Detailed information for compound 1522698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.627 | Formula: C25H34N4O4S
  • H donors: 1 H acceptors: 3 LogP: 1.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCN(CC1)C(=O)CN[C@H]1CCN(C1)S(=O)(=O)Cc1ccccc1
  • InChi: 1S/C25H34N4O4S/c1-33-24-9-5-8-22(16-24)18-27-12-14-28(15-13-27)25(30)17-26-23-10-11-29(19-23)34(31,32)20-21-6-3-2-4-7-21/h2-9,16,23,26H,10-15,17-20H2,1H3/t23-/m0/s1
  • InChiKey: AVWPNUIWAIAJAM-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0563 0.0492
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0101 0.1452 0.1387
Onchocerca volvulus 0.0055 0.0695 0.2188
Schistosoma mansoni hypothetical protein 0.0021 0.0151 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.0163 0.0089
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0101 0.1452 0.1387
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0489 0.7712 0.7695
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0434 0.6829 0.6805
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0793 0.0723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0793 0.0723
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Schistosoma mansoni ap endonuclease 0.0038 0.0434 0.0373
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0489 0.7712 0.7698
Echinococcus multilocularis nAChR subunit 0.0101 0.1452 0.1387
Brugia malayi MAP kinase sur-1 0.0053 0.0661 0.0768
Leishmania major protein phosphatase 2C, putative 0.0022 0.0163 0.0249
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0568 0.0497
Brugia malayi Cation transporter family protein 0.0101 0.1452 0.1803
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0101 0.1452 0.1387
Loa Loa (eye worm) protein phosphatase 2C containing protein 0.0168 0.253 0.2473
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0766 0.0697
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.038 0.0307
Leishmania major hypothetical protein, conserved 0.0082 0.1137 0.2685
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0514 0.0443
Plasmodium falciparum importin beta, putative 0.0059 0.0766 1
Plasmodium vivax importin-beta 2, putative 0.0059 0.0766 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0434 0.6829 0.6805
Schistosoma mansoni hypothetical protein 0.0035 0.038 0.0319
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0661 0.1494
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0101 0.1452 0.1387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0163 0.0089
Loa Loa (eye worm) hypothetical protein 0.0082 0.1137 0.1071
Onchocerca volvulus 0.0101 0.1452 0.5298
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0101 0.1452 0.1803
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.7496 0.7477
Schistosoma mansoni ap endonuclease 0.0038 0.0434 0.0373
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0101 0.1452 0.1387
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0568 0.0497
Trypanosoma brucei squalene synthase, putative 0.0263 0.4065 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0101 0.1452 0.1387
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0092 0.0029
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.1452 0.1397
Echinococcus granulosus geminin 0.0347 0.542 0.5386
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Schistosoma mansoni zinc finger protein 0.002 0.0133 0.0071
Echinococcus multilocularis glycine receptor subunit beta 0.0489 0.7712 0.7695
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0101 0.1452 0.1387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0563 0.0492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0563 0.0492
Echinococcus granulosus nAChR subunit 0.0055 0.0695 0.0625
Onchocerca volvulus 0.0047 0.0568 0.1666
Loa Loa (eye worm) ACC-1 protein 0.0101 0.1452 0.1387
Onchocerca volvulus 0.0097 0.1379 0.4999
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0434 0.0697
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Brugia malayi Cation transporter family protein 0.0101 0.1452 0.1803
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0182 0.0108
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0568 0.0646
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0661 0.1626
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0182 0.012
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0101 0.1452 0.1803
Brugia malayi Bromodomain containing protein 0.0039 0.0441 0.048
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0434 0.4498
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0101 0.1452 0.1387
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0434 0.4498
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0434 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0434 0.0927
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.0695 0.0636
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0695 0.0813
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0082 0.1137 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0695 0.0813
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0101 0.1452 0.1387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0568 0.0646
Leishmania major protein phosphatase 2C-like protein 0.0022 0.0163 0.0249
Trypanosoma brucei protein kinase, putative 0.0053 0.0661 0.1626
Schistosoma mansoni bromodomain containing protein 0.0064 0.0851 0.0793
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0568 0.0497
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0092 0.0017
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0568 0.0497
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.1452 0.1397
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0766 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0101 0.1452 0.1803
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0434 0.1068
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0182 0.0108
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0568 0.0508
Onchocerca volvulus 0.0101 0.1452 0.5298
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0661 0.0591
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0568 0.0508
Echinococcus granulosus glycine receptor subunit beta 0.0489 0.7712 0.7695
Schistosoma mansoni hypothetical protein 0.0082 0.1137 0.1081
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Schistosoma mansoni protein phosphatase 2C 0.0147 0.2186 0.2136
Echinococcus granulosus Squalene phytoene synthase 0.0082 0.1137 0.1071
Brugia malayi excitatory GABA receptor EXP-1A 0.0101 0.1452 0.1803
Schistosoma mansoni nAChR subunit 0.0047 0.0568 0.0508
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0563 0.064
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0442 0.6956 0.901
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Trichomonas vaginalis ran, putative 0.0043 0.0514 0.0903
Loa Loa (eye worm) hypothetical protein 0.0442 0.6956 0.6933
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0514 0.1127
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0101 0.1452 0.1387
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0434 0.6829 0.6805
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0402 0.033
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2596 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0563 0.0503
Echinococcus multilocularis Squalene phytoene synthase 0.0082 0.1137 0.1071
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0101 0.1452 0.1387
Schistosoma mansoni hypothetical protein 0.0097 0.1379 0.1324
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0661 0.1494
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.0906
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0563 0.0492
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0661 0.1494
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0643 0.0744
Schistosoma mansoni protein phosphatase 2C 0.0147 0.2186 0.2136
Brugia malayi probable protein phosphatase 2C 0.0022 0.0163 0.0115
Schistosoma mansoni nAChR subunit 0.0047 0.0568 0.0508
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Onchocerca volvulus 0.0101 0.1452 0.5298
Echinococcus granulosus glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Leishmania major importin beta-1 subunit, putative 0.0048 0.0586 0.1306
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0434 0.5097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0586 0.1086
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0092 0.0029
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0163 0.0089
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0101 0.1452 0.1803
Trypanosoma cruzi protein phosphatase 2C-like, putative 0.0022 0.0163 0.0249
Trypanosoma brucei ISWI complex protein 0.0016 0.0063 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Trypanosoma cruzi phytoene synthase, putative 0.0082 0.1137 0.2685
Schistosoma mansoni ran 0.0043 0.0514 0.0454
Echinococcus multilocularis geminin 0.0347 0.542 0.5386
Loa Loa (eye worm) hypothetical protein 0.0475 0.7496 0.7477
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0514 0.0575
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0661 0.0591
Echinococcus multilocularis protein phosphatase 1b 0.0147 0.2186 0.2127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Brugia malayi Importin beta-1 subunit 0.0059 0.0766 0.0905
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.7496 0.7477
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0661 0.0591
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0012
Echinococcus multilocularis protein phosphatase 1b 0.0168 0.253 0.2473
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0568 0.0646
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Brugia malayi Cation transporter family protein 0.0489 0.7712 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0434 0.0471
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0434 0.5447
Trypanosoma cruzi squalene synthase, putative 0.0263 0.4065 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0092 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0434 0.0697
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0012
Brugia malayi hypothetical protein 0.0047 0.0568 0.0646
Echinococcus granulosus zinc finger protein 0.002 0.0133 0.0059
Mycobacterium ulcerans phytoene synthase, CrtB 0.0082 0.1137 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0102 0.0028
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0434 0.0362
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0514 0.0443
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0586 0.1086
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0661 0.128
Brugia malayi PHD-finger family protein 0.0025 0.0221 0.0192
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0092 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0586 0.1306
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0514 0.1127
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0514 0.1265
Brugia malayi RNA, U transporter 1 0.0168 0.2526 0.3209
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0151 0.0077
Schistosoma mansoni hypothetical protein 0.0347 0.542 0.5391
Echinococcus multilocularis snurportin 1 0.063 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0661 0.8259
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0012
Leishmania major GTP-binding protein, putative 0.0043 0.0514 0.1127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0434 0.0362
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2746 0.6636
Schistosoma mansoni hypothetical protein 0.0347 0.542 0.5391
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0514 0.5823
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0563 0.0503
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0163 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Trypanosoma cruzi protein phosphatase 2C, putative 0.0022 0.0163 0.0249
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0434 0.6829 0.8843
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0489 0.7712 0.7695
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.0572
Echinococcus granulosus protein phosphatase 1b 0.0147 0.2186 0.2127
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0101 0.1452 0.1803
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Loa Loa (eye worm) LGC-31 protein 0.0101 0.1452 0.1387
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0101 0.1452 0.1387
Schistosoma mansoni survival motor neuron protein 0.0097 0.1379 0.1324
Schistosoma mansoni protein phosphatase 2c gamma 0.0022 0.0163 0.01
Brugia malayi Protein phosphatase 2C containing protein 0.0168 0.253 0.3214
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0661 0.0602
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0101 0.1452 0.1387
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.063 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2746 0.6636
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0661 0.1494
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0514 0.5823
Brugia malayi hypothetical protein 0.0047 0.0568 0.0646
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0514 0.7051
Echinococcus multilocularis glycine receptor subunit beta 0.0489 0.7712 0.7695
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Loa Loa (eye worm) hypothetical protein 0.0059 0.0766 0.0697
Schistosoma mansoni ran 0.0043 0.0514 0.0454
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0092 0.0017
Entamoeba histolytica hypothetical protein 0.0048 0.0586 0.7941
Entamoeba histolytica hypothetical protein 0.0055 0.0695 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0434 0.0927
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0163 0.0401
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0489 0.7712 0.7698
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0092 0.0017
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Brugia malayi hypothetical protein 0.0047 0.0568 0.0646
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.4055 0.5211
Onchocerca volvulus 0.0101 0.1452 0.5298
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0489 0.7712 0.7695
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0434 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0695 0.0636
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2596 0.6251
Brugia malayi hypothetical protein 0.0047 0.0568 0.0646
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0101 0.1452 0.1803
Echinococcus multilocularis zinc finger protein 0.002 0.0133 0.0059
Echinococcus granulosus protein phosphatase 1b 0.0168 0.253 0.2473
Schistosoma mansoni importin beta-1 0.0059 0.0766 0.0707
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0163 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0481 0.0409
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0101 0.1452 0.1803
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0101 0.1452 0.1803
Onchocerca volvulus 0.0047 0.0568 0.1666
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Echinococcus granulosus importin subunit beta 1 0.0059 0.0766 0.0697
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0434 0.0362
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0101 0.1452 0.1387
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0082 0.1137 0.4006
Onchocerca volvulus 0.0047 0.0568 0.1666
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0568 0.0646
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0661 0.128
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0163 0.01
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0568 0.0508
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0695 0.0813
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0661 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0766 0.1885
Schistosoma mansoni protein phosphatase 2C 0.0168 0.253 0.2482
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0101 0.1452 0.1803
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0101 0.1452 0.1397
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0766 0.1885
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0661 0.128
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Loa Loa (eye worm) hypothetical protein 0.0489 0.7712 0.7695
Echinococcus granulosus glycine receptor subunit beta 0.0489 0.7712 0.7695
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Loa Loa (eye worm) ACC-1 protein 0.0101 0.1452 0.1387
Onchocerca volvulus Putative nachr subunit 0.0101 0.1452 0.5298
Echinococcus granulosus nAChR subunit 0.0101 0.1452 0.1387
Echinococcus granulosus glycine receptor subunit alpha 1 0.0489 0.7712 0.7695
Leishmania major squalene synthase, putative 0.0263 0.4065 1
Brugia malayi Protein phosphatase 2C containing protein 0.0022 0.0163 0.0115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Loa Loa (eye worm) hypothetical protein 0.0055 0.0695 0.0625
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0101 0.1452 0.1803
Entamoeba histolytica Ran family GTPase 0.0043 0.0514 0.6599
Echinococcus multilocularis nAChR subunit 0.0055 0.0695 0.0625
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0163 0.0401
Trypanosoma cruzi squalene synthase, putative 0.0263 0.4065 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0442 0.037
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0568 0.0497
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0661 0.0591
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0661 0.1494
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0643 0.0744
Brugia malayi Bromodomain containing protein 0.0076 0.1044 0.1269
Schistosoma mansoni hypothetical protein 0.063 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4055 1
Onchocerca volvulus 0.0055 0.0695 0.2188
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0695 0.0636
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0101 0.1452 0.1387
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0101 0.1452 0.1387
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Onchocerca volvulus 0.0101 0.1452 0.5298
Brugia malayi hypothetical protein 0.0047 0.0568 0.0646
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1379 0.1708
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0661 0.1494
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0434 0.0927
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0514 0.5823
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0101 0.1452 0.1803
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0568 0.0646
Brugia malayi hypothetical protein 0.0475 0.7496 0.9717
Schistosoma mansoni nAChR subunit 0.0101 0.1452 0.1397
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0568 0.0508
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Loa Loa (eye worm) hypothetical protein 0.0047 0.0568 0.0497
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0661 0.128
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.038 0.0399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.0441
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0661 0.0591
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0101 0.1452 0.1387
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0514 0.0443
Onchocerca volvulus 0.0101 0.1452 0.5298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0643 0.0572
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0092 0.0017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0402 0.033
Toxoplasma gondii exonuclease III APE 0.0038 0.0434 0.4498
Loa Loa (eye worm) GABA receptor subunit 0.0442 0.6956 0.6933
Loa Loa (eye worm) hypothetical protein 0.0101 0.1452 0.1387
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0163 0.0089
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0586 0.1086
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0101 0.1452 0.1387
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0489 0.7712 0.7698
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.4055 0.401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0563 0.0503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0563 0.0492

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 60.8 uM Cytotoxicity against human K562 cells after 48 hrs by MTT assay ChEMBL. 21295380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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