Detailed information for compound 983977

Basic information

Technical information
  • TDR Targets ID: 983977
  • Name: methyl (E,5R)-5-[(1S,2R,4aR,8aS)-1,2,4a,5-tet ramethyl-7-oxo-3,4,8,8a-tetrahydro-2H-naphtha len-1-yl]-5-acetyloxy-3-methylpent-2-enoate
  • MW: 390.513 | Formula: C23H34O5
  • H donors: 0 H acceptors: 3 LogP: 4.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)/C=C(/C[C@H]([C@@]1(C)[C@H](C)CC[C@@]2([C@@H]1CC(=O)C=C2C)C)OC(=O)C)\C
  • InChi: 1S/C23H34O5/c1-14(11-21(26)27-7)10-20(28-17(4)24)23(6)15(2)8-9-22(5)16(3)12-18(25)13-19(22)23/h11-12,15,19-20H,8-10,13H2,1-7H3/b14-11+/t15-,19+,20-,22+,23+/m1/s1
  • InChiKey: DFFCAAPJUPLECN-XOHWVXQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl (E,5R)-5-[(1S,2R,4aR,8aS)-1,2,4a,5-tetramethyl-7-oxo-3,4,8,8a-tetrahydro-2H-naphthalen-1-yl]-5-acetoxy-3-methyl-pent-2-enoate
  • (E,5R)-5-[(1S,2R,4aR,8aS)-1,2,4a,5-tetramethyl-7-oxo-3,4,8,8a-tetrahydro-2H-naphthalen-1-yl]-5-acetoxy-3-methylpent-2-enoic acid methyl ester
  • (E,5R)-5-[(1S,2R,4aR,8aS)-7-keto-1,2,4a,5-tetramethyl-3,4,8,8a-tetrahydro-2H-naphthalen-1-yl]-5-acetoxy-3-methyl-pent-2-enoic acid methyl ester
  • methyl (E,5R)-5-[(1S,2R,4aR,8aS)-1,2,4a,5-tetramethyl-7-oxo-3,4,8,8a-tetrahydro-2H-naphthalen-1-yl]-5-acetyloxy-3-methyl-pent-2-enoate
  • 11R-Acetoxy-2-oxokolavenic acid methyl ester
  • 2-pentenoic acid, 5-(acetyloxy)-3-methyl-5-[(1S,2R,4aR,8aS)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-7-oxo-1-naphthalenyl]-, methyl ester, (2E,5R)-
  • 5-Acetoxy-3-methyl-5-(1,2,4a,5-tetramethyl-7-oxo-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl)-pent-2-enoic acid methyl ester
  • InChI=1/C23H34O5/c1-14(11-21(26)27-7)10-20(28-17(4)24)23(6)15(2)8-9-22(5)16(3)12-18(25)13-19(22)23/h11-12,15,19-20H,8-10,13H2,1-7H3/b14-11+/t15-,19+,20-,22+,23+/m1/s
  • Methyl 11R-acetoxy-2-oxoneocleroda-3,13E-dien-15-oate
  • Plectrornatin A
  • methyl rel-(2E,5R)-5-(acetyloxy)-3-methyl-5-[(1S,2R,4aR,8aS)-1,2,4a,5-tetramethyl-7-oxo-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]pent-2-enoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0273 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.03
Echinococcus multilocularis abhydrolase domain containing 3 0.0051 0.0073 0.0277
Toxoplasma gondii peptidase S15, putative 0.0051 0.0073 1
Brugia malayi CCG1-interacting factor B 0.0047 0.0061 0.0198
Echinococcus granulosus abhydrolase domain containing 3 0.0051 0.0073 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Mycobacterium ulcerans peptide amidase, GatA 0.0113 0.0236 0.0177
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.037
Toxoplasma gondii hypothetical protein 0.0047 0.0061 0.7322
Echinococcus multilocularis protein phosphatase methylesterase 1 0.0047 0.0061 0.0227
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.012 0.0471
Mycobacterium ulcerans hydrolase 0.0051 0.0073 0.0012
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0113 0.0236 0.0955
Loa Loa (eye worm) hypothetical protein 0.0054 0.008 0.0332
Trypanosoma brucei monoglyceride lipase, putative 0.0869 0.224 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.03
Echinococcus multilocularis abhydrolase domain containing protein 8 0.0047 0.0061 0.0227
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.03
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0869 0.224 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0025 0.0079
Schistosoma mansoni fatty-acid amide hydrolase 0.0113 0.0236 0.0977
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0051 0.0073 0.0055
Plasmodium vivax PST-A protein 0.0869 0.224 1
Brugia malayi Amidase family protein 0.0113 0.0236 0.0927
Mycobacterium ulcerans amidase 0.0113 0.0236 0.0177
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.3795 1 1
Plasmodium vivax PST-A protein 0.0051 0.0073 0.0201
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0113 0.0236 0.0955
Brugia malayi Protein C20orf22 0.0051 0.0073 0.0247
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0869 0.224 1
Plasmodium vivax PST-A protein 0.0051 0.0073 0.0201
Brugia malayi putative amidase 0.0113 0.0236 0.0927
Mycobacterium ulcerans amidase 0.0113 0.0236 0.0177
Plasmodium falciparum lysophospholipase, putative 0.0869 0.224 1
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0113 0.0236 0.0177
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.0236 1
Leishmania major hypothetical protein, conserved 0.0113 0.0236 0.0805
Brugia malayi Pre-SET motif family protein 0.0034 0.0028 0.0063
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0113 0.0236 0.0177
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.0236 0.0177
Brugia malayi Amidase family protein 0.0113 0.0236 0.0927
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0051 0.0073 0.0055
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0047 0.0061 0.7322
Brugia malayi MGC83647 protein 0.0051 0.0073 0.0247
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0073 0.0201
Echinococcus granulosus fatty acid amide hydrolase 1 0.0936 0.2419 1
Leishmania major hypothetical protein, conserved 0.0051 0.0073 0.0055
Toxoplasma gondii hypothetical protein 0.0051 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0062 0.0254
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0051 0.0073 1
Plasmodium vivax lysophospholipase, putative 0.0051 0.0073 0.0201
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.03
Brugia malayi hydrolase, alpha/beta fold family protein 0.0047 0.0061 0.0198
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0028 0.0093
Loa Loa (eye worm) protein phosphatase methylesterase 1 0.0047 0.0061 0.0251
Schistosoma mansoni protein phosphatase methylesterase 1 (S33 family) 0.0047 0.0061 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0061 0.000000017561
Plasmodium falciparum lysophospholipase, putative 0.0869 0.224 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0051 0.0073 0.03
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0006 0.0024
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0113 0.0236 0.0177
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0051 0.0073 0.03
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0869 0.224 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0915 0.2364 0.2318
Plasmodium falciparum lysophospholipase, putative 0.0869 0.224 1
Brugia malayi protein phosphatase methylesterase 1 0.0047 0.0061 0.0198
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0051 0.0073 1
Toxoplasma gondii phospholipase/carboxylesterase 0.0051 0.0073 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0089 0.0317
Mycobacterium ulcerans amidase 0.0113 0.0236 0.0177
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0869 0.224 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0051 0.0073 0.0201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0077 0.0294
Loa Loa (eye worm) amidase 0.0113 0.0236 0.0977
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0574 0.2373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0077 0.0318
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0869 0.224 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0936 0.2419 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0077 0.0294
Plasmodium vivax unspecified product 0.0051 0.0073 0.0201
Plasmodium falciparum esterase, putative 0.0869 0.224 1
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0113 0.0236 0.0177
Echinococcus granulosus Phospholipase carboxylesterase 0.0051 0.0073 0.0277
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.0236 0.0755
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0051 0.0073 0.0277
Onchocerca volvulus 0.0047 0.0061 0.0513
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0077 0.0294
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0113 0.0236 0.0977
Brugia malayi Pre-SET motif family protein 0.024 0.0574 0.2331
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0936 0.2419 1
Plasmodium vivax lysophospholipase, putative 0.0051 0.0073 0.0201
Trypanosoma cruzi monoglyceride lipase, putative 0.0869 0.224 1
Echinococcus multilocularis Phospholipase carboxylesterase 0.0051 0.0073 0.0277
Brugia malayi amidase 0.0936 0.2419 1
Toxoplasma gondii protein c14orf29, putative 0.0051 0.0073 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0051 0.0073 0.0055
Plasmodium vivax lysophospholipase, putative 0.0051 0.0073 0.0201
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.03
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0041 0.0117
Mycobacterium ulcerans amidase 0.0113 0.0236 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0073 0.0201
Schistosoma mansoni hypothetical protein 0.0039 0.0041 0.017
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0936 0.2419 1
Loa Loa (eye worm) hypothetical protein 0.0936 0.2419 1
Schistosoma mansoni amidase 0.0936 0.2419 1
Mycobacterium ulcerans amidase 0.0113 0.0236 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0077 0.0294
Mycobacterium ulcerans hypothetical protein 0.0869 0.224 0.2193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0077 0.0318
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.008 0.0309
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0047 0.0061 0.7322
Echinococcus multilocularis maspardin 0.0047 0.0061 0.0227
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0051 0.0073 0.0055
Toxoplasma gondii phospholipase 0.0051 0.0073 1
Trichomonas vaginalis conserved hypothetical protein 0.0869 0.224 1
Mycobacterium ulcerans lysophospholipase 0.0869 0.224 0.2193
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0051 0.0073 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.017
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0869 0.224 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0051 0.0073 0.0055
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0113 0.0236 0.0177
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0051 0.0073 0.0055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0054 0.0224
Echinococcus granulosus protein phosphatase methylesterase 1 0.0047 0.0061 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0061 0.000000017561
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.012 0.0471
Echinococcus multilocularis abhydrolase domain containing protein 13 0.0047 0.0061 0.0227
Onchocerca volvulus 0.0047 0.0061 0.0513
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0047 0.017
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0051 0.0073 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0051 0.0073 0.0055
Plasmodium vivax alpha/beta hydrolase, putative 0.0051 0.0073 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0869 0.224 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0089 0.0317
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0113 0.0236 0.0955
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0077 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0028 0.0117
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0113 0.0236 0.0762
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0051 0.0073 0.0055
Leishmania major hypothetical protein, conserved 0.0051 0.0073 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0073 0.0012
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0051 0.0073 0.0055
Plasmodium vivax PST-A protein 0.0051 0.0073 0.0201
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0051 0.0073 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0915 0.2364 1
Toxoplasma gondii hypothetical protein 0.0051 0.0073 1
Toxoplasma gondii hypothetical protein 0.0047 0.0061 0.7322
Echinococcus granulosus maspardin 0.0047 0.0061 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0113 0.0236 0.094
Mycobacterium ulcerans hypothetical protein 0.0051 0.0073 0.0012
Plasmodium vivax PST-A protein 0.0051 0.0073 0.0201
Onchocerca volvulus Alpha\/beta hydrolase2 homolog 0.0047 0.0061 0.0513
Toxoplasma gondii hypothetical protein 0.0051 0.0073 1
Leishmania major monoglyceride lipase, putative 0.0869 0.224 1
Onchocerca volvulus Putative protein phosphatase methylesterase 1 0.0047 0.0061 0.0513
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.008 0.0309
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0051 0.0073 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0047 0.017
Toxoplasma gondii chain a, pp2a-specific methylesterase apo form (pme), putative 0.0047 0.0061 0.7322
Echinococcus granulosus fatty acid amide hydrolase 1 0.0113 0.0236 0.0955
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.0236 1
Brugia malayi Bromodomain containing protein 0.0087 0.0166 0.0637
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0051 0.0073 0.0055
Brugia malayi MGC79044 protein 0.0051 0.0073 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.008 0.0332
Trypanosoma cruzi serine peptidase, putative 0.0051 0.0073 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0273 0.0662 0.2758
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0051 0.0073 0.0055
Trypanosoma cruzi amidase, putative 0.0113 0.0236 0.0805
Onchocerca volvulus Valacyclovir hydrolase homolog 0.0047 0.0061 0.0513
Schistosoma mansoni fatty-acid amide hydrolase 0.0936 0.2419 1
Mycobacterium ulcerans hypothetical protein 0.0051 0.0073 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0028 0.0117
Echinococcus granulosus abhydrolase domain containing protein 8 0.0047 0.0061 0.0227
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0051 0.0073 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0869 0.224 1
Trypanosoma cruzi serine peptidase, putative 0.0051 0.0073 0.0055
Plasmodium vivax unspecified product 0.0051 0.0073 0.0201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0077 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.008 0.0332
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0051 0.0073 0.0277
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0051 0.0073 0.0055
Loa Loa (eye worm) amidase 0.0113 0.0236 0.0977
Toxoplasma gondii hypothetical protein 0.0047 0.0061 0.7322
Schistosoma mansoni bromodomain containing protein 0.0073 0.0131 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Trypanosoma brucei Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative 0.0047 0.0061 0.000000017561
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0051 0.0073 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0089 0.037
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0051 0.0073 1
Plasmodium vivax PST-A protein 0.0051 0.0073 0.0201
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0113 0.0236 0.5
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0113 0.0236 0.0762
Schistosoma mansoni peptidase 0.0051 0.0073 0.03
Loa Loa (eye worm) hypothetical protein 0.0049 0.0067 0.0279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0077 0.0318
Brugia malayi Bromodomain containing protein 0.0044 0.0054 0.017
Trypanosoma brucei monoglyceride lipase, putative 0.0869 0.224 1
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0073 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Loa Loa (eye worm) CCG1-interacting factor B 0.0047 0.0061 0.0251
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0869 0.224 1
Toxoplasma gondii hypothetical protein 0.0051 0.0073 1
Trypanosoma cruzi amidase, putative 0.0113 0.0236 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0153 0.0634
Echinococcus granulosus abhydrolase domain containing protein 13 0.0051 0.0073 0.0277
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0051 0.0073 0.0055
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0113 0.0236 0.0805

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 62.5 ug ml-1 Antimicrobial activities against Candida albicans CIP 3153A by broth microdilution method ChEMBL. 12398532
MIC (functional) >= 125 ug ml-1 Antimicrobial activities against Escherichia coli ATCC 25922 by broth microdilution method ChEMBL. 12398532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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