Detailed information for compound 989244

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.444 | Formula: C20H27F2N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)F)O[C@@H]([C@H](n1nc(cc1C(C)C)C(C)C)C)C
  • InChi: 1S/C20H27F2N3O2/c1-11(2)18-10-19(12(3)4)25(24-18)13(5)14(6)27-20(26)23-17-8-7-15(21)9-16(17)22/h7-14H,1-6H3,(H,23,26)/t13-,14-/m1/s1
  • InChiKey: FYXUMHJKKLDQRY-ZIAGYGMSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0645 0.2435
Leishmania major farnesyltransferase beta subunit 0.0124 0.1765 0.9081
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0041 0.0154
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0113 0.0578
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0059 0.0271
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0061 0.0743 0.4174
Brugia malayi Serpin protein 6 0.0029 0.0236 0.089
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0113 0.0384
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0124 0.1765 0.9777
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0011 0.0042
Schistosoma mansoni o-methyltransferase 0.0066 0.0824 0.3342
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0061 0.0743 0.4174
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0124 0.1765 0.6634
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0124 0.1765 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0126 0.1805 0.6814
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0402 0.2228
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0061 0.0743 0.2775
Trypanosoma brucei glucosidase, putative 0.004 0.0402 0.1512
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0126 0.1805 1
Schistosoma mansoni DNA helicase recq5 0.0022 0.0113 0.0417
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0122
Onchocerca volvulus 0.0103 0.1432 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Leishmania major geranylgeranyltransferase, putative 0.0044 0.0478 0.246
Giardia lamblia Rab geranylgeranyltransferase 0.0061 0.0743 0.4012
Brugia malayi O-methyltransferase family protein 0.0066 0.0824 0.3109
Onchocerca volvulus 0.0066 0.0824 0.5754
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.265 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0113 0.0624
Schistosoma mansoni ap endonuclease 0.0018 0.0059 0.0196
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0402 0.1518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0112
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0122
Giardia lamblia Rab geranylgeranyltransferase 0.0044 0.0478 0.2457
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0478 0.1797
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0113 0.0425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0059 0.0053
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0113 0.0384
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Brugia malayi serpin precursor 0.0029 0.0236 0.089
Schistosoma mansoni ap endonuclease 0.0018 0.0059 0.0196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0041 0.0154
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.1765 0.6634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0113 0.0384
Loa Loa (eye worm) hypothetical protein 0.0037 0.0365 0.1379
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.2794
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0059 0.0222
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0061 0.0743 0.2775
Onchocerca volvulus 0.0029 0.0236 0.1648
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0124 0.1765 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0126 0.1805 0.7379
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1765 0.9777
Trypanosoma cruzi lanosterol synthase, putative 0.0179 0.2661 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1765 0.9777
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.1765 0.9777
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0179 0.2661 0.2968
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0124 0.1765 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.4117
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0113 0.0624
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0044 0.0478 0.2662
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.265 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0059 0.0271
Loa Loa (eye worm) hypothetical protein 0.0055 0.0645 0.2435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0059 0.5
Schistosoma mansoni alpha-glucosidase 0.0154 0.2248 0.9197
Onchocerca volvulus 0.0029 0.0236 0.1648
Trypanosoma cruzi lanosterol synthase, putative 0.0179 0.2661 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0059 0.0221
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.265 1
Onchocerca volvulus 0.0066 0.0824 0.5754
Trypanosoma brucei lanosterol synthase 0.0179 0.2661 1
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0122
Brugia malayi hypothetical protein 0.0029 0.0236 0.089
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0011 0.0043
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0061 0.0743 0.2805
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0061 0.0743 0.2805
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0059 0.018
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0743 0.2794
Giardia lamblia Serpin 1 0.0029 0.0236 0.1038
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0478 0.1797
Giardia lamblia Rab geranylgeranyltransferase 0.0061 0.0743 0.4012
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0402 0.2228
Schistosoma mansoni alpha glucosidase 0.004 0.0402 0.1608
Toxoplasma gondii protease inhibitor PI1 0.0029 0.0236 0.1281
Echinococcus multilocularis serine protease inhibitor 0.0029 0.0236 0.0851
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0122
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0113 0.058
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0402 0.2228
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0402 0.2228
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.4117
Mycobacterium tuberculosis Probable methyltransferase 0.0066 0.0824 0.091
Brugia malayi serpin (BmSERPIN) 0.0029 0.0236 0.089
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0061 0.0743 0.4117
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0124 0.1765 0.7213
Echinococcus granulosus plasminogen activator inhibitor 2 0.0029 0.0236 0.0851
Schistosoma mansoni hypothetical protein 0.0051 0.058 0.2338
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0478 0.1797
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0113 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0743 0.2794
Loa Loa (eye worm) hypothetical protein 0.0061 0.0743 0.2805
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.1765 0.6634
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0059 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0572 0.2307
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0402 0.2228
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0154
Onchocerca volvulus 0.0061 0.0743 0.5191
Mycobacterium ulcerans methyltransferase 0.0066 0.0824 0.077
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0113 0.0624
Brugia malayi serpin 0.0029 0.0236 0.089
Leishmania major lanosterol synthase, putative 0.0135 0.1944 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.265 1
Brugia malayi BmSERPIN 0.0029 0.0236 0.089
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0113 0.0425
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0113 0.0425
Loa Loa (eye worm) hypothetical protein 0.0066 0.0824 0.3109
Echinococcus multilocularis Estrogen regulated protein EP45 0.0029 0.0236 0.0851
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0743 0.2794
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0645 0.2435
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0402 0.2228
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.3824
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0041 0.0154
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0124 0.1765 0.6661
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0061 0.0743 0.4174
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0478 0.1797
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0059 0.0221
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0402 0.1518
Echinococcus granulosus serine protease inhibitor 0.0029 0.0236 0.0851
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0743 0.2794
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0124 0.1765 0.6661
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0042
Schistosoma mansoni alpha-glucosidase 0.0154 0.2248 0.9197
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0402 0.1482
Brugia malayi serpin 0.0029 0.0236 0.089
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0402 0.1512
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0478 0.2648
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0113 0.0624
Loa Loa (eye worm) RecQ helicase 0.0022 0.0113 0.0425
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0061 0.0743 0.4117
Toxoplasma gondii hypothetical protein 0.0061 0.0743 0.4174
Schistosoma mansoni hypothetical protein 0.0037 0.0365 0.1457
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0478 0.2648
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0478 0.2662
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0113 0.0423
Echinococcus granulosus serine protease inhibitor 0.0029 0.0236 0.0851
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0124 0.1765 0.9777
Brugia malayi serpin 0.0029 0.0236 0.089
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.4117
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0044 0.0478 0.2648
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0113 0.0384
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0044 0.0478 0.192
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0061 0.0743 0.2775
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0059 0.0326
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0567 0.8937 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0365 0.1379
Echinococcus granulosus GPCR family 2 0.0017 0.0041 0.0112
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0113 0.0578
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0126 0.1805 0.68
Schistosoma mansoni DNA helicase recq1 0.0022 0.0113 0.0417
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0011 0.0042
Plasmodium vivax conserved Plasmodium protein, unknown function 0.008 0.1048 0.5913
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0061 0.0743 0.2775
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0126 0.1805 0.68
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0743 0.3011
Entamoeba histolytica serine protease inhibitor, putative 0.0029 0.0236 0.1307
Plasmodium vivax geranylgeranyltransferase, putative 0.0044 0.0478 0.2662
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0044 0.0478 0.1804
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0402 0.2228
Loa Loa (eye worm) serpin 0.0029 0.0236 0.089
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Echinococcus granulosus serine protease inhibitor 0.0029 0.0236 0.0851
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Onchocerca volvulus 0.0029 0.0236 0.1648
Loa Loa (eye worm) serpin 0.0029 0.0236 0.089
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0066 0.0824 0.5
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0113 0.0384
Echinococcus granulosus Estrogen regulated protein EP45 0.0029 0.0236 0.0851
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0126 0.1805 0.7379
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0042
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0061 0.0743 0.4174
Schistosoma mansoni serpin 0.0029 0.0236 0.0924
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0402 0.2228
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.265 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0113 0.0425
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0126 0.1805 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0126 0.1805 0.6814
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0112
Plasmodium falciparum geranylgeranyltransferase, putative 0.0044 0.0478 0.2662
Schistosoma mansoni o-methyltransferase 0.0066 0.0824 0.3342
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0066 0.0824 1
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0061 0.0743 0.3011
Loa Loa (eye worm) serpin protein 6 0.0029 0.0236 0.089
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0061 0.0743 0.2805
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0059 0.0222
Brugia malayi hypothetical protein 0.0029 0.0236 0.089
Brugia malayi O-methyltransferase family protein 0.0066 0.0824 0.3109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0645 0.2435
Loa Loa (eye worm) hypothetical protein 0.0044 0.0478 0.1804
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0058
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0011 0.0043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0113 0.0578
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Brugia malayi BmSERPIN, truncated 0.0029 0.0236 0.089
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0478 0.2662
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0402 0.1512
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Schistosoma mansoni hypothetical protein 0.0166 0.2443 1
Brugia malayi O-methyltransferase family protein 0.0066 0.0824 0.3109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0059 0.0303
Giardia lamblia Prenyltransferase 0.0124 0.1765 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0572 0.216
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0124 0.1765 0.9777
Echinococcus granulosus geminin 0.0166 0.2443 0.9215
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0061 0.0743 0.2794
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.2794
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0059 0.018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Echinococcus granulosus Estrogen regulated protein EP45 0.0029 0.0236 0.0851
Schistosoma mansoni o-methyltransferase 0.0066 0.0824 0.3342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0572 0.2307
Schistosoma mansoni serine protease inhibitors serpins 0.0029 0.0236 0.0924
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0124 0.1765 0.6647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0572 0.2126
Loa Loa (eye worm) hypothetical protein 0.0044 0.0478 0.1804
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0402 0.2228
Onchocerca volvulus 0.0029 0.0236 0.1648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0572 0.2307
Schistosoma mansoni serpin 0.0029 0.0236 0.0924
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0112
Schistosoma mansoni hypothetical protein 0.0166 0.2443 1
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0478 0.2662
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0402 0.1482
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0059 0.0221
Brugia malayi serpin 0.0029 0.0236 0.089
Echinococcus multilocularis Estrogen regulated protein EP45 0.0029 0.0236 0.0851
Echinococcus multilocularis geminin 0.0166 0.2443 0.9215
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0044 0.0478 0.1769
Loa Loa (eye worm) hypothetical protein 0.0029 0.0236 0.089
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0124 0.1765 0.6647
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0572 0.216
Brugia malayi isocitrate dehydrogenase 0.0015 0.0011 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0113 0.0578
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0113 0.0423
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0061 0.0743 0.2775
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0402 0.2069
Loa Loa (eye worm) O-methyltransferase 0.0066 0.0824 0.3109
Brugia malayi serpin 0.0029 0.0236 0.089
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0029 0.0236 0.1281
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0743 0.2794
Echinococcus granulosus bloom syndrome protein 0.0022 0.0113 0.0384
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0112
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.2794
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0402 0.2228
Onchocerca volvulus 0.0029 0.0236 0.1648
Brugia malayi serpin (BmSERPIN) 0.0029 0.0236 0.089
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0061 0.0743 0.2805
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0402 0.2228
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0402 0.2229
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0113 0.0425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0572 0.2126
Toxoplasma gondii exonuclease III APE 0.0018 0.0059 0.0271
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0061 0.0743 0.4117
Loa Loa (eye worm) serpin 0.0029 0.0236 0.089
Echinococcus multilocularis GPCR, family 2 0.0017 0.0041 0.0112
Onchocerca volvulus 0.0029 0.0236 0.1648
Brugia malayi O-methyltransferase 0.0066 0.0824 0.3109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0572 0.2126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0572 0.2126
Brugia malayi serpin 0.0029 0.0236 0.089
Loa Loa (eye worm) serpin 0.0029 0.0236 0.089
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0124 0.1765 0.9777
Schistosoma mansoni o-methyltransferase 0.0066 0.0824 0.3342
Echinococcus multilocularis serine protease inhibitor 0.0029 0.0236 0.0851
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0059 0.0326
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0061 0.0743 0.2775

Activities

Activity type Activity value Assay description Source Reference
EC12 (binding) = 1.3 uM Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as potentiation of acetylcholine-induced response by patch-clamp electrophysiology ChEMBL. 18805006
Efficacy (binding) = 12 % Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as potentiation of acetylcholine-induced response by patch-clamp electrophysiology relative to nicotine ChEMBL. 18805006

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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