TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 469.575 | Formula: C29H31N3O3
H donors: 0 H acceptors: 2 LogP: 4.65 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)Oc1ccc2c(c1)CCC(=O)N2CCCN1CCN(CC1)c1ccccc1
InChi: 1S/C29H31N3O3/c33-28-15-12-24-22-26(35-29(34)23-8-3-1-4-9-23)13-14-27(24)32(28)17-7-16-30-18-20-31(21-19-30)25-10-5-2-6-11-25/h1-6,8-11,13-14,22H,7,12,15-21H2
InChiKey: XQBZNOVMFFCKGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Sigma opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0082	0.1093	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0046	0.0498	0.0572
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0575	0.0679
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0042	0.0426	0.0426
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.7209	0.9302
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0042	0.0426	0.0426
Echinococcus multilocularis	protein phosphatase 1b	0.015	0.2247	0.2247
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.7209	1
Brugia malayi	hypothetical protein	0.0046	0.0486	0.0515
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0476	0.0476
Brugia malayi	Cation transporter family protein	0.0099	0.1383	0.1688
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0099	0.1383	0.1688
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Brugia malayi	hypothetical protein	0.0046	0.0486	0.0515
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2677	0.6619
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0346	0.4856
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Trypanosoma cruzi	squalene synthase, putative	0.0262	0.4132	0.5678
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0445	0.7209	0.7209
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Onchocerca volvulus		0.0046	0.0486	0.162
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0091	0.0091
Onchocerca volvulus	Glucosylceramidase homolog	0.0167	0.2526	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0575	0.1237
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0053	0.0615	0.0615
Onchocerca volvulus		0.0046	0.0486	0.162
Schistosoma mansoni	hypothetical protein	0.0082	0.1093	0.1093
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0575	0.0679
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0099	0.1383	0.1383
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	hypothetical protein	0.002	0.0059	0.0059
Echinococcus multilocularis	nAChR subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0476	0.7743	0.7743
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0556	0.0607
Brugia malayi	Cation transporter family protein	0.0476	0.7743	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0346	0.0357
Loa Loa (eye worm)	hypothetical protein	0.005	0.0556	0.0556
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0476	0.7743	0.7743
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0423	0.6845	0.6845
Onchocerca volvulus		0.0097	0.1343	0.5141
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0476	0.0476
Schistosoma mansoni	protein phosphatase 2C	0.0172	0.2613	0.2613
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.0091
Echinococcus multilocularis	glycine receptor subunit beta	0.0476	0.7743	0.7743
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Schistosoma mansoni	ran	0.0042	0.0426	0.0426
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0046	0.0486	0.0486
Echinococcus granulosus	protein phosphatase 1b	0.0172	0.2613	0.2613
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0575	0.0679
Echinococcus granulosus	survival motor neuron protein 1	0.0473	0.7688	0.7688
Plasmodium falciparum	importin beta, putative	0.0057	0.0681	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0099	0.1383	0.1383
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0473	0.7688	0.7688
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0042	0.0426	0.047
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0346	0.065
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Schistosoma mansoni	hypothetical protein	0.0097	0.1343	0.1343
Brugia malayi	hypothetical protein	0.0046	0.0486	0.0515
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0346	0.4314
Schistosoma mansoni	hypothetical protein	0.0336	0.5378	0.5378
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Echinococcus granulosus	Squalene phytoene synthase	0.0082	0.1093	0.1093
Trypanosoma cruzi	phytoene synthase, putative	0.0082	0.1093	0.1408
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0431	0.6974	0.8996
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0091	0.0091
Echinococcus multilocularis	zinc finger protein	0.0019	0.0042	0.0042
Echinococcus multilocularis	importin subunit beta 1	0.0057	0.0681	0.0681
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0099	0.1383	0.1688
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Leishmania major	importin beta-1 subunit, putative	0.0046	0.0498	0.0572
Echinococcus granulosus	protein phosphatase 2c	0.0022	0.0091	0.0091
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0575	0.0679
Onchocerca volvulus		0.0099	0.1383	0.5306
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0346	0.0357
Schistosoma mansoni	ap endonuclease	0.0037	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.007	0.089	0.089
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0099	0.1383	0.1383
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2677	0.6619
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0099	0.1383	0.1688
Echinococcus multilocularis	Squalene phytoene synthase	0.0082	0.1093	0.1093
Schistosoma mansoni	protein phosphatase 2C	0.0022	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Echinococcus granulosus	nAChR subunit	0.0099	0.1383	0.1383
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0346	0.0332
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.7209	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0707	0.0707
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0766	0.0766
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0042	0.0426	0.5683
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0097	0.1343	0.1636
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0476	0.0476
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0099	0.1383	0.1688
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0476	0.0476
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0423	0.6845	0.6845
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.001	0.001
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Schistosoma mansoni	protein phosphatase 2C	0.015	0.2247	0.2247
Onchocerca volvulus		0.0099	0.1383	0.5306
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0423	0.6845	0.8827
Onchocerca volvulus		0.0046	0.0486	0.162
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0099	0.1383	0.1383
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0346	0.0357
Brugia malayi	hypothetical protein	0.0473	0.7688	0.9929
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	ACC-1 protein	0.0099	0.1383	0.1383
Trypanosoma brucei	squalene synthase, putative	0.0262	0.4132	0.5678
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0099	0.1383	0.1383
Onchocerca volvulus	Putative nachr subunit	0.0099	0.1383	0.5306
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0346	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0426	0.047
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0042	0.0426	0.0438
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0313	0.0313
Echinococcus granulosus	nAChR subunit	0.0053	0.0615	0.0615
Schistosoma mansoni	hypothetical protein	0.0034	0.0291	0.0291
Schistosoma mansoni	acetylcholine receptor-related	0.0046	0.0486	0.0486
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0099	0.1383	0.1383
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0346	0.0346
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0046	0.0486	0.0515
Schistosoma mansoni	importin beta-1	0.0057	0.0681	0.0681
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0082	0.1093	0.4115
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.0615	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.004	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0313	0.0313
Loa Loa (eye worm)	acetylcholine receptor protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0099	0.1383	0.1383
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0346	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0099	0.1383	0.1383
Trypanosoma brucei	importin beta-1 subunit, putative	0.0057	0.0681	0.0828
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0486	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Brugia malayi	hypothetical protein	0.0046	0.0486	0.0515
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Toxoplasma gondii	HEAT repeat-containing protein	0.0057	0.0681	1
Brugia malayi	Bromodomain containing protein	0.0074	0.0961	0.1136
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0486	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Brugia malayi	Importin beta-1 subunit	0.0057	0.0681	0.077
Schistosoma mansoni	protein phosphatase 2C	0.015	0.2247	0.2247
Entamoeba histolytica	hypothetical protein	0.0046	0.0498	0.7775
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0099	0.1383	0.1688
Echinococcus multilocularis	geminin	0.0336	0.5378	0.5378
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0681	0.0681
Echinococcus granulosus	glycine receptor subunit beta	0.0476	0.7743	0.7743
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Trypanosoma brucei	protein kinase, putative	0.0051	0.0575	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Schistosoma mansoni	nAChR subunit	0.0046	0.0486	0.0486
Schistosoma mansoni	protein phosphatase 2c gamma	0.0022	0.0091	0.0091
Schistosoma mansoni	nAChR subunit	0.0046	0.0486	0.0486
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0575	0.0575
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0046	0.0486	0.0486
Schistosoma mansoni	survival motor neuron protein	0.0097	0.1343	0.1343
Onchocerca volvulus		0.0099	0.1383	0.5306
Toxoplasma gondii	exonuclease III APE	0.0037	0.0346	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Brugia malayi	excitatory GABA receptor EXP-1A	0.0099	0.1383	0.1688
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0476	0.7743	0.7743
Echinococcus granulosus	importin subunit beta 1	0.0057	0.0681	0.0681
Onchocerca volvulus		0.0099	0.1383	0.5306
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0575	0.0575
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0707	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0575	0.0575
Schistosoma mansoni	hypothetical protein	0.0336	0.5378	0.5378
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0042	0.0426	0.5683
Brugia malayi	PHD-finger family protein	0.0025	0.013	0.0051
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0042	0.0426	0.5683
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.0615	0.0684
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0099	0.1383	0.1688
Echinococcus multilocularis	nAChR subunit	0.0053	0.0615	0.0615
Schistosoma mansoni	neurotransmitter gated ion channel	0.0053	0.0615	0.0615
Echinococcus multilocularis	protein phosphatase 2C	0.0022	0.0091	0.0091
Echinococcus granulosus	geminin	0.0336	0.5378	0.5378
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0476	0.7743	0.7743
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0099	0.1383	0.1688
Onchocerca volvulus		0.0053	0.0615	0.2149
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0099	0.1383	0.1383
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0053	0.0615	0.0684
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0254	0.3998	0.5106
Echinococcus multilocularis	snurportin 1	0.061	1	1
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0082	0.1093	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0575	0.8205
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0575	0.1237
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Onchocerca volvulus		0.0099	0.1383	0.5306
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1383	0.1688
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0046	0.0486	0.0515
Echinococcus multilocularis	survival motor neuron protein 1	0.0473	0.7688	0.7688
Schistosoma mansoni	neurotransmitter gated ion channel	0.0046	0.0486	0.0486
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0476	0.0476
Onchocerca volvulus		0.0099	0.1383	0.5306
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0346	0.5
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0575	0.0679
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0099	0.1383	0.1383
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0046	0.0486	0.0486
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0046	0.0486	0.0515
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0046	0.0486	0.0486
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0099	0.1383	0.1688
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0575	0.1237
Loa Loa (eye worm)	ACC-1 protein	0.0099	0.1383	0.1383
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0099	0.1383	0.1383
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0042	0.0426	0.0426
Entamoeba histolytica	hypothetical protein	0.0053	0.0615	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0476	0.0502
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0053	0.0615	0.0615
Brugia malayi	hypothetical protein	0.0046	0.0486	0.0515
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0498	0.1042
Leishmania major	squalene synthase, putative	0.0262	0.4132	0.5678
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0476	0.7743	0.7743
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0059	0.0059
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0575	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0099	0.1383	0.1688
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.7209	1
Brugia malayi	Bromodomain containing protein	0.0038	0.0352	0.0341
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0346	0.5257
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0575	0.0575
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0346	0.065
Brugia malayi	MAP kinase sur-1	0.0051	0.0575	0.0632
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0556	0.0607
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0099	0.1383	0.1383
Trichomonas vaginalis	ran, putative	0.0042	0.0426	0.0857
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0498	0.1042
Entamoeba histolytica	Ran family GTPase	0.0042	0.0426	0.6397
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0423	0.6845	0.6845
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0346	0.4314
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0476	0.0476
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0575	0.0679
Schistosoma mansoni	hypothetical protein	0.061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0431	0.6974	0.6974
Schistosoma mansoni	zinc finger protein	0.0019	0.0042	0.0042
Echinococcus multilocularis	protein phosphatase 1b	0.0172	0.2613	0.2613
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0476	0.0476
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0042	0.0426	0.6926
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	nAChR subunit	0.0099	0.1383	0.1383
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0575	0.1237
Echinococcus granulosus	glycine receptor subunit beta	0.0476	0.7743	0.7743
Loa Loa (eye worm)	GABA receptor subunit	0.0431	0.6974	0.6974
Echinococcus multilocularis	protein phosphatase 2C	0.0022	0.0091	0.0091
Trypanosoma cruzi	squalene synthase, putative	0.0262	0.4132	0.5678
Echinococcus granulosus	protein phosphatase 2c	0.0022	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0575	0.0679
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.2526	0.6232
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0091	0.0091
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0046	0.0486	0.0486
Leishmania major	GTP-binding protein, putative	0.0042	0.0426	0.047
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0476	0.0476
Brugia malayi	RNA, U transporter 1	0.0163	0.2456	0.3091
Echinococcus granulosus	protein phosphatase 1b	0.015	0.2247	0.2247
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0615	0.0615
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0575	0.0575
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.3998	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.061	1	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0476	0.7743	0.7743
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0291	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Loa Loa (eye worm)	LGC-31 protein	0.0099	0.1383	0.1383
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0426	0.047
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0556	0.0556
Plasmodium vivax	importin-beta 2, putative	0.0057	0.0681	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0424	0.0424
Trypanosoma brucei	importin beta-1 subunit, putative	0.0057	0.0681	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0486	0.0486
Echinococcus multilocularis	glycine receptor subunit beta	0.0476	0.7743	0.7743
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1383	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0476	0.7743	0.7743
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0099	0.1383	0.1383
Schistosoma mansoni	neurotransmitter gated ion channel	0.0046	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0227	0.3546	0.3546
Brugia malayi	Protein phosphatase 2C containing protein	0.0172	0.2613	0.3296
Onchocerca volvulus		0.0053	0.0615	0.2149
Schistosoma mansoni	ap endonuclease	0.0037	0.0346	0.0346
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0476	0.7743	0.7743
Brugia malayi	Cation transporter family protein	0.0099	0.1383	0.1688
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0254	0.3998	0.3998
Trichomonas vaginalis	importin beta-1, putative	0.0046	0.0498	0.1042
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0099	0.1383	0.1383
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0099	0.1383	0.1688
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0099	0.1383	0.1383
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0099	0.1383	0.1383
Schistosoma mansoni	ran	0.0042	0.0426	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0291	0.0291
Leishmania major	hypothetical protein, conserved	0.0082	0.1093	0.1408
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.0172	0.2613	0.2613
Echinococcus granulosus	zinc finger protein	0.0019	0.0042	0.0042

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 10000 nM	Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]-DTG to rat whole brain membranes.	ChEMBL.	10649973
IC50 (functional)	> 10000 nM	Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]-DTG to rat whole brain membranes.	ChEMBL.	10649973
Sleeping time (functional)	= 561 s	Effect on the sleeping time of mice before halothane load (control group)	ChEMBL.	10649973
Sleeping time (functional)	= 561 s	Effect on the sleeping time of mice before halothane load (control group)	ChEMBL.	10649973
Sleeping time (functional)	< 1097 s	Effect on the sleeping time of mice anesthetized with halothane (treated group)	ChEMBL.	10649973
Sleeping time (functional)	< 1097 s	Effect on the sleeping time of mice anesthetized with halothane (treated group)	ChEMBL.	10649973

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL55170

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 80419