TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 427.495 | Formula: C26H25N3O3
H donors: 4 H acceptors: 3 LogP: 3.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCNCc1cc2Cc3c(c2cc1OC)[nH]nc3c1ccc(cc1)c1ccc(cc1)O
InChi: 1S/C26H25N3O3/c1-32-24-14-22-19(12-20(24)15-27-10-11-30)13-23-25(28-29-26(22)23)18-4-2-16(3-5-18)17-6-8-21(31)9-7-17/h2-9,12,14,27,30-31H,10-11,13,15H2,1H3,(H,28,29)
InChiKey: TXYXKQLGTOSEMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	checkpoint kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Serine/threonine-protein kinase Chk1, putative	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130454	All targets in OG5_130454

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0041	0.0023
Loa Loa (eye worm)	ACC-1 protein	0.01	0.1336	0.1321
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0046	0.0441	0.0524
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus multilocularis	Squalene phytoene synthase	0.0088	0.1122	0.1122
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.1214	0.2735
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.043	0.6785	0.8828
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0313	0.0296
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0046	0.0441	0.0441
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0544	0.1169
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0041	0.0023
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0041	0.0041
Echinococcus multilocularis	serotonin receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0027
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0437	0.6914	0.6908
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.01	0.1336	0.1336
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0043	0.0386	0.5724
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1122	0.1107
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0041	0.0041
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0054	0.0569	0.0692
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus granulosus	geminin	0.0343	0.5358	0.5358
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0544	0.0544
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0041	0.0041
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0436	0.0436
Schistosoma mansoni	hypothetical protein	0.0343	0.5358	0.5358
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0239	0.3625	0.3625
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.01	0.1336	0.1336
Brugia malayi	Protein phosphatase 2C containing protein	0.0022	0.0044	0.0005
Schistosoma mansoni	protein phosphatase 2C	0.0151	0.2176	0.2176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0305	0.5
Echinococcus granulosus	gamma secretase subunit aph 1	0.0239	0.3625	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.01	0.1336	0.1336
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0041	0.0041
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0043	0.0386	0.0799
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0047	0.0458	0.0969
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0043	0.0386	0.0799
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0043	0.0386	0.5724
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0041	0.0041
Brugia malayi	probable protein phosphatase 2C	0.0022	0.0044	0.0005
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0043	0.0386	0.6838
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0041	0.0041
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0041	0.0041
Echinococcus granulosus	protein phosphatase 2c	0.0022	0.0044	0.0044
Echinococcus multilocularis	protein phosphatase 2C	0.0022	0.0044	0.0044
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.1214	0.2735
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	neurotransmitter gated ion channel	0.0054	0.0569	0.0569
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0305	0.061
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0054	0.0569	0.0692
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Schistosoma mansoni	survival motor neuron protein	0.0097	0.1284	0.1284
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Brugia malayi	hypothetical protein	0.0477	0.757	0.9856
Brugia malayi	hypothetical protein	0.0046	0.0441	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0041	0.0041
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0046	0.0441	0.0524
Onchocerca volvulus	Putative nachr subunit	0.01	0.1336	0.5275
Brugia malayi	gamma-secretase subunit aph-1	0.0239	0.3625	0.4692
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0305	0.0305
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0041	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Onchocerca volvulus		0.01	0.1336	0.5275
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Onchocerca volvulus		0.01	0.1336	0.5275
Loa Loa (eye worm)	acetylcholine receptor protein	0.0046	0.0441	0.0424
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0544	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Schistosoma mansoni	acetylcholine receptor-related	0.0046	0.0441	0.0441
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0041	0.0023
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0544	0.1272
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0043	0.0386	0.0452
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0484	0.768	0.7676
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	opsin-like receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	protein phosphatase 2c gamma	0.0022	0.0044	0.0044
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0441	0.0524
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.01	0.1336	0.1336
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0544	0.0544
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0054	0.0569	0.0569
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0484	0.768	0.768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0436	0.0436
Schistosoma mansoni	ap endonuclease	0.0038	0.0305	0.0305
Trypanosoma brucei	squalene synthase, putative	0.0281	0.4321	1
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0041	0.0041
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0305	0.0346
Brugia malayi	excitatory GABA receptor EXP-1A	0.01	0.1336	0.1696
Echinococcus multilocularis	importin subunit beta 1	0.0058	0.0641	0.0641
Onchocerca volvulus		0.0046	0.0441	0.1629
Echinococcus multilocularis	serotonin receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0544	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0305	0.061
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0046	0.0441	0.0524
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.043	0.6785	0.6785
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Schistosoma mansoni	hypothetical protein	0.0624	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.2648	0.6624
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0436	0.0436
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.026	0.3975	0.3964
Schistosoma mansoni	hypothetical protein	0.0343	0.5358	0.5358
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0441	0.0524
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0544	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0352	0.0335
Schistosoma mansoni	protein phosphatase 2C	0.0173	0.2539	0.2539
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Schistosoma mansoni	hypothetical protein	0.0035	0.025	0.025
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0041	0.0041
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0041	0.0041
Brugia malayi	PHD-finger family protein	0.0025	0.0089	0.0063
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0041	0.0041
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0041	0.0041
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0041	0.0041
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	protein phosphatase 2C	0.0022	0.0044	0.0044
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0054	0.0569	0.0692
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Echinococcus granulosus	nAChR subunit	0.0054	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Schistosoma mansoni	protein phosphatase 2C	0.0022	0.0044	0.0044
Leishmania major	GTP-binding protein, putative	0.0043	0.0386	0.0799
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0043	0.0386	0.5724
Brugia malayi	Bromodomain containing protein	0.0075	0.0923	0.1155
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0484	0.768	0.768
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0305	0.4965
Schistosoma mansoni	hypothetical protein	0.0021	0.0018	0.0018
Schistosoma mansoni	amine GPCR	0.0022	0.0041	0.0041
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0516	0.0622
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0041	0.0041
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	ap endonuclease	0.0038	0.0305	0.0305
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.01	0.1336	0.1696
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.01	0.1336	0.1336
Loa Loa (eye worm)	ACC-1 protein	0.01	0.1336	0.1321
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0041	0.0023
Onchocerca volvulus		0.0054	0.0569	0.2153
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0239	0.3625	0.3625
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.3026	0.3026
Trypanosoma cruzi	phytoene synthase, putative	0.0088	0.1122	0.2521
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.0173	0.2539	0.2526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Echinococcus multilocularis	nAChR subunit	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Entamoeba histolytica	hypothetical protein	0.0047	0.0458	0.7887
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0041	0.0041
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0041	0.0023
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0668	0.0668
Schistosoma mansoni	amine GPCR	0.0022	0.0041	0.0041
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0088	0.1122	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0047	0.0458	0.1054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0436	0.0419
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0049	0.0049
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0544	0.0544
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.01	0.1336	0.1336
Onchocerca volvulus		0.0046	0.0441	0.1629
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0041	0.0041
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus granulosus	sex peptide receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0668	0.0668
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.01	0.1336	0.1321
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	amine GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0041	0.0023
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0041	0.0041
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0305	0.4367
Echinococcus granulosus	importin subunit beta 1	0.0058	0.0641	0.0641
Trypanosoma brucei	importin beta-1 subunit, putative	0.0058	0.0641	0.1396
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0544	0.1272
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0041	0.0041
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.01	0.1336	0.1696
Onchocerca volvulus		0.0054	0.0569	0.2153
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0041	0.0041
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0041	0.0041
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.01	0.1336	0.1696
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.026	0.3975	0.515
Schistosoma mansoni	hypothetical protein	0.0097	0.1284	0.1284
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0544	0.1272
Entamoeba histolytica	hypothetical protein	0.0054	0.0569	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0046	0.0441	0.0424
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0041	0.0041
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.01	0.1336	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Schistosoma mansoni	neurotransmitter gated ion channel	0.0046	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0305	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	hypothetical protein	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0043	0.0386	0.0799
Brugia malayi	Cation transporter family protein	0.01	0.1336	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	neurotransmitter gated ion channel	0.0046	0.0441	0.0441
Trypanosoma cruzi	squalene synthase, putative	0.0281	0.4321	1
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.01	0.1336	0.1321
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0543	0.866	0.866
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0046	0.0441	0.0441
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0041	0.0041
Schistosoma mansoni	opsin-like receptor	0.0022	0.0041	0.0041
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0516	0.0622
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0041	0.0041
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Brugia malayi	Cation transporter family protein	0.01	0.1336	0.1696
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0484	0.768	0.7676
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	protein phosphatase 1b	0.0173	0.2539	0.2539
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0203	0.3026	0.3014
Onchocerca volvulus		0.01	0.1336	0.5275
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0041	0.0023
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0088	0.1122	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0041	0.0041
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0022	0.0041	0.0041
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	Squalene phytoene synthase	0.0088	0.1122	0.1122
Onchocerca volvulus		0.0097	0.1284	0.5066
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0305	0.0663
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Brugia malayi	RNA, U transporter 1	0.0166	0.2425	0.3121
Trichomonas vaginalis	ran, putative	0.0043	0.0386	0.087
Echinococcus granulosus	nAChR subunit	0.01	0.1336	0.1336
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0041	0.0041
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0046	0.0441	0.0524
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0041	0.0041
Echinococcus granulosus	protein phosphatase 1b	0.0151	0.2176	0.2176
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Onchocerca volvulus		0.0046	0.0441	0.1629
Entamoeba histolytica	Ran family GTPase	0.0043	0.0386	0.6508
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Onchocerca volvulus		0.01	0.1336	0.5275
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0041	0.0041
Schistosoma mansoni	bromodomain containing protein	0.0064	0.0728	0.0728
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.01	0.1336	0.1336
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.01	0.1336	0.1696
Schistosoma mansoni	amine GPCR	0.0022	0.0041	0.0041
Echinococcus multilocularis	nAChR subunit	0.0054	0.0569	0.0569
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0305	0.0663
Trichomonas vaginalis	importin beta-1, putative	0.0047	0.0458	0.1054
Leishmania major	importin beta-1 subunit, putative	0.0047	0.0458	0.0969
Brugia malayi	Importin beta-1 subunit	0.0058	0.0641	0.0786
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0097	0.1284	0.1628
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0043	0.0386	0.0369
Schistosoma mansoni	importin beta-1	0.0058	0.0641	0.0641
Schistosoma mansoni	hypothetical protein	0.0088	0.1122	0.1122
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.01	0.1336	0.1336
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Schistosoma mansoni	opsin-like receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.01	0.1336	0.1321
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0305	0.061
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.01	0.1336	0.1696
Toxoplasma gondii	exonuclease III APE	0.0038	0.0305	0.4367
Echinococcus granulosus	glycine receptor subunit beta	0.0484	0.768	0.768
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0041	0.0041
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0544	0.1169
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0041	0.0041
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0041	0.0023
Onchocerca volvulus		0.01	0.1336	0.5275
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0436	0.0436
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0046	0.0441	0.0441
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Loa Loa (eye worm)	hypothetical protein	0.0477	0.757	0.7566
Echinococcus granulosus	serotonin receptor	0.0022	0.0041	0.0041
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0239	0.3625	0.3614
Onchocerca volvulus	Putative protein phosphatase 2C	0.0022	0.0044	0.0014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0436	0.0436
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0437	0.6914	0.8997
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0544	0.1169
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Trypanosoma brucei	Aph-1 protein, putative	0.0093	0.1214	0.2735
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0544	0.0544
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0054	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0035	0.025	0.0232
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0544	0.0544
Echinococcus granulosus	tm gpcr rhodopsin	0.0543	0.866	0.866
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0041	0.0041
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0484	0.768	0.768
Onchocerca volvulus		0.01	0.1336	0.5275
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0203	0.3026	0.3908
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.025	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.043	0.6785	0.6779
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0852	0.0836
Echinococcus multilocularis	survival motor neuron protein 1	0.0477	0.757	0.757
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Onchocerca volvulus	Glucosylceramidase homolog	0.0171	0.2496	1
Brugia malayi	Cation transporter family protein	0.0484	0.768	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0436	0.0436
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Schistosoma mansoni	ran	0.0043	0.0386	0.0386
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0041	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.2648	0.6624
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0305	0.0288
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0544	0.837
Schistosoma mansoni	adenoreceptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	nAChR subunit	0.0046	0.0441	0.0441
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0046	0.0441	0.0524
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0441	0.0524
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0041	0.0041
Trypanosoma brucei	protein kinase, putative	0.0053	0.0544	0.1169
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.043	0.6785	0.6785
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0272	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.01	0.1336	0.1336
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.01	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	protein phosphatase 1b	0.0173	0.2539	0.2539
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0041	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Echinococcus granulosus	hypothetical protein	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	hypothetical protein	0.0022	0.0041	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Echinococcus multilocularis	snurportin 1	0.0624	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0436	0.0436
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Schistosoma mansoni	ran	0.0043	0.0386	0.0386
Plasmodium vivax	importin-beta 2, putative	0.0058	0.0641	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0544	0.1169
Schistosoma mansoni	myosin xvIII	0.0022	0.0041	0.0041
Echinococcus multilocularis	glycine receptor subunit beta	0.0484	0.768	0.768
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0516	0.0499
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	glycine receptor subunit beta	0.0484	0.768	0.768
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Loa Loa (eye worm)	LGC-31 protein	0.01	0.1336	0.1321
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0484	0.768	0.768
Brugia malayi	hypothetical protein	0.0046	0.0441	0.0524
Echinococcus granulosus	protein phosphatase 2c	0.0022	0.0044	0.0044
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0305	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0384	0.0367
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.01	0.1336	0.1321
Toxoplasma gondii	HEAT repeat-containing protein	0.0058	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0041	0.0041
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0088	0.1122	0.4406
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Brugia malayi	Protein phosphatase 2C containing protein	0.0173	0.2539	0.327
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Brugia malayi	MAP kinase sur-1	0.0053	0.0544	0.0659
Brugia malayi	Bromodomain containing protein	0.0039	0.0312	0.0355
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.01	0.1336	0.1696
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.2496	0.6238
Trypanosoma cruzi	squalene synthase, putative	0.0281	0.4321	1
Leishmania major	hypothetical protein, conserved	0.0088	0.1122	0.2521
Schistosoma mansoni	protein phosphatase 2C	0.0151	0.2176	0.2176
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.01	0.1336	0.1336
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0484	0.768	0.768
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0484	0.768	0.768
Loa Loa (eye worm)	hypothetical protein	0.01	0.1336	0.1321
Echinococcus granulosus	somatostatin receptor	0.0022	0.0041	0.0041
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0049	0.0049
Schistosoma mansoni	nAChR subunit	0.01	0.1336	0.1336
Echinococcus multilocularis	geminin	0.0343	0.5358	0.5358
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.01	0.1336	0.1696
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Leishmania major	squalene synthase, putative	0.0281	0.4321	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0043	0.0386	0.0386
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0544	0.1169
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0047	0.0458	0.1054
Trypanosoma brucei	importin beta-1 subunit, putative	0.0058	0.0641	0.1396
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0043	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.01	0.1336	0.1696
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3975	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0041	0.0041
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0041	0.0041
Echinococcus multilocularis	protein phosphatase 1b	0.0151	0.2176	0.2176
Plasmodium falciparum	importin beta, putative	0.0058	0.0641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0624	1	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0305	0.4367
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.01	0.1336	0.1696
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0516	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0041	0.0023
Echinococcus granulosus	survival motor neuron protein 1	0.0477	0.757	0.757
Schistosoma mansoni	nAChR subunit	0.0046	0.0441	0.0441
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.01	0.1336	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Schistosoma mansoni	amine GPCR	0.0022	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0569	0.0553
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0436	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0441	0.0424
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0544	0.1272
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0041	0.0041
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.01	0.1336	0.1696
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0041	0.0041
Loa Loa (eye worm)	GABA receptor subunit	0.0437	0.6914	0.6908
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0305	0.061
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0046	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0027
Echinococcus granulosus	glycine receptor subunit beta	0.0484	0.768	0.768
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0544	0.1169

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.43 nM	Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins	ChEMBL.	17490879
IC50 (binding)	= 0.43 nM	Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins	ChEMBL.	17490879

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 441877