TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.626 | Formula: C31H35N3O6
H donors: 4 H acceptors: 4 LogP: 5.21 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1c(C)cc(cc1C)C)Nc1cc2ccccc2cc1C(=O)NC(C1CCC2(CC1)OCCO2)C(=O)O
InChi: 1S/C31H35N3O6/c1-18-14-19(2)26(20(3)15-18)34-30(38)32-25-17-23-7-5-4-6-22(23)16-24(25)28(35)33-27(29(36)37)21-8-10-31(11-9-21)39-12-13-40-31/h4-7,14-17,21,27H,8-13H2,1-3H3,(H,33,35)(H,36,37)(H2,32,34,38)
InChiKey: PXLOSBDARKDVEX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 9	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	cytochrome P450, family 2, subfamily C, polypeptide 9	490 aa	441 aa	21.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	7TM GPCR rhodopsin	0.0077	0.2348	0.5655
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0379	0.0299
Echinococcus multilocularis	neuropeptide receptor A26	0.0077	0.2348	0.5655
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0791	0.3195
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0269	0.017
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0532	0.0815
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0379	0.0274
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0081	0.2476	0.5694
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Schistosoma mansoni	glycogen phosphorylase	0.013	0.4069	0.8752
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.1361	0.484
Loa Loa (eye worm)	G-protein coupled receptor	0.0077	0.2348	0.2356
Echinococcus granulosus	neuropeptide receptor A26	0.0077	0.2348	0.5655
Echinococcus multilocularis	neuropeptide Y receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Echinococcus multilocularis	g protein coupled receptor	0.0077	0.2348	0.5655
Onchocerca volvulus		0.0077	0.2348	0.4876
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	putative neuropeptide receptor NPR1	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0379	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0379	0.0274
Onchocerca volvulus		0.0077	0.2348	0.4876
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.071	0.0633
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0852	0.0783
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0309	0.1246
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Echinococcus multilocularis	serotonin receptor	0.0077	0.2348	0.5655
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0791	0.1141
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0077	0.2348	0.4876
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0791	0.2798
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0081	0.2476	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	intermediate filament protein	0.0026	0.071	0.0633
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1679	0.4126
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.1284	0.1189
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.1361	0.1266
Loa Loa (eye worm)	melatonin receptor type 1A	0.0077	0.2348	0.2356
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.071	0.0633
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.3312	0.337
Echinococcus granulosus	tm gpcr rhodopsin	0.0077	0.2348	0.5655
Brugia malayi	phosphofructokinase	0.0107	0.3312	0.337
Brugia malayi	neuropeptide F receptor	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	Serotonin receptor	0.0077	0.2348	0.2356
Echinococcus granulosus	glycogen phosphorylase	0.013	0.4069	1
Echinococcus granulosus	allatostatin A receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase	0.004	0.116	0.1107
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.4069	1
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0028	0.0767	0.1885
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0379	0.0046
Echinococcus multilocularis	neuropeptides capa receptor	0.0077	0.2348	0.5655
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Loa Loa (eye worm)	glutathione reductase	0.0047	0.1361	0.1317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0077	0.2348	0.5655
Schistosoma mansoni	hypothetical protein	0.0077	0.2348	0.505
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0028	0.0767	0.1294
Echinococcus granulosus	g-protein coupled receptor	0.0077	0.2348	0.5655
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.4069	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.1284	0.1189
Entamoeba histolytica	hypothetical protein	0.0053	0.1567	0.3851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Giardia lamblia	O-linked GlcNAc transferase	0.0023	0.0614	0.1215
Plasmodium vivax	glutathione reductase, putative	0.0047	0.1361	0.484
Toxoplasma gondii	thioredoxin reductase	0.0047	0.1361	0.5495
Brugia malayi	follicle stimulating hormone receptor	0.0302	0.9616	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0077	0.2348	0.5655
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1679	0.3085
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.045	0.1342
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0028	0.0767	0.1851
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.3312	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0379	0.0046
Schistosoma mansoni	neuropeptide receptor	0.0077	0.2348	0.505
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0136	0.0293
Schistosoma mansoni	amine GPCR	0.0077	0.2348	0.505
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0136	0.0072
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0791	0.1141
Echinococcus granulosus	tm gpcr rhodopsin	0.0077	0.2348	0.5655
Brugia malayi	G protein-coupled receptor F59B2.13	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	biogenic amine receptor	0.0077	0.2348	0.505
Schistosoma mansoni	biogenic amine receptor	0.0077	0.2348	0.505
Schistosoma mansoni	o-linked n-acetylglucosamine transferase ogt	0.004	0.1165	0.2505
Trypanosoma brucei	cytochrome P450, putative	0.0016	0.0385	0.028
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0218	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	lamin dm0	0.0026	0.071	0.152
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.3312	0.6292
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus granulosus	sex peptide receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0791	0.1944
Echinococcus granulosus	g protein coupled receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Entamoeba histolytica	hypothetical protein	0.0081	0.2476	0.6085
Echinococcus granulosus	neuropeptides capa receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0695	0.0617
Echinococcus granulosus	lamin dm0	0.0026	0.071	0.152
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0379	0.0532
Brugia malayi	ORL1-like opioid receptor	0.0077	0.2348	0.2356
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0684
Brugia malayi	Dopamine receptor protein 2	0.0077	0.2348	0.2356
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0028	0.0767	0.1885
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.3312	0.7123
Brugia malayi	G-protein coupled receptor	0.0077	0.2348	0.2356
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0077	0.2348	0.505
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.1284	0.1189
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0077	0.2348	0.5655
Echinococcus granulosus	orexin receptor type 2	0.0077	0.2348	0.5655
Leishmania major	cytochrome p450-like protein	0.0016	0.0385	0.028
Loa Loa (eye worm)	neuropeptide F receptor	0.0077	0.2348	0.2356
Entamoeba histolytica	hypothetical protein	0.0053	0.1567	0.3851
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0077	0.2348	0.5655
Treponema pallidum	hypothetical protein	0.0016	0.0369	0.1115
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0532
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0532	0.1071
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0241	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.4069	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0385	0.0291
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0241	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0077	0.2348	0.505
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.1284	0.1189
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0379	0.0532
Wolbachia endosymbiont of Brugia malayi	deoxycytidine triphosphate deaminase	0.0028	0.0767	0.1889
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Echinococcus multilocularis	lamin	0.0026	0.071	0.152
Brugia malayi	Melatonin receptor type 1A	0.0077	0.2348	0.2356
Plasmodium falciparum	thioredoxin reductase	0.0047	0.1361	0.5232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0791	0.1488
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.3312	0.8139
Schistosoma mansoni	amine GPCR	0.0077	0.2348	0.505
Loa Loa (eye worm)	dUTP diphosphatase	0.0081	0.2476	0.2491
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0385	0.0291
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.3668	0.699
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0385	0.028
Schistosoma mansoni	neuropeptide f receptor 76f	0.0077	0.2348	0.505
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus granulosus	g protein coupled receptor	0.0077	0.2348	0.5655
Plasmodium falciparum	glutathione reductase	0.0047	0.1361	0.5232
Echinococcus granulosus	lamin	0.0026	0.071	0.152
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0379	0.0417
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.3285	0.6239
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0077	0.2348	0.505
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.3312	0.8033
Brugia malayi	carbohydrate phosphorylase	0.013	0.4069	0.4166
Loa Loa (eye worm)	G-protein coupled receptor	0.0077	0.2348	0.2356
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0077	0.2348	0.505
Echinococcus multilocularis	fmrfamide receptor	0.0077	0.2348	0.5655
Echinococcus granulosus	neuropeptide Y receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0379	0.0417
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0379	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Toxoplasma gondii	O-linked N-acetylglucosamine transferase	0.004	0.115	0.4645
Echinococcus multilocularis	g protein coupled receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0135	0.0028
Toxoplasma gondii	hypothetical protein	0.0051	0.1494	0.6033
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0791	0.1665
Schistosoma mansoni	hypothetical protein	0.0077	0.2348	0.505
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0302	0.9616	1
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0532	0.0446
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0077	0.2348	0.505
Schistosoma mansoni	hypothetical protein	0.0077	0.2348	0.505
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0314	1	1
Schistosoma mansoni	lamin	0.0026	0.071	0.1528
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0379	0.0532
Schistosoma mansoni	histamine h1 receptor	0.0077	0.2348	0.505
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.4069	1
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0791	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus granulosus	hypothetical protein	0.0077	0.2348	0.5655
Onchocerca volvulus		0.0077	0.2348	0.4876
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0077	0.2348	0.5655
Schistosoma mansoni	glycogen phosphorylase	0.013	0.4069	0.8752
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.3312	0.9
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0077	0.2348	0.2356
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.3312	0.8088
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.1361	0.246
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0379	0.0274
Echinococcus granulosus	somatostatin receptor	0.0077	0.2348	0.5655
Echinococcus multilocularis	neuropeptide receptor	0.0077	0.2348	0.5655
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.4069	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.4069	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0077	0.2348	0.2356
Echinococcus multilocularis	g-protein coupled receptor	0.0077	0.2348	0.5655
Echinococcus multilocularis	allatostatin A receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0077	0.2348	0.505
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0379	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0254	0.0153
Brugia malayi	larval opioid receptor	0.0077	0.2348	0.2356
Treponema pallidum	NADH oxidase	0.0016	0.0379	0.1144
Echinococcus granulosus	neuropeptide receptor	0.0077	0.2348	0.5655
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0369	0.0513
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0815
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0077	0.2348	0.4876
Echinococcus granulosus	neuropeptide receptor	0.0077	0.2348	0.5655
Brugia malayi	Thioredoxin reductase	0.0047	0.1361	0.1317
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.3312	0.337
Brugia malayi	putative neuropeptide receptor	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0385	0.028
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0077	0.2348	0.5655
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0385	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Mycobacterium tuberculosis	Probable reductase	0.0106	0.3285	0.6239
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Onchocerca volvulus		0.0077	0.2348	0.4876
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.3312	0.8139
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0136	0.0072
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0269	0.0407
Echinococcus granulosus	neuropeptide s receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0218	0.0112
Echinococcus granulosus	G protein coupled receptor 139	0.0077	0.2348	0.5655
Schistosoma mansoni	opsin-like receptor	0.0077	0.2348	0.505
Echinococcus multilocularis	G protein coupled receptor 139	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	growth hormone secretagogue receptor	0.0077	0.2348	0.505
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0077	0.2348	0.505
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0077	0.2348	0.5655
Echinococcus granulosus	neuropeptide FF receptor 2	0.0077	0.2348	0.5655
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0852	0.0783
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus multilocularis	fmrfamide receptor	0.0077	0.2348	0.5655
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0081	0.2476	0.5863
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0077	0.2348	0.505
Brugia malayi	neuropeptide F receptor	0.0077	0.2348	0.2356
Schistosoma mansoni	cytochrome P450	0.0008	0.0108	0.0232
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.0081	0.2476	1
Echinococcus multilocularis	somatostatin receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.039	0.084
Brugia malayi	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase	0.004	0.116	0.1107
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0136	0.003
Brugia malayi	G-protein coupled receptor	0.0077	0.2348	0.2356
Echinococcus granulosus	neuropeptide Y receptor	0.0077	0.2348	0.5655
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0791	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0379	0.1036
Schistosoma mansoni	neuropeptide F-like receptor	0.0077	0.2348	0.505
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.3312	0.8033
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0077	0.2348	0.5655
Brugia malayi	AKH receptor	0.0077	0.2348	0.2356
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0379	0.0274
Echinococcus multilocularis	neuropeptide Y receptor	0.0077	0.2348	0.5655
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0081	0.2476	0.6085
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.4069	1
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.4069	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	musashi	0.0026	0.071	0.152
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0008	0.0108	0.0436
Treponema pallidum	hypothetical protein	0.0016	0.0369	0.1115
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.4658	0.46
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.3312	0.7123
Brugia malayi	G protein-coupled receptor	0.0077	0.2348	0.2356
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.3312	0.337
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0379	0.1036
Echinococcus granulosus	tm gpcr rhodopsin	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0254	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.3312	0.8033
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0379	0.0274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Onchocerca volvulus		0.0077	0.2348	0.4876
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.3285	0.6239
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0077	0.2348	0.505
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.1596	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	neuropeptide s receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	neuropeptide receptor	0.0077	0.2348	0.505
Brugia malayi	Dopamine receptor protein 1	0.0077	0.2348	0.2356
Schistosoma mansoni	hypothetical protein	0.0008	0.0108	0.0232
Echinococcus granulosus	g protein coupled receptor	0.0077	0.2348	0.5655
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0379	0.153
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0077	0.2348	0.5655
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0269	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.3285	0.6239
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0791	0.2798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0136	0.0072
Giardia lamblia	Glycogen phosphorylase	0.013	0.4069	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	opsin-like receptor	0.0077	0.2348	0.505
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0077	0.2348	0.5655
Brugia malayi	sulfakinin receptor protein	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0026	0.071	0.0633
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.4658	0.46
Echinococcus granulosus	biogenic amine 5HT receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0077	0.2348	0.505
Onchocerca volvulus		0.0077	0.2348	0.4876
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Schistosoma mansoni	neuropeptide receptor	0.0077	0.2348	0.505
Echinococcus granulosus	O glycosyltransferase	0.004	0.1165	0.2668
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0218	0.0112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.4658	0.46
Echinococcus multilocularis	neuropeptide receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0077	0.2348	0.505
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.3285	0.6239
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1679	0.4126
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.4069	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.0081	0.2476	0.7477
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0077	0.2348	0.5655
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0077	0.2348	0.505
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0077	0.2348	0.505
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0077	0.2348	0.5655
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0077	0.2348	0.5655
Onchocerca volvulus		0.0077	0.2348	0.4876
Mycobacterium ulcerans	hypothetical protein	0.0165	0.52	1
Echinococcus multilocularis	serotonin receptor	0.0077	0.2348	0.5655
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus granulosus	dro:myosuppressin receptor	0.0077	0.2348	0.5655
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.3285	0.6239
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1679	0.3085
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0077	0.2348	0.505
Echinococcus multilocularis	dro:myosuppressin receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	lamin	0.0026	0.071	0.1528
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.3668	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0077	0.2348	0.5655
Echinococcus granulosus	neuropeptides capa receptor	0.0077	0.2348	0.5655
Treponema pallidum	hypothetical protein	0.0016	0.0369	0.1115
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0274
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0081	0.2476	1
Echinococcus granulosus	serotonin receptor	0.0077	0.2348	0.5655
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0379	0.0274
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0165	0.52	1
Brugia malayi	Dopamine receptor	0.0077	0.2348	0.2356
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.1361	0.3162
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.3312	0.6292
Echinococcus granulosus	7tm_1 domain containing protein	0.0077	0.2348	0.5655
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0532	0.0815
Loa Loa (eye worm)	TYRA-2 protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.4069	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0081	0.2476	0.6085
Echinococcus granulosus	fmrfamide receptor	0.0077	0.2348	0.5655
Entamoeba histolytica	recQ family helicase, putative	0.0011	0.0218	0.0537
Echinococcus multilocularis	neuropeptides capa receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	neuropeptide receptor	0.0077	0.2348	0.505
Schistosoma mansoni	biogenic amine receptor	0.0077	0.2348	0.505
Giardia lamblia	O-linked GlcNAc transferase	0.004	0.115	0.2578
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.3312	0.3239
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0791	0.3195
Onchocerca volvulus		0.0077	0.2348	0.4876
Plasmodium falciparum	glutathione reductase	0.0016	0.0379	0.1036
Echinococcus granulosus	dUTP pyrophosphatase	0.0081	0.2476	0.5978
Schistosoma mansoni	amine GPCR	0.0077	0.2348	0.505
Entamoeba histolytica	hypothetical protein	0.0028	0.0767	0.1885
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0081	0.2476	0.5326
Entamoeba histolytica	hypothetical protein	0.0081	0.2476	0.6085
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.3312	0.8088
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0081	0.2476	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0077	0.2348	0.5655
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0077	0.2348	0.2356
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0081	0.2476	0.6085
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.3312	0.3239
Schistosoma mansoni	myosin xvIII	0.0077	0.2348	0.505
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.3312	0.8033
Brugia malayi	6-phosphofructokinase	0.0107	0.3312	0.337
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0136	0.003
Schistosoma mansoni	amine GPCR	0.0077	0.2348	0.505
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0081	0.2476	0.6085
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Trypanosoma brucei	trypanothione reductase	0.0047	0.1361	0.1266
Schistosoma mansoni	adenoreceptor	0.0077	0.2348	0.505
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.3668	0.699
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.1361	0.3162
Echinococcus multilocularis	g protein coupled receptor	0.0077	0.2348	0.5655
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0379	0.0274
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0077	0.2348	0.5655
Leishmania major	trypanothione reductase	0.0047	0.1361	0.1266
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0028	0.0767	0.1294
Echinococcus granulosus	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0077	0.2348	0.5655
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0077	0.2348	0.2356
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0532	0.0446
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0077	0.2348	0.505
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0081	0.2476	0.6085
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0385	0.0291
Schistosoma mansoni	opsin-like receptor	0.0077	0.2348	0.505
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.1361	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0379	0.0616
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0136	0.003
Echinococcus multilocularis	dUTP pyrophosphatase	0.0081	0.2476	0.5978
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0684
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0077	0.2348	0.2356
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.3312	0.8139
Echinococcus granulosus	glycogen phosphorylase	0.013	0.4069	1
Brugia malayi	6-phosphofructokinase	0.0107	0.3312	0.337
Treponema pallidum	hypothetical protein	0.0016	0.0369	0.1115
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0136	0.0551
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus granulosus	biogenic amine 5HT receptor	0.0077	0.2348	0.5655
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0077	0.2348	0.5655
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0136	0.0293
Echinococcus granulosus	intermediate filament protein	0.0026	0.071	0.152
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0077	0.2348	0.5655
Echinococcus multilocularis	O glycosyltransferase	0.004	0.1165	0.2668
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.3312	0.3239
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0028	0.0767	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Brugia malayi	Serotonin receptor	0.0077	0.2348	0.2356
Brugia malayi	RE15519p	0.0077	0.2348	0.2356
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0379	0.0026
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0077	0.2348	0.2356
Loa Loa (eye worm)	neuropeptide F receptor	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Echinococcus multilocularis	orexin receptor type 2	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0315	0.0217
Schistosoma mansoni	hypothetical protein	0.0077	0.2348	0.505
Brugia malayi	glutathione reductase	0.0047	0.1361	0.1317
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0077	0.2348	0.505
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0136	0.0551
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0379	0.0274
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1679	0.3611
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0077	0.2348	0.5655
Onchocerca volvulus		0.0077	0.2348	0.4876
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0791	0.2389
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0385	0.0291
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0077	0.2348	0.2356
Brugia malayi	GnHR receptor homolog	0.0077	0.2348	0.2356
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.071	0.0633
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0315	0.0217
Chlamydia trachomatis	deoxycytidine triphosphate deaminase	0.0028	0.0767	0.1075
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0077	0.2348	0.2356
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0077	0.2348	0.2356
Onchocerca volvulus		0.0077	0.2348	0.4876
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0532	0.1071
Onchocerca volvulus		0.0077	0.2348	0.4876
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0379	0.153
Schistosoma mansoni	neuropeptide F-like receptor	0.0077	0.2348	0.505
Brugia malayi	hypothetical protein	0.0077	0.2348	0.2356
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0791	0.1488
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0077	0.2348	0.505
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0136	0.0072
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0081	0.2476	0.6085
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0077	0.2348	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0791	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0396	0.0303
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.3285	0.8926
Brugia malayi	dUTP diphosphatase	0.0081	0.2476	0.2491
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1679	0.4126
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0016	0.0385	0.0544
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.3668	0.699
Schistosoma mansoni	amine GPCR	0.0077	0.2348	0.505
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0136	0.003
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0379	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Schistosoma mansoni	intermediate filament proteins	0.0026	0.071	0.1528
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.4069	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2348	0.2356
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0077	0.2348	0.5655
Echinococcus multilocularis	sex peptide receptor	0.0077	0.2348	0.5655

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 106 nM	Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose	ChEMBL.	19095442
IC50 (binding)	= 2053 nM	Inhibition of human liver glycogen phosphorylase A in HepG2 cells assessed as forskolin-induced glycogenolysis	ChEMBL.	19095442
IC50 (ADMET)	= 6700 nM	Inhibition of CYP2C9	ChEMBL.	19095442

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL475449

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 979090