TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 502.548 | Formula: C27H31N6O2P
H donors: 1 H acceptors: 4 LogP: 3.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Cc1cccc(c1/C=C/n1cnc2c1nc(nc2Nc1ccc(cc1)P(=O)(C)C)N1CCOCC1)C
InChi: 1S/C27H31N6O2P/c1-19-6-5-7-20(2)23(19)12-13-33-18-28-24-25(29-21-8-10-22(11-9-21)36(3,4)34)30-27(31-26(24)33)32-14-16-35-17-15-32/h5-13,18H,14-17H2,1-4H3,(H,29,30,31)/b13-12+
InChiKey: VWBZVMZFOBZQTD-OUKQBFOZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Schistosoma mansoni	amine oxidase	0.0041	0.0092	0.0099
Onchocerca volvulus	Putative endochitinase	0.0088	0.0961	0.5629
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0091	0.1023	0.1101
Entamoeba histolytica	protein kinase domain containing protein	0.0186	0.2771	0.422
Brugia malayi	GSG2	0.0503	0.8599	0.9251
Schistosoma mansoni	hypothetical protein	0.0087	0.0941	0.1012
Loa Loa (eye worm)	haspin protein kinase	0.0507	0.8679	0.9334
Entamoeba histolytica	hypothetical protein	0.0087	0.0941	0.1433
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.026	0.4121	0.4434
Echinococcus granulosus	neuroligin	0.0091	0.1023	0.1101
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Brugia malayi	hypothetical protein	0.0091	0.1023	0.1101
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0503	0.8599	0.9251
Echinococcus granulosus	mitogen activated protein kinase 15	0.0091	0.1021	0.1098
Onchocerca volvulus		0.0091	0.1023	0.6028
Loa Loa (eye worm)	hypothetical protein	0.0541	0.9295	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.2691	0.2871
Brugia malayi	hypothetical protein	0.0041	0.0092	0.0099
Brugia malayi	Carboxylesterase family protein	0.0091	0.1023	0.1101
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0041	0.0092	0.5
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0392	0.6567	0.7065
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0186	0.2771	0.4138
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Trichomonas vaginalis	spcc417.12 protein, putative	0.0091	0.1023	0.0004
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0091	0.1021	0.1068
Brugia malayi	endochitinase	0.0088	0.0961	0.1034
Leishmania major	serine/threonine kinase-like protein, putative	0.0091	0.1021	0.1435
Echinococcus multilocularis	acetylcholinesterase	0.0541	0.9295	1
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0392	0.6567	1
Entamoeba histolytica	protein kinase domain containing protein	0.0392	0.6567	1
Brugia malayi	protein-tyrosine kinase	0.0046	0.0183	0.0196
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0054	0.0329	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1137	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Loa Loa (eye worm)	haspin protein kinase	0.0503	0.8599	0.9248
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0054	0.0329	0.0354
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0091	0.1023	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0541	0.9295	1
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0574	0.0487
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0091	0.1021	0.1435
Loa Loa (eye worm)	cuticular endochitinase	0.0079	0.0787	0.0815
Loa Loa (eye worm)	TK/ABL protein kinase	0.026	0.4121	0.4414
Schistosoma mansoni	tyrosine kinase	0.0054	0.0329	0.0354
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0054	0.0329	0.0354
Onchocerca volvulus	Putative endochitinase	0.0088	0.0961	0.5629
Schistosoma mansoni	BC026374 protein (S09 family)	0.0091	0.1023	0.1101
Brugia malayi	amine oxidase, flavin-containing family protein	0.0041	0.0092	0.0099
Onchocerca volvulus		0.0125	0.1637	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.1021	0.1098
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0125	0.1637	0.1761
Echinococcus multilocularis	carboxylesterase 5A	0.0541	0.9295	1
Plasmodium falciparum	MO15-related protein kinase	0.0091	0.1021	0.6014
Echinococcus granulosus	para nitrobenzyl esterase	0.0091	0.1023	0.1101
Echinococcus multilocularis	neuroligin	0.0091	0.1023	0.1101
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.0329	0.0354
Echinococcus multilocularis	cyclin dependent kinase 9	0.0091	0.1021	0.1098
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0054	0.0329	0.0354
Plasmodium falciparum	conserved protein, unknown function	0.0125	0.1637	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.026	0.4121	0.4434
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0183	0.0163
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0574	0.0487
Onchocerca volvulus		0.0125	0.1637	1
Echinococcus granulosus	dual specificity	0.0392	0.6567	0.7065
Brugia malayi	Tyrosine-protein kinase abl-1	0.0114	0.1435	0.1544
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Echinococcus granulosus	dual specificity	0.0392	0.6567	0.7065
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0091	0.1023	0.1017
Schistosoma mansoni	amine oxidase	0.0041	0.0092	0.0099
Loa Loa (eye worm)	haspin protein kinase	0.0503	0.8599	0.9248
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0091	0.1021	0.1068
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0186	0.2771	0.3156
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.014	0.0151
Echinococcus granulosus	BC026374 protein S09 family	0.0091	0.1023	0.1101
Mycobacterium ulcerans	carboxylesterase, LipT	0.0091	0.1023	0.094
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1637	0.1732
Schistosoma mansoni	hypothetical protein	0.0125	0.1637	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Echinococcus granulosus	acetylcholinesterase	0.0541	0.9295	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0041	0.0092	0.0099
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0186	0.2771	0.4138
Echinococcus multilocularis	para nitrobenzyl esterase	0.0091	0.1023	0.1101
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0041	0.0092	0.0099
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0046	0.0183	0.0196
Echinococcus multilocularis	dual specificity	0.0392	0.6567	0.7065
Onchocerca volvulus	Putative endochitinase	0.0088	0.0961	0.5629
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Loa Loa (eye worm)	carboxylesterase	0.0541	0.9295	1
Brugia malayi	Endochitinase	0.0088	0.0961	0.1034
Schistosoma mansoni	gliotactin	0.0091	0.1023	0.1101
Brugia malayi	Protein kinase domain containing protein	0.0186	0.2771	0.2981
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0503	0.8599	0.9251
Entamoeba histolytica	protein kinase, putative	0.0392	0.6567	1
Echinococcus multilocularis	dual specificity	0.0186	0.2771	0.2981
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0091	0.1021	0.1098
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0091	0.1021	0.1435
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0058	0.0409	0.044
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0054	0.0329	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Loa Loa (eye worm)	acetylcholinesterase 1	0.0541	0.9295	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0186	0.2771	0.4138
Echinococcus multilocularis	hypothetical protein	0.0087	0.0941	0.1012
Onchocerca volvulus	Putative endochitinase	0.0079	0.0787	0.4501
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0091	0.1021	0.1098
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0541	0.9295	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0091	0.1023	0.1101
Brugia malayi	Carboxylesterase family protein	0.0541	0.9295	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0046	0.0183	0.0196
Echinococcus granulosus	tyrosine kinase	0.0046	0.0183	0.0196
Leishmania major	chitinase	0.0079	0.0787	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0574	0.0585
Onchocerca volvulus		0.0091	0.1023	0.6028
Loa Loa (eye worm)	chitinase I	0.0079	0.0787	0.0815
Schistosoma mansoni	tyrosine kinase	0.0251	0.397	0.4272
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0503	0.8599	0.9251
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0183	0.0196
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0091	0.1021	0.1435
Echinococcus multilocularis		0.0041	0.0092	0.0099
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.0032	0.0034
Brugia malayi	Carboxylesterase family protein	0.0091	0.1023	0.1101
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0091	0.1023	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Brugia malayi	SRC-1	0.0054	0.0329	0.0354
Echinococcus granulosus	dual specificity	0.0186	0.2771	0.2981
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0392	0.6567	0.7055
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.1021	0.1554
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.014	0.0151
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0054	0.0329	0.0354
Plasmodium vivax	hypothetical protein, conserved	0.0125	0.1637	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.2691	0.2871
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0392	0.6567	1
Loa Loa (eye worm)	carboxylesterase	0.0091	0.1023	0.107
Giardia lamblia	Kinase, CMGC DYRK	0.0392	0.6567	1
Brugia malayi	Carboxylesterase family protein	0.0541	0.9295	1
Onchocerca volvulus		0.0091	0.1023	0.6028
Entamoeba histolytica	protein kinase, putative	0.0186	0.2771	0.422
Brugia malayi	SWIRM domain containing protein	0.0041	0.0092	0.0099
Brugia malayi	Carboxylesterase family protein	0.0091	0.1023	0.1101
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0091	0.1021	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1637	0.1732
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0392	0.6567	1
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0091	0.1021	0.1098
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0091	0.1023	0.1101
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.2174	0.2339
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0092	0.0099
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0054	0.0329	0.0354
Schistosoma mansoni	serine/threonine protein kinase	0.0392	0.6567	0.7065
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0092	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0186	0.2771	0.2957
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0054	0.0329	0.0354
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0392	0.6567	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0091	0.1023	0.1101
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0125	0.1637	0.1761
Onchocerca volvulus		0.0091	0.1023	0.6028
Entamoeba histolytica	chitinase, putative	0.0079	0.0787	0.1198
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.1021	0.1098
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0125	0.1637	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Entamoeba histolytica	hypothetical protein	0.0186	0.2771	0.422
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0041	0.0092	0.5
Schistosoma mansoni	hypothetical protein	0.0503	0.8599	0.9251
Brugia malayi	Carboxylesterase family protein	0.0091	0.1023	0.1101
Echinococcus granulosus	tyrosine protein kinase Blk	0.0046	0.0183	0.0196
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0087	0.0941	0.1012
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0091	0.1021	0.6014
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0091	0.1021	0.1098
Brugia malayi	Cell division protein kinase 2	0.0091	0.1021	0.1098
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.0329	0.0354
Entamoeba histolytica	protein kinase, putative	0.0186	0.2771	0.422
Loa Loa (eye worm)	SRC-1	0.0054	0.0329	0.0321
Echinococcus multilocularis	dual specificity	0.0392	0.6567	0.7065
Entamoeba histolytica	cell division protein kinase 2, putative	0.0091	0.1021	0.1554
Brugia malayi	endochitinase	0.0079	0.0787	0.0847
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0065
Mycobacterium tuberculosis	Possible chitinase	0.0067	0.0574	0.0527
Onchocerca volvulus	Putative endochitinase	0.0079	0.0787	0.4501
Echinococcus multilocularis	dual specificity	0.0392	0.6567	0.7065
Entamoeba histolytica	protein kinase, putative	0.0038	0.0032	0.0048
Onchocerca volvulus		0.0091	0.1023	0.6028
Schistosoma mansoni	serine/threonine protein kinase	0.0186	0.2771	0.2981
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0091	0.1023	0.1017
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0114	0.1435	0.1544
Echinococcus granulosus	acetylcholinesterase	0.0541	0.9295	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0041	0.0092	0.0099
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0503	0.8599	0.9251
Toxoplasma gondii	hypothetical protein	0.0125	0.1637	0.2386
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0579	1	1
Loa Loa (eye worm)	carboxylesterase	0.0091	0.1023	0.107
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0091	0.1021	0.6014
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0046	0.0183	0.0196
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.0032	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Schistosoma mansoni	tyrosine kinase	0.0054	0.0329	0.0354
Schistosoma mansoni	acetylcholinesterase	0.0091	0.1023	0.1101
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0041	0.0092	0.0099
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0538	0.9249	1
Loa Loa (eye worm)	microfilarial chitinase	0.0076	0.0748	0.0774
Schistosoma mansoni	protein kinase	0.0091	0.1021	0.1098
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0503	0.8599	0.9251
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1023	0.107
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0091	0.1023	0.1101
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0329	0.0354
Brugia malayi	hypothetical protein	0.0503	0.8599	0.9251
Echinococcus granulosus	dual specificity	0.0392	0.6567	0.7065
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0091	0.1023	0.1101
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0091	0.1021	0.1435
Trichomonas vaginalis	CMGC family protein kinase	0.0392	0.6567	1
Echinococcus granulosus	cyclin dependent kinase 9	0.0091	0.1021	0.1098
Echinococcus granulosus	carboxylesterase 5A	0.0541	0.9295	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0091	0.1023	0.1017
Schistosoma mansoni	serine/threonine kinase	0.0091	0.1021	0.1098
Echinococcus multilocularis	acetylcholinesterase	0.0541	0.9295	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	< 0.23 nM	Inhibition of human Src kinase by TR-FRET assay	ChEMBL.	18691885
IC50 (binding)	= 3.02 nM	Inhibition of Abl kinase	ChEMBL.	18691885

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL454358

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 957637