TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.644 | Formula: C14H9Cl3O2S
H donors: 0 H acceptors: 2 LogP: 5.24 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)/C=C(/S(=O)(=O)c1ccccc1)\Cl
InChi: 1S/C14H9Cl3O2S/c15-11-7-6-10(13(16)9-11)8-14(17)20(18,19)12-4-2-1-3-5-12/h1-9H/b14-8+
InChiKey: PXKJXWCSDWYYLH-RIYZIHGNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.00687445	0.0583239	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.00555307	0.0425446	0.100345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Plasmodium vivax	plasmepsin V, putative	0.00687445	0.0583239	0.176477
Loa Loa (eye worm)	hypothetical protein	0.0290771	0.323456	0.762896
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Plasmodium vivax	vivapain-2	0.00221924	0.00273376	0.00827184
Brugia malayi	aspartic protease BmAsp-2, identical	0.00687445	0.0583239	0.137561
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0296661	0.33049	1
Entamoeba histolytica	cysteine proteinase, putative	0.00221924	0.00273376	0.00644778
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.00555307	0.0425446	0.100345
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0087142	0.0802932	0.248235
Trypanosoma brucei	hypothetical protein, conserved	0.00555307	0.0425446	0.529866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Brugia malayi	Ras-related protein R-Ras2	0.0374955	0.423985	1
Plasmodium vivax	aspartyl protease, putative	0.00687445	0.0583239	0.176477
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0087142	0.0802932	0.189378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Loa Loa (eye worm)	aspartyl protease 6	0.00687445	0.0583239	0.137561
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0087142	0.0802932	1
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0087142	0.0802932	0.189378
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.00555307	0.0425446	0.128732
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0290771	0.323456	0.762896
Plasmodium falciparum	cysteine proteinase falcipain 3	0.00221924	0.00273376	0.00827184
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0087142	0.0802932	0.189378
Schistosoma mansoni	cathepsin F (C01 family)	0.00221924	0.00273376	0.00273376
Echinococcus multilocularis	cysteine protease	0.00221924	0.00273376	0.00644778
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.00199031	0	0.5
Toxoplasma gondii	aspartyl protease	0.00687445	0.0583239	0.180315
Trichomonas vaginalis	dexras1, putative	0.0374955	0.423985	1
Entamoeba histolytica	Ras family GTPase	0.0374955	0.423985	1
Plasmodium falciparum	plasmepsin VII	0.00687445	0.0583239	0.176477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trypanosoma cruzi	cysteine peptidase, putative	0.00221924	0.00273376	0.0340472
Brugia malayi	aspartic protease BmAsp-1, identical	0.00687445	0.0583239	0.137561
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.00221924	0.00273376	0.00827184
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.00555307	0.0425446	0.100345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0290771	0.323456	0.762896
Loa Loa (eye worm)	hypothetical protein	0.00687445	0.0583239	0.137561
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Echinococcus granulosus	cathepsin l cysteine peptidase	0.00221924	0.00273376	0.00644778
Loa Loa (eye worm)	hypothetical protein	0.0296661	0.33049	0.779485
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0087142	0.0802932	0.189378
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.00555307	0.0425446	0.128732
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.00555307	0.0425446	0.529866
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00221924	0.00273376	0.00644778
Plasmodium falciparum	plasmepsin II	0.0290771	0.323456	0.978718
Echinococcus multilocularis	cysteine protease	0.00221924	0.00273376	0.00644778
Onchocerca volvulus		0.00555307	0.0425446	0.71615
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.00221924	0.00273376	0.00644778
Entamoeba histolytica	Ras family GTPase	0.0374955	0.423985	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.00555307	0.0425446	0.529866
Trypanosoma cruzi	cysteine peptidase, putative	0.00221924	0.00273376	0.0340472
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.00555307	0.0425446	0.529866
Plasmodium falciparum	plasmepsin IV	0.0290771	0.323456	0.978718
Brugia malayi	Pepsin A precursor	0.00687445	0.0583239	0.137561
Trypanosoma cruzi	cysteine peptidase, putative	0.00221924	0.00273376	0.0340472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	ral, putative	0.0374955	0.423985	1
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.00555307	0.0425446	0.529866
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0087142	0.0802932	0.189378
Plasmodium falciparum	plasmepsin IX	0.00687445	0.0583239	0.176477
Echinococcus granulosus	ras gtpase	0.0374955	0.423985	1
Plasmodium falciparum	plasmepsin III	0.00687445	0.0583239	0.176477
Brugia malayi	Papain family cysteine protease containing protein	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.00687445	0.0583239	0.180315
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.00555307	0.0425446	0.100345
Brugia malayi	Ras protein let-60	0.0374955	0.423985	1
Brugia malayi	Eukaryotic aspartyl protease family protein	0.00687445	0.0583239	0.137561
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0296661	0.33049	0.779485
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Plasmodium vivax	aspartyl proteinase, putative	0.0290771	0.323456	0.978718
Giardia lamblia	Rab geranylgeranyltransferase	0.00555307	0.0425446	0.128732
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0087142	0.0802932	0.189378
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Plasmodium vivax	vivapain-2	0.00221924	0.00273376	0.00827184
Schistosoma mansoni	cathepsin F (C01 family)	0.00221924	0.00273376	0.00273376
Loa Loa (eye worm)	hypothetical protein	0.00221924	0.00273376	0.00644778
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.00687445	0.0583239	0.137561
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.00555307	0.0425446	0.529866
Loa Loa (eye worm)	ctsf protein	0.00221924	0.00273376	0.00644778
Toxoplasma gondii	aspartyl protease ASP1	0.0290771	0.323456	1
Loa Loa (eye worm)	Ras protein let-60	0.0374955	0.423985	1
Plasmodium vivax	plasmepsin IV, putative	0.0290771	0.323456	0.978718
Plasmodium falciparum	plasmepsin VIII, putative	0.00687445	0.0583239	0.176477
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0296661	0.33049	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0290771	0.323456	0.762896
Trypanosoma cruzi	cysteine peptidase, putative	0.00221924	0.00273376	0.0340472
Onchocerca volvulus		0.00687445	0.0583239	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0087142	0.0802932	0.189378
Echinococcus multilocularis	cathepsin L cysteine protease	0.00221924	0.00273376	0.00644778
Plasmodium falciparum	plasmepsin X	0.00687445	0.0583239	0.176477
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0087142	0.0802932	0.189378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Brugia malayi	hypothetical protein	0.00687445	0.0583239	0.137561
Plasmodium falciparum	plasmepsin VI	0.0290771	0.323456	0.978718
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0374955	0.423985	1
Toxoplasma gondii	hypothetical protein	0.024113	0.264178	0.816735
Echinococcus granulosus	cathepsin L cysteine proteinase	0.00221924	0.00273376	0.00644778
Echinococcus multilocularis	ras gtpase	0.0374955	0.423985	1
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.00672389	0.0565259	0.171037
Loa Loa (eye worm)	hypothetical protein	0.0374955	0.423985	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.00555307	0.0425446	0.100345
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.00221924	0.00273376	0.00827184
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.00555307	0.0425446	0.529866
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Leishmania major	farnesyltransferase beta subunit	0.0087142	0.0802932	1
Entamoeba histolytica	cysteine protease, putative	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	rap1 and, putative	0.0374955	0.423985	1
Trichomonas vaginalis	rheb, putative	0.0374955	0.423985	1
Schistosoma mansoni	cathepsin D (A01 family)	0.085732	1	1
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trypanosoma cruzi	hypothetical protein, conserved	0.00555307	0.0425446	0.529866
Echinococcus granulosus	cathepsin l1	0.00221924	0.00273376	0.00644778
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.00555307	0.0425446	0.100345
Leishmania major	cysteine peptidase A (CPA)	0.00221924	0.00273376	0.0340472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Brugia malayi	hypothetical protein	0.00687445	0.0583239	0.137561
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Giardia lamblia	Rab geranylgeranyltransferase	0.0296661	0.33049	1
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0087142	0.0802932	0.0802932
Toxoplasma gondii	cathepsin CPL	0.00221924	0.00273376	0.00845172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Entamoeba histolytica	cysteine proteinase, putative	0.00221924	0.00273376	0.00644778
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0296661	0.33049	0.779485
Entamoeba histolytica	ras-1, putative	0.0374955	0.423985	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0296661	0.33049	0.33049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0087142	0.0802932	0.242952
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.00221924	0.00273376	0.00644778
Plasmodium falciparum	plasmepsin V	0.00687445	0.0583239	0.176477
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0296661	0.33049	0.779485
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0296661	0.33049	0.779485
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0290771	0.323456	0.762896
Loa Loa (eye worm)	fibroinase	0.00221924	0.00273376	0.00644778
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0296661	0.33049	0.779485
Plasmodium falciparum	plasmepsin I	0.0290771	0.323456	0.978718
Toxoplasma gondii	aspartyl protease ASP3	0.00687445	0.0583239	0.180315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Schistosoma mansoni	cathepsin D (A01 family)	0.085732	1	1
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0087142	0.0802932	0.189378
Trypanosoma cruzi	cruzipain precursor, putative	0.00221924	0.00273376	0.0340472
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.024113	0.264178	0.623083
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0296661	0.33049	0.779485
Plasmodium vivax	aspartyl protease, putative	0.00687445	0.0583239	0.176477
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0296661	0.33049	0.779485
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0087142	0.0802932	1
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0087142	0.0802932	0.242952
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0087142	0.0802932	0.189378
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0087142	0.0802932	1
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0087142	0.0802932	0.189378
Giardia lamblia	Prenyltransferase	0.0087142	0.0802932	0.242952
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.00555307	0.0425446	0.0425446
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Loa Loa (eye worm)	cysteine protease	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0374955	0.423985	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0290771	0.323456	1
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.00555307	0.0425446	0.100345
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.00555307	0.0425446	0.100345
Leishmania major	cathepsin L-like protease	0.00221924	0.00273376	0.0340472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00221924	0.00273376	0.0340472
Toxoplasma gondii	hypothetical protein	0.00555307	0.0425446	0.131531
Echinococcus multilocularis	cathepsin L cysteine protease	0.00221924	0.00273376	0.00644778
Plasmodium vivax	aspartyl protease, putative	0.00687445	0.0583239	0.176477
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.00687445	0.0583239	0.0583239
Loa Loa (eye worm)	hypothetical protein	0.00687445	0.0583239	0.137561
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00221924	0.00273376	0.00644778
Plasmodium vivax	aspartyl proteinase, putative	0.00687445	0.0583239	0.176477
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0290771	0.323456	0.323456
Schistosoma mansoni	memapsin-2 (A01 family)	0.00687445	0.0583239	0.0583239
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0296661	0.33049	0.779485
Brugia malayi	Cathepsin L-like precursor	0.00221924	0.00273376	0.00644778
Trypanosoma cruzi	hypothetical protein, conserved	0.00555307	0.0425446	0.529866
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.00555307	0.0425446	0.529866

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	< 5 %	Inhibition of acetate buffer-induced hemozoin formation at 1.25 to 25 mM/well after 48 hrs	ChEMBL.	19036479
Activity (functional)	= 75.3 %	Antimalarial activity as inhibition of chloroquine-resistant Plasmodium falciparum mediated mice (Mus musculus) hemoglobin hydrolysis at 5 mM after 18 hrs	ChEMBL.	19036479
IC50 (functional)	= 0.96 uM	Antimalarial activity as parasite development after 48 hrs against chloroquine-sensitive Plasmodium falciparum W2 by FACS analysis	ChEMBL.	19036479

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	19036479

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL488578

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 989203