TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.496 | Formula: C20H26N2O4S
H donors: 1 H acceptors: 2 LogP: 2.37 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1c2CCNCCc2c(cc1S(=O)(=O)N(Cc1ccccc1)C)OC
InChi: 1S/C20H26N2O4S/c1-22(14-15-7-5-4-6-8-15)27(23,24)19-13-18(25-2)16-9-11-21-12-10-17(16)20(19)26-3/h4-8,13,21H,9-12,14H2,1-3H3
InChiKey: QQMIIWZERKKDBK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	conserved hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	ecdysteroid receptor	0.0027	0.0193	0.0262
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0217	0.0221
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0027	0.0193	0.0195
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0342	0.0346
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0193	0.0196
Brugia malayi	hypothetical protein	0.0065	0.0639	0.0943
Echinococcus granulosus	ecdysone induced protein 78C	0.0027	0.0193	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0177	0.0713
Brugia malayi	Steroid receptor seven-up type 2	0.0027	0.0193	0.0262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0301	0.5101
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0027	0.0193	0.0262
Echinococcus multilocularis	peregrin	0.0029	0.0209	0.0213
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0033	0.0263	0.1421
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0026	0.0175	0.0179
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0018	0.0083	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0258	0.0918
Echinococcus granulosus	expressed protein	0.0033	0.0258	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0193	0.1043
Echinococcus multilocularis	jun protein	0.0082	0.085	0.0865
Echinococcus multilocularis	dna polymerase kappa	0.0059	0.0574	0.0584
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0249	0.4163
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0148	0.0194
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0193	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0452	0.1915
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Brugia malayi	steroid hormone receptor	0.0027	0.0193	0.0262
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0263	0.4406
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0163	0.5104
Leishmania major	DNA polymerase kappa, putative	0.004	0.034	1
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0209	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Brugia malayi	photoreceptor-specific nuclear receptor	0.0027	0.0193	0.0262
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0021	0.0114
Brugia malayi	hypothetical protein	0.0018	0.0083	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0027	0.0193	0.0195
Echinococcus multilocularis	ecdysone induced protein 78C	0.0027	0.0193	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0111
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0163	0.2604
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Schistosoma mansoni	rotamase	0.0033	0.0258	0.1397
Echinococcus granulosus	FTZ F1 alpha	0.0027	0.0193	0.0195
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.0574	1
Trypanosoma brucei	unspecified product	0.0023	0.014	0.2202
Schistosoma mansoni	nuclear receptor nhr-48	0.0013	0.0021	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Schistosoma mansoni	RAR-like nuclear receptor	0.0027	0.0193	0.1043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0027	0.0193	0.0781
Echinococcus granulosus	geminin	0.0166	0.1849	0.187
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.0984	0.1002
Schistosoma mansoni	thyroid hormone receptor	0.015	0.1665	0.9003
Schistosoma mansoni	DNA polymerase eta	0.0033	0.0263	0.1421
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0013	0.0021	0.003
Schistosoma mansoni	zinc finger protein	0.0013	0.0021	0.0114
Trichomonas vaginalis	rotamase, putative	0.0033	0.0258	0.0918
Echinococcus granulosus	jun protein	0.0082	0.085	0.0859
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0033	0.0263	0.0266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0027	0.0193	0.0781
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.0709	0.0717
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0193	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Echinococcus multilocularis	geminin	0.0166	0.1849	0.1883
Onchocerca volvulus	Alhambra homolog	0.0029	0.0209	0.0717
Trichomonas vaginalis	rotamase, putative	0.0032	0.0249	0.0883
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0013	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor-like 1	0.0014	0.0039	0.0028
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0013	0.0021	0.003
Loa Loa (eye worm)	steroid hormone receptor	0.0027	0.0193	0.0781
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0209	0.1129
Entamoeba histolytica	hypothetical protein	0.007	0.0709	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0263	0.1086
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0209	0.085
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.0301
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0217	0.3589
Schistosoma mansoni	hypothetical protein	0.0166	0.1849	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0163	0.553
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0249	0.3346
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0027	0.0193	0.1043
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.134	0.1364
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0027	0.0193	0.1043
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0217	0.1173
Echinococcus granulosus	lamin dm0	0.0026	0.0183	0.0185
Schistosoma mansoni	hypothetical protein	0.0166	0.1849	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0013	0.0021	0.0114
Echinococcus granulosus	peregrin	0.0029	0.0209	0.0211
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0574	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.13	0.5623
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.0301
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0027	0.0193	0.1043
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0027	0.0193	0.0195
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0027	0.0193	0.1043
Echinococcus granulosus	dna polymerase eta	0.0033	0.0263	0.0266
Brugia malayi	hypothetical protein	0.0014	0.0039	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0027	0.0193	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0027	0.0193	0.0781
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0027	0.0193	0.0195
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Loa Loa (eye worm)	DR-78	0.0013	0.0021	0.003
Echinococcus multilocularis	FTZ F1 alpha	0.0027	0.0193	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1281	0.5538
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0014	0.0039	0.004
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0014	0.0039	0.004
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0183	0.0739
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0037	0.0098
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0217	0.8333
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0249	0.7184
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0027	0.0193	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0027	0.0193	0.0781
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0027	0.0193	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0111
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.028	0.0284
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0148	0.015
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.0574	1
Brugia malayi	jmjC domain containing protein	0.0035	0.028	0.0396
Onchocerca volvulus	Protein ultraspiracle homolog	0.0027	0.0193	0.0656
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0027	0.0193	0.0195
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0574	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.0263	0.0369
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0027	0.0193	0.1043
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.002	0.002
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0342	0.0348
Echinococcus granulosus	thyroid hormone receptor alpha	0.0013	0.0021	0.0021
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.0709	0.3836
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0249	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0301	0.5101
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0249	0.4163
Brugia malayi	hypothetical protein	0.0026	0.0175	0.0236
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0037	0.0024
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0217	0.3589
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0209	0.0213
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0027	0.0193	0.0196
Schistosoma mansoni	lamin	0.0026	0.0183	0.099
Echinococcus multilocularis	lamin dm0	0.0026	0.0183	0.0186
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.034	1
Echinococcus multilocularis	musashi	0.0026	0.0183	0.0186
Trypanosoma brucei	DNA polymerase IV, putative	0.0053	0.0496	0.8612
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0193	0.0262
Plasmodium vivax	SET domain protein, putative	0.0029	0.0217	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0027	0.0193	0.0262
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0574	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0021	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0027	0.0193	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Brugia malayi	nuclear receptor RXR	0.0014	0.0039	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0217	0.3589
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0209	0.0211
Brugia malayi	hypothetical protein	0.0018	0.0083	0.0095
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0183	0.0247
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.012	0.13	0.5623
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0148	0.0151
Mycobacterium ulcerans	proteasome PrcA	0.0848	1	1
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0193	0.0262
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0574	1
Onchocerca volvulus		0.0065	0.0639	0.2362
Onchocerca volvulus	Huntingtin homolog	0.012	0.13	0.4889
Echinococcus granulosus	aryl hydrocarbon receptor	0.0026	0.0175	0.0177
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0014	0.0039	0.0214
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0033	0.0263	0.3542
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Brugia malayi	polk-prov protein	0.0036	0.0301	0.0428
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0204	0.0206
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0033	0.0263	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.0301
Entamoeba histolytica	hypothetical protein	0.007	0.0709	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0472	0.2555
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Echinococcus granulosus	lamin	0.0026	0.0183	0.0185
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0163	0.0649
Brugia malayi	bZIP transcription factor family protein	0.0082	0.085	0.1265
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0033	0.0263	0.0267
Onchocerca volvulus	Protein cycle homolog	0.0018	0.0083	0.0237
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0217	0.1173
Onchocerca volvulus		0.0026	0.0183	0.0619
Onchocerca volvulus		0.0026	0.0175	0.059
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0027	0.0193	0.0781
Schistosoma mansoni	hypothetical protein	0.0123	0.134	0.7246
Onchocerca volvulus		0.0232	0.2637	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0027	0.0193	0.0262
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0193	0.0196
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0014	0.0039	0.0214
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0217	0.1173
Schistosoma mansoni	thyroid hormone receptor	0.015	0.1665	0.9003
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0013	0.0021	0.0114
Onchocerca volvulus		0.0029	0.0217	0.0748
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0148	0.0499
Schistosoma mansoni	coup transcription factor	0.0027	0.0193	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0886
Trypanosoma brucei	unspecified product	0.0053	0.0496	0.8612
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0209	0.9488
Entamoeba histolytica	hypothetical protein	0.007	0.0709	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.0263	0.0369
Brugia malayi	PHD-finger family protein	0.0029	0.0209	0.0286
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.034	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0193	0.0781
Onchocerca volvulus		0.0026	0.0183	0.0619
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0018	0.0083	0.0449
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0021	0.0021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0217	0.1173
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0193	0.0262
Schistosoma mansoni	nuclear receptor	0.0013	0.0021	0.0114
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0301	0.1255
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0258	0.1067
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0163	0.2604
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.028	0.1517
Brugia malayi	Pre-SET motif family protein	0.0029	0.0217	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0193	0.0262
Leishmania major	DNA polymerase eta, putative	0.0033	0.0263	0.7605
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0183	0.0739
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.028	0.1164
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0193	0.0262
Echinococcus granulosus	dna polymerase kappa	0.0059	0.0574	0.058
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.028	0.1517
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.034	0.5794
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.0984	0.0995
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0027	0.0193	0.0656
Brugia malayi	Bromodomain containing protein	0.0029	0.0209	0.0286
Echinococcus multilocularis	dna polymerase eta	0.0033	0.0263	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0217	0.0221
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0027	0.0193	0.1043
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0183	0.0739
Onchocerca volvulus	Bile acid receptor homolog	0.0027	0.0193	0.0656
Echinococcus multilocularis	nuclear receptor nhr 48	0.0013	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.0301
Brugia malayi	jmjC domain containing protein	0.0093	0.0984	0.147
Trypanosoma brucei	unspecified product	0.0023	0.014	0.2202
Giardia lamblia	DINP protein human, muc B family	0.004	0.034	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0033	0.0263	0.1421
Onchocerca volvulus		0.0027	0.0193	0.0656
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0209	0.7912
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0249	0.4163
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0027	0.0193	0.0262
Echinococcus granulosus	intermediate filament protein	0.0026	0.0183	0.0185
Echinococcus granulosus	nuclear receptor nhr 48	0.0013	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0013	0.002	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0018	0.0083	0.0095
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0017	0.0068	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0111
Leishmania major	hypothetical protein, conserved	0.0025	0.0163	0.4495
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0183	0.099
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0148	0.0587
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0193	0.1043
Schistosoma mansoni	retinoic acid receptor RXR	0.0027	0.0193	0.1043
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0021	0.0114
Echinococcus multilocularis	thyroid hormone receptor alpha	0.015	0.1665	0.1695
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0027	0.0193	0.0781
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0209	0.7912
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0013	0.0021	0.0022
Loa Loa (eye worm)	nuclear hormone receptor	0.0013	0.0021	0.003
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0163	0.5104
Trypanosoma brucei	DNA polymerase eta, putative	0.0033	0.0263	0.4406
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2301	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0163	0.6589
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0027	0.0193	0.0196
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0021	0.0022
Brugia malayi	hypothetical protein	0.0016	0.0058	0.0056
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0848	1	1
Brugia malayi	Pre-SET motif family protein	0.0204	0.2301	0.3481
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0148	0.0499
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0018	0.0083	0.0301
Trichomonas vaginalis	DNA polymerase eta, putative	0.0059	0.0574	0.2122
Echinococcus multilocularis	conserved hypothetical protein	0.0833	0.9819	1
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0755	0.4082
Brugia malayi	hypothetical protein	0.012	0.13	0.1953
Echinococcus granulosus	hypothetical protein	0.0839	0.9888	1
Schistosoma mansoni	nuclear receptor	0.0013	0.0021	0.0114
Brugia malayi	hypothetical protein	0.007	0.0709	0.1051
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0193	0.0262
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.085	0.0859
Schistosoma mansoni	lamin	0.0026	0.0183	0.099
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.0709	0.0722
Brugia malayi	Serotonin receptor	0.0561	0.6571	1
Schistosoma mansoni	jun-related protein	0.0067	0.0666	0.3602
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.028	0.0286
Echinococcus multilocularis	expressed protein	0.0033	0.0258	0.0263
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0027	0.0193	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0193	0.0262
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.085	0.0865
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0013	0.0021	0.0022
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0026	0.0175	0.0705
Loa Loa (eye worm)	hypothetical protein	0.008	0.0823	0.3537
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0089	0.0484
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0258	0.0362
Brugia malayi	Nuclear hormone receptor-like 1	0.0014	0.0039	0.0028
Brugia malayi	hypothetical protein	0.0025	0.0163	0.0216
Brugia malayi	intermediate filament protein	0.0026	0.0183	0.0247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0217	0.0219
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0163	0.2604
Schistosoma mansoni	hypothetical protein	0.0029	0.0209	0.1129
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0014	0.0039	0.0111
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0021	0.0021
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.2637	1
Echinococcus multilocularis	lamin	0.0026	0.0183	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.003
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0572	0.2437
Entamoeba histolytica	hypothetical protein	0.007	0.0709	1
Schistosoma mansoni	hypothetical protein	0.007	0.0709	0.3836
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0193	0.0195
Onchocerca volvulus	Huntingtin homolog	0.012	0.13	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0209	0.085
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0574	1
Brugia malayi	hypothetical protein	0.0014	0.0039	0.0028
Brugia malayi	nuclear hormone receptor	0.0027	0.0193	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	0.0705
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.134	0.1355
Schistosoma mansoni	hypothetical protein	0.0067	0.0666	0.3602
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0018	0.0083	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0027	0.0193	0.0781
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0059	0.0574	0.2122

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 170 nM	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL.	19269173
EC50 (functional)	> 9940 nM	Agonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL.	19269173
Emax (functional)	= 50 %	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay relative to serotonin	ChEMBL.	19269173

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL492362

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 992472