Detailed information for compound 1833816

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 551.556 | Formula: C30H28F3N3O4
  • H donors: 2 H acceptors: 4 LogP: 3.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC(c1ccccc1n1cc(c2c1cccc2)CN1CCN(CC1)c1ccccc1)(F)F.OC(=O)/C=C/C(=O)O
  • InChi: 1S/C26H24F3N3.C4H4O4/c27-26(28,29)23-11-5-7-13-25(23)32-19-20(22-10-4-6-12-24(22)32)18-30-14-16-31(17-15-30)21-8-2-1-3-9-21;5-3(6)1-2-4(7)8/h1-13,19H,14-18H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
  • InChiKey: BJIJQYZKSLXYDW-WLHGVMLRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus short transient receptor potential channel 6 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0282 0.4187 0.4187
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0282 0.4187 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0282 0.4187 0.4187
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-dependent calcium channel 0.0282 0.4187 0.4187
Schistosoma mansoni 60S ribosomal protein L21 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0282 0.4187 0.4187
Loa Loa (eye worm) ryanodine receptor 0.0282 0.4187 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0282 0.4187 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0282 0.4187 0.5
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0282 0.4187 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0282 0.4187 0.4187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0282 0.4187 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus potassium voltage gated channel protein 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage dependent calcium channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0282 0.4187 1
Echinococcus granulosus potassium voltage gated channel protein 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0282 0.4187 0.4187
Echinococcus multilocularis hyperpolarization activated cyclic 0.0282 0.4187 0.4187
Schistosoma mansoni hypothetical protein 0.0282 0.4187 0.4187
Loa Loa (eye worm) voltage-gated calcium channel 0.0282 0.4187 1
Echinococcus multilocularis calcium activated potassium channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Toxoplasma gondii hypothetical protein 0.0282 0.4187 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential channel 0.0282 0.4187 0.4187
Toxoplasma gondii transporter, cation channel family protein 0.0282 0.4187 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Toxoplasma gondii transporter, cation channel family protein 0.0282 0.4187 0.5
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0282 0.4187 0.4187
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0282 0.4187 0.4187
Echinococcus multilocularis ryanodine receptor 44f 0.0282 0.4187 0.4187
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0282 0.4187 0.4187
Loa Loa (eye worm) ion channel NompC 0.0282 0.4187 1
Schistosoma mansoni two-pore calcium channel 0.0282 0.4187 0.4187
Echinococcus granulosus voltage dependent calcium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0282 0.4187 0.5
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Onchocerca volvulus 0.0282 0.4187 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0282 0.4187 0.4187
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel protein 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0282 0.4187 1
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential channel 4 0.0282 0.4187 0.4187
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni ryanodine receptor related 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Leishmania major hypothetical protein, conserved 0.0282 0.4187 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0282 0.4187 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0282 0.4187 0.4187
Echinococcus granulosus calcium activated potassium channel 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus voltage gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0282 0.4187 0.4187
Echinococcus granulosus potassium large conductance calcium activated 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0282 0.4187 0.4187
Echinococcus granulosus ryanodine receptor 44f 0.0282 0.4187 0.4187
Loa Loa (eye worm) voltage-gated potassium channel 0.0282 0.4187 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0282 0.4187 0.4187
Schistosoma mansoni vesicular amine transporter 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis sodium channel protein 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus hyperpolarization activated cyclic 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Toxoplasma gondii transporter, cation channel family protein 0.0282 0.4187 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential gamma protein 0.0282 0.4187 0.4187
Echinococcus multilocularis two pore calcium channel protein 2 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) voltage-gated potassium channel 0.0282 0.4187 1
Echinococcus granulosus potassium voltage gated channel protein 0.0282 0.4187 0.4187
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0282 0.4187 1
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0282 0.4187 0.4187
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0282 0.4187 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0282 0.4187 0.4187
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0282 0.4187 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis shaker cognate 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium large conductance calcium activated 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0282 0.4187 0.4187
Schistosoma mansoni calcium-activated potassium channel 0.0282 0.4187 0.4187
Echinococcus multilocularis sodium leak channel non selective protein 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated ion channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage gated potassium channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus multilocularis conserved hypothetical protein 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage dependent calcium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus multilocularis short transient receptor potential channel 6 0.0282 0.4187 0.4187
Echinococcus multilocularis two pore calcium channel protein 1 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential channel 0.0282 0.4187 0.4187
Leishmania major hypothetical protein, unknown function 0.0282 0.4187 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Echinococcus multilocularis hyperpolarization activated cyclic 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel protein 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0282 0.4187 0.5
Echinococcus granulosus sodium leak channel non selective protein 0.0282 0.4187 0.4187
Echinococcus granulosus voltage gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential cation channel 0.0282 0.4187 0.4187
Echinococcus granulosus hypothetical protein 0.0282 0.4187 0.4187
Echinococcus multilocularis transient receptor potential cation channel 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0282 0.4187 0.5
Echinococcus granulosus two pore calcium channel protein 2 0.0282 0.4187 0.4187
Echinococcus multilocularis transfer RNA-Gly 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0282 0.4187 0.4187
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0282 0.4187 0.4187
Echinococcus granulosus two pore calcium channel protein 1 0.0282 0.4187 0.4187
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0282 0.4187 0.4187
Echinococcus granulosus transient receptor potential gamma protein 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus TRP transient receptor potential channel 0.0282 0.4187 0.4187
Echinococcus multilocularis short transient receptor potential channel 6 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Loa Loa (eye worm) calcium channel 0.0282 0.4187 1
Echinococcus granulosus shaker cognate 0.0282 0.4187 0.4187
Echinococcus granulosus potassium voltage gated channel protein 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0282 0.4187 0.4187
Brugia malayi olfactory channel protein osm-9 0.0282 0.4187 1
Echinococcus granulosus sodium channel protein 0.0282 0.4187 0.4187
Echinococcus granulosus hyperpolarization activated cyclic 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0282 0.4187 0.4187
Schistosoma mansoni voltage-gated potassium channel 0.0282 0.4187 0.4187
Echinococcus granulosus voltage gated hydrogen channel 1 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage gated potassium channel 0.0282 0.4187 0.4187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0282 0.4187 0.5
Toxoplasma gondii hypothetical protein 0.0282 0.4187 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0282 0.4187 0.4187
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0282 0.4187 0.4187
Echinococcus granulosus voltage dependent calcium channel 0.0282 0.4187 0.4187
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0282 0.4187 0.4187
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0282 0.4187 0.4187
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0282 0.4187 0.4187
Echinococcus granulosus short transient receptor potential channel 6 0.0282 0.4187 0.4187
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0282 0.4187 0.4187
Loa Loa (eye worm) hypothetical protein 0.0282 0.4187 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0282 0.4187 0.4187

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 20 nM Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting ChEMBL. 24531229
Ki (binding) = 81 nM Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat hippocampus homogenates after 15 mins by scintillation counting ChEMBL. 24531229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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