TDR Targets

Basic information

Technical information

TDR Targets ID: 1383221
Name: 1-[2-[7-chloro-4-oxo-3-(phenylmethyl)quinazol in-2-yl]sulfanylacetyl]piperidine-4-carboxyli c acid
MW: 471.956 | Formula: C23H22ClN3O4S
H donors: 1 H acceptors: 4 LogP: 3.49 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1CCN(CC1)C(=O)CSc1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
InChi: 1S/C23H22ClN3O4S/c24-17-6-7-18-19(12-17)25-23(27(21(18)29)13-15-4-2-1-3-5-15)32-14-20(28)26-10-8-16(9-11-26)22(30)31/h1-7,12,16H,8-11,13-14H2,(H,30,31)
InChiKey: JKEMJNJYLCBTLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[2-[[7-chloro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]thio]-1-oxoethyl]-4-piperidinecarboxylic acid
1-[2-[[3-(benzyl)-7-chloro-4-keto-quinazolin-2-yl]thio]acetyl]isonipecotic acid
1-[2-[7-chloro-4-oxo-3-(phenylmethyl)quinazolin-2-yl]sulfanylethanoyl]piperidine-4-carboxylic acid
T0520-4816

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serine:threonine protein phosphatase 2A 56 kDa	0.0009	0.0056	0.0056
Brugia malayi	Protein phosphatase 2C containing protein	0.0187	0.2864	0.2864
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus granulosus	protein phosphatase 1 catalytic subunit	0.0007	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	type 2A protein phosphatase catalytic subunit	0.0065	0.0932	0.0932
Trichomonas vaginalis	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative	0.0397	0.6166	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.0173	0.0173
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0601	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Trichomonas vaginalis	pten, drome, putative	0.0016	0.0173	0.0246
Schistosoma mansoni	protein phosphatase 2C	0.0024	0.0298	0.0298
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0016	0.0173	0.0173
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	protein phosphatase 1 catalytic subunit	0.0007	0.0022	0.0022
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-beta catalytic subunit	0.0007	0.0022	0.0022
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0016	0.0173	0.0173
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Schistosoma mansoni	protein tyrosine phosphatase	0.0016	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	0.0024	0.0298	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.4285	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Leishmania major	protein phosphatase 2C, putative	0.0024	0.0298	0.0449
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.0173	0.0173
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Trypanosoma cruzi	serine/threonine-protein phosphatase	0.0065	0.0932	0.148
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus multilocularis	serine:threonine protein phosphatase 2A	0.0065	0.0932	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0641	1	1
Leishmania major	protein phosphatase 2A regulatory subunit, putative	0.0397	0.6166	1
Brugia malayi	probable protein phosphatase 2C	0.0024	0.0298	0.0298
Trichomonas vaginalis	protein phosphatase-1, putative	0.0065	0.0932	0.148
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus granulosus	serine:threonine protein phosphatase 2A 56 kDa	0.0009	0.0056	0.0056
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0016	0.0173	0.0173
Toxoplasma gondii	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, putative	0.0065	0.0932	1
Onchocerca volvulus		0.0016	0.0173	0.0281
Loa Loa (eye worm)	protein phosphatase 2A regulatory subunit B' delta isoform	0.0009	0.0056	0.0056
Onchocerca volvulus		0.0016	0.0173	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus		0.0016	0.0173	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Entamoeba histolytica	protein phosphatase, putative	0.0024	0.0298	0.0208
Echinococcus multilocularis	protein phosphatase pp2a regulatory subunit b	0.0397	0.6166	0.6166
Echinococcus granulosus	protein phosphatase pp2a regulatory subunit b	0.0397	0.6166	0.6166
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0601	0.5
Onchocerca volvulus		0.0016	0.0173	0.0281
Giardia lamblia	Ser/Thr phosphatase 2C, putative	0.0024	0.0298	0.0449
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus	Protein phosphatase PP2A 55 kDa regulatory subunit homolog	0.0397	0.6166	1
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0601	0.0601
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0016	0.0173	0.0173
Schistosoma mansoni	protein tyrosine phosphatase	0.0016	0.0173	0.0173
Schistosoma mansoni	pcd6 interacting protein-related	0.0016	0.0173	0.0173
Echinococcus granulosus	protein phosphatase 2c	0.0024	0.0298	0.0298
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 isozyme	0.0007	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.0173	0.0173
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0601	0.0942
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0601	0.0601
Entamoeba histolytica	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, putative	0.0065	0.0932	0.1266
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0016	0.0173	0.0173
Plasmodium vivax	protein phosphatase PPM2, putative	0.0024	0.0298	0.3034
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus		0.0016	0.0173	0.0281
Schistosoma mansoni	protein tyrosine phosphatase	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Toxoplasma gondii	protein phosphatase 2a regulatory b subunit (b56 family) protein	0.0009	0.0056	0.0367
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0601	0.0942
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0298	0.0298
Giardia lamblia	Protein phosphatase PP2A regulatory subunit B	0.0397	0.6166	1
Schistosoma mansoni	protein phosphatase type 1	0.0007	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0298	0.0298
Loa Loa (eye worm)	LEThal family member	0.0065	0.0932	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Trypanosoma cruzi	protein phosphatase 2C, putative	0.0024	0.0298	0.0449
Leishmania major	protein phosphatase 2C-like protein	0.0024	0.0298	0.0449
Leishmania major	hypothetical protein, conserved	0.0397	0.6166	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0043	0.0601	0.0975
Onchocerca volvulus		0.0043	0.0601	0.0975
Echinococcus multilocularis	serine:threonine protein phosphatase 2A 56 kDa	0.0009	0.0056	0.0056
Giardia lamblia	Protein phosphatase 2A B regulatory subunit Wdb1	0.0009	0.0056	0.0054
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0016	0.0173	0.0246
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0397	0.6166	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0397	0.6166	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase 2c gamma	0.0024	0.0298	0.0298
Trichomonas vaginalis	esterase, putative	0.0043	0.0601	0.0942
Leishmania major	tyrosine specific protein phosphatase, putative	0.0016	0.0173	0.0246
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Trypanosoma brucei	Serine/threonine-protein phosphatase 2A, putative	0.0065	0.0932	0.148
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0641	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.0009	0.0056	0.0056
Toxoplasma gondii	ABC1 family protein	0.0043	0.0601	0.6366
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0601	0.0601
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0.0173	0.0246
Echinococcus granulosus	protein phosphatase 2c	0.0024	0.0298	0.0298
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Leishmania major	hypothetical protein, conserved	0.0043	0.0601	0.0942
Echinococcus multilocularis	protein phosphatase 1b	0.0164	0.2491	0.2491
Entamoeba histolytica	protein phosphatase regulatory subunit, putative	0.0397	0.6166	1
Giardia lamblia	Ser/Thr phosphatase PP2A-2 catalytic subunit	0.0065	0.0932	0.148
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0601	0.0942
Brugia malayi	beta-lactamase	0.0043	0.0601	0.0601
Trypanosoma cruzi	protein phosphatase 2C-like, putative	0.0024	0.0298	0.0449
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase 2C	0.0164	0.2491	0.2491
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0641	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0601	0.0942
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0016	0.0173	0.0173
Leishmania major	serine/threonine protein phosphatase, putative	0.0065	0.0932	0.148
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0932	0.0932
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Brugia malayi	Serine/threonine protein phosphatase PP1-beta catalytic subunit	0.0007	0.0022	0.0022
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.0007	0.0022	0.0022
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0601	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Onchocerca volvulus	Putative protein phosphatase 2C	0.0024	0.0298	0.0484
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.0007	0.0022	0.0022
Schistosoma mansoni	protein phsophatase-2a	0.0065	0.0932	0.0932
Echinococcus granulosus	serine:threonine protein phosphatase PP1 beta	0.0007	0.0022	0.0022
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.0007	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0016	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.0187	0.2864	0.2864
Onchocerca volvulus		0.0043	0.0601	0.0975
Trypanosoma brucei	hypothetical protein, conserved	0.0397	0.6166	1
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	0.0024	0.0298	0.3034
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Plasmodium falciparum	protein phosphatase PPM2	0.0024	0.0298	0.3034
Echinococcus multilocularis		0.0016	0.0173	0.0173
Trypanosoma brucei	protein phosphatase 2A regulatory subunit, putative	0.0397	0.6166	1
Brugia malayi	Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit,epsilon isoform	0.0009	0.0056	0.0056
Giardia lamblia	Phosphatase	0.0024	0.0298	0.0449
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0601	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0601	0.5
Trypanosoma brucei	protein phosphatase 2C, putative	0.0024	0.0298	0.0449
Toxoplasma gondii	serine/threonine-protein phosphatase PP2A catalytic subunit	0.0065	0.0932	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0641	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0397	0.6166	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Echinococcus multilocularis	protein phosphatase 2a regulatory subunit	0.0009	0.0056	0.0056
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Loa Loa (eye worm)	serine/threonine protein phosphatase 2A	0.0397	0.6166	0.6166
Brugia malayi	Protein-tyrosine phosphatase 1	0.0016	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0016	0.0173	0.0173
Mycobacterium ulcerans	lipase LipD	0.0043	0.0601	0.5
Brugia malayi	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0016	0.0173	0.0173
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0601	0.6366
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Plasmodium falciparum	protein phosphatase-beta	0.0065	0.0932	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Plasmodium vivax	protein phosphatase-beta, putative	0.0065	0.0932	1
Echinococcus granulosus	protein phosphatase 1b	0.0164	0.2491	0.2491
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0601	0.0601
Schistosoma mansoni	protein phosphatase 2C	0.0187	0.2864	0.2864
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0016	0.0173	0.0173
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0601	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0016	0.0173	0.0173
Echinococcus multilocularis	protein phosphatase 1b	0.0187	0.2864	0.2864
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0397	0.6166	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0.0173	0.0246
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0016	0.0173	0.0246
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0601	0.0601
Trypanosoma brucei	protein phosphatase 2C, putative	0.0024	0.0298	0.0449
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0016	0.0173	0.0173
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0016	0.0173	0.0173
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0.0173	0.0246
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 beta	0.0007	0.0022	0.0022
Brugia malayi	Protein phosphatase 2C containing protein	0.0024	0.0298	0.0298
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase-1	0.0007	0.0022	0.0022
Brugia malayi	delta isoform of regulatory subunit B56, protein phosphatase 2A	0.0009	0.0056	0.0056
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0016	0.0173	0.0173
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Trichomonas vaginalis	protein phosphatase 2A, regulatory subunit, putative	0.0009	0.0056	0.0054
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0016	0.0173	0.0173
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase-1	0.0007	0.0022	0.0022
Trichomonas vaginalis	protein phosphatase 2A, regulatory subunit, putative	0.0009	0.0056	0.0054
Loa Loa (eye worm)	type 2A protein phosphatase catalytic subunit	0.0065	0.0932	0.0932
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0016	0.0173	0.0173
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0601	0.0942
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus granulosus	serine:threonine protein phosphatase 2A 56 kDa	0.0009	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Brugia malayi	Ser/Thr protein phosphatase family protein	0.0065	0.0932	0.0932
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0601	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0056	0.0056
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.0009	0.0056	0.0056
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase type 1	0.0007	0.0022	0.0022
Brugia malayi	protein phosphatase 2A.	0.0065	0.0932	0.0932
Trichomonas vaginalis	protein phosphatase type 2C, putative	0.0024	0.0298	0.0449
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0601	0.0601
Echinococcus granulosus	protein phosphatase 2a regulatory subunit	0.0009	0.0056	0.0056
Giardia lamblia	Protein tyrosine phosphatase	0.0016	0.0173	0.0246
Echinococcus multilocularis	hypothetical protein	0.0016	0.0173	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0601	0.0942
Schistosoma mansoni	protein phosphatase pp2a regulatory subunit B	0.0397	0.6166	0.6166
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Trypanosoma cruzi	serine/threonine-protein phosphatase	0.0065	0.0932	0.148
Trichomonas vaginalis	protein phosphatase pp2a regulatory subunit B, putative	0.0397	0.6166	1
Echinococcus granulosus	serine:threonine protein phosphatase 2A	0.0065	0.0932	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	beta-lactamase family protein	0.0043	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Echinococcus granulosus	protein phosphatase 1b	0.0187	0.2864	0.2864
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0016	0.0173	0.0173
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.0009	0.0056	0.0056
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus		0.0016	0.0173	0.0281
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0016	0.0173	0.0173
Brugia malayi	Serine/threonine protein phosphatase F56C9.1 in chromosomeIII	0.0007	0.0022	0.0022
Echinococcus multilocularis	protein phosphatase 2C	0.0024	0.0298	0.0298
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0016	0.0173	0.0173
Echinococcus multilocularis	protein phosphatase 2C	0.0024	0.0298	0.0298
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0601	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	beta-lactamase family protein	0.0043	0.0601	0.0601
Echinococcus granulosus	protein phosphatase 1, catalytic subunit, beta isozyme	0.0007	0.0022	0.0022
Onchocerca volvulus	4.1 G protein, putative homolog	0.0016	0.0173	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.0007	0.0022	0.0022
Trichomonas vaginalis	protein phosphatase PP2A regulatory subunit B, putative	0.0397	0.6166	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0601
Brugia malayi	serine/threonine protein phosphatase 2A	0.0397	0.6166	0.6166
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0016	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0016	0.0173	0.0173
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0016	0.0173	0.0173
Onchocerca volvulus		0.0016	0.0173	0.0281
Onchocerca volvulus		0.0016	0.0173	0.0281
Schistosoma mansoni	protein phosphatase 2C	0.0164	0.2491	0.2491

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1534246

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1383221