TDR Targets

Basic information

Technical information

TDR Targets ID: 991831
Name: 7-(1H-pyrrol-2-yl)-2,3-dihydroisoindol-1-one
MW: 198.221 | Formula: C12H10N2O
H donors: 2 H acceptors: 1 LogP: 1.22 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NCc2c1c(ccc2)c1ccc[nH]1
InChi: 1S/C12H10N2O/c15-12-11-8(7-14-12)3-1-4-9(11)10-5-2-6-13-10/h1-6,13H,7H2,(H,14,15)
InChiKey: WKRPBUDNPJYGTO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-(1H-pyrrol-2-yl)isoindolin-1-one
7-(1H-pyrrol-2-yl)-1-isoindolinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	thyroid hormone receptor alpha	0.0007	0.0003	0.0003
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0277	0.088	0.088
Onchocerca volvulus		0.0016	0.003	0.0032
Brugia malayi	nuclear hormone receptor family member odr-7	0.0007	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.003	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Echinococcus granulosus	nuclear receptor nhr 48	0.0007	0.0003	0.0003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.003	0.003
Echinococcus multilocularis	roundabout 2	0.0018	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0006	0.0006
Brugia malayi	nuclear hormone receptor	0.0007	0.0003	0.0003
Brugia malayi	tailless protein	0.0007	0.0003	0.0003
Echinococcus granulosus	twitchin	0.0015	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	neuroglian	0.0014	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0016	0.003	0.003
Trypanosoma cruzi	arginine N-methyltransferase, type III	0.0277	0.088	1
Brugia malayi	Nuclear hormone receptor E75	0.0007	0.0003	0.0003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0007	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.003	0.003
Entamoeba histolytica	hypothetical protein	0.0277	0.088	1
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.308	1	1
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0277	0.088	1
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.308	1	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.02	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0007	0.0003	0.0003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.003	0.003
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0277	0.088	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.0534	0.0587
Echinococcus granulosus	methyltransferase protein 5	0.0277	0.088	0.088
Schistosoma mansoni	protein arginine n-methyltransferase	0.308	1	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.02	1
Onchocerca volvulus		0.0167	0.0521	0.0573
Loa Loa (eye worm)	Carm1-pending protein	0.308	1	1
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.02	0.02
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0006	0.0006
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0039	0.0219
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0016	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0008	0.0006	0.0006
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0277	0.088	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0016	0.003	0.003
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.0573	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Schistosoma mansoni	tyrosine kinase	0.0008	0.0003	0.0003
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0007	0.0003	0.0003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.003	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.02	0.1916
Entamoeba histolytica	protein kinase, putative	0.0068	0.02	0.1916
Entamoeba histolytica	protein kinase , putative	0.0068	0.02	0.1916
Schistosoma mansoni	zinc finger protein	0.0007	0.0003	0.0003
Onchocerca volvulus		0.2803	0.9099	1
Brugia malayi	conserved hypotetical protein	0.0007	0.0003	0.0003
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0007	0.0003	0.0003
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0016	0.003	0.003
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.02	0.1916
Schistosoma mansoni	nuclear receptor	0.0007	0.0003	0.0003
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.02	0.02
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.0434	0.0434
Entamoeba histolytica	protein kinase, putative	0.0068	0.02	0.1916
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0277	0.088	1
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0015	0.0015
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0016	0.003	0.003
Leishmania major	protein kinase, putative	0.0068	0.02	0.1916
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0008	0.0006	0.0006
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0277	0.088	0.0776
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.02	0.1916
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0007	0.0003	0.0003
Trypanosoma brucei	unspecified product	0.0019	0.0039	0.0219
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0123	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0016	0.003	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.0573	0.0573
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0003	0.0003
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0039	0.5
Brugia malayi	ecdysteroid receptor	0.0016	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor	0.0007	0.0003	0.0003
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.02	0.02
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.02	0.02
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0003	0.0003
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0277	0.088	0.088
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0277	0.088	1
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0006	0.0006
Schistosoma mansoni	retinoic acid receptor RXR	0.0016	0.003	0.003
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.02	0.02
Schistosoma mansoni	nuclear receptor	0.0007	0.0003	0.0003
Brugia malayi	Protein arginine N-methyltransferase	0.0277	0.088	0.088
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.003	0.003
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.02	0.1916
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0016	0.003	0.003
Brugia malayi	nuclear receptor NHR-67	0.0007	0.0003	0.0003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.003	0.003
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.003	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Loa Loa (eye worm)	acetyltransferase	0.014	0.0434	0.0434
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0123	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.003	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0016	0.003	0.003
Brugia malayi	Nuclear hormone receptor E75	0.0007	0.0003	0.0003
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0007	0.0003	0.0003
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0113	0.0113
Echinococcus granulosus	dna polymerase eta	0.0019	0.0039	0.0039
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0007	0.0003	0.0003
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0015	0.0015
Loa Loa (eye worm)	steroid hormone receptor	0.0016	0.003	0.003
Brugia malayi	nuclear receptor RXR	0.0008	0.0006	0.0006
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.0219
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0102	0.074
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0016	0.003	0.003
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0102	0.3861
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.02	0.1916
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0123	0.0123
Trypanosoma brucei	protein arginine n-methyltransferase 7	0.0277	0.088	1
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0027	0.0027
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0039	0.5
Echinococcus granulosus	roundabout 2	0.0018	0.0037	0.0037
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0277	0.088	1
Brugia malayi	nuclear receptor RXR	0.0007	0.0003	0.0003
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0277	0.088	0.088
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0277	0.088	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0016	0.003	0.003
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.02	0.1916
Brugia malayi	hypothetical protein	0.0011	0.0015	0.0015
Schistosoma mansoni	nephrin	0.0014	0.0025	0.0025
Brugia malayi	Steroid receptor seven-up type 2	0.0016	0.003	0.003
Brugia malayi	photoreceptor-specific nuclear receptor	0.0016	0.003	0.003
Brugia malayi	nuclear hormone receptor	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Toxoplasma gondii	aurora kinase	0.0068	0.02	0.0089
Schistosoma mansoni	hypothetical protein	0.0277	0.088	0.088
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0016	0.003	0.003
Echinococcus multilocularis	nuclear receptor nhr 48	0.0007	0.0003	0.0003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0037
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0006	0.0006
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0015	0.0015
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.003	0.003
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0039	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.003	0.003
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.02	0.1916
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0016	0.003	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Onchocerca volvulus		0.0007	0.0003	0.0003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.003	0.003
Echinococcus granulosus	aurora kinase A	0.0068	0.02	0.02
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.02	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0027
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0123	0.0123
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0039	0.0039
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0113	0.0873
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0007	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0037	0.0037
Onchocerca volvulus		0.0007	0.0003	0.0003
Echinococcus multilocularis	aurora kinase A	0.0068	0.02	0.02
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0123	0.0123
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0007	0.0003	0.0003
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0016	0.003	0.0032
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Brugia malayi	hypothetical protein	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Trypanosoma brucei	aurora B kinase	0.0068	0.02	0.2093
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0016	0.003	0.003
Onchocerca volvulus	Bile acid receptor homolog	0.0016	0.003	0.0032
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0016	0.003	0.003
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0007	0.0003	0.0003
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0007	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.308	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0016	0.003	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0008	0.0006	0.0006
Trypanosoma cruzi	protein arginine n-methyltransferase 7	0.0277	0.088	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0006	0.0006
Loa Loa (eye worm)	DR-78	0.0007	0.0003	0.0003
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.02	0.02
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0277	0.088	1
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.02	0.1916
Brugia malayi	nuclear receptor NHR-88	0.0016	0.003	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.003	0.003
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0123	0.0123
Echinococcus multilocularis	FTZ F1 alpha	0.0016	0.003	0.003
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0113	0.0873
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0008	0.0006	0.0006
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0016	0.003	0.003
Echinococcus multilocularis	neuroglian	0.0014	0.0025	0.0025
Brugia malayi	serine/threonine kinase 12	0.0068	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.0015
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.0219
Brugia malayi	steroid hormone receptor	0.0016	0.003	0.003
Giardia lamblia	Aurora kinase	0.0068	0.02	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0039	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0016	0.003	0.003
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0015	0.0015
Leishmania major	arginine N-methyltransferase, type I	0.0277	0.088	1
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.02	0.02
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0016	0.003	0.003
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0007	0.0003	0.0003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0123	0.0123
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0016	0.003	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0006	0.0006
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.0219
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0123	0.0123
Brugia malayi	orphan nuclear receptor NR2E1	0.0007	0.0003	0.0003
Schistosoma mansoni	coup transcription factor	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0016	0.003	0.003
Brugia malayi	ecdysone receptor	0.0007	0.0003	0.0003
Echinococcus granulosus	Immunoglobulin	0.0011	0.0015	0.0015
Echinococcus granulosus	ecdysone induced protein 78C	0.0016	0.003	0.003
Echinococcus granulosus	FTZ F1 alpha	0.0016	0.003	0.003
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0003	0.0003
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0039	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0016	0.003	0.003
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0027	0.0027
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0277	0.088	0.088
Schistosoma mansoni	protein kinase	0.0068	0.02	0.02
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0003	0.0003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.0219
Leishmania major	arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490	0.0277	0.088	1
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0277	0.088	0.088
Entamoeba histolytica	arginine N-methyltransferase 1, putative	0.0277	0.088	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0039	0.0039
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0039	0.0039
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0016	0.003	0.003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.003	0.003
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0277	0.088	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Echinococcus multilocularis	ecdysone induced protein 78C	0.0016	0.003	0.003
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.0422	0.0422
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0039	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0007	0.0003	0.0003
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0039	0.0039
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0016	0.003	0.003
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.003	0.003
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0039	0.0039
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0016	0.003	0.003
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0007	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0016	0.003	0.003
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0277	0.088	0.0776
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0016	0.003	0.003
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0007	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.338 uM	Inhibition of Aurora A	ChEMBL.	18718756
IC50 (binding)	= 1.1 uM	Inhibition of VEGFR2	ChEMBL.	18718756
Inhibition (binding)	= 63 %	Inhibition of CDK1 at 100 uM	ChEMBL.	18718756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL491045

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 991831