Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.005 | 0.2238 | 0.5497 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0024 | 0.0463 | 0.1002 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0022 | 0.0347 | 0.0231 |
Loa Loa (eye worm) | phosphatidylinositol-specific phospholipase C | 0.0018 | 0.0068 | 0.0068 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0053 | 0.2421 | 0.2421 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0077 | 0.4016 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0077 | 0.4016 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.2237 | 0.2236 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0347 | 0.0347 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0077 | 0.4016 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0022 | 0.0347 | 0.022 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0077 | 0.4016 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0022 | 0.0347 | 0.0865 |
Brugia malayi | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | 0.0039 | 0.1508 | 0.1508 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0347 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1576 | 0.1576 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0053 | 0.2414 | 0.2141 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0077 | 0.4016 | 0.3937 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0077 | 0.4016 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0024 | 0.0463 | 0.1002 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0022 | 0.0347 | 0.0865 |
Echinococcus granulosus | RUN | 0.0022 | 0.0347 | 0.0231 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0347 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2241 | 0.2241 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0077 | 0.4016 | 0.4016 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0024 | 0.0463 | 0.1002 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0053 | 0.2414 | 0.6012 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.005 | 0.2241 | 0.4737 |
Brugia malayi | ThiF family protein | 0.0053 | 0.2414 | 0.2414 |
Leishmania major | phospholipase c-like protein | 0.0018 | 0.0068 | 0.0169 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0077 | 0.4016 | 0.3937 |
Loa Loa (eye worm) | Plcb4 protein | 0.0039 | 0.1508 | 0.1508 |
Echinococcus multilocularis | RUN | 0.0022 | 0.0347 | 0.022 |
Brugia malayi | Variant SH3 domain containing protein | 0.0123 | 0.7135 | 0.7135 |
Loa Loa (eye worm) | doublecortin family protein | 0.0022 | 0.0347 | 0.0347 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0347 | 0.0231 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0077 | 0.4016 | 1 |
Onchocerca volvulus | 0.004 | 0.1576 | 1 | |
Schistosoma mansoni | CREB-binding protein 2 | 0.0119 | 0.6828 | 0.6714 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0159 | 0.9557 | 1 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0077 | 0.4016 | 0.5 |
Leishmania major | glyceraldehyde-3-phosphate dehydrogenase-like protein | 0.005 | 0.2238 | 0.5574 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.005 | 0.2238 | 0.5497 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Onchocerca volvulus | 0.004 | 0.1576 | 1 | |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0027 | 0.0647 | 0.5 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.005 | 0.2241 | 0.2239 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.005 | 0.2241 | 0.4737 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0077 | 0.4016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2414 | 0.2414 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0026 | 0.0644 | 0.0644 |
Schistosoma mansoni | phospholipase C-like protein 2 plc-L2 | 0.003 | 0.0853 | 0.0524 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0024 | 0.0463 | 0.1002 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.2237 | 0.4726 |
Schistosoma mansoni | phospholipase C beta | 0.0039 | 0.1508 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2479 | 0.2479 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0077 | 0.4016 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0053 | 0.2421 | 0.2421 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.005 | 0.2238 | 0.1855 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.2237 | 0.4726 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0123 | 0.7135 | 0.7135 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.005 | 0.2241 | 0.2139 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0024 | 0.0463 | 0.1002 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0077 | 0.4016 | 0.38 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.005 | 0.2241 | 0.2241 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0347 | 0.0347 |
Echinococcus multilocularis | CREB binding protein | 0.0083 | 0.4412 | 0.4339 |
Brugia malayi | TAZ zinc finger family protein | 0.0119 | 0.6828 | 0.6828 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.2237 | 0.5495 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0053 | 0.2414 | 0.6012 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.2237 | 0.5495 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0053 | 0.2414 | 0.2315 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0077 | 0.4016 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0347 | 0.0347 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0077 | 0.4016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0347 | 0.0347 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Brugia malayi | Doublecortin family protein | 0.0022 | 0.0347 | 0.0347 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0077 | 0.4016 | 0.38 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0132 | 0.7712 | 0.8043 |
Echinococcus granulosus | CREB binding protein | 0.0119 | 0.6828 | 0.7106 |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0018 | 0.0068 | 0.0068 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0077 | 0.4016 | 0.4122 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.005 | 0.2241 | 0.2241 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0077 | 0.4016 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.2237 | 0.5572 |
Echinococcus granulosus | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 0.004 | 0.1576 | 0.1534 |
Brugia malayi | phospholipase C homolog | 0.003 | 0.0853 | 0.0853 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0077 | 0.4016 | 0.5 |
Echinococcus multilocularis | 1 phosphatidylinositol 4,5 bisphosphate | 0.004 | 0.1576 | 0.1465 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0053 | 0.2414 | 0.2423 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0347 | 0.022 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0027 | 0.0647 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0084 | 0.4479 | 0.4479 |
Schistosoma mansoni | lipoxygenase | 0.0092 | 0.5051 | 0.4873 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.2414 | 0.5943 |
Loa Loa (eye worm) | acetyltransferase | 0.0166 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0077 | 0.4016 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0077 | 0.4016 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.1833 | 0.4565 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0132 | 0.7712 | 0.7682 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1576 | 0.1576 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.005 | 0.2238 | 0.5497 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0077 | 0.4016 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0075 | 0.3881 | 0.398 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0077 | 0.4016 | 0.38 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0077 | 0.4016 | 0.38 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0077 | 0.4016 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0119 | 0.6828 | 0.6714 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0077 | 0.4016 | 0.4122 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0024 | 0.0463 | 0.0463 |
Schistosoma mansoni | lipoxygenase | 0.0132 | 0.7712 | 0.7629 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.005 | 0.219 | 0.1909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.