Detailed information for compound 999506

Basic information

Technical information
  • TDR Targets ID: 999506
  • Name: N-[(2R,3S)-1-carbamimidoyl-2-ethoxypiperidin- 3-yl]-6-hydroxy-1-[(2R)-2-[[(2R)-2-hydroxy-3- (4-hydroxyphenyl)propanoyl]amino]-3-(4-hydrox yphenyl)propanoyl]-2,3,3a,4,5,6,7,7a-octahydr oindole-2-carboxamide
  • MW: 680.791 | Formula: C35H48N6O8
  • H donors: 7 H acceptors: 7 LogP: 1.7 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCO[C@@H]1[C@H](CCCN1C(=N)N)NC(=O)C1CC2C(N1C(=O)[C@@H](Cc1ccc(cc1)O)NC(=O)[C@@H](Cc1ccc(cc1)O)O)CC(CC2)O
  • InChi: 1S/C35H48N6O8/c1-2-49-34-26(4-3-15-40(34)35(36)37)38-31(46)29-18-22-9-14-25(44)19-28(22)41(29)33(48)27(16-20-5-10-23(42)11-6-20)39-32(47)30(45)17-21-7-12-24(43)13-8-21/h5-8,10-13,22,25-30,34,42-45H,2-4,9,14-19H2,1H3,(H3,36,37)(H,38,46)(H,39,47)/t22?,25?,26-,27+,28?,29?,30+,34+/m0/s1
  • InChiKey: ZHFMOYWZDUNUOY-IQYNOVPGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2R,3S)-1-carbamimidoyl-2-ethoxy-3-piperidyl]-6-hydroxy-1-[(2R)-2-[[(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
  • N-[(2R,3S)-1-carbamimidoyl-2-ethoxy-3-piperidinyl]-6-hydroxy-1-[(2R)-2-[[(2R)-2-hydroxy-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
  • N-[(2R,3S)-1-amidino-2-ethoxy-3-piperidyl]-6-hydroxy-1-[(2R)-2-[[(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
  • N-[(2R,3S)-1-carbamimidoyl-2-ethoxy-piperidin-3-yl]-6-hydroxy-1-[(2R)-2-[[(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni fkbp-rapamycin associated protein 0.0123 0.079 0.2149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0123 0.079 0.079
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.0068
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0042 0.0003 0.0008
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0042 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0003 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0519 0.2434
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0123 0.079 0.2149
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Loa Loa (eye worm) MH2 domain-containing protein 0.0095 0.0515 0.2415
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.0008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0261 0.2132 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0003 0.0014
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0137 0.0926 0.4345
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0383 0.1794
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0042 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0042 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0003 0.0014
Toxoplasma gondii target of rapamycin (TOR), putative 0.0218 0.1713 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0003 0.0014
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0123 0.079 0.3705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trypanosoma cruzi target of rapamycin kinase 3 0.0218 0.1713 0.466
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0643 0.5846 0.5846
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.014 0.0954 0.2595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0218 0.1713 0.8036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0926 0.4345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0218 0.1713 0.466
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0218 0.1713 0.2931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Loa Loa (eye worm) hypothetical protein 0.0137 0.0926 0.4345
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.0003 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0261 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0003 0.0014
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.0003 0.0003
Leishmania major phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0003 0.0014
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1071 1 1
Echinococcus granulosus serine protein kinase ATM 0.0182 0.1362 0.1362
Echinococcus multilocularis sodium channel protein 0.0643 0.5846 0.5846
Loa Loa (eye worm) phosphatidylinositol kinase 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0003 0.0014
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0218 0.1713 0.2931
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.1362 0.3703
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.3677 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Brugia malayi MH2 domain containing protein 0.0095 0.0515 0.1401
Echinococcus multilocularis serine protein kinase ATM 0.0182 0.1362 0.1362
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.0003 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0003 0.0018
Leishmania major phosphatidylinositol kinase related protein, putative 0.0101 0.0575 0.0983
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0218 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.0042 0.0003 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0182 0.1362 0.3703
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0003 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Leishmania major phosphatidylinositol 3-kinase, putative 0.0218 0.1713 0.2931
Schistosoma mansoni hypothetical protein 0.0042 0.0003 0.0008
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0137 0.0926 0.5407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0218 0.1713 0.1713
Giardia lamblia GTOR 0.0218 0.1713 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0003 0.0014
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0003 0.0003
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0166 0.1209 0.705
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0003 0.0014
Toxoplasma gondii FATC domain-containing protein 0.0182 0.1362 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Schistosoma mansoni hypothetical protein 0.0095 0.0519 0.1412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0003 0.0014
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0003 0.0005
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0643 0.5846 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0042 0.0003 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.1713 0.8036
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0042 0.0003 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0042 0.0003 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0003 0.0014
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.0003 0.0008
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0042 0.0003 0.0014
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.042 0.3677 0.3677
Echinococcus multilocularis 0.0042 0.0003 0.0003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0218 0.1713 0.2931
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0261 0.2132 0.3647
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0042 0.0003 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0042 0.0003 0.0008
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0042 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0003 0.0014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.042 0.3677 0.3677
Leishmania major phosphatidylinositol 3-kinase, putative 0.0042 0.0003 0.0005
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0519 0.2434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0218 0.1713 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.0003 0.0003
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0218 0.1713 0.8036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0003 0.0014
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.0003 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0926 0.4345
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0218 0.1713 0.8036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.1713 0.466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Brugia malayi FAT domain containing protein 0.0095 0.0519 0.1412
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.014 0.0954 0.4474
Onchocerca volvulus 0.0042 0.0003 1
Loa Loa (eye worm) transcription factor SMAD2 0.0095 0.0515 0.2415
Onchocerca volvulus 0.0042 0.0003 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0042 0.0003 0.0008
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0042 0.0003 0.0008
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0095 0.0519 0.0519
Leishmania major hypothetical protein, conserved 0.0407 0.3547 0.6067
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0218 0.1713 0.8036
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0042 0.0003 0.0003
Leishmania major hypothetical protein, unknown function 0.0042 0.0003 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0003 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.0003 0.0014
Echinococcus granulosus sodium channel protein 0.0643 0.5846 0.5846
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0003 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0003 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0123 0.079 0.079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1362 0.6385
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0218 0.1713 0.466
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0218 0.1713 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.042 0.3677 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0182 0.1362 0.3703
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.1209 0.5669
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0095 0.0519 0.0519
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.0003 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0101 0.0575 0.1563
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.0068
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0003 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0003 0.0018
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0003 0.0014
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0003 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0261 0.2132 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0042 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0042 0.0003 0.0014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0218 0.1713 0.466
Entamoeba histolytica protein kinase rad3, putative 0.0123 0.079 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Leishmania major phosphatidylinositol kinase, putative 0.0042 0.0003 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.079 0.2149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.1713 0.8036
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.0003 0.0008
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0042 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0003 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.0003 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0003 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.042 0.3677 1
Trypanosoma cruzi hypothetical protein, conserved 0.0365 0.314 0.8539
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.042 0.3677 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0182 0.1362 0.6385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.079 0.3705
Plasmodium vivax hypothetical protein 0.0042 0.0003 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0003 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0383 0.1794
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0042 0.0003 0.5
Entamoeba histolytica hypothetical protein 0.0182 0.1362 0.7942

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 ug ml-1 Inhibition of thrombin ChEMBL. 9722497
IC50 (binding) = 68 ug ml-1 Inhibition of plasmin ChEMBL. 9722497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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