Detailed information for compound 1341233

Basic information

Technical information
  • TDR Targets ID: 1341233
  • Name: N-[2-(2,2-dimethyl-4-phenyloxan-4-yl)ethyl]be nzenesulfonamide
  • MW: 373.509 | Formula: C21H27NO3S
  • H donors: 1 H acceptors: 2 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(C)OCCC(C1)(CCNS(=O)(=O)c1ccccc1)c1ccccc1
  • InChi: 1S/C21H27NO3S/c1-20(2)17-21(14-16-25-20,18-9-5-3-6-10-18)13-15-22-26(23,24)19-11-7-4-8-12-19/h3-12,22H,13-17H2,1-2H3
  • InChiKey: IZSJYYWHCBWQOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(2,2-dimethyl-4-phenyl-tetrahydropyran-4-yl)ethyl]benzenesulfonamide
  • N-[2-(2,2-dimethyl-4-phenyl-4-tetrahydropyranyl)ethyl]benzenesulfonamide
  • N-[2-(2,2-dimethyl-4-phenyl-oxan-4-yl)ethyl]benzenesulfonamide
  • SMR000172283
  • BAS 04915129
  • N-[2-(2,2-Dimethyl-4-phenyl-tetrahydro-pyran-4-yl)-ethyl]-benzenesulfonamide
  • STOCK2S-31035
  • MLS000548318

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GABA receptor subunit 0.0443 0.6974 0.6964
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.005
Echinococcus granulosus Squalene phytoene synthase 0.0085 0.1241 0.1231
Trypanosoma cruzi phytoene synthase, putative 0.0085 0.1241 0.2695
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Onchocerca volvulus 0.0047 0.0626 0.2247
Echinococcus granulosus importin subunit beta 1 0.0059 0.0823 0.0812
Brugia malayi CXXC zinc finger family protein 0.0035 0.043 0.0518
Echinococcus granulosus allatostatin A receptor 0.001 0.0031 0.0019
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0431 0.052
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0031 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0707 0.1705
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.007 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0493 0.0481
Onchocerca volvulus 0.0047 0.0626 0.2247
Brugia malayi Bromodomain containing protein 0.004 0.0508 0.062
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0019
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0132 0.012
Brugia malayi probable protein phosphatase 2C 0.0022 0.0223 0.025
Echinococcus granulosus GPCR family 2 0.0016 0.0132 0.012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0132 0.012
Toxoplasma gondii exonuclease III APE 0.0039 0.0493 0.4815
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.007 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0752 0.0937
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0431 0.0401
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.007 0.0058
Onchocerca volvulus 0.0102 0.1504 0.5565
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.007 0.005
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0061 0.0018
Echinococcus granulosus g-protein coupled receptor 0.001 0.0031 0.0019
Onchocerca volvulus 0.0097 0.1432 0.5294
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0572 0.6744
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0031 0.0019
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0085 0.1241 0.4573
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0019
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0443 0.6974 0.9023
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0435 0.6847 0.6844
Echinococcus multilocularis gamma secretase subunit aph 1 0.0239 0.3699 0.3691
Schistosoma mansoni zinc finger protein 0.0016 0.0127 0.0115
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0102 0.1504 0.1494
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0631 0.062
Echinococcus granulosus translational activator gcn1 0.0011 0.0054 0.0041
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0102 0.1504 0.1494
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0707 0.1705
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0031 0.0019
Schistosoma mansoni hypothetical protein 0.0348 0.5448 0.5443
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus multilocularis GPCR, family 2 0.0016 0.0132 0.012
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0075 0.0058
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0572 0.6744
Leishmania major importin beta-1 subunit, putative 0.0048 0.0643 0.1402
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0572 0.5686
Echinococcus granulosus transportin 1 0.0011 0.0054 0.0041
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.1504 0.1494
Trichomonas vaginalis ran, putative 0.0044 0.0572 0.138
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0019
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0626 0.0615
Brugia malayi gamma-secretase subunit aph-1 0.0239 0.3699 0.4767
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.007 0.0039
Schistosoma mansoni cpg binding protein 0.0039 0.0493 0.0481
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0031 0.0019
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0031 0.0019
Leishmania major protein phosphatase 2C, putative 0.0022 0.0223 0.0403
Schistosoma mansoni ran 0.0044 0.0572 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.007 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0631 0.062
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0752 0.0741
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.0058
Schistosoma mansoni hypothetical protein 0.0085 0.1241 0.1231
Schistosoma mansoni cpg binding protein 0.0039 0.0493 0.0481
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.007 0.005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0626 0.0615
Trypanosoma brucei ISWI complex protein 0.0016 0.0127 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.007 0.005
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0223 0.0211
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.007 0.0146
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0626 0.0615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0058
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0102 0.1504 0.1494
Brugia malayi hypothetical protein 0.0047 0.0626 0.0773
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1432 0.1821
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0019
Onchocerca volvulus 0.0047 0.0626 0.2247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0631 0.062
Echinococcus granulosus survival motor neuron protein 1 0.0477 0.7514 0.7511
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.007 0.0146
Echinococcus granulosus hypothetical protein 0.001 0.0031 0.0019
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0102 0.1504 0.1494
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0019
Echinococcus multilocularis nAChR subunit 0.0102 0.1504 0.1494
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0493 0.5711
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.007 0.0146
Schistosoma mansoni gamma-secretase subunit aph-1 0.0239 0.3699 0.3691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0631 0.062
Brugia malayi Cation transporter family protein 0.0102 0.1504 0.1914
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.007 0.0058
Schistosoma mansoni adenoreceptor 0.001 0.0031 0.0019
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0626 0.0773
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0707 0.1554
Schistosoma mansoni zinc finger protein 0.0022 0.023 0.0218
Brugia malayi Protein phosphatase 2C containing protein 0.0169 0.2575 0.3306
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Brugia malayi Cation transporter family protein 0.0102 0.1504 0.1914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0058
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0019
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0019
Echinococcus granulosus glycine receptor subunit beta 0.049 0.7725 0.7723
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0102 0.1504 0.1914
Schistosoma mansoni cpg binding protein 0.0035 0.043 0.0418
Echinococcus multilocularis zinc finger protein 0.0022 0.023 0.0218
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.007 0.005
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0572 0.0561
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0223 0.0211
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0707 0.0696
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0168 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.007 0.005
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0031 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.005
Onchocerca volvulus 0.0102 0.1504 0.5565
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0626 0.0773
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0031 0.0019
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.049 0.7725 0.7723
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0752 0.0937
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0031 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0102 0.1504 0.1914
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0031 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.007 0.0058
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0707 0.0696
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0626 0.0615
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0279 0.0267
Schistosoma mansoni hypothetical protein 0.0097 0.1432 0.1422
Schistosoma mansoni importin beta-1 0.0059 0.0823 0.0812
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0493 0.1044
Schistosoma mansoni hypothetical protein 0.0348 0.5448 0.5443
Plasmodium vivax protein phosphatase PPM2, putative 0.0022 0.0223 0.2204
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0031 0.0019
Schistosoma mansoni ap endonuclease 0.0039 0.0493 0.0481
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0019
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0031 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.0058
Echinococcus multilocularis translational activator gcn1 0.0011 0.0054 0.0041
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.007 0.0058
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0493 0.06
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0223 0.0211
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0707 0.0696
Loa Loa (eye worm) hypothetical protein 0.0042 0.0548 0.0519
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0707 0.1554
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0626 0.0615
Echinococcus multilocularis geminin 0.0348 0.5448 0.5443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0435 0.6847 0.6838
Echinococcus multilocularis nAChR subunit 0.0055 0.0752 0.0741
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0019
Echinococcus multilocularis allatostatin A receptor 0.001 0.0031 0.0019
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0031 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1504 0.1914
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0493 0.5
Brugia malayi steroid hormone receptor 0.0012 0.007 0.005
Loa Loa (eye worm) hypothetical protein 0.049 0.7725 0.7718
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Echinococcus granulosus nAChR subunit 0.0055 0.0752 0.0741
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0102 0.1504 0.1477
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0132 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0469 0.0457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.0058
Echinococcus granulosus protein phosphatase 1b 0.0169 0.2575 0.2566
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0572 0.7212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0019
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0752 0.0937
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.0058
Echinococcus granulosus neuropeptide s receptor 0.001 0.0031 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0689 0.0855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0493 0.0884
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0019
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.049 0.7725 0.7723
Trypanosoma cruzi protein phosphatase 2C-like, putative 0.0022 0.0223 0.0232
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0073 0.1044 0.1016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0611 0.0582
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Onchocerca volvulus 0.0055 0.0752 0.2724
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2829 0.6821
Echinococcus granulosus gamma secretase subunit aph 1 0.0239 0.3699 0.3691
Plasmodium falciparum protein phosphatase PPM2 0.0022 0.0223 0.2204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0102 0.1504 0.1494
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0102 0.1504 0.1477
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0102 0.1504 0.1494
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0031 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0031 0.0019
Echinococcus granulosus cpg binding protein 0.0039 0.0493 0.0481
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0031 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.007 0.005
Brugia malayi excitatory GABA receptor EXP-1A 0.0102 0.1504 0.1914
Echinococcus multilocularis somatostatin receptor 0.001 0.0031 0.0019
Echinococcus granulosus orexin receptor type 2 0.001 0.0031 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Echinococcus multilocularis Squalene phytoene synthase 0.0085 0.1241 0.1231
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0894 0.0883
Schistosoma mansoni opsin-like receptor 0.001 0.0031 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0034
Brugia malayi kap beta 3 protein 0.0011 0.0054 0.0029
Entamoeba histolytica hypothetical protein 0.0048 0.0643 0.8442
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.007 0.0058
Schistosoma mansoni protein phosphatase 2C 0.0169 0.2575 0.2566
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0707 0.7166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0643 0.1551
Onchocerca volvulus 0.0035 0.043 0.1506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0631 0.062
Onchocerca volvulus 0.0055 0.0752 0.2724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0039
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0223 0.0211
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.049 0.7725 0.7723
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.007 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1052 0.1042
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0031 0.0019
Entamoeba histolytica hypothetical protein 0.0055 0.0752 1
Brugia malayi ecdysteroid receptor 0.0012 0.007 0.005
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0894 0.0883
Loa Loa (eye worm) ACC-1 protein 0.0102 0.1504 0.1477
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.012
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0823 0.1828
Plasmodium vivax importin-beta 2, putative 0.0059 0.0823 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0493 0.5571
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0019
Schistosoma mansoni hypothetical protein 0.0021 0.0216 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0168 0.0156
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0031 0.0019
Echinococcus multilocularis glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.1364 0.2993
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0707 0.1554
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0031 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Onchocerca volvulus 0.0102 0.1504 0.5565
Schistosoma mansoni hypothetical protein 0.0016 0.0127 0.0115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0031 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus multilocularis fmrfamide receptor 0.001 0.0031 0.0019
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0707 1
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0031 0.0019
Onchocerca volvulus 0.0102 0.1504 0.5565
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0626 0.0773
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0102 0.1504 0.1477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1504 0.1914
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0631 0.062
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.0752 0.0741
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0019
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0019
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0019
Echinococcus granulosus zinc finger protein 0.0022 0.023 0.0218
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0054 0.0023
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Echinococcus multilocularis cpg binding protein 0.0039 0.0493 0.0481
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Schistosoma mansoni hypothetical protein 0.0035 0.0431 0.042
Echinococcus granulosus g protein coupled receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Trypanosoma brucei squalene synthase, putative 0.0274 0.426 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Onchocerca volvulus 0.0012 0.007 0.0146
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0572 0.1077
Onchocerca volvulus 0.0102 0.1504 0.5565
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0031 0.0019
Schistosoma mansoni coup transcription factor 0.0012 0.007 0.0058
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0156 0.0144
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0031 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0689 0.066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.007 0.0039
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0102 0.1504 0.1477
Schistosoma mansoni hypothetical protein 0.0494 0.7786 0.7783
Schistosoma mansoni histamine h1 receptor 0.001 0.0031 0.0019
Echinococcus multilocularis orexin receptor type 2 0.001 0.0031 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0019
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0031 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0012 0.007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0085 0.1241 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0239 0.3699 0.3679
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0493 0.0463
Schistosoma mansoni survival motor neuron protein 0.0097 0.1432 0.1422
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0132 0.012
Mycobacterium ulcerans phytoene synthase, CrtB 0.0085 0.1241 1
Echinococcus multilocularis sex peptide receptor 0.001 0.0031 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.007 0.0058
Entamoeba histolytica protein phosphatase, putative 0.0022 0.0223 0.2427
Schistosoma mansoni protein phosphatase 2C 0.0147 0.2233 0.2224
Trichomonas vaginalis protein phosphatase type 2C, putative 0.0022 0.0223 0.0538
Echinococcus granulosus glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0279 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0631 0.078
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus multilocularis glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Schistosoma mansoni ran 0.0044 0.0572 0.0561
Echinococcus granulosus protein phosphatase 1b 0.0147 0.2233 0.2224
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Loa Loa (eye worm) hypothetical protein 0.0022 0.0223 0.0193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0493 0.1044
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0102 0.1504 0.1477
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Trypanosoma cruzi squalene synthase, putative 0.0274 0.426 1
Schistosoma mansoni bromodomain containing protein 0.0067 0.0953 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.005
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0102 0.1504 0.1494
Onchocerca volvulus Putative nachr subunit 0.0102 0.1504 0.5565
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0572 0.0703
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0572 0.1077
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0823 0.1828
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0031 0.0019
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0823 0.8432
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.1364 0.3116
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0643 0.1248
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0643 0.1551
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0102 0.1504 0.1914
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0031 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0493 0.0884
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0493 0.1188
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Echinococcus granulosus fmrfamide receptor 0.001 0.0031 0.0019
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0626 0.0615
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0019
Brugia malayi Bromodomain containing protein 0.0079 0.1147 0.145
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0019
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0707 0.1705
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0031 0.0019
Echinococcus granulosus glycine receptor subunit beta 0.049 0.7725 0.7723
Brugia malayi hypothetical protein 0.0477 0.7514 0.9725
Echinococcus multilocularis protein phosphatase 1b 0.0169 0.2575 0.2566
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0626 0.0773
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0031 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0626 0.0773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0019
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0019
Onchocerca volvulus 0.0102 0.1504 0.5565
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0443 0.6974 0.6964
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0626 0.0597
Onchocerca volvulus Putative protein phosphatase 2C 0.0022 0.0223 0.0725
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Schistosoma mansoni neuropeptide receptor 0.001 0.0031 0.0019
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0031 0.0019
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0058
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0054 0.0023
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0469 0.0457
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0102 0.1504 0.1914
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0707 0.1705
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0019
Echinococcus granulosus nAChR subunit 0.0102 0.1504 0.1494
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.007 0.005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.007 0.005
Brugia malayi MAP kinase sur-1 0.0052 0.0707 0.0879
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.1364 0.2993
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0166 0.0136
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0102 0.1504 0.1914
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7786 0.7783
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0031 0.0019
Echinococcus multilocularis importin 5 0.0011 0.0054 0.0041
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0707 0.1403
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7786 0.7783
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.005
Echinococcus multilocularis g protein coupled receptor 0.001 0.0031 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.0058
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0435 0.6847 0.6844
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Loa Loa (eye worm) LGC-31 protein 0.0102 0.1504 0.1477
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0493 0.5
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0223 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2829 0.6821
Schistosoma mansoni biogenic amine receptor 0.001 0.0031 0.0019
Echinococcus multilocularis serotonin receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Trypanosoma cruzi protein phosphatase 2C, putative 0.0022 0.0223 0.0232
Echinococcus multilocularis neuropeptide receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0168 0.0138
Leishmania major GTP-binding protein, putative 0.0044 0.0572 0.1233
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Echinococcus multilocularis glycine receptor subunit beta 0.049 0.7725 0.7723
Schistosoma mansoni nAChR subunit 0.0047 0.0626 0.0615
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0102 0.1504 0.1494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0058
Loa Loa (eye worm) protein phosphatase 2C containing protein 0.0169 0.2575 0.2552
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0966 1
Loa Loa (eye worm) hypothetical protein 0.0477 0.7514 0.7506
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0031 0.0019
Schistosoma mansoni myosin xvIII 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0223 0.0193
Brugia malayi Protein phosphatase 2C containing protein 0.0022 0.0223 0.025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0493 0.0481
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0019
Echinococcus granulosus sex peptide receptor 0.001 0.0031 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0019
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0031 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0019
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0031 0.0019
Brugia malayi hypothetical protein 0.0047 0.0626 0.0773
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0707 0.1403
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0752 0.0723
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0019
Leishmania major hypothetical protein, conserved 0.0016 0.0127 0.0175
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0019
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0156 0.0144
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0156 0.0144
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0626 0.0615
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Brugia malayi PHD-finger family protein 0.0028 0.0318 0.0373
Toxoplasma gondii protein phosphatase 2C domain-containing protein 0.0022 0.0223 0.1858
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0102 0.1504 0.1914
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0102 0.1504 0.1494
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.1504 0.1494
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0493 0.6288
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0031 0.0019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.4147 0.535
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0435 0.6847 0.8859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0034
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0707 0.1403
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0031 0.0019
Trichomonas vaginalis hypothetical protein 0.0011 0.0054 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0216 0.0185
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0019
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2678 0.6457
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0031 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0019
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Schistosoma mansoni hypothetical protein 0.0632 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Leishmania major protein phosphatase 2C-like protein 0.0022 0.0223 0.0403
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.0058
Schistosoma mansoni importin-beta 2 0.0011 0.0054 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0031 0.0019
Schistosoma mansoni protein phosphatase 2C 0.0147 0.2233 0.2224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.005
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.049 0.7725 0.7718
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0689 0.0855
Loa Loa (eye worm) hypothetical protein 0.0059 0.0823 0.0794
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0707 0.1403
Toxoplasma gondii protein phosphatase 2C domain-containing protein 0.0022 0.0223 0.1858
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0572 0.0543
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0031 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.007 0.0058
Echinococcus multilocularis transportin 1 0.0011 0.0054 0.0041
Brugia malayi hypothetical protein 0.0047 0.0626 0.0773
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Brugia malayi Cation transporter family protein 0.049 0.7725 1
Brugia malayi hypothetical protein 0.0047 0.0626 0.0773
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.4147 0.4129
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.049 0.7725 0.7723
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.007 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.1504 0.1494
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) ACC-1 protein 0.0102 0.1504 0.1477
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0223 0.0403
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0279 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0493 0.1188
Entamoeba histolytica Ran family GTPase 0.0044 0.0572 0.7425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0631 0.062
Leishmania major hypothetical protein, conserved 0.0085 0.1241 0.2823
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.007 0.0058
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0223 0.0403
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0031 0.0019
Plasmodium falciparum importin beta, putative 0.0059 0.0823 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Leishmania major squalene synthase, putative 0.0274 0.426 1
Brugia malayi RNA, U transporter 1 0.0168 0.2571 0.3302
Loa Loa (eye worm) hypothetical protein 0.004 0.0509 0.0479
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Brugia malayi hypothetical protein 0.0047 0.0626 0.0773
Trypanosoma brucei protein kinase, putative 0.0052 0.0707 0.1554
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.2678 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.007 0.0058
Echinococcus multilocularis glycine receptor subunit beta 0.049 0.7725 0.7723
Echinococcus granulosus glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0102 0.1504 0.1494
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0102 0.1504 0.1494
Echinococcus granulosus somatostatin receptor 0.001 0.0031 0.0019
Schistosoma mansoni nAChR subunit 0.0102 0.1504 0.1494
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0085 0.1241 1
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0102 0.1504 0.1477
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0572 0.1233
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0019
Brugia malayi Importin beta-1 subunit 0.0059 0.0823 0.1029
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0707 0.0696
Trypanosoma cruzi squalene synthase, putative 0.0274 0.426 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0643 0.1551
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0572 0.0561
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0102 0.1504 0.1914
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0168 0.0156
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.1504 0.1494
Echinococcus granulosus geminin 0.0348 0.5448 0.5443
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.043 0.04
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0031 0.0019
Echinococcus multilocularis snurportin 1 0.0632 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0132 0.012
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0823 0.0812
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0039
Echinococcus multilocularis protein phosphatase 1b 0.0147 0.2233 0.2224
Echinococcus granulosus importin 5 0.0011 0.0054 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.4147 1
Schistosoma mansoni protein phosphatase 2c gamma 0.0022 0.0223 0.0211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0031 0.0019
Echinococcus granulosus serotonin receptor 0.001 0.0031 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0102 0.1504 0.1494
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0046 0.0015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.049 0.7725 0.7723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0031 0.0019
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0156 0.0144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0689 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0168 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1504 0.1914
Schistosoma mansoni ap endonuclease 0.0039 0.0493 0.0481
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1504 0.1914
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.007 0.0058
Echinococcus granulosus neuropeptide receptor 0.001 0.0031 0.0019
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0707 0.0678
Schistosoma mansoni nAChR subunit 0.0047 0.0626 0.0615
Loa Loa (eye worm) hypothetical protein 0.0047 0.0626 0.0597
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0752 0.0741
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0031 0.0019
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0707 0.0696
Echinococcus multilocularis glycine receptor subunit alpha 1 0.049 0.7725 0.7723
Schistosoma mansoni amine GPCR 0.001 0.0031 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0631 0.0602
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0493 0.5711
Echinococcus multilocularis survival motor neuron protein 1 0.0477 0.7514 0.7511
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0031 0.0019

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 52.948 uM PUBCHEM_BIOASSAY: Bacterial Growth Inhibition Counterscreen using BacTiter-Glo Measured in Microorganism System Using Plate Reader - 2093-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488938] ChEMBL. No reference
AC50 (functional) = 250.871 uM PUBCHEM_BIOASSAY: High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488938] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.