Detailed information for compound 993952

Basic information

Technical information
  • TDR Targets ID: 993952
  • Name: 1-[4-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3,17-d ihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12 ,14,15,16,17-tetradecahydro-1H-cyclopenta[a]p henanthren-2-yl]piperazin-1-yl]butan-1-one
  • MW: 446.666 | Formula: C27H46N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)N1CCN(CC1)[C@H]1C[C@@]2(C)[C@H](C[C@@H]1O)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
  • InChi: 1S/C27H46N2O3/c1-4-5-25(32)29-14-12-28(13-15-29)22-17-27(3)18(16-23(22)30)6-7-19-20-8-9-24(31)26(20,2)11-10-21(19)27/h18-24,30-31H,4-17H2,1-3H3/t18-,19-,20-,21-,22-,23-,24-,26-,27-/m0/s1
  • InChiKey: KUONZJIOVTTYDV-QATZYRQISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-1-piperazinyl]butan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0148 0.0237
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0016 0.0004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0148 0.0237
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1063 0.1053
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.003 0.0036
Onchocerca volvulus 0.0005 0.0016 0.0007
Schistosoma mansoni survival motor neuron protein 0.0049 0.1089 0.1089
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0148 0.0233
Schistosoma mansoni ap endonuclease 0.002 0.0377 0.0377
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0062
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0148 0.0136
Loa Loa (eye worm) paired box protein 0.0005 0.0012 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0288 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1063 0.1063
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0016 0.0011
Brugia malayi hypothetical protein 0.0005 0.003 0.0036
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.2564 0.438
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0016 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0377 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0148 0.0148
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0016 0.0011
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0377 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1089 0.1852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0148 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0148 0.0237
Loa Loa (eye worm) hypothetical protein 0.011 0.2551 0.4358
Schistosoma mansoni thyroid hormone receptor 0.001 0.0148 0.0148
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.5842 1
Brugia malayi nuclear hormone receptor 0.0005 0.0016 0.0011
Brugia malayi Pax transcription factor protein 2 0.0245 0.5842 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0148 0.0148
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0016 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.003 0.003
Schistosoma mansoni paired box protein pax-1-related 0.0005 0.0012 0.0012
Onchocerca volvulus 0.0049 0.1089 0.1848
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2847 0.4864
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0154
Loa Loa (eye worm) Smad1 0.0008 0.0099 0.0154
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0099 0.0087
Echinococcus granulosus cpg binding protein 0.0031 0.0648 0.0637
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0148 0.0136
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0012 0.0005
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0148 0.0237
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0148 0.0233
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0377 0.0366
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0148 0.0136
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0377 0.0366
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0036
Echinococcus multilocularis geminin 0.0173 0.4083 0.4076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0148 0.0237
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0012 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0148 0.0136
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0148 0.0237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0016 0.0007
Onchocerca volvulus 0.0005 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0036
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Echinococcus multilocularis smad 0.0008 0.0099 0.0087
Schistosoma mansoni smad 0.0008 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0148 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0148 0.0237
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0288 0.0277
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0148 0.0136
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1242 1
Brugia malayi paired box pox-meso protein 0.0005 0.0012 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0099 0.0154
Loa Loa (eye worm) vab-3 0.0005 0.0012 0.0005
Schistosoma mansoni hypothetical protein 0.0049 0.1089 0.1089
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0148 0.0136
Brugia malayi steroid hormone receptor 0.001 0.0148 0.0237
Schistosoma mansoni hypothetical protein 0.0173 0.4083 0.4083
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0377 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0148 0.0136
Brugia malayi CXXC zinc finger family protein 0.0029 0.0608 0.1026
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0148 0.0237
Onchocerca volvulus 0.0245 0.5842 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1063 0.1053
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0016 0.0004
Brugia malayi nuclear receptor RXR 0.0005 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi vab-3 gene. 0.0005 0.0012 0.0005
Brugia malayi hypothetical protein 0.0005 0.003 0.0036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0377 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0016 0.0004
Brugia malayi nuclear receptor NHR-88 0.0005 0.0016 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0148 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0148 0.0237
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0288 0.0277
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.003 0.0018
Onchocerca volvulus 0.0029 0.0608 0.1021
Schistosoma mansoni coup transcription factor 0.001 0.0148 0.0148
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0016 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0016 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0377 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0648 0.0637
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.003 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0148 0.0136
Brugia malayi isocitrate dehydrogenase 0.0016 0.0288 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0148 0.0237
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0016 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0377 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0288 0.0277
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0148 0.0237
Schistosoma mansoni cpg binding protein 0.0029 0.0608 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0148 0.0237
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0016 0.0016
Brugia malayi nuclear hormone receptor 0.001 0.0148 0.0237
Brugia malayi conserved hypotetical protein 0.0005 0.0016 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0016 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0148 0.0237
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1063 0.1063
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0288 0.0478
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0608 0.1026
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0016 0.0004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0148 0.0148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0148 0.0148
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2847 0.4864
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1063 0.1807
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0377 0.0631
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0148 0.0136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0288 0.0277
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0099 0.0087
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0154
Echinococcus granulosus FTZ F1 alpha 0.001 0.0148 0.0136
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0016 0.0016
Schistosoma mansoni paired box protein pax-6 0.0005 0.0012 0.0012
Onchocerca volvulus 0.001 0.0148 0.0233
Schistosoma mansoni nuclear hormone receptor 0.001 0.0148 0.0148
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0106
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0148 0.0136
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0148 0.0136
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0148 0.0148
Schistosoma mansoni paired box protein pax-6 0.0005 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0417 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Brugia malayi nuclear receptor NHR-67 0.0005 0.0016 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0099 0.0154
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1063 0.1807
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Schistosoma mansoni paired box protein pax-6 0.0005 0.0012 0.0012
Brugia malayi Gooseberry protein 0.0005 0.0012 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0148 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0148 0.0237
Echinococcus granulosus transcription factor eb 0.011 0.2564 0.2555
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0148 0.0233
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0148 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0148 0.0237
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.003 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0288 0.0288
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0074 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0016 0.0016
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0288 0.0478
Brugia malayi hypothetical protein 0.0005 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0005 0.003 0.0036
Schistosoma mansoni hypothetical protein 0.0173 0.4083 0.4083
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0148 0.0136
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0099 0.0087
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.011 0.2551 0.4358
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0012 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0148 0.0136
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0377 1
Brugia malayi nuclear receptor RXR 0.0005 0.0016 0.0011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0074 0.0062
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0016 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0377 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0148 0.0136
Brugia malayi Smad1 0.0008 0.0099 0.0154
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0377 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0148 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0148 0.0237
Schistosoma mansoni zinc finger protein 0.0005 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1063 0.1063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1063 0.1053
Loa Loa (eye worm) hypothetical protein 0.0241 0.5738 0.9822
Schistosoma mansoni ap endonuclease 0.002 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0148 0.0237
Brugia malayi MH2 domain containing protein 0.0122 0.2847 0.4864
Schistosoma mansoni Smad4 0.0008 0.0099 0.0099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0005
Echinococcus multilocularis Smad4 0.0008 0.0099 0.0087
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0377 0.0631
Brugia malayi paired box protein 0.0005 0.0012 0.0005
Echinococcus granulosus smad 0.0008 0.0099 0.0087
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0016 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0016 0.0007
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0016 0.0004
Echinococcus granulosus geminin 0.0173 0.4083 0.4076
Brugia malayi ecdysone receptor 0.0005 0.0016 0.0011
Brugia malayi hypothetical protein 0.0241 0.5738 0.9822
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0148 0.0237
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0099 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0115 0.0181
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0377 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.003 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0074 0.0062
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.5738 0.5733
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.0237
Brugia malayi tailless protein 0.0005 0.0016 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1403 0.1403
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0005
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0377 0.5
Toxoplasma gondii exonuclease III APE 0.002 0.0377 0.0932
Brugia malayi nuclear receptor NHR-88 0.001 0.0148 0.0237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0148 0.0136
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.5738 0.5733
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0118 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1063 0.1053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0148 0.0136
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0288 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0148 0.0237
Echinococcus granulosus Smad4 0.0008 0.0099 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0377 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0377 0.5
Brugia malayi ecdysteroid receptor 0.001 0.0148 0.0237
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0016 0.0011
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0016 0.0004
Schistosoma mansoni nuclear receptor 0.0005 0.0016 0.0016
Loa Loa (eye worm) DR-78 0.0005 0.0016 0.0011
Echinococcus multilocularis transcription factor eb 0.011 0.2564 0.2555
Brugia malayi hypothetical protein 0.0005 0.0016 0.0011

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Growth inhibition of human HL60 cells at 1 uM after 3 days ChEMBL. 18375126
Inhibition (functional) = 4.6 % Growth inhibition of human HL60 cells at 10 uM after 3 days ChEMBL. 18375126

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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