TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.521 | Formula: C22H28O3S
H donors: 0 H acceptors: 2 LogP: 6.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)OC(C(C)(C)C)CCc1ccc(cc1)/C=C/c1ccccc1
InChi: 1S/C22H28O3S/c1-22(2,3)21(25-26(4,23)24)17-16-20-14-12-19(13-15-20)11-10-18-8-6-5-7-9-18/h5-15,21H,16-17H2,1-4H3/b11-10+
InChiKey: PMPTWNKLAJIRNJ-ZHACJKMWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 24, subfamily A, polypeptide 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_127298	All targets in OG5_127298
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127298	All targets in OG5_127298
Brugia malayi	hypothetical protein	Get druggable targets OG5_127298	All targets in OG5_127298
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127298	All targets in OG5_127298

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 24, subfamily A, polypeptide 1	514 aa	467 aa	20.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0536	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus granulosus	snurportin 1	0.026	0.7494	0.7494
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0036	0.0927	0.2375
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	Intermediate filament tail domain containing protein	0.0018	0.039	0.071
Loa Loa (eye worm)	kap beta 3 protein	0.0005	0.0007	0.0009
Echinococcus granulosus	intermediate filament protein	0.0018	0.039	0.039
Trichomonas vaginalis	penicillin-binding protein, putative	0.0024	0.0571	0.6131
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0024	0.0571	0.0762
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0007	0.0074	0.0074
Echinococcus granulosus	cpg binding protein	0.0026	0.0623	0.0623
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0033	0.0851	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0563	0.6689
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	hypothetical protein	0.0034	0.0863	0.0863
Loa Loa (eye worm)	D-ets-2 protein	0.0007	0.0074	0.0098
Schistosoma mansoni	gabp alpha	0.0048	0.1264	0.1264
Trichomonas vaginalis	importin beta-1, putative	0.002	0.045	0.4823
Echinococcus multilocularis	serotonin receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	7tm_1 domain containing protein	0.0034	0.0863	0.0863
Schistosoma mansoni	hypothetical protein	0.001	0.0179	0.0179
Toxoplasma gondii	hypothetical protein	0.0009	0.013	0.0318
Leishmania major	GTP-binding protein, putative	0.0018	0.0397	0.3781
Brugia malayi	Importin beta-1 subunit	0.0024	0.0586	0.1066
Toxoplasma gondii	ABC1 family protein	0.0024	0.0571	0.1456
Echinococcus multilocularis	musashi	0.0018	0.039	0.039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Schistosoma mansoni	amine GPCR	0.0034	0.0863	0.0863
Toxoplasma gondii	HEAT repeat-containing protein	0.0024	0.0586	0.1494
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0034	0.0863	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.004	0.1039	1
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0009	0.013	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Entamoeba histolytica	acetyltransferase, GNAT family	0.0033	0.0839	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.013	0.0173
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0863	0.0863
Entamoeba histolytica	hypothetical protein	0.0024	0.0563	0.6689
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0089	0.0162
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0863	0.0863
Echinococcus granulosus	hypothetical protein	0.0034	0.0863	0.0863
Schistosoma mansoni	lamin	0.0018	0.039	0.039
Brugia malayi	neuropeptide F receptor	0.0034	0.0863	0.1571
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0863	0.0863
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0069	0.1893	0.1893
Echinococcus granulosus	GA binding protein alpha chain	0.0048	0.1264	0.1264
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.1039	1
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	DNA-binding protein D-ETS-3	0.0007	0.0074	0.0134
Schistosoma mansoni	hypothetical protein	0.0034	0.0863	0.0863
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	orexin receptor type 2	0.0034	0.0863	0.0863
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0034	0.0863	0.1367
Schistosoma mansoni	hypothetical protein	0.0024	0.0563	0.0563
Toxoplasma gondii	microneme protein MIC4	0.0009	0.013	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0192	0.5494	0.7331
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0851	0.9179
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0005	0.0033	0.0283
Brugia malayi	G protein-coupled receptor F59B2.13	0.0034	0.0863	0.1571
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0863	0.0863
Onchocerca volvulus		0.0034	0.0863	0.1367
Schistosoma mansoni	cpg binding protein	0.0026	0.0623	0.0623
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0863	0.0863
Mycobacterium leprae	conserved hypothetical protein	0.0024	0.0571	0.5
Brugia malayi	hypothetical protein	0.0024	0.0563	0.1026
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0018	0.0397	0.0723
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0851	0.9179
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0034	0.0863	0.0863
Trichomonas vaginalis	ran, putative	0.0018	0.0397	0.4242
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3613	0.4822
Onchocerca volvulus		0.0034	0.0863	0.1367
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.013	0.0318
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0571	0.3825
Loa Loa (eye worm)	fli-1 protein	0.0144	0.41	0.5471
Loa Loa (eye worm)	ets-domain-containing protein	0.0007	0.0074	0.0098
Echinococcus multilocularis	g-protein coupled receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	hypothetical protein	0.0034	0.0863	0.0863
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0851	0.0851
Brugia malayi	intermediate filament protein	0.0018	0.039	0.071
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0034	0.0863	0.1152
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Brugia malayi	beta-lactamase family protein	0.0024	0.0571	0.1039
Onchocerca volvulus		0.0128	0.3613	0.6494
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Echinococcus granulosus	g-protein coupled receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.0092	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Onchocerca volvulus		0.0034	0.0863	0.1367
Onchocerca volvulus		0.0034	0.0863	0.1367
Schistosoma mansoni	opsin-like receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	dnaJ subfamily B	0.0346	1	1
Echinococcus multilocularis	sex peptide receptor	0.0034	0.0863	0.0863
Brugia malayi	AKH receptor	0.0034	0.0863	0.1571
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Brugia malayi	beta-lactamase family protein	0.0024	0.0571	0.1039
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	amine GPCR	0.0034	0.0863	0.0863
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.002	0.045	0.4823
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0033	0.0851	0.8181
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0034	0.0863	0.1571
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0033	0.0843	0.1534
Echinococcus multilocularis	neuropeptide receptor A26	0.0034	0.0863	0.0863
Onchocerca volvulus		0.0018	0.039	0.0486
Schistosoma mansoni	amine GPCR	0.0034	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.039	0.0521
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.013	0.0173
Echinococcus granulosus	dro:myosuppressin receptor	0.0034	0.0863	0.0863
Entamoeba histolytica	hypothetical protein	0.0024	0.0563	0.6689
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0033	0.0843	0.1534
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.013	0.0173
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	ran	0.0018	0.0397	0.0397
Echinococcus granulosus	7TM GPCR rhodopsin	0.0034	0.0863	0.0863
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0863	0.0863
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	lamin dm0	0.0018	0.039	0.039
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.004	0.1039	0.1039
Echinococcus multilocularis	cpg binding protein	0.0026	0.0623	0.0623
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Onchocerca volvulus		0.0034	0.0863	0.1367
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus multilocularis	importin 5	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	aldehyde dehydrogenase	0.004	0.1039	0.1039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0007	0.0074	0.0074
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0112	0.015
Brugia malayi	Serotonin receptor	0.0034	0.0863	0.1571
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0051	0.138	0.138
Brugia malayi	Serotonin receptor	0.0034	0.0863	0.1571
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0036	0.0927	1
Brugia malayi	Dopamine receptor protein 2	0.0034	0.0863	0.1571
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0018	0.0397	0.1008
Echinococcus multilocularis	importin subunit beta 1	0.0024	0.0586	0.0586
Echinococcus multilocularis	snurportin 1	0.026	0.7494	0.7494
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0034	0.0863	0.1571
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0018	0.0397	0.4621
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0034	0.0863	0.0863
Trichomonas vaginalis	D-aminoacylase, putative	0.0024	0.0571	0.6131
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.001	0.0179	0.0179
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0007	0.0074	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0036	0.0927	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Echinococcus granulosus	transportin 1	0.0005	0.0007	0.0007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0069	0.1893	0.2526
Toxoplasma gondii	aldehyde dehydrogenase	0.004	0.1039	0.2665
Schistosoma mansoni	ets-related	0.0007	0.0074	0.0074
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.004	0.1039	0.1039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0034	0.0863	0.0863
Schistosoma mansoni	hypothetical protein	0.0034	0.0863	0.0863
Brugia malayi	larval opioid receptor	0.0034	0.0863	0.1571
Echinococcus granulosus	importin 5	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	adenoreceptor	0.0034	0.0863	0.0863
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0024	0.0571	0.1039
Schistosoma mansoni	hypothetical protein	0.0007	0.0074	0.0074
Loa Loa (eye worm)	acetyltransferase	0.0123	0.3461	0.4618
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0034	0.0863	0.1152
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	amine GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0034	0.0863	0.1152
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0863	0.0863
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0005	0.0015	0.0105
Schistosoma mansoni	hypothetical protein	0.0007	0.0074	0.0074
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0034	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0192	0.5494	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.001	0.0179	0.0239
Schistosoma mansoni	ran	0.0018	0.0397	0.0397
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0863	0.0863
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0069	0.1893	0.1893
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.1893	0.1893
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0007	0.0074	0.0074
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0069	0.1893	0.1893
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	growth hormone secretagogue receptor	0.0034	0.0863	0.0863
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Onchocerca volvulus		0.0034	0.0863	0.1367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.1893	0.1893
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0034	0.0863	0.0863
Toxoplasma gondii	hypothetical protein	0.0009	0.013	0.0318
Echinococcus granulosus	beta LACTamase domain containing family member	0.0024	0.0571	0.0571
Echinococcus multilocularis	dro:myosuppressin receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0033	0.0851	0.1136
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0863	0.1152
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0863	0.0863
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0009	0.013	0.0318
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Echinococcus granulosus	ETS transcription factor Elf 1	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Trichomonas vaginalis	penicillin-binding protein, putative	0.0024	0.0571	0.6131
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0586	0.6853
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Brugia malayi	beta-lactamase	0.0024	0.0571	0.1039
Schistosoma mansoni	transcription factor LCR-F1	0.0024	0.0563	0.0563
Echinococcus granulosus	fmrfamide receptor	0.0034	0.0863	0.0863
Brugia malayi	MAP kinase sur-1	0.0033	0.0851	0.155
Entamoeba histolytica	hypothetical protein	0.0024	0.0563	0.6689
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0381	0.0508
Brugia malayi	ORL1-like opioid receptor	0.0034	0.0863	0.1571
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0048	0.0048
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus multilocularis	protein C ets 2	0.0007	0.0074	0.0074
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0006	0.0048	0.0048
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0018	0.0397	0.053
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Echinococcus granulosus	allatostatin A receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Echinococcus granulosus	somatostatin receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0033	0.0851	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0033	0.0851	0.0851
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	serotonin receptor	0.0034	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0034	0.0863	0.0863
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0119	0.336	0.336
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Entamoeba histolytica	Ran family GTPase	0.0018	0.0397	0.469
Schistosoma mansoni	opsin-like receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Brugia malayi	hypothetical protein	0.0128	0.3613	0.6577
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0112	0.015
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0863	0.0863
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.0571	0.6131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	cytoplasmic intermediate filament protein	0.0009	0.0149	0.0272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Schistosoma mansoni	hypothetical protein	0.0023	0.0536	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0074	0.0098
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0843	0.1125
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0007	0.0074	0.0074
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0069	0.1893	0.1893
Brugia malayi	Ets-domain containing protein	0.0048	0.1264	0.2301
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus multilocularis	neuropeptide s receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0024	0.0571	0.0571
Brugia malayi	acetyltransferase, GNAT family protein	0.0123	0.3461	0.6299
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0863	0.0863
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	G protein coupled receptor 139	0.0034	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0092	0.0092
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0863	0.0863
Loa Loa (eye worm)	melatonin receptor type 1A	0.0034	0.0863	0.1152
Schistosoma mansoni	amine GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Brugia malayi	follicle stimulating hormone receptor	0.0034	0.0863	0.1571
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0033	0.0851	1
Onchocerca volvulus		0.0024	0.0571	0.0823
Onchocerca volvulus		0.0024	0.0571	0.0823
Schistosoma mansoni	neuropeptide f receptor 76f	0.0034	0.0863	0.0863
Schistosoma mansoni	elf1	0.0007	0.0074	0.0074
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0033	0.0843	0.1125
Echinococcus granulosus	importin subunit beta 1	0.0024	0.0586	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.013	0.0318
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0009	0.0149	0.0199
Brugia malayi	Dopamine receptor protein 1	0.0034	0.0863	0.1571
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus granulosus	neuropeptide FF receptor 2	0.0034	0.0863	0.0863
Onchocerca volvulus		0.0034	0.0863	0.1367
Entamoeba histolytica	hypothetical protein	0.002	0.045	0.5333
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0034	0.0863	0.1571
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0006	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0036	0.0927	0.2375
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.026	0.7494	1
Schistosoma mansoni	cpg binding protein	0.0024	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Onchocerca volvulus		0.0024	0.0571	0.0823
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0018	0.039	0.0521
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	TYRA-2 protein	0.0034	0.0863	0.1152
Schistosoma mansoni	hypothetical protein	0.001	0.0179	0.0179
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0033	0.0851	0.218
Echinococcus multilocularis	somatostatin receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0034	0.0863	0.0863
Toxoplasma gondii	PAN domain-containing protein	0.0137	0.3882	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0863	0.0863
Brugia malayi	Ets-domain containing protein	0.0007	0.0074	0.0134
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0005	0.0033	0.0283
Echinococcus granulosus	translational activator gcn1	0.0005	0.0007	0.0007
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus multilocularis	GA binding protein alpha chain	0.0048	0.1264	0.1264
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0034	0.0863	0.1571
Giardia lamblia	Kinase, CMGC MAPK	0.0033	0.0851	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0024	0.0563	0.0563
Leishmania major	hypothetical protein, conserved	0.0024	0.0571	0.5464
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0048	0.1264	0.1687
Echinococcus granulosus	sex peptide receptor	0.0034	0.0863	0.0863
Brugia malayi	Melatonin receptor type 1A	0.0034	0.0863	0.1571
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0007	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.001	0.0179	0.0179
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0571	0.6679
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0863	0.0863
Mycobacterium leprae	Probable lipase LipE	0.0024	0.0571	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0586	0.0781
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0009	0.0122	0.0122
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Schistosoma mansoni	ets-related	0.0144	0.41	0.41
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Echinococcus multilocularis	GPCR, family 2	0.001	0.0179	0.0179
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.001	0.0179	0.0326
Echinococcus granulosus	protein C ets 2	0.0007	0.0074	0.0074
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0069	0.1893	0.3445
Echinococcus multilocularis	lamin dm0	0.0018	0.039	0.039
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Brugia malayi	sulfakinin receptor protein	0.0034	0.0863	0.1571
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0034	0.0863	0.1367
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0863	0.1152
Trypanosoma brucei	protein kinase, putative	0.0033	0.0851	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0048	0.0048
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0049	0.1307	0.3355
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.1039	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.013	0.0173
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0863	0.0863
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.004	0.1039	0.1243
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	cpg binding protein	0.0026	0.0623	0.0623
Echinococcus granulosus	ETS transcription factor Elf 2	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Toxoplasma gondii	microneme protein MIC17C	0.0009	0.013	0.0318
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0024	0.0571	0.0571
Toxoplasma gondii	subtilisin SUB12	0.0009	0.013	0.0318
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0033	0.0851	0.0851
Brugia malayi	Dopamine receptor	0.0034	0.0863	0.1571
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0034	0.0863	0.1571
Schistosoma mansoni	aldehyde dehydrogenase	0.004	0.1039	0.1039
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0009	0.0122	0.0122
Echinococcus multilocularis	serotonin receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	intermediate filament proteins	0.0018	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Brugia malayi	Fli-1 protein	0.0144	0.41	0.7462
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0034	0.0863	0.0863
Echinococcus granulosus	neuropeptide s receptor	0.0034	0.0863	0.0863
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0018	0.0397	0.0397
Plasmodium falciparum	histone acetyltransferase GCN5	0.0033	0.0839	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0024	0.0571	0.0571
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Schistosoma mansoni	histamine h1 receptor	0.0034	0.0863	0.0863
Trichomonas vaginalis	esterase, putative	0.0024	0.0571	0.6131
Echinococcus granulosus	lamin	0.0018	0.039	0.039
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0005	0.0033	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus granulosus	mitogen activated protein kinase	0.0033	0.0851	0.0851
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.013	0.0318
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0092	0.0092
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0583	0.1061
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0005	0.0007	0.0009
Trichomonas vaginalis	D-aminoacylase, putative	0.0024	0.0571	0.6131
Echinococcus multilocularis	mitogen activated protein kinase	0.0033	0.0851	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0192	0.5494	0.7331
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.001	0.0179	0.0179
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0034	0.0863	0.0863
Echinococcus multilocularis	orexin receptor type 2	0.0034	0.0863	0.0863
Toxoplasma gondii	microneme protein, putative	0.0009	0.013	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0122	0.0163
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0583	0.0778
Schistosoma mansoni	opsin-like receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0034	0.0863	0.0863
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0123	0.3461	0.3461
Echinococcus granulosus	ETS transcription factor Elf 2	0.0007	0.0074	0.0074
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.002	0.045	0.4823
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0018	0.0397	0.0397
Schistosoma mansoni	hypothetical protein	0.026	0.7494	0.7494
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0048	0.0048
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0863	0.0863
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0036	0.0927	0.0927
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0007	0.0074	0.0098
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0863	0.0863
Trichomonas vaginalis	D-aminoacylase, putative	0.0024	0.0571	0.6131
Echinococcus multilocularis	G protein coupled receptor 139	0.0034	0.0863	0.0863
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0034	0.0863	0.1152
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.013	0.0173
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0033	0.0851	1
Echinococcus multilocularis	transportin 1	0.0005	0.0007	0.0007
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0863	0.0863
Echinococcus multilocularis	allatostatin A receptor	0.0034	0.0863	0.0863
Brugia malayi	GnHR receptor homolog	0.0034	0.0863	0.1571
Brugia malayi	putative neuropeptide receptor	0.0034	0.0863	0.1571
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.001	0.0179	0.0179
Onchocerca volvulus		0.0192	0.5494	1
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.001	0.0179	0.0239
Toxoplasma gondii	microneme protein MIC17A	0.0009	0.013	0.0318
Brugia malayi	latrophilin 2 splice variant baaae	0.0023	0.0536	0.0975
Brugia malayi	G-protein coupled receptor	0.0034	0.0863	0.1571
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0018	0.0397	0.469
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0018	0.0397	0.4242
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	transcription factor E74 isoform	0.0007	0.0074	0.0134
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Schistosoma mansoni	hypothetical protein	0.0346	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0571	0.3825
Brugia malayi	neuropeptide F receptor	0.0034	0.0863	0.1571
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.013	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Echinococcus multilocularis	lamin	0.0018	0.039	0.039
Toxoplasma gondii	PAN domain-containing protein	0.0137	0.3882	1
Schistosoma mansoni	ets	0.0007	0.0074	0.0074
Brugia malayi	Ets-domain containing protein	0.0048	0.1264	0.2301
Onchocerca volvulus		0.0034	0.0863	0.1367
Leishmania major	importin beta-1 subunit, putative	0.002	0.045	0.4299
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Echinococcus multilocularis	ets variant gene 4	0.0007	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Schistosoma mansoni	myosin xvIII	0.0034	0.0863	0.0863
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0123	0.3461	0.3461
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	kap beta 3 protein	0.0005	0.0007	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Schistosoma mansoni	lamin	0.0018	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0074	0.0098
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0851	0.9179
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0863	0.0863
Onchocerca volvulus		0.0034	0.0863	0.1367
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.001	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0571	0.0762
Echinococcus granulosus	ewsr:fli fusion protein type	0.0007	0.0074	0.0074
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0033	0.0851	0.8181
Trichomonas vaginalis	helicase, putative	0.0005	0.0033	0.0283
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Plasmodium vivax	importin-beta 2, putative	0.0024	0.0586	0.629
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Echinococcus granulosus	GPCR family 2	0.001	0.0179	0.0179
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Plasmodium falciparum	importin beta, putative	0.0024	0.0586	0.6955
Echinococcus multilocularis	translational activator gcn1	0.0005	0.0007	0.0007
Loa Loa (eye worm)	beta-lactamase	0.0024	0.0571	0.0762
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0863	0.0863
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0586	0.6853
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0007	0.0074	0.0074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0069	0.1893	0.1893
Schistosoma mansoni	importin-beta 2	0.0005	0.0007	0.0007
Giardia lamblia	Histone acetyltransferase GCN5	0.0033	0.0839	0.9727
Echinococcus granulosus	ETS transcription factor Elf 5	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0863	0.0863
Brugia malayi	PAN domain containing protein	0.0009	0.013	0.0236
Echinococcus granulosus	neuropeptide receptor A26	0.0034	0.0863	0.0863
Brugia malayi	G protein-coupled receptor	0.0034	0.0863	0.1571
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0863	0.0863
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.039	0.0521
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0153	0.4339	1
Schistosoma mansoni	importin beta-1	0.0024	0.0586	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Trypanosoma cruzi	importin beta-1 subunit, putative	0.002	0.045	0.1177
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0024	0.0563	0.0563
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0863	0.0863
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0033	0.0283
Onchocerca volvulus		0.0034	0.0863	0.1367
Toxoplasma gondii	microneme protein MIC17B	0.0009	0.013	0.0318
Brugia malayi	G-protein coupled receptor	0.0034	0.0863	0.1571
Trichomonas vaginalis	CMGC family protein kinase	0.0033	0.0851	0.9179
Schistosoma mansoni	hypothetical protein	0.001	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0009	0.013	0.0173
Brugia malayi	putative neuropeptide receptor NPR1	0.0034	0.0863	0.1571
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0034	0.0863	0.1571
Brugia malayi	Latrophilin receptor protein 2	0.001	0.0179	0.0326
Onchocerca volvulus		0.0024	0.0583	0.0845
Onchocerca volvulus		0.0018	0.039	0.0486
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0863	0.0863
Brugia malayi	RNA, U transporter 1	0.0069	0.1902	0.3462
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0863	0.0863
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0036	0.0927	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0033	0.0851	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0863	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0863	0.1152
Brugia malayi	RE15519p	0.0034	0.0863	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1062	0.1417
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.1039	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6 uM	Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 25 mins by HPLC method	ChEMBL.	25148392
Ki (binding)	= 0.4 uM	Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 25 mins by HPLC method	ChEMBL.	25148392

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329775

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 927977