Detailed information for compound 1007429

Basic information

Technical information
  • TDR Targets ID: 1007429
  • Name: 2-[2-(3,5-ditert-butyl-4-hydroxyphenyl)-4-oxo chromen-7-yl]oxy-N,N-diethylacetamide
  • MW: 479.608 | Formula: C29H37NO5
  • H donors: 1 H acceptors: 3 LogP: 6.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)COc1ccc2c(c1)oc(cc2=O)c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)CC
  • InChi: 1S/C29H37NO5/c1-9-30(10-2)26(32)17-34-19-11-12-20-23(31)16-24(35-25(20)15-19)18-13-21(28(3,4)5)27(33)22(14-18)29(6,7)8/h11-16,33H,9-10,17H2,1-8H3
  • InChiKey: GQRSKNPQTMHKAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(3,5-ditert-butyl-4-hydroxy-phenyl)-4-oxo-chromen-7-yl]oxy-N,N-diethyl-acetamide
  • 2-[[2-(3,5-ditert-butyl-4-hydroxyphenyl)-4-oxo-7-chromenyl]oxy]-N,N-diethylacetamide
  • 2-[2-(3,5-ditert-butyl-4-hydroxy-phenyl)-4-keto-chromen-7-yl]oxy-N,N-diethyl-acetamide
  • 2-[2-(3,5-ditert-butyl-4-hydroxy-phenyl)-4-oxo-chromen-7-yl]oxy-N,N-diethyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3583
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0445 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0142 0.2965 0.7385
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1015
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0506
Loa Loa (eye worm) TAR-binding protein 0.0142 0.2965 0.5187
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0478 0.0768
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0602 0.1034
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3583
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0602 0.1034
Mycobacterium tuberculosis Conserved protein 0.0039 0.0602 0.1034
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0068 0.0045
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7353
Brugia malayi hypothetical protein 0.0018 0.0112 0.0122
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0444 0.0708
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Brugia malayi hypothetical protein 0.0018 0.0112 0.0122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0478 0.1102
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.7353
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0068 0.0045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.012 0.0196
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.012 0.0078
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0602 0.1034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.5455 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.5037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0112 0.0175
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0602 0.0986
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0602 0.1413
Onchocerca volvulus 0.0039 0.0602 1
Echinococcus granulosus GPCR family 2 0.0053 0.0914 0.2203
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.2965 0.5151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Brugia malayi ecdysone receptor 0.0016 0.0068 0.0045
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0602 0.1034
Entamoeba histolytica hypothetical protein 0.0041 0.0655 1
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0068 0.0064
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0445 0.0617
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.02 0.2815
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.2322 0.4017
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.7353
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0478 0.7794
Schistosoma mansoni rotamase 0.0036 0.0537 0.1249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0196
Schistosoma mansoni zinc finger protein 0.0016 0.0068 0.0064
Schistosoma mansoni smad 0.0018 0.0111 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0914 0.2202
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.02 0.0398
Echinococcus multilocularis tar DNA binding protein 0.0142 0.2965 0.7385
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0111 0.0173
Onchocerca volvulus 0.0039 0.0602 1
Brugia malayi nuclear hormone receptor 0.0016 0.0068 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.02 0.0158
Mycobacterium tuberculosis Conserved protein 0.0039 0.0602 0.1034
Brugia malayi MH1 domain containing protein 0.0018 0.0111 0.0121
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Echinococcus granulosus smad 0.0018 0.0111 0.0173
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Mycobacterium tuberculosis Conserved protein 0.0039 0.0602 0.1034
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3622 0.3595
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.012 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0914 0.2202
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0445 0.0617
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0445 0.0404
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.907
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0068 0.0064
Schistosoma mansoni hypothetical protein 0.0114 0.2322 0.5759
Brugia malayi MH2 domain containing protein 0.0018 0.0111 0.0121
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0444 0.0777
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.02 0.2815
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.012 0.0196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3583
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0751
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0478 0.1102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Loa Loa (eye worm) hypothetical protein 0.0053 0.0914 0.1599
Loa Loa (eye worm) sugar transporter 0.0106 0.2128 0.3722
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0142 0.2965 0.7385
Schistosoma mansoni hypothetical protein 0.0187 0.4001 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.02 0.0158
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0478 0.0768
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0478 0.1102
Brugia malayi nuclear receptor NHR-88 0.0016 0.0068 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0914 0.2203
Schistosoma mansoni glucose transport protein 0.0106 0.2128 0.5268
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.02 0.0755
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0068 0.0064
Schistosoma mansoni hypothetical protein 0.0187 0.4001 1
Plasmodium falciparum protein kinase 7 0.0298 0.6557 0.6542
Schistosoma mansoni glucose transport protein 0.0106 0.2128 0.5268
Brugia malayi hypothetical protein 0.0016 0.0068 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0914 0.2202
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3622 0.5495
Echinococcus multilocularis GPCR, family 2 0.0053 0.0914 0.2203
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.02 0.2815
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0068 0.0064
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0068 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0478 0.0768
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0517 0.8484
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0068 0.0119
Schistosoma mansoni hypothetical protein 0.0053 0.0914 0.2203
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0602 0.1413
Trichomonas vaginalis rotamase, putative 0.0035 0.0517 0.2276
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7353
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0068 0.0455
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0074
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.907
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.3535 0.6155
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0602 0.2683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0478 0.0837
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7353
Schistosoma mansoni hypothetical protein 0.0053 0.0914 0.2203
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0112 0.0175
Brugia malayi beta-lactamase family protein 0.0039 0.0602 0.0986
Brugia malayi nuclear receptor NHR-67 0.0016 0.0068 0.0045
Brugia malayi nuclear receptor RXR 0.0018 0.0112 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0914 0.2202
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.012 0.0196
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0478 0.1102
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7353
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.012 0.0196
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0602 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.907
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0068 0.0455
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0478 0.7794
Trichomonas vaginalis esterase, putative 0.0039 0.0602 0.2683
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.012 0.0196
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1015
Schistosoma mansoni nuclear receptor 0.0016 0.0068 0.0064
Mycobacterium ulcerans hypothetical protein 0.0039 0.0602 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.02 0.035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Loa Loa (eye worm) Smad1 0.0018 0.0111 0.0194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0602 0.1413
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0602 0.1053
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0068 0.0064
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.012 0.1389
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.1853
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3583
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.055 0.051
Mycobacterium leprae Probable lipase LipE 0.0039 0.0602 1
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0478 0.0768
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Toxoplasma gondii exonuclease III APE 0.0022 0.02 0.0242
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0517 0.6966
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 0.5367
Onchocerca volvulus 0.0016 0.0068 0.0455
Schistosoma mansoni hypothetical protein 0.0053 0.0914 0.2203
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0478 0.1102
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.012 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0478 0.0768
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0032 0.0444 0.0777
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0602 0.1034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0068 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0602 1
Leishmania major protein kinase, putative 0.0032 0.0444 0.7183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0537 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0478 0.0768
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0517 0.8484
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0478 0.1102
Onchocerca volvulus 0.0034 0.0478 0.7794
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0068 0.0064
Brugia malayi conserved hypotetical protein 0.0016 0.0068 0.0045
Entamoeba histolytica hypothetical protein 0.0041 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Brugia malayi hypothetical protein 0.0041 0.0655 0.108
Loa Loa (eye worm) hypothetical protein 0.0167 0.3535 0.6183
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.7353
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0478 0.0768
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0444 0.0777
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0196
Plasmodium falciparum hexose transporter 0.0106 0.2128 0.2094
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0602 1
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0478 0.1102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0478 0.1102
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.02 0.4072
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0196
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.7353
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 0.5367
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0478 0.0768
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0914 0.2203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0914 0.2202
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0602 0.2683
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0506
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.012 0.1389
Brugia malayi hypothetical protein 0.0016 0.0068 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.02 0.2815
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0977
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0478 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2128 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0445 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0478 0.1102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0914 0.2203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0398 0.0899
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0478 0.1102
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.0977
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Brugia malayi nuclear receptor RXR 0.0016 0.0068 0.0045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0478 0.0837
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0445 0.0617
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Onchocerca volvulus 0.0039 0.0602 1
Echinococcus multilocularis General substrate transporter 0.0091 0.1787 0.4406
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0478 0.1102
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0517 0.8484
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.055 0.0779
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0655 0.1548
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Schistosoma mansoni ap endonuclease 0.0022 0.02 0.0398
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0478 0.1102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 0.6082
Brugia malayi MH1 domain containing protein 0.0018 0.0111 0.0121
Brugia malayi RNA binding protein 0.0142 0.2965 0.5151
Schistosoma mansoni glucose transport protein 0.0106 0.2128 0.5268
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0506
Brugia malayi beta-lactamase 0.0039 0.0602 0.0986
Echinococcus granulosus General substrate transporter 0.0091 0.1787 0.4406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0478 0.0837
Schistosoma mansoni hypothetical protein 0.0106 0.2128 0.5268
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.5717 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.02 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0655 0.1548
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0478 0.0768
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0445 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0037 0.055 0.051
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0478 0.1102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0914 0.2202
Brugia malayi isocitrate dehydrogenase 0.0018 0.012 0.0137
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0445 0.0404
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.02 0.0398
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0914 0.2203
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0074
Brugia malayi nuclear hormone receptor 0.0034 0.0478 0.0768
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0445 0.0404
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0112 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.3535 0.6183
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.0219
Echinococcus granulosus expressed protein 0.0036 0.0537 0.1249
Plasmodium vivax hexose transporter 0.0106 0.2128 0.2094
Schistosoma mansoni hypothetical protein 0.0053 0.0914 0.2203
Leishmania major hypothetical protein, conserved 0.0039 0.0602 1
Brugia malayi Sugar transporter family protein 0.0106 0.2128 0.3675
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0751
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0602 0.1034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Brugia malayi Smad1 0.0018 0.0111 0.0121
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0068 0.0045
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.02 0.0278
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0111 0.0173
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0112 0.0175
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.2322 0.4062
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0682
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0478 0.1102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.012 0.0196
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0478 0.1102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Brugia malayi ecdysteroid receptor 0.0034 0.0478 0.0768
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.012 0.1389
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.2965 0.5187
Brugia malayi steroid hormone receptor 0.0034 0.0478 0.0768
Trichomonas vaginalis rotamase, putative 0.0036 0.0537 0.2371
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1254
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.012 0.1389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0478 0.0837
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0111 0.0173
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0517 0.0729
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0068 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0478 0.0768
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0602 0.2683
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0111 0.0194
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0068 0.0064
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0398 0.0899
Loa Loa (eye worm) RNA binding protein 0.0142 0.2965 0.5187
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.0353
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0517 0.8484
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0478 0.1102
Echinococcus granulosus geminin 0.0187 0.4001 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0478 0.0837
Toxoplasma gondii ABC1 family protein 0.0039 0.0602 0.0859
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0914 0.1599
Echinococcus granulosus tar DNA binding protein 0.0142 0.2965 0.7385
Brugia malayi MH2 domain containing protein 0.0262 0.5717 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0478 0.1102
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0444 0.1927
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.02 0.0755
Entamoeba histolytica hypothetical protein 0.0041 0.0655 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Toxoplasma gondii protein kinase, putative 0.0298 0.6557 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0068 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2128 0.5268
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Echinococcus multilocularis expressed protein 0.0036 0.0537 0.1249
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Loa Loa (eye worm) DR-78 0.0016 0.0068 0.0119
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0074
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0444 0.7183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0478 0.1102
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0112 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0914 0.2202
Brugia malayi tailless protein 0.0016 0.0068 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.02 0.2815
Entamoeba histolytica hypothetical protein 0.0024 0.0243 0.0943
Brugia malayi MH2 domain containing protein 0.0018 0.0111 0.0121
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0478 0.0837
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0682
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0602 0.2683
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0602 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0602 1
Loa Loa (eye worm) beta-lactamase 0.0039 0.0602 0.1053
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0478 0.1102
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.907
Brugia malayi TAR-binding protein 0.0142 0.2965 0.5151
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0068 0.0064
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.012 0.0119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0478 0.1102
Mycobacterium ulcerans lipase LipD 0.0039 0.0602 1
Schistosoma mansoni tar DNA-binding protein 0.0142 0.2965 0.7385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0445 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0034 0.0478 0.0837
Entamoeba histolytica hypothetical protein 0.0041 0.0655 1
Schistosoma mansoni coup transcription factor 0.0034 0.0478 0.1102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Brugia malayi Isocitrate dehydrogenase 0.0018 0.012 0.0137
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.012 0.1389
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0068 0.0064
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0111 0.0173
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.907
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0478 0.1102
Loa Loa (eye worm) hypothetical protein 0.0039 0.0602 0.1053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.02 0.0291
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.7353
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0478 0.0837
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.012 0.0196
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0537 0.0939
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0914 0.1536
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0478 0.1102
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2128 0.5268
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2128 0.3201
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0478 0.1102
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0444 0.1015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0478 0.0768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0478 0.0837
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0478 0.1102
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0068 0.0045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0914 0.1536
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0068 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0068 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0602 0.2683
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0602 0.0562
Brugia malayi beta-lactamase family protein 0.0039 0.0602 0.0986
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0444 0.1015
Echinococcus granulosus Smad4 0.0018 0.0111 0.0173
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0111 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0478 0.0768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0914 0.1599
Schistosoma mansoni tar DNA-binding protein 0.0142 0.2965 0.7385
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0478 0.1102
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 1 1
Schistosoma mansoni tar DNA-binding protein 0.0142 0.2965 0.7385
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0478 0.1102
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0112 0.0196
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0478 0.1102
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0068 0.0064
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7353
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3622 0.3595
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.0977
Onchocerca volvulus 0.0016 0.0068 0.0455
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0602 0.1413
Mycobacterium ulcerans beta-lactamase 0.0039 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.012 0.021
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0478 0.0768
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0445 0.0404
Schistosoma mansoni smad1 5 8 and 0.0018 0.0111 0.0173
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7353
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0068 0.0064
Brugia malayi Cam kinase protein 1 0.0032 0.0444 0.0708
Echinococcus multilocularis geminin 0.0187 0.4001 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.012 0.0144
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.0219
Schistosoma mansoni nuclear receptor 0.0016 0.0068 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0537 0.2371
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0478 0.1102
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.5717 1
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0068 0.0119
Schistosoma mansoni Smad4 0.0018 0.0111 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0478 0.0768
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0478 0.0768
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0478 0.0768
Brugia malayi nuclear receptor NHR-88 0.0034 0.0478 0.0768
Schistosoma mansoni smad1 5 8 and 0.0018 0.0111 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0112 0.0175
Schistosoma mansoni ap endonuclease 0.0022 0.02 0.0398
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.7353
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0111 0.0194
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.7353
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.3535 0.6155
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3583
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0506
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0478 0.7794
Echinococcus multilocularis smad 0.0018 0.0111 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0914 0.1536
Schistosoma mansoni smad1 5 8 and 0.0018 0.0111 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0602 0.1034
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0977
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0655 0.1548
Echinococcus multilocularis Smad4 0.0018 0.0111 0.0173
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0655 0.1548
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0478 0.1102

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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