Detailed information for compound 1017405

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.373 | Formula: C13H19N3O3S
  • H donors: 1 H acceptors: 3 LogP: -0.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cccc2n1C[C@@H]1CN(C[C@H]2C1)CCS(=O)(=O)N
  • InChi: 1S/C13H19N3O3S/c14-20(18,19)5-4-15-7-10-6-11(9-15)12-2-1-3-13(17)16(12)8-10/h1-3,10-11H,4-9H2,(H2,14,18,19)/t10-,11+/m0/s1
  • InChiKey: PMXGBTXKWGGXHH-WDEREUQCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-4 subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128160 All targets in OG5_128160
Onchocerca volvulus Putative nachr subunit Get druggable targets OG5_128160 All targets in OG5_128160
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0516 0.0407
Onchocerca volvulus Neuropeptide F receptor homolog 0.005 0.034 0.2277
Brugia malayi larval opioid receptor 0.005 0.034 0.0653
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0145
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.005 0.034 0.0653
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0113 0.0614
Loa Loa (eye worm) hypothetical protein 0.0064 0.0497 0.156
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.034 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.034 0.0445
Leishmania major protein kinase, putative 0.0066 0.0516 0.5597
Brugia malayi beta-NAC-like protein 0.0035 0.017 0.0322
Echinococcus multilocularis g protein coupled receptor 0.005 0.034 0.0377
Echinococcus granulosus heat shock protein 0.0033 0.0142 0.0183
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus multilocularis serotonin receptor 0.005 0.034 0.0377
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0181 0.0199
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0142 0.0368
Brugia malayi Sugar transporter family protein 0.003 0.0113 0.0213
Loa Loa (eye worm) PHD-finger family protein 0.0146 0.1419 0.4471
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0142 0.0437
Echinococcus multilocularis neuropeptide s receptor 0.005 0.034 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0312 0.0408
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0305 0.0338
Onchocerca volvulus 0.003 0.0113 0.0744
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Onchocerca volvulus 0.005 0.034 0.2277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0199 0.0219
Schistosoma mansoni biogenic amine receptor 0.005 0.034 0.0445
Schistosoma mansoni opsin-like receptor 0.005 0.034 0.0445
Plasmodium vivax CDK-related protein kinase 6, putative 0.0907 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0677
Onchocerca volvulus 0.003 0.0113 0.0744
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Plasmodium falciparum mitogen-activated protein kinase 2 0.0345 0.367 0.367
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.034 0.0445
Brugia malayi putative neuropeptide receptor NPR1 0.005 0.034 0.0653
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3076 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Leishmania major glucose transporter, lmgt1 0.0066 0.0522 0.5668
Brugia malayi follicle stimulating hormone receptor 0.005 0.034 0.0653
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.034 0.0445
Echinococcus multilocularis g-protein coupled receptor 0.005 0.034 0.0377
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0199 0.038
Brugia malayi G-protein coupled receptor 0.005 0.034 0.0653
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.005 0.034 0.0653
Echinococcus multilocularis G-protein coupled receptor, putative 0.005 0.034 0.0377
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Giardia lamblia Kinase, PLK 0.0099 0.0888 0.2727
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0043 0.0076
Brugia malayi G protein-coupled receptor F59B2.13 0.005 0.034 0.0653
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0199 0.0259
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0113 0.0614
Leishmania major glucose transporter, lmgt2 0.0066 0.0522 0.5668
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.052 0.5523
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0199 0.0259
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.005 0.034 0.1063
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Schistosoma mansoni glucose transport protein 0.0214 0.2183 0.2881
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0516 0.0516
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0199 0.0219
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Echinococcus multilocularis heat shock protein 0.0033 0.0142 0.0155
Schistosoma mansoni protein kinase 0.0066 0.0516 0.0677
Brugia malayi Dopamine receptor protein 2 0.005 0.034 0.0653
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Onchocerca volvulus 0.005 0.034 0.2277
Echinococcus granulosus dro:myosuppressin receptor 0.005 0.034 0.0445
Onchocerca volvulus 0.003 0.0113 0.0744
Entamoeba histolytica hypothetical protein 0.0036 0.0181 0.0578
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0677
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0043 0.0093
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.034 0.0445
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0467 0.0612
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Schistosoma mansoni hypothetical protein 0.017 0.1689 0.2228
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0142 0.0911
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0183 0.1412
Plasmodium vivax endoplasmin, putative 0.0033 0.0142 0.0029
Loa Loa (eye worm) hypothetical protein 0.0064 0.0497 0.156
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus granulosus metabotropic glutamate receptor 2 0.0139 0.134 0.1766
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.052 0.1682
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0254 0.0485
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Toxoplasma gondii PHD-finger domain-containing protein 0.0146 0.1419 0.2018
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0199 0.0219
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0497 0.0653
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Schistosoma mansoni biogenic amine receptor 0.005 0.034 0.0445
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0516 0.1618
Onchocerca volvulus 0.0038 0.0199 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0522 0.1696
Brugia malayi RE15519p 0.005 0.034 0.0653
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Schistosoma mansoni hypothetical protein 0.005 0.034 0.0445
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0145
Schistosoma mansoni myosin xvIII 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.017 0.125
Schistosoma mansoni histamine h1 receptor 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0522 0.1696
Loa Loa (eye worm) hypothetical protein 0.0042 0.0254 0.079
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0312 0.208
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Plasmodium falciparum phd finger protein, putative 0.0146 0.1419 0.1419
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Echinococcus granulosus neuropeptide Y receptor 0.005 0.034 0.0445
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.034 0.0377
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0305 0.0954
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0142 0.0029
Brugia malayi Dopamine receptor protein 1 0.005 0.034 0.0653
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.017 0.0727
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus multilocularis nAChR subunit 0.0038 0.0199 0.0219
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Giardia lamblia Sugar-proton symporter 0.003 0.0113 0.0154
Brugia malayi Bromodomain containing protein 0.0146 0.1419 0.2745
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Brugia malayi metabotropic glutamate receptor type 2 0.0081 0.0685 0.1322
Mycobacterium ulcerans sugar transporter 0.003 0.0113 0.0614
Onchocerca volvulus 0.005 0.034 0.2277
Echinococcus multilocularis somatostatin receptor 0.005 0.034 0.0377
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0312 0.0346
Brugia malayi AKH receptor 0.005 0.034 0.0653
Schistosoma mansoni neuropeptide receptor 0.005 0.034 0.0445
Entamoeba histolytica protein kinase, putative 0.0066 0.0516 0.1667
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0199 0.0259
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0047 0.0305 0.0297
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Schistosoma mansoni microtubule-associated protein tau 0.0691 0.757 1
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0139 0.134 0.1496
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0677
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0142 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0522 0.1696
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0199 0.0259
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0142 0.0451
Schistosoma mansoni glucose transporter 0.003 0.0113 0.0145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0477 0.5159 0.6814
Treponema pallidum heat shock protein 90 0.0026 0.0067 0.0122
Schistosoma mansoni alpha-1 adrenergic receptor 0.005 0.034 0.0445
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0043 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0312 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0176 0.1765 0.5563
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0142 0.0248
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2881
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0199 0.0259
Echinococcus multilocularis allatostatin A receptor 0.005 0.034 0.0377
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Schistosoma mansoni hypothetical protein 0.005 0.034 0.0445
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0043 0.0093
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0113 0.0369
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0516 0.0623
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Loa Loa (eye worm) melatonin receptor type 1A 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Echinococcus granulosus neuropeptide s receptor 0.005 0.034 0.0445
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0067 0.0218
Brugia malayi Sugar transporter family protein 0.0214 0.2183 0.4228
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0617 0.6796
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0199 0.0618
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Schistosoma mansoni phosphatidylserine receptor 0.0047 0.0305 0.0399
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0145
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.034 0.0445
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.015 0.1467 0.2839
Onchocerca volvulus 0.003 0.0113 0.0744
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0312 0.2988
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0516 0.1676
Echinococcus multilocularis microtubule associated protein 2 0.0691 0.757 0.8472
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0113 0.0614
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0305 0.0399
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0067 0.0183
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0497 0.1429
Schistosoma mansoni glucose transport protein 0.0214 0.2183 0.2881
Schistosoma mansoni phd/f-box containing protein 0.0047 0.0305 0.0399
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0142 0.0368
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0199 0.0219
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.017 0.0057
Brugia malayi G-protein coupled receptor 0.005 0.034 0.0653
Brugia malayi neuropeptide F receptor 0.005 0.034 0.0653
Echinococcus granulosus sex peptide receptor 0.005 0.034 0.0445
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Schistosoma mansoni adenoreceptor 0.005 0.034 0.0445
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.017 0.017
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0113 0.0123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0146 0.1419 0.1871
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0617 0.0509
Echinococcus granulosus neuropeptide FF receptor 2 0.005 0.034 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Echinococcus granulosus allatostatin A receptor 0.005 0.034 0.0445
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0312 0.0815
Trypanosoma cruzi hexose transporter, putative 0.003 0.0113 0.0564
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0199 0.0618
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0199 0.0259
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0199 0.0618
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.034 0.0377
Echinococcus multilocularis dro:myosuppressin receptor 0.005 0.034 0.0377
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Loa Loa (eye worm) glutamate receptor 0.0065 0.051 0.1599
Onchocerca volvulus 0.005 0.034 0.2277
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.2183 0.7097
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0246 0.08
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0574
Schistosoma mansoni endoplasmin 0.0033 0.0142 0.0183
Echinococcus granulosus jumonji domain containing protein 0.0203 0.2063 0.2722
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0888 0.1169
Echinococcus multilocularis neuropeptide FF receptor 2 0.005 0.034 0.0377
Trypanosoma brucei glucose transporter 1E 0.0066 0.0522 0.5272
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0113 0.0527
Schistosoma mansoni amine GPCR 0.005 0.034 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0516 0.0677
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0617 0.0778
Onchocerca volvulus 0.003 0.0113 0.0744
Echinococcus granulosus heat shock protein 90 0.0026 0.0067 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0176 0.1765 0.2328
Schistosoma mansoni protein kinase 0.0066 0.0516 0.0677
Plasmodium vivax JmjC domain containing protein 0.0047 0.0305 0.0194
Brugia malayi Cam kinase protein 1 0.0066 0.0516 0.0994
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0888 0.5983
Echinococcus granulosus g protein coupled receptor 0.005 0.034 0.0445
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Schistosoma mansoni amine GPCR 0.005 0.034 0.0445
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.034 0.0445
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0199 0.038
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.034 0.0377
Brugia malayi PHD-finger family protein 0.0048 0.0312 0.0599
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0199 0.0259
Echinococcus granulosus neuropeptide receptor 0.005 0.034 0.0445
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0497 0.0553
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0145
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi putative neuropeptide receptor 0.005 0.034 0.0653
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0199 0.038
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0312 0.1015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0199 0.0618
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0199 0.0259
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0312 0.2569
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0113 0.0145
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Loa Loa (eye worm) TYRA-2 protein 0.005 0.034 0.1063
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0305 0.0954
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Onchocerca volvulus 0.005 0.034 0.2277
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Plasmodium vivax hexose transporter 0.0214 0.2183 0.2093
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Entamoeba histolytica hypothetical protein 0.0048 0.0312 0.1005
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.0146 0.1419 0.4471
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0142 0.0911
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0231 0.1403
Echinococcus granulosus phd:f box containing protein 0.0047 0.0305 0.0399
Trypanosoma cruzi glucose transporter, putative 0.003 0.0113 0.0564
Brugia malayi jmjC domain containing protein 0.0047 0.0305 0.0586
Leishmania major hypothetical protein, conserved 0.003 0.0113 0.0838
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0123 0.1163 0.1533
Onchocerca volvulus 0.005 0.034 0.2277
Schistosoma mansoni endoplasmin 0.0033 0.0142 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.052 0.5256
Echinococcus granulosus neuropeptides capa receptor 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0522 0.1696
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.052 0.0683
Loa Loa (eye worm) hypothetical protein 0.0052 0.0362 0.1132
Echinococcus multilocularis GPCR, family 3, C terminal 0.0027 0.0078 0.0083
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0123 0.1163 0.1299
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0199 0.0259
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.034 0.0445
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0199 0.0259
Brugia malayi G protein-coupled receptor 0.005 0.034 0.0653
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0522 0.5668
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0888 0.1169
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.0312 0.0307
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0617 0.67
Giardia lamblia Hexose transporter 0.003 0.0113 0.0154
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0113 0.0527
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0123 0.1163 0.1533
Echinococcus multilocularis alpha 1A adrenergic receptor 0.005 0.034 0.0377
Onchocerca volvulus 0.005 0.034 0.2277
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.005 0.034 0.0445
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0199 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0043 0.0093
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.005 0.034 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0617 0.0617
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.005 0.034 0.0445
Schistosoma mansoni opsin-like receptor 0.005 0.034 0.0445
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0516 0.0994
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0231 0.1403
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Echinococcus multilocularis geminin 0.017 0.1689 0.1887
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0345 0.367 0.5498
Brugia malayi jmjC domain containing protein 0.0047 0.0305 0.0586
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Onchocerca volvulus 0.005 0.034 0.2277
Schistosoma mansoni jumonji/arid domain-containing protein 0.0176 0.1765 0.2328
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0047 0.0305 0.0399
Schistosoma mansoni neuropeptide receptor 0.005 0.034 0.0445
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0113 0.0347
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0305 0.0338
Loa Loa (eye worm) hypothetical protein 0.0123 0.1163 0.3663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Echinococcus granulosus somatostatin receptor 0.005 0.034 0.0445
Echinococcus multilocularis fmrfamide receptor 0.005 0.034 0.0377
Loa Loa (eye worm) jmjC domain-containing protein 0.0301 0.3169 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0516 0.0407
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0027 0.0078 0.0504
Schistosoma mansoni peptide (allatostatin)-like receptor 0.005 0.034 0.0445
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0312 0.2006
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.052 0.0683
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0199 0.038
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0349 0.1135
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0142 0.0044
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.034 0.1063
Echinococcus granulosus neuropeptides capa receptor 0.005 0.034 0.0445
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0254 0.079
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Onchocerca volvulus 0.003 0.0113 0.0744
Onchocerca volvulus 0.003 0.0113 0.0744
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0345 0.367 0.3597
Onchocerca volvulus Poor gastrulation protein homolog 0.0027 0.0078 0.0504
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0522 0.1696
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0113 0.0369
Brugia malayi sulfakinin receptor protein 0.005 0.034 0.0653
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0067 0.0291
Echinococcus multilocularis tachykinin peptides receptor 99D 0.005 0.034 0.0377
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.034 0.0377
Echinococcus granulosus neuropeptide receptor A26 0.005 0.034 0.0445
Brugia malayi jmjC domain containing protein 0.0477 0.5159 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Echinococcus granulosus geminin 0.017 0.1689 0.2228
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2441
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi Tachykinin-like peptides receptor 99D 0.005 0.034 0.0653
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0123 0.1163 0.3663
Schistosoma mansoni hypothetical protein 0.0146 0.1419 0.1871
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0305 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0369
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0145
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0067 0.0274
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1123 0.3537
Loa Loa (eye worm) hypothetical protein 0.0047 0.0305 0.0954
Entamoeba histolytica hypothetical protein 0.0036 0.0181 0.0578
Onchocerca volvulus 0.0038 0.0199 0.1325
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Echinococcus multilocularis fmrfamide receptor 0.005 0.034 0.0377
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0047 0.0305 0.0297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.034 0.0377
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1388 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0497 0.1617
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0067 0.0218
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Trypanosoma cruzi hexose transporter 0.0066 0.0522 0.5538
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0043 0.0127
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0305 0.2903
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0888 0.2793
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Trypanosoma brucei polo-like protein kinase 0.0099 0.0888 1
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.017 0.0552
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.034 0.1063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0113 0.0347
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0123 0.1163 0.2249
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0305 0.2903
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0235
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Schistosoma mansoni amine GPCR 0.005 0.034 0.0445
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0522 0.5538
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0113 0.0123
Onchocerca volvulus 0.0038 0.0199 0.1325
Echinococcus granulosus serotonin receptor 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0516 0.5195
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0199 0.0259
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0516 0.0516
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0124
Brugia malayi major facilitator superfamily protein 0.003 0.0113 0.0213
Echinococcus multilocularis g protein coupled receptor 0.005 0.034 0.0377
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi Serotonin/octopamine receptor family protein 7 0.005 0.034 0.0653
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0142 0.0368
Toxoplasma gondii protein kinase, putative 0.0604 0.6583 1
Schistosoma mansoni kinase 0.0052 0.0363 0.0475
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0312 0.0408
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Onchocerca volvulus 0.0038 0.0199 0.1325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus granulosus peregrin 0.0146 0.1419 0.1871
Schistosoma mansoni metabotropic glutamate receptor 0.0139 0.134 0.1766
Schistosoma mansoni biogenic amine receptor 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Echinococcus granulosus General substrate transporter 0.0184 0.1845 0.2433
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0199 0.0259
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0516 0.0623
Echinococcus multilocularis neuropeptide receptor 0.005 0.034 0.0377
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.005 0.034 0.1063
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0305 0.0338
Mycobacterium ulcerans hypothetical protein 0.0024 0.0043 0.0093
Onchocerca volvulus 0.005 0.034 0.2277
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0497 0.0958
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.2446 0.2735
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0312 0.0408
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.034 0.0445
Toxoplasma gondii NAC domain-containing protein 0.0035 0.017 0.0087
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Echinococcus multilocularis General substrate transporter 0.0184 0.1845 0.2061
Schistosoma mansoni amine GPCR 0.005 0.034 0.0445
Brugia malayi Cation transporter family protein 0.0038 0.0199 0.038
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis G protein coupled receptor 139 0.005 0.034 0.0377
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0516 0.1618
Entamoeba histolytica hypothetical protein 0.0035 0.017 0.0541
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.017 0.0552
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.005 0.034 0.0445
Schistosoma mansoni jumonji domain containing protein 0.0379 0.4053 0.5352
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Onchocerca volvulus 0.003 0.0113 0.0744
Onchocerca volvulus Putative nachr subunit 0.0123 0.1163 0.7845
Onchocerca volvulus 0.003 0.0113 0.0744
Leishmania major hypothetical protein, conserved 0.0047 0.0305 0.311
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0199 0.0259
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0124
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.034 0.1063
Echinococcus granulosus lysine specific demethylase 5A 0.0176 0.1765 0.2328
Brugia malayi jmjC domain containing protein 0.0047 0.0305 0.0586
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0204 0.2075 0.2319
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) sugar transporter 0.003 0.0113 0.0347
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0199 0.038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.005 0.034 0.1063
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0181 0.0235
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.005 0.034 0.0377
Schistosoma mansoni protein kinase 0.0066 0.0516 0.0677
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0888 0.2878
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1419 0.132
Leishmania major basic transcription factor 3a, putative 0.0035 0.017 0.1504
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.005 0.034 0.0445
Echinococcus granulosus tachykinin peptides receptor 99D 0.005 0.034 0.0445
Echinococcus multilocularis serotonin receptor 0.005 0.034 0.0377
Leishmania major glucose transporter, lmgt3 0.0066 0.0522 0.5668
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0047 0.0305 0.248
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.005 0.034 0.0377
Brugia malayi Serotonin receptor 0.005 0.034 0.0653
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0888 0.1715
Onchocerca volvulus 0.003 0.0113 0.0744
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.0312 0.2566
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0206 0.0268
Brugia malayi hypothetical protein 0.0036 0.0181 0.0345
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0312 0.0312
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0199 0.0219
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0199 0.0259
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0043 0.0127
Schistosoma mansoni growth hormone secretagogue receptor 0.005 0.034 0.0445
Loa Loa (eye worm) ICD-1 protein 0.0035 0.017 0.0525
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0888 0.099
Echinococcus multilocularis peregrin 0.0146 0.1419 0.1585
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0071 0.0215
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0522 0.5538
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1388 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0123
Echinococcus multilocularis biogenic amine (5HT) receptor 0.005 0.034 0.0377
Onchocerca volvulus Alhambra homolog 0.0146 0.1419 0.9575
Echinococcus granulosus neuropeptide Y receptor 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.025 0.2593 0.8181
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0617 0.67
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0113 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0142 0.0911
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0312 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0231 0.1403
Plasmodium falciparum hexose transporter 0.0214 0.2183 0.2183
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.005 0.034 0.0377
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0574
Echinococcus granulosus microtubule associated protein 2 0.0691 0.757 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Onchocerca volvulus 0.005 0.034 0.2277
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0305 0.0954
Echinococcus granulosus GPCR family 3 C terminal 0.0027 0.0078 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0043 0.0076
Brugia malayi Endoplasmin precursor 0.0033 0.0142 0.0269
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0199 0.038
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0048 0.0312 0.0312
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Brugia malayi major facilitator superfamily protein 0.003 0.0113 0.0213
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.017 0.0541
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0142 0.0911
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.052 0.5523
Echinococcus granulosus g-protein coupled receptor 0.005 0.034 0.0445
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0305 0.0399
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0199 0.0219
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0312 0.3191
Brugia malayi gonadotropin-releasing hormone receptor 2 0.005 0.034 0.0653
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0522 0.1696
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Brugia malayi heat shock protein 90 0.0033 0.0142 0.0269
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0199 0.0219
Schistosoma mansoni neuropeptide f receptor 76f 0.005 0.034 0.0445
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0113 0.0145
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0888 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0522 0.5272
Onchocerca volvulus 0.003 0.0113 0.0744
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.034 0.0445
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0497 0.3381
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0145
Loa Loa (eye worm) hypothetical protein 0.0237 0.2446 0.7715
Loa Loa (eye worm) hypothetical protein 0.0151 0.1482 0.4669
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0123
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0113 0.0838
Entamoeba histolytica hypothetical protein 0.0036 0.0181 0.0578
Echinococcus multilocularis heat shock protein 90 0.0026 0.0067 0.0071
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.034 0.1063
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0312 0.208
Onchocerca volvulus 0.005 0.034 0.2277
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0516 0.0407
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.3076 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0067 0.0183
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0574
Plasmodium falciparum JmjC domain-containing protein, putative 0.0047 0.0305 0.0305
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Brugia malayi GnHR receptor homolog 0.005 0.034 0.0653
Schistosoma mansoni metabotropic glutamate receptor 0.0081 0.0685 0.0901
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0124
Echinococcus multilocularis orexin receptor type 2 0.005 0.034 0.0377
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Schistosoma mansoni glucose transport protein 0.0214 0.2183 0.2881
Brugia malayi AF-10 protein 0.0048 0.0312 0.0599
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0617 0.6796
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0043 0.0093
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0497 0.1607
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0305 0.0338
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0213
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1388 1
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0199 0.0618
Onchocerca volvulus 0.003 0.0113 0.0744
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0305 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0369
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.005 0.034 0.0653
Brugia malayi Cation transporter family protein 0.0038 0.0199 0.038
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Echinococcus granulosus alpha 1A adrenergic receptor 0.005 0.034 0.0445
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2441
Giardia lamblia PHD finger protein 15 0.0146 0.1419 0.4492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Echinococcus granulosus fmrfamide receptor 0.005 0.034 0.0445
Echinococcus granulosus endoplasmin 0.0026 0.0067 0.0084
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.052 0.1003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.034 0.0377
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0497 0.0958
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0199 0.0219
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0206 0.0227
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0199 0.038
Schistosoma mansoni hypothetical protein 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.0048 0.0312 0.0976
Brugia malayi jmjC domain containing protein 0.0047 0.0305 0.0586
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0199 0.038
Echinococcus granulosus 7tm_1 domain containing protein 0.005 0.034 0.0445
Trypanosoma brucei glucose transporter 2A 0.0066 0.0522 0.5272
Brugia malayi Dopamine receptor 0.005 0.034 0.0653
Loa Loa (eye worm) hypothetical protein 0.0204 0.2075 0.6542
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0142 0.0461
Brugia malayi ORL1-like opioid receptor 0.005 0.034 0.0653
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Brugia malayi hypothetical protein 0.003 0.0113 0.0213
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0067 0.0084
Schistosoma mansoni heat shock protein 0.0033 0.0142 0.0183
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0516 0.0574
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0188 0.1899 0.2505
Brugia malayi hypothetical protein 0.005 0.034 0.0653
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Schistosoma mansoni transcription factor btf3 0.0035 0.017 0.022
Onchocerca volvulus 0.003 0.0113 0.0744
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0312 0.0408
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3076 1
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0199 0.0618
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Echinococcus granulosus metabotropic glutamate receptor 5 0.0204 0.2075 0.2737
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0369
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0522 0.1696
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi PHD-finger family protein 0.0146 0.1419 0.2745
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0349 0.1135
Onchocerca volvulus 0.003 0.0113 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Onchocerca volvulus 0.0151 0.1482 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.005 0.034 0.0445
Onchocerca volvulus 0.005 0.034 0.2277
Entamoeba histolytica protein kinase, putative 0.0066 0.0516 0.1667
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2881
Echinococcus granulosus peptide allatostatin:somatostatin 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2881
Echinococcus multilocularis g protein coupled receptor 0.005 0.034 0.0377
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.034 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.032 0.0613
Echinococcus multilocularis endoplasmin 0.0026 0.0067 0.0071
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.005 0.034 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0888 0.2886
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Brugia malayi Sugar transporter family protein 0.003 0.0113 0.0213
Loa Loa (eye worm) hypothetical protein 0.0047 0.0305 0.0954
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0497 0.0653
Echinococcus granulosus nAChR subunit 0.0038 0.0199 0.0259
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0312 0.0307
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0067 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0516 0.1618
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.1163 0.1299
Echinococcus granulosus 7TM GPCR rhodopsin 0.005 0.034 0.0445
Schistosoma mansoni hypothetical protein 0.017 0.1689 0.2228
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.034 0.0445
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.052 0.5654
Onchocerca volvulus 0.005 0.034 0.2277
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0522 0.5272
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Plasmodium falciparum heat shock protein 90 0.0033 0.0142 0.0142
Schistosoma mansoni opsin-like receptor 0.005 0.034 0.0445
Echinococcus granulosus PHD finger protein rhinoceros 0.0146 0.1419 0.1871
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3076 1
Trichomonas vaginalis glucose transporter, putative 0.003 0.0113 0.0369
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi hypothetical protein 0.003 0.0113 0.0213
Onchocerca volvulus Putative transporter 0.003 0.0113 0.0744
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0312 0.0201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0516 0.0677
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.005 0.034 0.0445
Schistosoma mansoni hypothetical protein 0.0048 0.0312 0.0408
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.052 0.0579
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus granulosus hypothetical protein 0.005 0.034 0.0445
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1123 0.3537
Brugia malayi neuropeptide F receptor 0.005 0.034 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0369
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0043 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Onchocerca volvulus 0.0038 0.0199 0.1325
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.0312 0.2566
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.034 0.0445
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0199 0.038
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0369
Onchocerca volvulus 0.005 0.034 0.2277
Schistosoma mansoni amine GPCR 0.005 0.034 0.0445
Echinococcus multilocularis neuropeptide receptor A26 0.005 0.034 0.0377
Brugia malayi Cation transporter family protein 0.0038 0.0199 0.038
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus granulosus neuropeptide receptor 0.005 0.034 0.0445
Echinococcus multilocularis heat shock protein 90 0.0033 0.0142 0.0155
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0467 0.0519
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0142 0.0911
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0213
Onchocerca volvulus 0.003 0.0113 0.0744
Entamoeba histolytica hypothetical protein 0.0036 0.0181 0.0578
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0305 0.0399
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.005 0.034 0.0445
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Schistosoma mansoni survival motor neuron protein 0.0048 0.032 0.0418
Echinococcus multilocularis PHD finger protein rhinoceros 0.0146 0.1419 0.1585
Brugia malayi F/Y-rich N-terminus family protein 0.0048 0.0312 0.0599
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0113 0.0145
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0497 0.0653
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0145
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0123
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0516 0.0516
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0142 0.0044
Brugia malayi hypothetical protein 0.0151 0.1482 0.2867
Echinococcus multilocularis neuropeptide receptor 0.005 0.034 0.0377
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0254 0.079
Schistosoma mansoni neuropeptide receptor 0.005 0.034 0.0445
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.005 0.034 0.0445
Brugia malayi hypothetical protein 0.003 0.0113 0.0213
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0516 0.0623
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0305 0.0399
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.034 0.0445
Brugia malayi Serotonin receptor 0.005 0.034 0.0653
Loa Loa (eye worm) hypothetical protein 0.0048 0.0312 0.0975
Loa Loa (eye worm) glutamate receptor 0.0166 0.1643 0.5178
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.005 0.034 0.0377
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.052 0.1633
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0617 0.6503
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0312 0.0599
Schistosoma mansoni hypothetical protein 0.0048 0.032 0.0418
Schistosoma mansoni protein phosphatase 2C 0.0047 0.0305 0.0399
Onchocerca volvulus 0.005 0.034 0.2277
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0043 0.0093
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0516 0.0516
Schistosoma mansoni hypothetical protein 0.0036 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.017 0.125
Echinococcus multilocularis transcription factor btf3 0.0035 0.017 0.0186
Brugia malayi jmjC domain containing protein 0.0176 0.1765 0.3416
Brugia malayi MH2 domain containing protein 0.012 0.1123 0.2172
Schistosoma mansoni neuropeptide receptor 0.005 0.034 0.0445
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0043 0.0093
Echinococcus granulosus G protein coupled receptor 139 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Toxoplasma gondii facilitative glucose transporter GT1 0.0214 0.2183 0.3199
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0477 0.5159 0.5773
Schistosoma mansoni heat shock protein 0.0033 0.0142 0.0183
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.8935 1
Loa Loa (eye worm) sugar transporter 0.0214 0.2183 0.6885
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Echinococcus multilocularis jumonji domain containing protein 0.0203 0.2063 0.2306
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0043 0.0076
Echinococcus multilocularis sex peptide receptor 0.005 0.034 0.0377
Trypanosoma brucei heat shock protein, putative 0.0033 0.0142 0.0368
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.034 0.0445
Schistosoma mansoni hypothetical protein 0.0214 0.2183 0.2881
Onchocerca volvulus 0.003 0.0113 0.0744
Trypanosoma brucei glucose transporter, putative 0.0066 0.0522 0.5272
Echinococcus granulosus g protein coupled receptor 0.005 0.034 0.0445
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0199 0.0259
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0888 1
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi hypothetical protein 0.0237 0.2446 0.4737
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Echinococcus multilocularis lysine specific demethylase 5A 0.0176 0.1765 0.1972
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Schistosoma mansoni hypothetical protein 0.005 0.034 0.0445
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0199 0.0618
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.1163 0.1533
Brugia malayi Melatonin receptor type 1A 0.005 0.034 0.0653
Echinococcus granulosus heat shock protein 90 0.0033 0.0142 0.0183
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0347
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0199 0.038
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0123 0.1163 0.1299
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0199 0.0618
Leishmania major heat shock protein 83-1 0.0033 0.0142 0.1175
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.3076 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.005 0.034 0.2277
Brugia malayi Metabotropic glutamate receptor precursor. 0.0166 0.1643 0.318
Toxoplasma gondii PHD-finger domain-containing protein 0.0146 0.1419 0.2018
Schistosoma mansoni nAChR subunit 0.0038 0.0199 0.0259
Echinococcus granulosus thyrotropin releasing hormone receptor 0.005 0.034 0.0445
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.2446 0.3228
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0516 0.0407
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.034 0.0445
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.005 0.034 0.0377
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.005 0.034 0.1063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0522 0.5538
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.017 0.0552
Echinococcus granulosus g protein coupled receptor 0.005 0.034 0.0445
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.034 0.0377
Echinococcus granulosus orexin receptor type 2 0.005 0.034 0.0445
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0369
Onchocerca volvulus 0.005 0.034 0.2277
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.005 0.034 0.1063
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0199 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Schistosoma mansoni hypothetical protein 0.0027 0.0078 0.0099
Onchocerca volvulus 0.005 0.034 0.2277
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0888 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0522 0.5272
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0214 0.2183 0.2441
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2183 0.2881
Onchocerca volvulus 0.0038 0.0199 0.1325
Plasmodium falciparum protein kinase 7 0.0604 0.6583 0.6583
Loa Loa (eye worm) hypothetical protein 0.005 0.034 0.1063
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0213
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0618
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0048 0.0312 0.0307
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.034 0.0377
Onchocerca volvulus 0.0048 0.032 0.2139
Loa Loa (eye worm) endoplasmin 0.0033 0.0142 0.0437
Echinococcus granulosus transcription factor btf3 0.0035 0.017 0.022
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0199 0.038
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.034 0.0445
Trypanosoma cruzi sugar transporter, putative 0.003 0.0113 0.0564
Onchocerca volvulus 0.0024 0.0043 0.0265
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0181 0.0235

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 564 nM Displacement of (+/-)-[3H]epibatidine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates ChEMBL. 19548687
Ki (binding) > 50000 nM Displacement of [125I]alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates ChEMBL. 19548687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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