TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.357 | Formula: C20H15FN4O3
H donors: 1 H acceptors: 4 LogP: 2.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccccc1n1c(C)nc2c(c1=O)cc(cc2)C(=O)c1cnn(c1O)C
InChi: 1S/C20H15FN4O3/c1-11-23-16-8-7-12(18(26)14-10-22-24(2)19(14)27)9-13(16)20(28)25(11)17-6-4-3-5-15(17)21/h3-10,27H,1-2H3
InChiKey: WLEJDSUDDHGCTO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	4-hydroxyphenylpyruvate dioxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448
Onchocerca volvulus	Putative protein	Get druggable targets OG5_129448	All targets in OG5_129448
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	Get druggable targets OG5_129448	All targets in OG5_129448
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448
Candida albicans	similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0582	0.0687
Loa Loa (eye worm)	sugar transporter	0.0102	0.2253	0.2659
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0582	0.2583
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.3529
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Brugia malayi	Sugar transporter family protein	0.0102	0.2253	0.2659
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	0.6204
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	0.3529
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0597	0.0597
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Plasmodium vivax	sugar transporter, putative	0.0014	0.0201	0.0201
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Plasmodium vivax	glyoxalase I, putative	0.0054	0.1129	0.1129
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	0.6204
Mycobacterium ulcerans	glyoxalase GloA	0.0054	0.1129	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0164	0.3724	0.3724
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0238
Onchocerca volvulus	Lactoylglutathione lyase homolog	0.0054	0.1129	0.1122
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0164	0.3724	0.5632
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	0.0366	0.8475	1
Mycobacterium ulcerans	glyoxalase GloA	0.0054	0.1129	1
Leishmania major	hypothetical protein, conserved	0.0014	0.0201	0.1783
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Schistosoma mansoni	hypothetical protein	0.0102	0.2253	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0582	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.1129	0.5012
Schistosoma mansoni	gynecophoral canal protein	0.0054	0.1129	0.5012
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0201	0.1783
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0552	0.2448
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8651
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2253	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5367
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0597	0.0903
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Mycobacterium leprae	conserved hypothetical protein	0.0054	0.1129	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0597	0.0903
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0597	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Brugia malayi	Cam kinase protein 1	0.0031	0.0597	0.0704
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0164	0.3724	0.3724
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium falciparum	hexose transporter	0.0102	0.2253	0.2253
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2253	1
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.0704
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0597	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0597	0.2648
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0238
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0201	0.1783
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0238
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.003	0.0582	0.0687
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0201	0.0305
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	0.2818
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Mycobacterium tuberculosis	Conserved protein TB27.3	0.0054	0.1129	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0597	0.0704
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0054	0.1129	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Leishmania major	glyoxalase I,trypanothione-dependent glyoxalase I	0.0054	0.1129	1
Plasmodium falciparum	glyoxalase I	0.0054	0.1129	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0201	0.0305
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0582	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0054	0.1129	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	glyoxalase family protein	0.0054	0.1129	0.1708
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0597	0.0903
Loa Loa (eye worm)	sugar transporter	0.0014	0.0201	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0597	0.0704
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0597	0.2648
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0238
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0201	0.1783
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.1783
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.5367
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2253	0.3408
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	glucose transporter	0.0014	0.0201	0.0894
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	0.3529
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	0.6204
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.2395
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Giardia lamblia	Sugar-proton symporter	0.0014	0.0201	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0582	0.2583
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0597	0.0597
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0582	0.5153
Leishmania major	protein kinase, putative	0.0031	0.0597	0.5284
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0582	0.2583
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0597	0.0597
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0201	0.0201
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.5367
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Onchocerca volvulus	Putative protein	0.0366	0.8475	1
Brugia malayi	lactoylglutathione lyase	0.0054	0.1129	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.0528
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.047
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0201	0.2874
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.5367
Toxoplasma gondii	protein kinase, putative	0.0287	0.6612	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	4-hydroxyphenylpyruvate dioxygenase	0.0054	0.1129	0.5012
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0201	0.1783
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.047
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.5367
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0054	0.1129	1
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.2818
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0201	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Plasmodium vivax	glyoxalase I, putative	0.0054	0.1129	0.1129
Mycobacterium tuberculosis	Conserved protein	0.0054	0.1129	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0582	0.9752
Toxoplasma gondii	glyoxalase I, putative	0.0054	0.1129	0.1708
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0597	0.0704
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0597	0.0597
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0188
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.3529
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	0.0366	0.8475	1
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1129	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.1129	0.5012
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0582	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Plasmodium vivax	hexose transporter	0.0102	0.2253	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Mycobacterium tuberculosis	Cadmium inducible protein CadI	0.0054	0.1129	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0552	0.2448
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0238
Plasmodium falciparum	protein kinase 7	0.0287	0.6612	0.6612
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.3529
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0201	0.1783
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0201	0.0305
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0597	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0201	0.0305
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Mycobacterium ulcerans	biphenyl-2,3-diol 1,2-dioxygenase	0.0054	0.1129	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0431	1	1
Echinococcus multilocularis	General substrate transporter	0.0087	0.1918	0.851
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0238
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0238
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0201	0.1783
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	0.6204
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5367
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0582	0.2583
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0597	0.0597
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Mycobacterium tuberculosis	Conserved protein	0.0054	0.1129	1
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0201	0.1783
Plasmodium falciparum	glyoxalase I	0.0054	0.1129	0.1129
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0201	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1129	0.1333
Loa Loa (eye worm)	hypothetical protein	0.003	0.0582	0.0687
Echinococcus granulosus	General substrate transporter	0.0087	0.1918	0.851
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0238
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Giardia lamblia	Hexose transporter	0.0014	0.0201	0.346
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.1051
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Mycobacterium ulcerans	sugar transporter	0.0014	0.0201	0.1783
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.2818
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.5367
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0597	0.8517
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.5367
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 15 nM	Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrophotometry	ChEMBL.	25182962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3342432

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 935471