Detailed information for compound 954638

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 495.62 | Formula: C23H25N7O2S2
  • H donors: 0 H acceptors: 5 LogP: 1.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)N(Cc1cncn1C)CCN(S(=O)(=O)c1ncn(c1)C)Cc1cscc1
  • InChi: 1S/C23H25N7O2S2/c1-27-15-23(26-18-27)34(31,32)30(13-20-7-10-33-16-20)9-8-29(14-22-12-25-17-28(22)2)21-5-3-19(11-24)4-6-21/h3-7,10,12,15-18H,8-9,13-14H2,1-2H3
  • InChiKey: PRLPUFDEFXKPJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, beta References
Mus musculus farnesyltransferase, CAAX box, beta Starlite/ChEMBL References
Homo sapiens protein geranylgeranyltransferase type I, beta subunit Starlite/ChEMBL References
Mus musculus farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References
Mus musculus protein geranylgeranyltransferase type I, beta subunit Starlite/ChEMBL References
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania major farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_129786 All targets in OG5_129786
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_129786 All targets in OG5_129786
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum protein geranyl-geranyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium hominis chain B, structure of fpt bound to ggpp Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania braziliensis farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus granulosus geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania donovani farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium yoelii Prenyltransferase and squalene oxidase repeat, putative Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma mansoni geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Trypanosoma brucei protein farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative Get druggable targets OG5_129786 All targets in OG5_129786
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) Get druggable targets OG5_129786 All targets in OG5_129786
Giardia lamblia Prenyltransferase Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus granulosus protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania infantum farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) Get druggable targets OG5_129786 All targets in OG5_129786
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Trypanosoma brucei gambiense protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma mansoni geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica geranylgeranyl transferase beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_129786 All targets in OG5_129786
Plasmodium knowlesi protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania mexicana farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum protein farnesyltranstransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein farnesyltransferase beta subunit protein geranylgeranyltransferase type I, beta subunit 377 aa 361 aa 26.3 %
Trypanosoma brucei protein farnesyltransferase beta subunit protein geranylgeranyltransferase type I, beta subunit 377 aa 361 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0146 0.2581 0.3649
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0553 1 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0386 0.6945 0.6945
Brugia malayi Patatin-like phospholipase family protein 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0146 0.2581 0.2581
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.01 0.1744 0.2833
Toxoplasma gondii Hit family protein involved in cell-cycle regulation, putative 0.0008 0.0073 0.0116
Trichomonas vaginalis ankyrin, putative 0.0004 0.0001 0.000000055105
Trypanosoma brucei Bis(5'-adenosyl)-triphosphatase, putative 0.0087 0.1502 0.2441
Giardia lamblia Protein 21.1 0.0004 0.0001 0.000000079345
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0342 0.6151 0.615
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0342 0.6151 0.615
Trichomonas vaginalis ankyrin, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.01 0.1744 0.2833
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.01 0.1744 0.1743
Mycobacterium ulcerans hypothetical protein 0.0087 0.1502 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0342 0.6151 0.615
Toxoplasma gondii hypothetical protein 0.01 0.1744 0.2833
Chlamydia trachomatis Hit family hydrolase 0.0008 0.0073 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0089 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.2581 0.4195
Echinococcus multilocularis serine:threonine protein kinase KDX1 0.0008 0.0073 0.0072
Trichomonas vaginalis inversin, putative 0.0004 0.0001 0.000000055105
Giardia lamblia Rab geranylgeranyltransferase 0.0386 0.6945 1
Brugia malayi Hypothetical HIT-like protein F21C3.3 0.0008 0.0073 0.0072
Trichomonas vaginalis homeobox-containing protein wariai, putative 0.0004 0.0001 0.000000055105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0089 0.0087
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.1744 0.2833
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.01 0.1744 0.1744
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.01 0.1744 0.1743
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.000000055105
Giardia lamblia HIT family protein 0.0008 0.0073 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.01 0.1744 0.1743
Echinococcus granulosus cpg binding protein 0.0031 0.0489 0.0488
Plasmodium falciparum histidine triad protein, putative 0.0087 0.1502 0.208
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.000000055105
Trypanosoma brucei hypothetical protein, conserved 0.01 0.1744 0.2833
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0342 0.6151 0.615
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.01 0.1744 0.2833
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0146 0.2581 0.3649
Trichomonas vaginalis cask-interacting protein (caskin) 1,2, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus serine:threonine protein kinase KDX1 0.0008 0.0073 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Giardia lamblia Rab geranylgeranyltransferase 0.01 0.1744 0.2509
Loa Loa (eye worm) IRE protein kinase 0.0091 0.1585 0.1584
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Brugia malayi Uncoordinated protein 44 0.0004 0.0001 0.000000055105
Schistosoma mansoni hypothetical protein 0.0004 0.0001 0.0001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Giardia lamblia Ankyrin 1 0.0004 0.0001 0.000000079345
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 10 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.000000055105
Giardia lamblia Kinase, NEK-frag 0.0005 0.0012 0.0015
Schistosoma mansoni cpg binding protein 0.0031 0.0489 0.0489
Brugia malayi CXXC zinc finger family protein 0.0029 0.0459 0.0457
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0004 0.0001 0.000000055105
Onchocerca volvulus 0.01 0.1744 1
Trichomonas vaginalis ion channel nompc, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.01 0.1744 0.1743
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis fibronectin type 3 and ankyrin repeat domains, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0342 0.6151 0.6151
Echinococcus granulosus Ankyrin 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ion channel nompc, putative 0.0004 0.0001 0.000000055105
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.01 0.1744 0.2833
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0286 0.5125 0.5124
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0553 1 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0342 0.6151 0.615
Toxoplasma gondii hypothetical protein 0.0286 0.5125 0.8332
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0553 1 1
Leishmania major farnesyltransferase beta subunit 0.0342 0.6151 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0342 0.6151 0.615
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0342 0.6151 0.615
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Brugia malayi Leucine Rich Repeat family protein 0.0004 0.0001 0.000000055105
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0553 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi lanosterol synthase, putative 0.0146 0.2581 0.4195
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus dnaJ subfamily B 0.0419 0.7547 0.7547
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0553 1 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0386 0.6945 0.6945
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0056 0.0055
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0004 0.0001 0.000000055105
Brugia malayi Ribonuclease 2-5A family protein 0.0091 0.1585 0.1584
Schistosoma mansoni hypothetical protein 0.0419 0.7547 0.7547
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi adenosine 5'-monophosphoramidase, putative 0.0008 0.0073 0.0116
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin, putative 0.0004 0.0001 0.000000055105
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0342 0.6151 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1585 0.1585
Giardia lamblia Kinase, NEK 0.0005 0.0012 0.0015
Trypanosoma cruzi protein farnesyltransferase, putative 0.0342 0.6151 1
Trichomonas vaginalis unc-44 ankyrins, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0091 0.1585 0.1584
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0056 0.0055
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0196 0.3493 0.4976
Trichomonas vaginalis unc-44 ankyrins, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0386 0.6945 0.6945
Trypanosoma brucei Ankyrin repeats (many copies), putative 0.0004 0.0001 0.000000089599
Trypanosoma brucei lanosterol synthase 0.0146 0.2581 0.4195
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0342 0.6151 0.615
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0386 0.6945 0.6945
Echinococcus multilocularis Nitrilase and fragile histidine triad fusion 0.0008 0.0073 0.0072
Schistosoma mansoni tankyrase 0.0004 0.0001 0.0001
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0342 0.6151 0.615
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.2581 0.4195
Plasmodium vivax geranylgeranyltransferase, putative 0.0146 0.2581 0.3649
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0073 0.0072
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat domain-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0553 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0146 0.2581 0.258
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0146 0.2581 0.258
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0146 0.2581 0.4195
Onchocerca volvulus 0.0029 0.0459 0.2624
Trypanosoma brucei adenosine 5'-monophosphoramidase, putative 0.0008 0.0073 0.0116
Entamoeba histolytica protein kinase, putative 0.0091 0.1585 0.1584
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Entamoeba histolytica protein kinase, putative 0.0091 0.1585 0.1584
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) tnks protein 0.0004 0.0001 0.000000055105
Leishmania major ankyrin/TPR repeat protein 0.0004 0.0001 0.000000089599
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0146 0.2581 0.4195
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.01 0.1744 0.2833
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi adenosine 5'-monophosphoramidase, putative 0.0008 0.0073 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.1744 0.2833
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis ion channel nompc, putative 0.0004 0.0001 0.000000055105
Giardia lamblia Kinase, NEK 0.0005 0.0012 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Echinococcus granulosus protein prenyltransferase alpha subunit 0.01 0.1744 0.1743
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Mycobacterium leprae Conserved hypothetical protein 0.0087 0.1502 1
Trichomonas vaginalis E3 ubiquitin protein ligase, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hydrolase 0.0008 0.0073 0.0072
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.01 0.1744 0.1743
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis TKL family protein kinase 0.0005 0.0012 0.001
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0146 0.2581 0.258
Echinococcus multilocularis tankyrase 0.0004 0.0001 0.000000055105
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0342 0.6151 0.615
Giardia lamblia Kinase, NEK 0.0005 0.0012 0.0015
Toxoplasma gondii histidine triad domain-containing protein 0.0087 0.1502 0.2441
Giardia lamblia Rab geranylgeranyltransferase 0.0146 0.2581 0.3715
Trichomonas vaginalis histidine triad (hit) protein, putative 0.0087 0.1502 0.1501
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1575 0.1573
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0091 0.1585 0.1584
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0386 0.6945 0.6945
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0342 0.6151 0.615
Trypanosoma cruzi protein farnesyltransferase, putative 0.0342 0.6151 1
Toxoplasma gondii diadenosine tetraphosphatase family protein 0.0087 0.1502 0.2441
Trichomonas vaginalis cortactin-binding protein, putative 0.0004 0.0001 0.000000055105
Leishmania major geranylgeranyltransferase, putative 0.0146 0.2581 0.4195
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0386 0.6945 0.6945
Giardia lamblia Kinase, NEK 0.0005 0.0012 0.0015
Leishmania major hypothetical protein, conserved 0.0004 0.0001 0.000000089599
Trichomonas vaginalis nf kappa B inhibitor I-kappa-B, putative 0.0004 0.0001 0.000000055105
Leishmania major hypothetical protein, conserved 0.0087 0.1502 0.2441
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0146 0.2581 0.258
Trypanosoma cruzi ankyrin repeat protein, putative 0.0004 0.0001 0.000000089599
Schistosoma mansoni phospholipase 0.0004 0.0001 0.0001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat and sam domain-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis mind bomb, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0386 0.6945 1
Schistosoma mansoni histidine triad (hit) protein 0.0008 0.0073 0.0073
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12B, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.1502 0.2441
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Leishmania major hypothetical protein, conserved 0.0008 0.0073 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Schistosoma mansoni cpg binding protein 0.0029 0.0459 0.0459
Plasmodium vivax histidine triad protein, putative 0.0087 0.1502 0.208
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0342 0.6151 0.8844
Trichomonas vaginalis ion channel nompc, putative 0.0004 0.0001 0.000000055105
Mycobacterium tuberculosis Conserved protein 0.0087 0.1502 0.5699
Giardia lamblia Prenyltransferase 0.0342 0.6151 0.8856
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0089 0.0087
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0386 0.6945 0.6945
Trichomonas vaginalis tankyrase, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis rolling pebbles, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni ankyrin 23/unc44 0.0004 0.0001 0.0001
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.01 0.1744 0.2431
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0342 0.6151 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma cruzi lanosterol synthase, putative 0.0146 0.2581 0.4195
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.000000055105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Brugia malayi Patatin-like phospholipase family protein 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.000000055105
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0146 0.2581 0.4195
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0073 0.0072
Schistosoma mansoni 26S proteasome subunit 0.0004 0.0001 0.0001
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0386 0.6945 0.6945
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0386 0.6945 1
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0004 0.0001 0.000000055105
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.7547 0.7547
Echinococcus granulosus Nitrilase and fragile histidine triad fusion 0.0008 0.0073 0.0072
Echinococcus multilocularis Ankyrin 0.0004 0.0001 0.000000055105
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0091 0.1575 0.1573
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0146 0.2581 0.4195
Schistosoma mansoni ankyrin repeat domain protein 0.0004 0.0001 0.0001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.01 0.1744 0.2833
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.01 0.1744 0.1743
Loa Loa (eye worm) hypothetical protein 0.0146 0.2581 0.258
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0045 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0937 0.1522
Trichomonas vaginalis unc-44 ankyrins, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis helicase, putative 0.0007 0.0045 0.0043
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis fetal globin-inducing factor, putative 0.0004 0.0001 0.000000055105
Echinococcus multilocularis ankyrin repeat domain containing protein 6 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni cpg binding protein 0.0031 0.0489 0.0489
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 10 0.0004 0.0001 0.000000055105
Echinococcus granulosus Ankyrin 0.0004 0.0001 0.000000055105
Wolbachia endosymbiont of Brugia malayi HIT family hydrolase 0.0008 0.0073 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0459 0.0457
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0056 0.0055
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.01 0.1744 0.2431
Plasmodium falciparum geranylgeranyltransferase, putative 0.0146 0.2581 0.3649
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Echinococcus multilocularis cpg binding protein 0.0031 0.0489 0.0488
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.01 0.1744 0.1743
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.1502 0.2441
Echinococcus granulosus tankyrase 0.0004 0.0001 0.000000055105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1059 0.1059
Leishmania major protein farnesyltransferase alpha subunit, putative 0.01 0.1744 0.2833
Echinococcus multilocularis Ankyrin 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0342 0.6151 0.8844
Loa Loa (eye worm) hypothetical protein 0.0146 0.2581 0.258
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0146 0.2581 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0386 0.6945 0.6945
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0004 0.0001 0.000000055105
Loa Loa (eye worm) hypothetical protein 0.0386 0.6945 0.6945
Giardia lamblia Protein 21.1 0.0004 0.0001 0.000000079345
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0004 0.0001 0.000000055105
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0056 0.0055
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0553 1 1
Entamoeba histolytica ankyrin repeat protein, putative 0.0004 0.0001 0.000000055105
Schistosoma mansoni ga binding protein beta chain (transcription factor e4tf1-47) 0.0004 0.0001 0.0001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.000000055105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0045 0.0043
Brugia malayi hydrolase, carbon-nitrogen family protein 0.0008 0.0073 0.0072
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0087 0.0085
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0004 0.0001 0.000000055105
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0146 0.2581 0.258

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 150 nM Antimalarial activity in Plasmodium falciparum 3D7 infected erythrocytes as [3H]hypoxanthine uptake ChEMBL. 18686940
IC50 (binding) = 67 nM Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS ChEMBL. 20822181
IC50 (binding) = 940 nM Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLL ChEMBL. 20822181
IC50 (functional) = 0.4 uM Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells ChEMBL. 20822181
IC50 (functional) > 10 uM Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cells ChEMBL. 20822181

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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