TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.526 | Formula: C29H26N2O7
H donors: 1 H acceptors: 3 LogP: 3.9 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: N#CC1=C(N)OC2=C(C1c1cc(C)c3c(c1)cc(c(=O)o3)c1cc(OC)c(c(c1)OC)OC)C(=O)CCC2
InChi: 1S/C29H26N2O7/c1-14-8-16(24-19(13-30)28(31)37-21-7-5-6-20(32)25(21)24)9-17-10-18(29(33)38-26(14)17)15-11-22(34-2)27(36-4)23(12-15)35-3/h8-12,24H,5-7,31H2,1-4H3
InChiKey: DSRRIIZRHNXSQA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Onchocerca volvulus	Arrow homolog	0.0027	0.0344	0.0344
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.1035
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1138	0.1138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Echinococcus multilocularis	geminin	0.0165	0.6255	0.6136
Onchocerca volvulus		0.0026	0.0309	0.0309
Brugia malayi	beta-lactamase family protein	0.0035	0.0712	0.0712
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1138	0.0856
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0712	0.5
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0774	0.0774
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0774	0.1511
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0043	0.1035	0.075
Loa Loa (eye worm)	serotonin transporter b	0.0252	1	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.1035	0.075
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0774	0.0076
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0309	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0309	0.243
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0048	0.1271	1
Onchocerca volvulus		0.0035	0.0712	0.0712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0309	0.0309
Schistosoma mansoni	sodium/chloride dependent transporter	0.0252	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0712	0.0712
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0027	0.0344	0.037
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.1035	0.1035
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0712	0.0712
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0138	0.512	0.512
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0048	0.1271	0.2482
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0309	0.0309
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0252	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0309	0.0309
Brugia malayi	Fibulin-1 precursor	0.0027	0.0344	0.0344
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0774	0.048
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0027	0.0344	0.0344
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0027	0.0344	0.0344
Echinococcus granulosus	serotonin transporter	0.0252	1	1
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0774	0.609
Loa Loa (eye worm)	hypothetical protein	0.0252	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0712	0.5605
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0027	0.0344	0.0344
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0138	0.512	0.512
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0027	0.0344	0.0344
Echinococcus granulosus	geminin	0.0165	0.6255	0.6255
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1138	0.1138
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0344	0.0344
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0774	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.1035
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.7553
Loa Loa (eye worm)	hypothetical protein	0.0252	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0712	0.1391
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0138	0.512	1
Schistosoma mansoni	ap endonuclease	0.0037	0.0774	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0309	0.399
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.1035	0.1035
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0774	0.4835
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.1035
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.1035
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.1035	0.1035
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0043	0.1035	0.075
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0309	0.0603
Onchocerca volvulus		0.0252	1	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0712	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.0344
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.1271	0.1271
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0048	0.1271	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1035	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0138	0.512	0.512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Onchocerca volvulus		0.0026	0.0309	0.0309
Echinococcus granulosus	Tolloid protein 1	0.0027	0.0344	0.0344
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0309	0.0603
Plasmodium vivax	amine transporter, putative	0.0043	0.1035	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0252	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0712	0.4195
Echinococcus multilocularis	Tolloid protein 1	0.0027	0.0344	0.0037
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0027	0.0344	0.037
Loa Loa (eye worm)	fibroinase	0.0026	0.0309	0.0309
Loa Loa (eye worm)	ctsf protein	0.0026	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Plasmodium falciparum	transporter, putative	0.0043	0.1035	1
Toxoplasma gondii	exonuclease III APE	0.0037	0.0774	0.4835
Brugia malayi	beta-lactamase	0.0035	0.0712	0.0712
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Toxoplasma gondii	ABC1 family protein	0.0035	0.0712	0.4195
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0774	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.8848	1
Onchocerca volvulus		0.0035	0.0712	0.0712
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0309	0.0309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0043	0.1035	0.075
Schistosoma mansoni	ap endonuclease	0.0037	0.0774	0.0774
Onchocerca volvulus		0.0026	0.0309	0.0309
Echinococcus granulosus	cathepsin b	0.0138	0.512	0.512
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0712	0.5605
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.7553
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0712	0.0712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Onchocerca volvulus		0.0026	0.0309	0.0309
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0309	0.0309
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0712	0.1391
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.1035	0.7553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1138	0.1138
Giardia lamblia	Cathepsin B precursor	0.0048	0.1271	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0309	0.399
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.0344
Schistosoma mansoni	egf-like domain protein	0.0027	0.0344	0.0344
Echinococcus multilocularis	cathepsin b	0.0138	0.512	0.4964
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.0344
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Plasmodium falciparum	amino acid transporter, putative	0.0043	0.1035	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0043	0.1035	0.1035
Onchocerca volvulus		0.0043	0.1035	0.1035
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0774	0.64
Loa Loa (eye worm)	hypothetical protein	0.0138	0.512	0.512
Echinococcus multilocularis	serotonin transporter	0.0252	1	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0252	1	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0712	0.0712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Toxoplasma gondii	hypothetical protein	0.0043	0.1035	0.7553
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0309	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Onchocerca volvulus		0.0026	0.0309	0.0309
Schistosoma mansoni	hypothetical protein	0.0165	0.6255	0.6255
Echinococcus granulosus	cathepsin b	0.0138	0.512	0.512
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0774	0.0774
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0712	0.5553
Echinococcus multilocularis	fibrillin 1	0.0027	0.0344	0.0037
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1138	0.1138
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.1035	0.1035
Echinococcus multilocularis	cathepsin b	0.0138	0.512	0.4964
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0712	0.5605
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Giardia lamblia	Cathepsin B precursor	0.0048	0.1271	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0309	0.0603
Trichomonas vaginalis	esterase, putative	0.0035	0.0712	0.5605
Onchocerca volvulus		0.0035	0.0712	0.0712
Loa Loa (eye worm)	norepinephrine transporter	0.0252	1	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.0252	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0712	0.0712
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Echinococcus multilocularis	laminin	0.0027	0.0344	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.0344
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0027	0.0344	0.0344
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0309	0.0309
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0712	0.5605
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Brugia malayi	cathepsin B-like cysteine proteinase	0.0138	0.512	0.512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0309	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Onchocerca volvulus		0.0026	0.0309	0.0309
Loa Loa (eye worm)	cysteine protease	0.0026	0.0309	0.0309
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0712	0.0416
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0712	0.5605
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0309	0.243
Onchocerca volvulus		0.0026	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1138	0.1138
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0774	0.0774
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0043	0.1035	0.5
Loa Loa (eye worm)	cathepsin B	0.0048	0.1271	0.1271
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0774	0.609
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.1035	0.1035
Onchocerca volvulus		0.0043	0.1035	0.1035
Giardia lamblia	Cathepsin B precursor	0.0048	0.1271	1
Brugia malayi	hypothetical protein	0.0043	0.1035	0.1035
Schistosoma mansoni	hypothetical protein	0.0165	0.6255	0.6255
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0712	0.0712
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0309	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.1271	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0774	0.64
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0043	0.1035	0.1035
Leishmania major	hypothetical protein, conserved	0.0035	0.0712	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1035	0.1035
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0138	0.512	0.512
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0309	0.0309
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0309	0.399
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0309	0.0603
Toxoplasma gondii	cathepsin B	0.0048	0.1271	1
Toxoplasma gondii	hypothetical protein	0.0043	0.1035	0.7553
Echinococcus granulosus	cathepsin l1	0.0026	0.0309	0.0309
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1138	0.1138
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.1035	0.1035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1138	0.1138
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Echinococcus granulosus	laminin	0.0027	0.0344	0.0344
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1138	0.0856
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0774	0.4835
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.1035	0.075
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0774	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0043	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0309	0.243
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0309	0.0309
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0712	0.0712
Onchocerca volvulus		0.0043	0.1035	0.1035
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0774	0.1511

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 5.22 %	Antidepressant-like activity in Swiss albino mouse assessed as decrease in immobility time at 0.5 mg/kg, ip measured for 5 mins by forced swimming test relative to control	ChEMBL.	25488839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3354424

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 944648