Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.3959 | 0.8038 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.3959 | 0.8038 | 0.802 |
Giardia lamblia | UPL-1 | 0.1485 | 0.2987 | 0.2924 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.492 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0065 | 0.0089 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.1485 | 0.2987 | 0.8567 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.3959 | 0.8038 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1485 | 0.2987 | 0.2924 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.1485 | 0.2987 | 0.3646 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0512 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.1273 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.1485 | 0.2987 | 0.2924 |
Treponema pallidum | pfs protein (pfs) | 0.1485 | 0.2987 | 0.3646 |
Loa Loa (eye worm) | uridine phosphorylase | 0.1485 | 0.2987 | 0.4286 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.1485 | 0.2987 | 0.2924 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.0435 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0065 | 0.0089 | 0.0089 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.1485 | 0.2987 | 0.2924 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.052 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.1273 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.1273 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3436 | 0.697 | 0.6968 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0276 | 0.052 | 0.0542 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.1722 | 0.3472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3436 | 0.697 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.492 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1722 | 0.3472 | 0.3472 |
Echinococcus granulosus | adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0081 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.3959 | 0.8038 | 0.802 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.1273 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.3959 | 0.8038 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.1485 | 0.2987 | 0.2924 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1485 | 0.2987 | 0.2924 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0276 | 0.052 | 0.052 |
Trypanosoma brucei | uridine phosphorylase | 0.1485 | 0.2987 | 0.8567 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0276 | 0.052 | 0.0435 |
Loa Loa (eye worm) | adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0128 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.3959 | 0.8038 | 1 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.1722 | 0.3472 | 0.3467 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0008 | 0.0011 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.0542 |
Echinococcus multilocularis | adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0081 |
Brugia malayi | MTAP | 0.1722 | 0.3472 | 0.3472 |
Brugia malayi | Adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1722 | 0.3472 | 0.3472 |
Mycobacterium leprae | probable uridine phosphorylase | 0.1485 | 0.2987 | 0.2924 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.052 |
Onchocerca volvulus | Adenine phosphoribosyltransferase homolog | 0.0065 | 0.0089 | 0.0089 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1485 | 0.2987 | 0.2987 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.2924 |
Schistosoma mansoni | uridine phosphorylase | 0.1485 | 0.2987 | 0.2987 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.8567 |
Brugia malayi | uridine phosphorylase family protein | 0.1485 | 0.2987 | 0.2987 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0276 | 0.052 | 0.1273 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.8567 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0512 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.1485 | 0.2987 | 0.2982 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.1722 | 0.3472 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.1485 | 0.2987 | 0.2987 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0542 |
Onchocerca volvulus | 0.0276 | 0.052 | 0.052 | |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0512 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1722 | 0.3472 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.3959 | 0.8038 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.2924 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.1722 | 0.3472 | 0.3413 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3436 | 0.697 | 0.6968 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0512 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.1273 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0065 | 0.0089 | 0.0081 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.492 | 1 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.3959 | 0.8038 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.1485 | 0.2987 | 0.2982 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.2924 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.2924 |
Toxoplasma gondii | phosphorylase family protein | 0.1485 | 0.2987 | 0.3646 |
Brugia malayi | plexin A | 0.0025 | 0.0008 | 0.0008 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0065 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0128 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.3959 | 0.8038 | 1 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.1722 | 0.3472 | 0.3467 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0211 | 0.0388 | 0.0302 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.8567 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0237 | 0.0442 | 0.0356 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.492 | 1 | 1 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1485 | 0.2987 | 0.2924 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.1273 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0065 | 0.0089 | 0.0081 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.1722 | 0.3472 | 0.4982 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1485 | 0.2987 | 0.2924 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0276 | 0.052 | 0.1273 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.0435 |
Wolbachia endosymbiont of Brugia malayi | amidophosphoribosyltransferase | 0.0065 | 0.0089 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.3436 | 0.697 | 0.6968 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.492 | 1 | 1 |
Schistosoma mansoni | uracil phosphoribosyltransferase | 0.0065 | 0.0089 | 0.0089 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0276 | 0.052 | 0.1273 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0211 | 0.0388 | 0.0302 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1485 | 0.2987 | 0.2924 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.492 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.1485 | 0.2987 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1722 | 0.3472 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.