Detailed information for compound 991099

Basic information

Technical information
  • TDR Targets ID: 991099
  • Name: 2-(3,4-dimethoxyphenyl)sulfanyl-3-phenylquino xaline-5,7-diamine
  • MW: 404.485 | Formula: C22H20N4O2S
  • H donors: 2 H acceptors: 2 LogP: 3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)Sc1nc2cc(N)cc(c2nc1c1ccccc1)N
  • InChi: 1S/C22H20N4O2S/c1-27-18-9-8-15(12-19(18)28-2)29-22-20(13-6-4-3-5-7-13)26-21-16(24)10-14(23)11-17(21)25-22/h3-12H,23-24H2,1-2H3
  • InChiKey: KOHRHYAQFXASFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,4-dimethoxyphenyl)sulfanyl-3-phenyl-quinoxaline-5,7-diamine
  • 2-[(3,4-dimethoxyphenyl)thio]-3-phenylquinoxaline-5,7-diamine
  • [7-amino-2-[(3,4-dimethoxyphenyl)thio]-3-phenyl-quinoxalin-5-yl]amine
  • 2-[(3,4-dimethoxy)phenylthio]-3-phenyl-5,7-diaminoquinoxalin e
  • NSC724863

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6182 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0433 0.0608 0.0596
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0479 0.0684 0.0678
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0433 0.0608 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.2105 0.334 0.3336
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2581 0.4116 0.4113
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.041 0.0571 0.9272
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0121 0.0098 0.0098
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.041 0.0571 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.6182 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0121 0.0098 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.2105 0.334 0.3336
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0608 0.0596
Loa Loa (eye worm) phosphatidylinositol 3 0.0782 0.1179 0.1179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.0265 0.0258
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0433 0.0608 0.0608
Echinococcus multilocularis fk506 binding protein 0.0121 0.0098 0.0085
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.063 0.0929 0.0923
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0326 0.0313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.041 0.0571 0.0571
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.078 0.1175 0.1163
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6182 1 1
Onchocerca volvulus 0.041 0.0571 0.5
Leishmania major phosphatidylinositol kinase related protein, putative 0.041 0.0571 0.0478
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.041 0.0571 0.0559
Echinococcus granulosus serine protein kinase ATM 0.119 0.1845 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.2105 0.334 0.3336
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.041 0.0571 0.0769
Giardia lamblia GTOR 0.6182 1 1
Leishmania major phosphatidylinositol kinase, putative 0.041 0.0571 0.0478
Brugia malayi Protein kinase domain containing protein 0.0065 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.055 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.041 0.0571 0.0571
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0479 0.0684 0.0671
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6182 1 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.119 0.1845 0.1845
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4932 0.7958 0.7938
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0098 0.0091
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.041 0.0571 0.0565
Entamoeba histolytica hypothetical protein 0.041 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6182 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0433 0.0608 0.0608
Loa Loa (eye worm) phosphatidylinositol 3 0.041 0.0571 0.0571
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0608 0.0596
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2163 0.3435 0.3426
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.119 0.1845 0.1834
Loa Loa (eye worm) phosphatidylinositol 3 0.041 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.3695 0.5937 0.5935
Trichomonas vaginalis PIKK family atypical protein kinase 0.3356 0.5382 0.5379
Trypanosoma cruzi target of rapamycin kinase 3 0.4932 0.7958 0.7955
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0121 0.0098 0.5
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0121 0.0098 0.0098
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.119 0.1845 0.184
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0829 0.1254 0.1242
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.9272
Echinococcus granulosus serine:threonine protein kinase SMG1 0.119 0.1845 0.1834
Loa Loa (eye worm) phosphatidylinositol 3 0.0069 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2163 0.3435 0.3435
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0121 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.2105 0.334 0.3336
Trichomonas vaginalis conserved hypothetical protein 0.1326 0.2066 0.2061
Loa Loa (eye worm) hypothetical protein 0.0104 0.0071 0.0071
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0098 0.0091
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.041 0.0571 0.0565
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0504 0.0724 0.0724
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0238 0.029 0.0277
Loa Loa (eye worm) hypothetical protein 0.0915 0.1396 0.1396
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.9272
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2163 0.3435 0.3426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.041 0.0571 0.0571
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.119 0.1845 0.1834
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6182 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.119 0.1845 0.1834
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0121 0.0098 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.6182 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.041 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Schistosoma mansoni immunophilin 0.0121 0.0098 0.0085
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.119 0.1845 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.3361 0.539 0.5387
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0706 0.1054 0.1041
Loa Loa (eye worm) hypothetical protein 0.008 0.0031 0.0031
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.063 0.0929 0.0917
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0479 0.0684 0.0678
Loa Loa (eye worm) FKBP5 protein 0.0121 0.0098 0.0098
Giardia lamblia Hypothetical protein 0.041 0.0571 0.0478
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.041 0.0571 0.0558
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.063 0.0929 0.0917
Brugia malayi FAT domain containing protein 0.0915 0.1396 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.3695 0.5937 0.5935
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0433 0.0608 0.0608
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0829 0.1254 0.1242
Entamoeba histolytica hypothetical protein 0.041 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.3356 0.5382 0.5379
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0098 0.0091
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0584 0.0854 0.0854
Trichomonas vaginalis conserved hypothetical protein 0.078 0.1175 0.1169
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0479 0.0684 0.0678
Plasmodium vivax hypothetical protein, conserved 0.041 0.0571 0.9272
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0098 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.3677 0.5908 0.5905
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.063 0.0929 0.0929
Loa Loa (eye worm) phosphatidylinositol 3 0.041 0.0571 0.0571
Onchocerca volvulus 0.041 0.0571 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5267 0.8505 0.8504
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0433 0.0608 0.0819
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0433 0.0608 0.0608
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.0565
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0098 0.0085
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0608 0.0515
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6182 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0433 0.0608 0.0515
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2118 0.336 0.3295
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.041 0.0571 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.4927 0.795 0.7948
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0433 0.0608 0.0596
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0915 0.1396 0.1384
Loa Loa (eye worm) hypothetical protein 0.078 0.1175 0.1175
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3361 0.539 0.5387
Echinococcus multilocularis serine protein kinase ATM 0.119 0.1845 0.1834
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0326 0.0313
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0559 0.0814 0.0808
Loa Loa (eye worm) hypothetical protein 0.125 0.1943 0.1943
Trichomonas vaginalis PIKK family atypical protein kinase 0.078 0.1175 0.1169
Schistosoma mansoni immunophilin 0.0104 0.0071 0.0057
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0829 0.1254 0.1242
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0098 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.1661 0.2613 0.2608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3677 0.5908 0.5905
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0457 0.0647 0.0554
Schistosoma mansoni fkbp-rapamycin associated protein 0.119 0.1845 0.1834
Loa Loa (eye worm) hypothetical protein 0.0069 0.0014 0.0014
Mycobacterium leprae conserved hypothetical protein 0.041 0.0571 0.5
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0915 0.1396 0.1384
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1203 0.1865 0.1865
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0121 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0559 0.0814 0.0808
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0098 0.0085
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0071 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.041 0.0571 0.0571
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0706 0.1054 0.1041
Echinococcus multilocularis Zinc finger, PHD finger 0.0433 0.0608 0.0596
Entamoeba histolytica protein kinase rad3, putative 0.119 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0199 0.0226 0.0226
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.055 0.0799 0.0787
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0098 0.0085
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0513 0.0738 0.0647
Entamoeba histolytica hypothetical protein 0.119 0.1845 0.1845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.041 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4927 0.795 0.7948
Plasmodium falciparum phosphatidylinositol 4-kinase 0.041 0.0571 0.9272
Trichomonas vaginalis PIKK family atypical protein kinase 0.3361 0.539 0.5387
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0219 0.0259 0.0259
Plasmodium vivax hypothetical protein 0.041 0.0571 0.9272
Trichomonas vaginalis PIKK family atypical protein kinase 0.3356 0.5382 0.5379
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.336 0.3356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.119 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.6182 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0098 0.0085
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.041 0.0571 0.0558
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.063 0.0929 0.0923
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0571 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.1203 0.1865 0.186
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1326 0.2066 0.278
Schistosoma mansoni hypothetical protein 0.0915 0.1396 0.1384
Leishmania major hypothetical protein, unknown function 0.041 0.0571 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.4147 0.6676 0.6674
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.041 0.0571 0.0565
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.0265 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0915 0.1396 0.139
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.0559
Echinococcus multilocularis 0.041 0.0571 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Leishmania major phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.0478
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0433 0.0608 0.0602
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0433 0.0608 0.0602
Schistosoma mansoni phosphatidylinositol 4-kinase 0.041 0.0571 0.0558
Toxoplasma gondii target of rapamycin (TOR), putative 0.4611 0.7432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4611 0.7432 0.7431
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.041 0.0571 0.0559
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6182 1 1
Loa Loa (eye worm) hypothetical protein 0.1326 0.2066 0.2066
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0121 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.063 0.0929 0.0923
Schistosoma mansoni immunophilin 0.0121 0.0098 0.0085
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.041 0.0571 0.0558
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.063 0.0929 0.0929
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.041 0.0571 0.0769
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0069 0.0014 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.0684 0.0684
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6182 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0479 0.0684 0.0678
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0238 0.029 0.029
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2163 0.3435 0.3426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3695 0.5937 0.5935
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6182 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.041 0.0571 0.0558
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0098 0.0085
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.055 0.0799 0.0787
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2163 0.3435 0.3426
Trichomonas vaginalis fk506-binding protein, putative 0.0121 0.0098 0.0091
Leishmania major hypothetical protein, conserved 0.0515 0.0742 0.0651
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2163 0.3435 0.3426
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0433 0.0608 0.0602
Entamoeba histolytica protein kinase, putative 0.0065 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2105 0.334 0.3336
Trichomonas vaginalis PIKK family atypical protein kinase 0.4927 0.795 0.7948
Loa Loa (eye worm) phosphatidylinositol kinase 0.041 0.0571 0.0571
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0608 0.0602
Trichomonas vaginalis immunophilin, putative 0.0121 0.0098 0.0091
Entamoeba histolytica hypothetical protein 0.0584 0.0854 0.0854
Giardia lamblia Phosphatidylinositol 4-kinase 0.041 0.0571 0.0478
Toxoplasma gondii FATC domain-containing protein 0.119 0.1845 0.2483
Schistosoma mansoni hypothetical protein 0.041 0.0571 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.4927 0.795 0.7948
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.119 0.1845 0.1845
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.041 0.0571 0.9272
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4932 0.7958 0.7957
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0433 0.0608 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.041 0.0571 0.0559
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0238 0.029 0.0277
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0071 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.055 0.0799 0.0799
Entamoeba histolytica protein kinase, putative 0.0065 0.0007 0.0007
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0433 0.0608 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2916 0.4663 0.466
Trichomonas vaginalis PIKK family atypical protein kinase 0.4927 0.795 0.7948
Trichomonas vaginalis PIKK family atypical protein kinase 0.3361 0.539 0.5387
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0479 0.0684 0.0684
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2118 0.336 0.3356
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.041 0.0571 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.119 0.1845 0.184
Loa Loa (eye worm) phosphatidylinositol 3 0.6182 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.041 0.0571 0.0558
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0479 0.0684 0.0684
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0433 0.0608 0.0596
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.041 0.0571 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.119 0.1845 0.184
Mycobacterium tuberculosis Conserved hypothetical protein 0.041 0.0571 0.5
Leishmania major phosphatidylinositol 3-kinase, putative 0.2105 0.334 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.4012 0.6455 0.6453
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0238 0.029 0.029
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0121 0.0098 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0571 0.0565
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0433 0.0608 0.0819
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0433 0.0608 0.0596
Entamoeba histolytica hypothetical protein 0.041 0.0571 0.0571
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6182 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0065 0.0007 0.0007
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6182 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0479 0.0684 0.0671
Loa Loa (eye worm) phosphatidylinositol 3 0.2118 0.336 0.336
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0072 0.0059

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 119 % Anticancer activity against human NCI-H460 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay ChEMBL. 18774202
Activity (functional) = 121 % Anticancer activity against human MCF7 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay ChEMBL. 18774202
Activity (functional) = 136 % Anticancer activity against human SF268 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay ChEMBL. 18774202

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.