Detailed view for LOAG_04869

Basic information

TDR Targets ID: 948997
Loa Loa (eye worm), protein phosphatase 2C containing protein
Source Database / ID:  KEGG  

pI: 5.2169 | Length (AA): 433 | MW (Da): 47549 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00481   Protein phosphatase 2C
PF07830   Protein serine/threonine phosphatase 2C, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0043169   cation binding  
GO:0030145   manganese ion binding  
GO:0004722   protein serine/threonine phosphatase activity  
GO:0004721   phosphoprotein phosphatase activity  
GO:0003824   catalytic activity  
GO:0000287   magnesium ion binding  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

MAPK signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 418 4rag (A) 2 367 48.00 0 1 1.47409 -0.69
42 341 2p8e (A) 4 295 54.00 0 1 1.33594 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126741)

Species Accession Gene Product
Arabidopsis thaliana AT2G25070   probable protein phosphatase 2C 21
Arabidopsis thaliana AT4G31860   putative protein phosphatase 2C 60
Babesia bovis BBOV_I000710   protein phosphatase 2C, putative
Brugia malayi Bm1_34490   Protein phosphatase 2C containing protein
Brugia malayi Bm1_41255   probable protein phosphatase 2C
Brugia malayi Bm1_28345   Protein phosphatase 2C containing protein
Candida albicans CaO19.10072   type 2C protein phosphatase similar to S. cerevisiae PTC2 (YER089C) involved in G1/S cell cycle transition
Candida albicans CaO19.2538   type 2C protein phosphatase similar to S. cerevisiae PTC2 (YER089C) involved in G1/S cell cycle transition
Caenorhabditis elegans CELE_T23F11.1   Protein PPM-2
Caenorhabditis elegans CELE_F25D1.1   Protein PPM-1, isoform B
Caenorhabditis elegans CELE_F42G9.1   Protein F42G9.1, isoform B
Cryptosporidium hominis Chro.30238   Ppm1g-prov protein
Cryptosporidium parvum cgd3_2020   PP2C like protein phosphatase
Drosophila melanogaster Dmel_CG12169   CG12169 gene product from transcript CG12169-RA
Drosophila melanogaster Dmel_CG1906   alphabet
Drosophila melanogaster Dmel_CG10417   CG10417 gene product from transcript CG10417-RB
Drosophila melanogaster Dmel_CG17746   CG17746 gene product from transcript CG17746-RB
Drosophila melanogaster Dmel_CG6036   CG6036 gene product from transcript CG6036-RA
Echinococcus granulosus EgrG_001151300   protein phosphatase 2c
Echinococcus granulosus EgrG_000221800   protein phosphatase 2c
Echinococcus granulosus EgrG_000892100   protein phosphatase 1b
Entamoeba histolytica EHI_110320   protein phosphatase, putative
Echinococcus multilocularis EmuJ_000221800   protein phosphatase 2C
Echinococcus multilocularis EmuJ_001151300   protein phosphatase 2C
Echinococcus multilocularis EmuJ_000892100   protein phosphatase 1b
Giardia lamblia GL50803_14404   Phosphatase
Giardia lamblia GL50803_14650   Ser/Thr phosphatase 2C, putative
Homo sapiens ENSG00000138032   protein phosphatase, Mg2+/Mn2+ dependent, 1B
Homo sapiens ENSG00000100614   protein phosphatase, Mg2+/Mn2+ dependent, 1A
Homo sapiens ENSG00000115241   protein phosphatase, Mg2+/Mn2+ dependent, 1G
Leishmania braziliensis LbrM.35.0620   protein phosphatase 2C-like protein
Leishmania braziliensis LbrM.32.1860   protein phosphatase 2C, putative
Leishmania braziliensis LbrM.30.0990   protein phosphatase 2C, putative
Leishmania donovani LdBPK_321770.1   protein phosphatase 2C, putative
Leishmania donovani LdBPK_360560.1   protein phosphatase 2C-like protein
Leishmania infantum LinJ.36.0560   protein phosphatase 2C-like protein
Leishmania infantum LinJ.32.1770   protein phosphatase 2C, putative
Leishmania major LmjF.32.1690   protein phosphatase 2C, putative
Leishmania major LmjF.36.0530   protein phosphatase 2C-like protein
Leishmania mexicana LmxM.31.1690   protein phosphatase 2C, putative
Leishmania mexicana LmxM.36.0530   protein phosphatase 2C-like protein
Loa Loa (eye worm) LOAG_04869   protein phosphatase 2C containing protein
Loa Loa (eye worm) LOAG_07965   hypothetical protein
Loa Loa (eye worm) LOAG_02685   hypothetical protein
Mus musculus ENSMUSG00000021096   protein phosphatase 1A, magnesium dependent, alpha isoform
Mus musculus ensembl-mmu:ENSMUSG00000061130   protein phosphatase 1B, magnesium dependent, beta isoform
Mus musculus ENSMUSG00000029147   protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
Neospora caninum NCLIV_038980   hypothetical protein
Neospora caninum NCLIV_032320   hypothetical protein
Oryza sativa 4347831   Os09g0558000
Oryza sativa 4328505   Os02g0180000
Oryza sativa 4341693   Os06g0651600
Oryza sativa 9269012   Os04g0500900
Onchocerca volvulus OVOC7720   Putative protein phosphatase 2C
Plasmodium berghei PBANKA_0910200   protein phosphatase PPM2
Plasmodium falciparum PF3D7_1138500   protein phosphatase PPM2
Plasmodium knowlesi PKNH_0936700   protein phosphatase PPM2, putative
Plasmodium vivax PVX_092540   protein phosphatase PPM2, putative
Plasmodium yoelii PY06845   Protein phosphatase 2C, putative
Saccharomyces cerevisiae YBL056W   type 2C protein phosphatase PTC3
Saccharomyces cerevisiae YER089C   type 2C protein phosphatase PTC2
Schistosoma japonicum Sjp_0071680   ko:K01090 protein phosphatase [EC3.1.3.16], putative
Schistosoma japonicum Sjp_0081110   ko:K01090 protein phosphatase [EC3.1.3.16], putative
Schistosoma japonicum Sjp_0059610   ko:K04461 protein phosphatase 1B (formerly 2C), putative
Schistosoma mansoni Smp_148510   protein phosphatase 2C
Schistosoma mansoni Smp_169320   protein phosphatase 2c gamma
Schistosoma mansoni Smp_146530   protein phosphatase 2C
Schmidtea mediterranea mk4.001024.00  
Schmidtea mediterranea mk4.001612.06  
Schmidtea mediterranea mk4.000440.01  
Schmidtea mediterranea mk4.001612.05  
Schmidtea mediterranea mk4.001401.09   Probable protein phosphatase 2C
Schmidtea mediterranea mk4.003536.00   Probable protein phosphatase 2C
Schmidtea mediterranea mk4.004681.00  
Schmidtea mediterranea mk4.001612.04  
Trypanosoma brucei gambiense Tbg972.11.16720   protein phosphatase 2C, putative
Trypanosoma brucei gambiense Tbg972.10.5980   protein phosphatase 2C-like, putative,protein phosphatase 2C homolog 2
Trypanosoma brucei Tb927.11.14910   protein phosphatase 2C, putative
Trypanosoma brucei Tb927.10.4930   protein phosphatase 2C, putative
Trypanosoma congolense TcIL3000_0_30950   protein phosphatase 2C, putative
Trypanosoma congolense TcIL3000_10_4120   protein phosphatase 2C-like, putative
Trypanosoma cruzi TcCLB.506221.30   protein phosphatase 2C, putative
Trypanosoma cruzi TcCLB.510291.30   protein phosphatase 2C-like, putative
Toxoplasma gondii TGME49_267100   protein phosphatase 2C domain-containing protein
Toxoplasma gondii TGME49_232340   protein phosphatase 2C domain-containing protein
Theileria parva TP02_0861   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_177940   protein phosphatase type 2C, putative

Essentiality

LOAG_04869 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.4930 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.4930 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.4930 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.4930 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.6540 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.6540 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.6540 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.6540 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F42G9.1 Caenorhabditis elegans sterile wormbase
PBANKA_0910200 Plasmodium berghei Slow plasmo
TGME49_267100 Toxoplasma gondii Essentiality uncertain sidik
TGME49_232340 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1A Compounds References
Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0081 0.3112 0.3112
0.0064 1 1
0.0169 0.2575 0.2552
0.008 1 1
0.01 1 1
0.01 1 1
0.008 1 0.5
0.0169 0.5476 0.5476
0.008 0.6184 0.6184
0.0187 0.2864 0.2864
0.0073 1 1
0.0172 0.2613 0.2613
0.008 0.749 0.7342
0.0168 0.253 0.2473
0.0173 0.2539 0.2526
0.0174 0.288 0.288
0.0091 1 1
0.0461366 0.325261 0.325261
0.007 0.6596 0.6596
0.0092 0.344 0.344

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_04869 (Loa Loa (eye worm)), protein phosphatase 2C containing protein
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