium ulcerans lipase LipD 0.004 0.0176 0.0176
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0511 0.2798
Loa Loa (eye worm) hypothetical protein 0.0107 0.0859 0.3044
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0316 0.1726
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0203 0.1828 0.6483
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0895 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0186 0.0659
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0176 0.0002
Echinococcus granulosus GPCR family 2 0.0034 0.0118 0.0644
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1727 0.9447
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.011 0.0887 0.3145
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.025 0.0886
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0316 0.1119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0118 0.0418
Loa Loa (eye worm) hypothetical protein 0.0073 0.0516 0.1828
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0174 0.0183
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0418
Brugia malayi CXXC zinc finger family protein 0.0058 0.0366 0.1298
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0197 0.1078
Brugia malayi beta-lactamase 0.004 0.0176 0.0624
Schistosoma mansoni patched 1 0.0042 0.0197 0.0699
Loa Loa (eye worm) hypothetical protein 0.0097 0.0759 0.269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1029 0.3649
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0511 0.2336
Toxoplasma gondii hypothetical protein 0.011 0.0887 0.9908
Leishmania major hypothetical protein, conserved 0.004 0.0176 0.0804
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0316 0.1726
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0174 0.0793
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0203 0.1828 0.8348
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.011 0.0887 0.3145
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2373 0.2239
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0511 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0511 0.1814
Leishmania major cytochrome p450-like protein 0.0041 0.0186 0.0848
Brugia malayi mbt repeat family protein 0.0047 0.025 0.0886
Leishmania major carbonic anhydrase family protein, putative 0.0049 0.0268 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0516 0.1828
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0511 0.2798
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.011 0.0887 0.3145
Trichomonas vaginalis conserved hypothetical protein 0.101 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0859 0.3044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0118 0.0644
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0197 0.1078
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0203 0.1828 0.6483
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0174 0.095
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0176 0.0963
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.01 0.0458
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0759 0.4149
Loa Loa (eye worm) hypothetical protein 0.0053 0.0316 0.1119
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0645
Echinococcus multilocularis carbonic anhydrase 0.011 0.0887 0.4851
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0418
Brugia malayi CHE-14 protein 0.0042 0.0197 0.0699
Echinococcus multilocularis expressed conserved protein 0.0091 0.0699 0.3823
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0118 0.0644
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0418
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0282 0.2628 0.2764
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0511 0.2798
Loa Loa (eye worm) hypothetical protein 0.0051 0.0292 0.1036
Loa Loa (eye worm) MBCTL1 0.0053 0.0316 0.1119
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0511 0.2336
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0511 0.1814
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0176 0.0804
Mycobacterium ulcerans carbonic anhydrase 0.0049 0.0268 0.0268
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0176 0.0002
Toxoplasma gondii ABC1 family protein 0.004 0.0176 0.1966
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.025 0.1367
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0759 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.148 0.1329
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0174 0.0999
Schistosoma mansoni ap endonuclease 0.0039 0.0174 0.0616
Echinococcus granulosus carbonic anhydrase II 0.0203 0.1828 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0174 0.0793
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.025 0.0886
Brugia malayi Cytochrome P450 family protein 0.0062 0.0405 0.1434
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0176 0.0963
Brugia malayi mbt repeat family protein 0.0047 0.025 0.0886
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0176 0.0185
Mycobacterium tuberculosis Conserved protein 0.004 0.0176 0.0185
Echinococcus granulosus carbonic anhydrase 0.011 0.0887 0.4851
Onchocerca volvulus 0.0202 0.1818 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1572 0.1423
Echinococcus multilocularis protein patched 0.0042 0.0197 0.1078
Schistosoma mansoni hypothetical protein 0.0073 0.0516 0.1828
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0186 0.0659
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.025 0.045
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0316 0.1119
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0759 0.4149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0197 0.0699
Echinococcus granulosus carbonic anhydrase 0.011 0.0887 0.4851
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0319 0.1745
Mycobacterium leprae Probable lipase LipE 0.004 0.0176 0.0824
Loa Loa (eye worm) glutaminase 0.0301 0.282 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0174 0.194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0732 0.2595
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1181 0.6459
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0624
Schistosoma mansoni carbonic anhydrase 0.0049 0.0268 0.095
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0961 0.9507 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.18 uM Inhibition of urokinase-type plasminogen activator ChEMBL. 12113832
Ki (binding) = 0.18 uM Inhibition of urokinase-type plasminogen activator ChEMBL. 12113832
Ki (binding) = 0.65 uM Inhibition of plasmin ChEMBL. 12113832
Ki (binding) = 0.65 uM Inhibition of plasmin ChEMBL. 12113832
Ki (binding) = 0.88 uM Inhibition of tissue-type plasminogen activator ChEMBL. 12113832
Ki (binding) = 0.88 uM Inhibition of tissue-type plasminogen activator ChEMBL. 12113832
Ki (binding) = 1.7 uM Inhibition of Coagulation factor X ChEMBL. 12113832
Ki (binding) = 1.7 uM Inhibition of Coagulation factor X ChEMBL. 12113832
Ki (binding) = 7.5 uM Inhibition of thrombin ChEMBL. 12113832
Ki (binding) = 7.5 uM Inhibition of thrombin ChEMBL. 12113832

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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