Detailed information for compound 931931

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.334 | Formula: C18H17F3N2O3
  • H donors: 3 H acceptors: 3 LogP: 0.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[C@@H](C(=O)O)N)Nc1ccc(c(c1)C)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C18H17F3N2O3/c1-10-8-13(23-16(24)9-15(22)17(25)26)6-7-14(10)11-2-4-12(5-3-11)18(19,20)21/h2-8,15H,9,22H2,1H3,(H,23,24)(H,25,26)/t15-/m0/s1
  • InChiKey: JHPMJNZQSSOYSF-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA Get druggable targets OG5_126739 All targets in OG5_126739
Loa Loa (eye worm) excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Onchocerca volvulus Excitatory amino acid transporter homolog Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Brugia malayi Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Theileria parva glutamate transporter, putative Get druggable targets OG5_126739 All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Excitatory amino acid transporter 2, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Chlamydia trachomatis glutamate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter Get druggable targets OG5_126739 All targets in OG5_126739
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0554 0.1942 0.6011
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0063 0.0014 0.0042
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0592 0.209 1
Brugia malayi hypothetical protein 0.0146 0.0339 0.0339
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0309 0.098 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0309 0.098 0.3032
Treponema pallidum glutamate transporter 0.0135 0.0296 1
Schistosoma mansoni RAR-like nuclear receptor 0.0309 0.098 0.1019
Echinococcus granulosus Excitatory amino acid transporter 0.0304 0.0962 0.2976
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0309 0.098 0.098
Brugia malayi Serotonin receptor 0.0487 0.1679 0.1679
Schistosoma mansoni nuclear hormone receptor 0.0146 0.0339 0.0352
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0146 0.0339 0.1048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0309 0.098 0.3032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0309 0.098 0.3032
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0146 0.0339 0.1048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0309 0.098 0.3032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0309 0.098 0.3032
Echinococcus granulosus excitatory amino acid transporter 2 0.0304 0.0962 0.2976
Echinococcus multilocularis Excitatory amino acid transporter 0.0304 0.0962 0.2976
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0146 0.0339 0.1048
Schistosoma mansoni vesicular acetylcholine transporter 0.0882 0.3232 0.3362
Schistosoma mansoni thyroid hormone receptor 0.0309 0.098 0.1019
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0309 0.098 0.098
Schistosoma mansoni thyroid hormone receptor 0.0309 0.098 0.1019
Echinococcus granulosus vesicular acetylcholine transporter 0.0882 0.3232 1
Schistosoma mansoni retinoic acid receptor RXR 0.0309 0.098 0.1019
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0163 0.0407 0.0424
Trypanosoma cruzi C-14 sterol reductase, putative 0.0088 0.0112 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0309 0.098 0.1019
Brugia malayi Nuclear hormone receptor E75 0.0146 0.0339 0.0339
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0146 0.0339 0.1048
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0288 0.0238
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.0407
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0163 0.0407 0.126
Brugia malayi nuclear receptor NHR-88 0.0309 0.098 0.098
Echinococcus multilocularis nuclear receptor nhr 48 0.0146 0.0339 0.1048
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Schistosoma mansoni nuclear hormone receptor 0.0309 0.098 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0309 0.098 0.098
Brugia malayi nuclear hormone receptor 0.0146 0.0339 0.0339
Echinococcus multilocularis vesicular acetylcholine transporter 0.0882 0.3232 1
Trypanosoma brucei C-14 sterol reductase, putative 0.0088 0.0112 0.0061
Echinococcus multilocularis neutral amino acid transporter A 0.0304 0.0962 0.2976
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Loa Loa (eye worm) inositol-1 0.0073 0.0051 0.0051
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0288 0.0238
Loa Loa (eye worm) hypothetical protein 0.1332 0.4997 0.4997
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0309 0.098 0.1019
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.0407
Schistosoma mansoni zinc finger protein 0.0146 0.0339 0.0352
Brugia malayi Steroid receptor seven-up type 2 0.0309 0.098 0.098
Echinococcus multilocularis ecdysone induced protein 78C 0.0309 0.098 0.3032
Schistosoma mansoni glutamate receptor NMDA 0.0063 0.0014 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0163 0.0407 0.0407
Echinococcus granulosus neutral amino acid transporter A 0.0304 0.0962 0.2976
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0309 0.098 0.098
Loa Loa (eye worm) steroid hormone receptor 0.0309 0.098 0.098
Brugia malayi nuclear receptor NHR-67 0.0146 0.0339 0.0339
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0051 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0146 0.0339 0.1048
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.2506 0.9611 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Brugia malayi hypothetical protein 0.0163 0.0407 0.0407
Schistosoma mansoni nuclear receptor 0.0146 0.0339 0.0352
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0051 0.5
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2605 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0309 0.098 0.098
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0135 0.0296 0.0308
Schistosoma mansoni Lamin B receptor (ERG24) 0.0088 0.0112 0.0116
Brugia malayi hypothetical protein 0.0146 0.0339 0.0339
Echinococcus multilocularis thyroid hormone receptor alpha 0.0309 0.098 0.3032
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0135 0.0296 0.0308
Leishmania major hypothetical protein, conserved 0.0133 0.0288 0.0238
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0309 0.098 0.3032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0309 0.098 0.098
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0309 0.098 0.3032
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Loa Loa (eye worm) DR-78 0.0146 0.0339 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0309 0.098 0.098
Leishmania major C-14 sterol reductase, putative 0.0088 0.0112 0.0061
Echinococcus granulosus excitatory amino acid transporter 3 0.0304 0.0962 0.2976
Echinococcus granulosus thyroid hormone receptor alpha 0.0146 0.0339 0.1048
Echinococcus granulosus microtubule associated protein 2 0.0673 0.2408 0.7451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0309 0.098 0.3032
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.2408 0.7451
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0304 0.0962 0.2976
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0163 0.0407 0.0407
Schistosoma mansoni steroid hormone receptor ad4bp 0.0309 0.098 0.1019
Echinococcus multilocularis FTZ F1 alpha 0.0309 0.098 0.3032
Treponema pallidum glutamate/aspartate transporter 0.0135 0.0296 1
Trypanosoma brucei Emopamil binding protein, putative 0.0133 0.0288 0.0238
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0051 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0051 0.0159
Onchocerca volvulus 0.0133 0.0288 0.0891
Brugia malayi ecdysone receptor 0.0146 0.0339 0.0339
Echinococcus granulosus lamin b receptor 0.0088 0.0112 0.0346
Trypanosoma cruzi C-14 sterol reductase, putative 0.0088 0.0112 0.0061
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0592 0.209 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0288 0.0238
Loa Loa (eye worm) nuclear receptor NHR-67 0.0146 0.0339 0.0339
Echinococcus granulosus neutral amino acid transporter A 0.0304 0.0962 0.2976
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0304 0.0962 0.1001
Echinococcus granulosus sodium:dicarboxylate symporter 0.0304 0.0962 0.2976
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0309 0.098 0.098
Onchocerca volvulus 0.0146 0.0339 0.1048
Brugia malayi nuclear receptor RXR 0.0163 0.0407 0.0407
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0304 0.0962 1
Schistosoma mansoni nuclear receptor nhr-48 0.0146 0.0339 0.0352
Echinococcus granulosus Nuclear hormone receptor HR96 0.0146 0.0339 0.1048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0309 0.098 0.1019
Schistosoma mansoni inositol monophosphatase 0.0073 0.0051 0.0053
Echinococcus granulosus neutral amino acid transporter 0.0304 0.0962 0.2976
Brugia malayi nuclear hormone receptor family member odr-7 0.0146 0.0339 0.0339
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0554 0.1942 0.6011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0163 0.0407 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0309 0.098 0.098
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Brugia malayi Excitatory amino acid transporter 0.0304 0.0962 0.0962
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0135 0.0296 0.0916
Brugia malayi tailless protein 0.0146 0.0339 0.0339
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0163 0.0407 0.126
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0304 0.0962 0.2976
Onchocerca volvulus Bile acid receptor homolog 0.0309 0.098 0.3032
Brugia malayi nuclear receptor NHR-88 0.0146 0.0339 0.0339
Echinococcus granulosus nuclear receptor nhr 48 0.0146 0.0339 0.1048
Brugia malayi ecdysteroid receptor 0.0309 0.098 0.098
Onchocerca volvulus 0.0309 0.098 0.3032
Loa Loa (eye worm) excitatory amino acid transporter 0.0304 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Schistosoma mansoni nuclear receptor 0.0146 0.0339 0.0352
Brugia malayi Nuclear hormone receptor-like 1 0.0309 0.098 0.098
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0309 0.098 0.098
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0309 0.098 0.3032
Echinococcus multilocularis excitatory amino acid transporter 2 0.0304 0.0962 0.2976
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0309 0.098 0.1019
Onchocerca volvulus 0.0146 0.0339 0.1048
Echinococcus multilocularis excitatory amino acid transporter 3 0.0304 0.0962 0.2976
Echinococcus granulosus ecdysone induced protein 78C 0.0309 0.098 0.3032
Echinococcus granulosus excitatory amino acid transporter 2 0.0304 0.0962 0.2976
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Echinococcus multilocularis excitatory amino acid transporter 2 0.0304 0.0962 0.2976
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0882 0.3232 0.3232
Brugia malayi nuclear receptor RXR 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0309 0.098 0.3032
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0051 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0146 0.0339 0.0339
Echinococcus multilocularis Excitatory amino acid transporter 0.0304 0.0962 0.2976
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0288 0.0238
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0309 0.098 0.098
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0146 0.0339 0.1048
Schistosoma mansoni inositol monophosphatase 0.0073 0.0051 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0309 0.098 0.098
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.2408 0.2505
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0021 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.0407
Echinococcus multilocularis lamin b receptor 0.0088 0.0112 0.0346
Brugia malayi Nuclear hormone receptor E75 0.0146 0.0339 0.0339
Brugia malayi Nuclear hormone receptor-like 1 0.0163 0.0407 0.0407
Brugia malayi vesicular acetylcholine transporter unc-17 0.0882 0.3232 0.3232
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Onchocerca volvulus Protein ultraspiracle homolog 0.0309 0.098 0.3032
Brugia malayi orphan nuclear receptor NR2E1 0.0146 0.0339 0.0339
Trypanosoma brucei C-8 sterol isomerase, putative 0.2605 1 1
Echinococcus multilocularis neutral amino acid transporter A 0.0304 0.0962 0.2976
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0288 0.0238
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0146 0.0339 0.0352
Brugia malayi nuclear hormone receptor 0.0309 0.098 0.098
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.055 0.1926 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0304 0.0962 0.4937
Brugia malayi steroid hormone receptor 0.0309 0.098 0.098
Brugia malayi conserved hypotetical protein 0.0146 0.0339 0.0339
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0146 0.0339 0.1048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0309 0.098 0.3032
Echinococcus granulosus Excitatory amino acid transporter 0.0304 0.0962 0.2976
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0309 0.098 0.3032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0146 0.0339 0.1048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0309 0.098 0.098
Echinococcus multilocularis neutral amino acid transporter A 0.0304 0.0962 0.2976
Brugia malayi hypothetical protein 0.0163 0.0407 0.0407
Echinococcus granulosus glutamate NMDA receptor subunit 0.0063 0.0014 0.0042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0309 0.098 0.1019
Loa Loa (eye worm) nuclear hormone receptor 0.0146 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0146 0.0339 0.0339
Brugia malayi photoreceptor-specific nuclear receptor 0.0309 0.098 0.098
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0304 0.0962 0.2976
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0146 0.0339 0.1048
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0146 0.0339 0.0339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0309 0.098 0.3032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0309 0.098 0.098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0309 0.098 0.098
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0309 0.098 0.3032
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0135 0.0296 0.0916
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.0407
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0051 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0146 0.0339 0.1048
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0882 0.3232 1
Chlamydia trachomatis glutamate symporter 0.0304 0.0962 1
Schistosoma mansoni coup transcription factor 0.0309 0.098 0.1019
Echinococcus granulosus FTZ F1 alpha 0.0309 0.098 0.3032
Loa Loa (eye worm) hypothetical protein 0.0309 0.098 0.098
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0309 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.2605 1 1
Leishmania major C-8 sterol isomerase-like protein 0.2605 1 1
Brugia malayi Inositol-1 0.0073 0.0051 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0146 0.0339 0.0352
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0051 0.0159

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.3 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2 ChEMBL. 16165356
IC50 (binding) = 3 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3 ChEMBL. 16165356
IC50 (binding) = 20 uM Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1 ChEMBL. 16165356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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