Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0655 | 0.4721 | 0.4897 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0216 | 0.1279 | 0.1179 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Conserved protein | 0.0211 | 0.1245 | 0.1453 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0176 | 0.0969 | 0.2104 |
Echinococcus multilocularis | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0745 | 0.5423 | 0.6903 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0701 | 0.5082 | 0.6451 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.2667 | 0.2973 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0176 | 0.0969 | 0.1032 |
Onchocerca volvulus | 0.008 | 0.0214 | 0.0074 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0259 | 0.162 | 0.1524 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0464 | 0.3222 | 0.402 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.013 | 0.0043 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trypanosoma brucei | protein kinase, putative | 0.0571 | 0.406 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0701 | 0.5082 | 0.6458 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.019 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0145 | 0.0019 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6954 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0108 | 0.0433 | 0.0394 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0171 | 0.0932 | 0.1046 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0109 | 0.0446 | 0.3656 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.071 | 0.1511 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0071 | 0.0145 | 0.0186 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6903 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.1178 | 0.8816 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0071 | 0.0145 | 0.0186 |
Echinococcus granulosus | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0655 | 0.4721 | 0.5987 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0745 | 0.5423 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0571 | 0.406 | 0.4565 |
Echinococcus multilocularis | GPCR, family 2 | 0.0082 | 0.0232 | 0.0302 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0108 | 0.0433 | 0.0394 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0211 | 0.1245 | 0.2711 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6458 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.068 | 0.4914 | 0.6238 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.022 | 0.1315 | 0.1687 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0143 | 0.071 | 0.1511 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0071 | 0.0145 | 0.0186 |
Loa Loa (eye worm) | fatty acid synthase | 0.0692 | 0.5009 | 0.5649 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0108 | 0.0433 | 0.0394 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.1245 | 0.2836 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0745 | 0.5423 | 0.6954 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0211 | 0.1245 | 0.1453 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0354 | 0.2366 | 0.4224 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.022 | 0.1315 | 0.1529 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0176 | 0.0969 | 0.2167 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0176 | 0.0969 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0198 | 0.015 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0176 | 0.0969 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0143 | 0.071 | 0.1511 |
Schistosoma mansoni | acyl carrier protein | 0.0071 | 0.0145 | 0.008 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.2081 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.007 | 0.0135 | 0.0022 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0745 | 0.5423 | 0.6897 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0564 | 0.4009 | 0.5141 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0464 | 0.3222 | 0.4132 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0584 | 0.4167 | 0.5255 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Echinococcus multilocularis | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Brugia malayi | Melibiase family protein | 0.0078 | 0.0198 | 0.0085 |
Echinococcus granulosus | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.0032 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0176 | 0.0969 | 0.1584 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.007 | 0.0135 | 0.0054 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0464 | 0.3222 | 0.4132 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.0071 | 0.0145 | 0.0019 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0571 | 0.406 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.0113 | 0.0054 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.007 | 0.0135 | 0.0012 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0145 | 0.0186 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0232 | 0.019 |
Onchocerca volvulus | 0.1221 | 0.9149 | 0.9635 | |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0176 | 0.0969 | 0.0865 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0399 | 0.2712 | 0.3367 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0259 | 0.162 | 0.1524 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1048 | 0.7799 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0564 | 0.4009 | 0.5141 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0978 | 0.2191 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0108 | 0.0433 | 0.0376 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0176 | 0.0969 | 0.2167 |
Loa Loa (eye worm) | acyl carrier protein | 0.0071 | 0.0145 | 0.009 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.022 | 0.1315 | 0.1546 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0241 | 0.1478 | 0.1758 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Mycobacterium ulcerans | polyketide synthase | 0.0745 | 0.5423 | 0.6954 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0504 | 0.3535 | 0.4441 |
Treponema pallidum | acyl carrier protein | 0.0071 | 0.0145 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.532 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0571 | 0.406 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0499 | 0.35 | 0.6366 |
Leishmania major | acyl carrier protein, putative | 0.0071 | 0.0145 | 0.0037 |
Brugia malayi | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.4661 |
Toxoplasma gondii | acyl carrier protein ACP | 0.0071 | 0.0145 | 0.0028 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0071 | 0.0145 | 0.0186 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0564 | 0.4009 | 0.5049 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0176 | 0.0969 | 0.2167 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0574 | 0.4082 | 0.5153 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0216 | 0.1279 | 0.1498 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.1794 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0145 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0745 | 0.5423 | 0.6903 |
Echinococcus granulosus | GPCR family 2 | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Mycobacterium ulcerans | thioesterase TesA | 0.0584 | 0.4167 | 0.5343 |
Mycobacterium ulcerans | thioesterase | 0.0584 | 0.4167 | 0.5343 |
Toxoplasma gondii | type I fatty acid synthase | 0.0108 | 0.0433 | 0.0571 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0701 | 0.5082 | 0.5026 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0745 | 0.5423 | 0.6897 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0071 | 0.0145 | 0.0186 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0978 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.162 | 0.1776 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0701 | 0.5082 | 0.6451 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.0121 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0284 | 0.1811 | 0.2192 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0745 | 0.5423 | 0.6897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0259 | 0.162 | 0.1776 |
Toxoplasma gondii | melibiase subfamily protein | 0.0116 | 0.0501 | 0.0701 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0108 | 0.0433 | 0.0394 |
Loa Loa (eye worm) | acyl carrier protein | 0.0322 | 0.2116 | 0.2342 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0211 | 0.1245 | 0.1144 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0176 | 0.0969 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Schistosoma mansoni | methyltransferase-related | 0.0211 | 0.1245 | 0.2866 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.068 | 0.4914 | 0.6238 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0082 | 0.0232 | 0.0121 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0176 | 0.0969 | 0.1242 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Toxoplasma gondii | aminotransferase, putative | 0.0385 | 0.2603 | 0.4672 |
Brugia malayi | MAP kinase sur-1 | 0.0571 | 0.406 | 0.3992 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0584 | 0.4167 | 0.5264 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1264 | 0.949 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 0.08 | 0.1739 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0192 | 0.1097 | 0.1019 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0701 | 0.5082 | 0.6458 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0216 | 0.1279 | 0.164 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0455 | 0.3153 | 0.5711 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0177 | 0.0978 | 0.0875 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.013 | 0.0043 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0571 | 0.406 | 0.7425 |
Plasmodium vivax | hypothetical protein, conserved | 0.0109 | 0.0446 | 0.3656 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay | ChEMBL. | 22537683 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 22 hrs by broth microdilution method | ChEMBL. | 22537683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.