Detailed information for compound 1003991

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 678.41 | Formula: C33H30Br2N2O4
  • H donors: 1 H acceptors: 1 LogP: 8.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)C1CC(=C(C(N1c1ccc(cc1)Br)c1ccc(cc1)OC)C(=O)OC)Nc1ccc(cc1)Br
  • InChi: 1S/C33H30Br2N2O4/c1-39-27-16-4-21(5-17-27)30-20-29(36-25-12-8-23(34)9-13-25)31(33(38)41-3)32(22-6-18-28(40-2)19-7-22)37(30)26-14-10-24(35)11-15-26/h4-19,30,32,36H,20H2,1-3H3
  • InChiKey: OLHQFUFHPLFADP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0573 0.0573
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.2434 0.4075
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1612 0.1612
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1892 0.1892
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.3589 0.5668
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.2434 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.2434 0.2346
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1517 0.2396
Brugia malayi Carboxylesterase family protein 0.0082 0.2454 0.2449
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.1892 0.1797
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0132 0.0132
Echinococcus granulosus geminin 0.0185 0.6331 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0573 0.0905
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0006 0.0009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.3151 0.3151
Echinococcus granulosus acetylcholinesterase 0.0082 0.2454 0.3875
Schistosoma mansoni inositol monophosphatase 0.0081 0.2434 0.2434
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.2454 0.2454
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0573 0.0905
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1517 0.1418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.2454 0.2454
Schistosoma mansoni glutaminase 0.0282 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1059 0.1673
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.8903 0.8903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1059 0.1059
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0573 0.0905
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0664 0.0658
Loa Loa (eye worm) acetyltransferase 0.016 0.5412 0.5412
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0573 0.0568
Brugia malayi steroid hormone receptor 0.0032 0.0573 0.0568
Loa Loa (eye worm) inositol-1 0.0081 0.2434 0.2434
Brugia malayi Probable ClpP-like protease 0.0171 0.5806 0.5804
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0171 0.5806 0.917
Brugia malayi Carboxylesterase family protein 0.0082 0.2454 0.2449
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0025 0.03 0.0294
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0976 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.1852 0.1852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0573 0.0573
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0073 0.2113 0.1246
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.1588 0.2587
Loa Loa (eye worm) hypothetical protein 0.0082 0.2454 0.2454
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1541 0.2435
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.1209 0.1909
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0573 0.0905
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0573 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0573 0.0568
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0171 0.5806 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.3589 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0573 0.0568
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0573 0.0568
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.3589 0.4744
Loa Loa (eye worm) hypothetical protein 0.005 0.1263 0.1263
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0573 0.0573
Schistosoma mansoni hypothetical protein 0.0185 0.6331 0.6331
Schistosoma mansoni zinc finger protein 0.0023 0.0239 0.0239
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0573 0.0905
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.2434 0.3845
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.002 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0573 0.0573
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2454 0.3875
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi Bromodomain containing protein 0.0041 0.093 0.0925
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0976 0.1511
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0573 0.0573
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0116 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0046 0.1091 0.1091
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.2434 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1263 0.1263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0787 0.0787
Loa Loa (eye worm) carboxylesterase 0.0082 0.2454 0.2454
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.2434 1
Schistosoma mansoni inositol monophosphatase 0.0081 0.2434 0.2434
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0573 0.0573
Brugia malayi ecdysteroid receptor 0.0032 0.0573 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0573 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.5962 0.5915
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0171 0.5806 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.3151 0.3151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0573 0.0568
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.5412 0.5409
Brugia malayi jmjC domain containing protein 0.006 0.1612 0.1607
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0116 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0573 0.0573
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0573 0.0573
Brugia malayi Melibiase family protein 0.0067 0.1892 0.1887
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0573 0.0905
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1059 0.1673
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.1517 0.6044
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.3589 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0976 0.3709
Loa Loa (eye worm) glutaminase 2 0.0282 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0573 0.0905
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.5962 0.5915
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1059 0.1054
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.2434 0.3845
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 1
Brugia malayi Bromodomain containing protein 0.0077 0.2285 0.228
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.5806 1
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0573 0.0905
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0044 0.102 0.102
Echinococcus multilocularis zinc finger protein 0.0023 0.0239 0.0377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Mycobacterium ulcerans glutaminase 0.0282 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.5625 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0573 0.0568
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0697 0.1101
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1892 0.1892
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0573 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1059 0.1059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0573 0.0905
Schistosoma mansoni hypothetical protein 0.002 0.0132 0.0132
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0168 0.0168
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0203 0.032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0573 0.0905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1263 0.1258
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0573 0.0568
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0573 0.0573
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1059 0.1059
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.3151 0.4977
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.1209 0.1921
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1517 0.2396
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.3151 0.4977
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.1588 0.2587
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 0.5757
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0171 0.5806 0.917
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1541 0.2435
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1612 0.1612
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.5412 0.5412
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0573 0.0568
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.2434 1
Brugia malayi Inositol-1 0.0081 0.2434 0.243
Schistosoma mansoni hypothetical protein 0.0185 0.6331 0.6331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1059 0.1059
Brugia malayi PHD-finger family protein 0.0028 0.0436 0.043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 0.5757
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.2434 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0573 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0573 0.0568
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0573 0.0905
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0073 0.2113 0.5751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0573 0.0573
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.3151 0.3151
Brugia malayi nuclear receptor NHR-88 0.0032 0.0573 0.0568
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.2434 0.2346
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.172 0.2717
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0573 0.0573
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.8903 0.8902
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1541 0.1541
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.3589 0.5668
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.5625 0.5574
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0006 0.0006
Loa Loa (eye worm) glutaminase 0.0282 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1892 0.1892
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Brugia malayi nuclear hormone receptor 0.0032 0.0573 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis glutaminase, putative 0.0282 1 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.3151 0.4977
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1059 0.1673
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.2434 0.2346
Schistosoma mansoni hypothetical protein 0.0034 0.0664 0.0664
Schistosoma mansoni peptidase Clp (S14 family) 0.0171 0.5806 0.5806
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0573 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0573 0.0573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1059 0.1673
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1209 0.1106
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1541 0.2435
Loa Loa (eye worm) hypothetical protein 0.0082 0.2454 0.2454
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.1517 0.1517
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0573 0.0568
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1517 0.1418
Loa Loa (eye worm) hypothetical protein 0.0034 0.0664 0.0664
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0203 0.0203
Toxoplasma gondii melibiase subfamily protein 0.01 0.3151 0.5335
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.1209 0.1921
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.1588 0.2587
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.03 0.03
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.5158 0.8146
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.1209 0.1921
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0573 0.0905
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0006 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0573 0.0568
Echinococcus multilocularis geminin 0.0185 0.6331 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.5806 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1517 0.1512
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0573 0.0905
Echinococcus multilocularis acetylcholinesterase 0.0082 0.2454 0.3875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0573 0.0573
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0116 0.0116
Schistosoma mansoni ap endonuclease 0.002 0.0116 0.0116
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0573 0.0905
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.1209 0.1106
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.172 0.2717
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0203 0.032
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.2434 0.4075
Toxoplasma gondii hypothetical protein 0.0059 0.1588 0.2587
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.1612 0.2546
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.2454 0.3875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0573 0.0573
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0573 0.0905
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.2434 0.2346
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.1373 0.1373
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0573 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1263 0.1258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0573 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0573 0.0573
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0573 0.0573
Brugia malayi jmjC domain containing protein 0.0058 0.1541 0.1536
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.5412 0.8548
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.3151 0.3151
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0697 0.1101
Echinococcus granulosus acetylcholinesterase 0.0082 0.2454 0.3875
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1612 0.1612
Schistosoma mansoni coup transcription factor 0.0032 0.0573 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0573 0.0568
Loa Loa (eye worm) hypothetical protein 0.0171 0.5806 0.5806
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0573 0.0905
Schistosoma mansoni ap endonuclease 0.002 0.0116 0.0116
Echinococcus granulosus carboxylesterase 5A 0.0082 0.2454 0.3875
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0171 0.5806 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.8903 0.889
Loa Loa (eye worm) hypothetical protein 0.0069 0.1981 0.1981
Echinococcus granulosus zinc finger protein 0.0023 0.0239 0.0377
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0573 0.0573
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.1517 0.4035

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 25 % Antimalarial schizonticidal activity against Plasmodium falciparum 3D7 infected erythrocytes at 1.25 ug/ml after 30-39 hrs ChEMBL. 19095455
Inhibition (functional) = 91 % Antimalarial schizonticidal activity against Plasmodium falciparum 3D7 infected erythrocytes at 2.5 ug/ml after 30-39 hrs ChEMBL. 19095455
Inhibition (functional) = 100 % Antimalarial schizonticidal activity against Plasmodium falciparum 3D7 infected erythrocytes at 10 ug/ml after 30-39 hrs ChEMBL. 19095455
Inhibition (functional) = 100 % Antimalarial schizonticidal activity against Plasmodium falciparum 3D7 infected erythrocytes at 5 ug/ml after 30-39 hrs ChEMBL. 19095455

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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