Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0143 | 0.071 | 0.1511 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0176 | 0.0969 | 0.2104 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Schistosoma mansoni | acyl carrier protein | 0.0071 | 0.0145 | 0.008 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0216 | 0.1279 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.1178 | 0.8816 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0211 | 0.1245 | 0.1144 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1264 | 0.949 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Echinococcus granulosus | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0701 | 0.5082 | 0.6451 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium ulcerans | polyketide synthase | 0.0745 | 0.5423 | 0.6954 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0745 | 0.5423 | 0.6903 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0259 | 0.162 | 0.1524 |
Mycobacterium ulcerans | thioesterase TesA | 0.0584 | 0.4167 | 0.5343 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0564 | 0.4009 | 0.5049 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0259 | 0.162 | 0.1776 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0176 | 0.0969 | 0.1584 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.013 | 0.0043 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6903 |
Toxoplasma gondii | acyl carrier protein ACP | 0.0071 | 0.0145 | 0.0028 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0571 | 0.406 | 0.7425 |
Toxoplasma gondii | type I fatty acid synthase | 0.0108 | 0.0433 | 0.0571 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Loa Loa (eye worm) | fatty acid synthase | 0.0692 | 0.5009 | 0.5649 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Trypanosoma brucei | protein kinase, putative | 0.0571 | 0.406 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.0113 | 0.0054 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0109 | 0.0446 | 0.3656 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0186 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.007 | 0.0135 | 0.0054 |
Treponema pallidum | acyl carrier protein | 0.0071 | 0.0145 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.0071 | 0.0145 | 0.0019 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.013 | 0.0043 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0145 | 0.0186 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium tuberculosis | Conserved protein | 0.0211 | 0.1245 | 0.1453 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0571 | 0.406 | 1 |
Onchocerca volvulus | 0.1221 | 0.9149 | 0.9635 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.022 | 0.1315 | 0.1546 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0701 | 0.5082 | 0.6451 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0259 | 0.162 | 0.1524 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0176 | 0.0969 | 0.1032 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0571 | 0.406 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0108 | 0.0433 | 0.0394 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0745 | 0.5423 | 0.6954 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0006 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.007 | 0.0135 | 0.0012 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0455 | 0.3153 | 0.5711 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0745 | 0.5423 | 0.6897 |
Brugia malayi | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.4661 |
Brugia malayi | AMP-binding enzyme family protein | 0.0216 | 0.1279 | 0.1179 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0464 | 0.3222 | 0.4132 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0978 | 0.2191 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0464 | 0.3222 | 0.4132 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0082 | 0.0232 | 0.0302 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0745 | 0.5423 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0284 | 0.1811 | 0.2192 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0176 | 0.0969 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0176 | 0.0969 | 0.0865 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0198 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0978 | 0.1042 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Leishmania major | acyl carrier protein, putative | 0.0071 | 0.0145 | 0.0037 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0108 | 0.0433 | 0.0394 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.1245 | 0.2836 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.068 | 0.4914 | 0.6238 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0071 | 0.0145 | 0.0019 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0108 | 0.0433 | 0.0394 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0655 | 0.4721 | 0.5987 |
Brugia malayi | MAP kinase sur-1 | 0.0571 | 0.406 | 0.3992 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.071 | 0.1511 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.2081 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.162 | 0.1776 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1048 | 0.7799 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0071 | 0.0145 | 0.0186 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Echinococcus multilocularis | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0176 | 0.0969 | 0.2167 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0584 | 0.4167 | 0.5264 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0571 | 0.406 | 0.4565 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0216 | 0.1279 | 0.164 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0071 | 0.0145 | 0.0186 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.007 | 0.0135 | 0.0022 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.022 | 0.1315 | 0.1687 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0192 | 0.1097 | 0.1019 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0171 | 0.0932 | 0.1046 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Loa Loa (eye worm) | acyl carrier protein | 0.0071 | 0.0145 | 0.009 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0176 | 0.0969 | 0.2167 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6954 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0082 | 0.0232 | 0.0121 |
Onchocerca volvulus | 0.0655 | 0.4721 | 0.4897 | |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0701 | 0.5082 | 0.5026 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0143 | 0.071 | 0.1511 |
Onchocerca volvulus | 0.008 | 0.0214 | 0.0074 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6458 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0564 | 0.4009 | 0.5141 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.068 | 0.4914 | 0.6238 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0176 | 0.0969 | 0.1242 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0399 | 0.2712 | 0.3367 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.019 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0701 | 0.5082 | 0.6458 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0574 | 0.4082 | 0.5153 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0241 | 0.1478 | 0.1758 |
Mycobacterium ulcerans | thioesterase | 0.0584 | 0.4167 | 0.5343 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.2667 | 0.2973 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.0071 | 0.0145 | 0.0019 |
Toxoplasma gondii | aminotransferase, putative | 0.0385 | 0.2603 | 0.4672 |
Brugia malayi | Melibiase family protein | 0.0078 | 0.0198 | 0.0085 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.532 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6517 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0176 | 0.0969 | 0.2133 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0322 | 0.2116 | 0.2342 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0354 | 0.2366 | 0.4224 |
Echinococcus multilocularis | GPCR, family 2 | 0.0082 | 0.0232 | 0.0302 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0745 | 0.5423 | 0.6897 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0108 | 0.0433 | 0.0376 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0145 | 0.008 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0464 | 0.3222 | 0.402 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.0121 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0211 | 0.1245 | 0.2711 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0232 | 0.019 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0584 | 0.4167 | 0.5255 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0745 | 0.5423 | 0.6903 |
Plasmodium vivax | hypothetical protein, conserved | 0.0109 | 0.0446 | 0.3656 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0504 | 0.3535 | 0.4441 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | methyltransferase-related | 0.0211 | 0.1245 | 0.2866 |
Echinococcus multilocularis | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0071 | 0.0145 | 0.0019 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0211 | 0.1245 | 0.1453 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0564 | 0.4009 | 0.5141 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0176 | 0.0969 | 0.2167 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 0.08 | 0.1739 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.022 | 0.1315 | 0.1529 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0176 | 0.0969 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0701 | 0.5082 | 0.6458 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0499 | 0.35 | 0.6366 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.1794 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0108 | 0.0433 | 0.0394 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0745 | 0.5423 | 0.6897 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0177 | 0.0978 | 0.0875 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0571 | 0.406 | 1 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Echinococcus granulosus | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Toxoplasma gondii | melibiase subfamily protein | 0.0116 | 0.0501 | 0.0701 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay | ChEMBL. | 22537683 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 22 hrs by broth microdilution method | ChEMBL. | 22537683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.