Detailed information for compound 102755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.299 | Formula: C14H19N4O4P
  • H donors: 3 H acceptors: 6 LogP: -0.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(CP(=O)(O)O)Cn1cncn1)CCc1ccccc1
  • InChi: 1S/C14H19N4O4P/c19-14(7-6-12-4-2-1-3-5-12)17-13(9-23(20,21)22)8-18-11-15-10-16-18/h1-5,10-11,13H,6-9H2,(H,17,19)(H2,20,21,22)
  • InChiKey: CSPVQORIGIAYHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cryptococcus neoformans var. neoformans B-3501A Imidazoleglycerol-phosphate dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Nanchung homolog Imidazoleglycerol-phosphate dehydratase   202 aa 162 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0289 0.0295
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0346 0.0346
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0322 0.3233
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.1007 0.422
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Brugia malayi Endoplasmin precursor 0.0063 0.057 0.0582
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0083 0.0083
Loa Loa (eye worm) RNA binding protein 0.0142 0.1473 0.1503
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0083 0.0083
Echinococcus multilocularis geminin 0.0888 1 1
Loa Loa (eye worm) glutaminase 0.087 0.9798 1
Brugia malayi Hsp90 protein 0.0026 0.0144 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0172 0.016
Schistosoma mansoni hypothetical protein 0.0088 0.0856 0.0856
Leishmania major hypothetical protein, conserved 0.0051 0.0428 0.38
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0083 0.0083
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0083 0.0085
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0083 0.0085
Brugia malayi hypothetical protein 0.0033 0.0223 0.0227
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0144 0.0144
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0461 0.5762
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0299 0.0299
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0428 0.38
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4452 0.4452
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0693 1
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0337 0.37 1
Trichomonas vaginalis esterase, putative 0.0074 0.0693 0.0693
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0083 0.0083
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0322 0.0313
Loa Loa (eye worm) hypothetical protein 0.0112 0.1129 0.1152
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1235 0.126
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0403 0.4452 0.4452
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0076
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0693 0.0817
Trichomonas vaginalis chromobox protein, putative 0.0043 0.034 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1473 0.1473
Loa Loa (eye worm) beta-lactamase 0.0074 0.0693 0.0708
Leishmania major hypothetical protein, conserved 0.0074 0.0693 0.6641
Brugia malayi beta-lactamase 0.0074 0.0693 0.0708
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0074 0.0699
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0693 0.0817
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0299 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0172 0.016
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1019 0.1019
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0147 0.0147
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0083 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0777 0.0777
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0045 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0493 0.0503
Trichomonas vaginalis chaperonin, putative 0.0026 0.0147 0.0135
Echinococcus granulosus cpg binding protein 0.003 0.019 0.019
Loa Loa (eye worm) heat shock protein 90 0.0063 0.057 0.0582
Loa Loa (eye worm) hypothetical protein 0.0054 0.0461 0.0471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Schistosoma mansoni hypothetical protein 0.0088 0.0856 0.0856
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0291 0.0282
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0322 0.2656
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1594 0.1594
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0305 0.0296
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1473 0.1473
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0428 0.38
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0322 0.4165
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0108 0.0108
Toxoplasma gondii heat shock protein HSP90 0.0063 0.057 0.7763
Schistosoma mansoni hypothetical protein 0.0888 1 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0147 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1594 0.1594
Brugia malayi jmjC domain containing protein 0.0102 0.1019 0.104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0322 0.2656
Brugia malayi chromobox protein homolog 3 0.004 0.0305 0.0311
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0091 0.0893 0.0912
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0664
Schistosoma mansoni hypothetical protein 0.0088 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0693
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0493 0.0503
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.0683 0.7658 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0083 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1594 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1473 0.1473
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0147 0.0057
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0147 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Echinococcus multilocularis GPCR, family 2 0.0018 0.0052 0.0052
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0083 0.0083
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0777 0.0793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Schistosoma mansoni heat shock protein 0.0063 0.057 0.057
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.1007 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0055 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0055 0.004
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0083 0.0083
Leishmania major heat shock protein, putative 0.0026 0.0144 0.0752
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1007 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0693 0.0693
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.0042
Entamoeba histolytica heat shock protein 90, putative 0.0063 0.057 0.2247
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0693 0.0817
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Echinococcus multilocularis tar DNA binding protein 0.0142 0.1473 0.1473
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.0042
Schistosoma mansoni hypothetical protein 0.0888 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0493 0.0503
Loa Loa (eye worm) hypothetical protein 0.0069 0.0642 0.0655
Schistosoma mansoni heat shock protein 0.0063 0.057 0.057
Echinococcus granulosus tar DNA binding protein 0.0142 0.1473 0.1473
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0083 0.0085
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0083 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0693 0.0708
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0322 0.0322
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0216 0.2321 0.2321
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0693 0.0824
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0423 0.3746
Toxoplasma gondii ABC1 family protein 0.0074 0.0693 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0305 0.0296
Echinococcus multilocularis peregrin 0.0031 0.0206 0.0206
Plasmodium falciparum heat shock protein 90 0.0063 0.057 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0693 0.0637
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0087 0.0087
Echinococcus multilocularis heat shock protein 90 0.005 0.0423 0.0423
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0346 0.0346
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0428 0.6667
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.0817
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0083 0.0085
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0144 0.0752
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0534 0.0534
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0052 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0693
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0291 0.0282
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0322 0.0255
Schistosoma mansoni cpg binding protein 0.003 0.019 0.019
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0422 0.0415
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0322 0.2656
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0074 0.0074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0322 0.0322
Brugia malayi glutaminase DH11.1 0.087 0.9798 1
Loa Loa (eye worm) TAR-binding protein 0.0142 0.1473 0.1503
Schistosoma mansoni patched 1 0.0091 0.0893 0.0893
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0147 0.0147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0493 0.0503
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.0211
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0693 0.0817
Echinococcus multilocularis Niemann Pick C1 protein 0.0213 0.2284 0.2284
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0206 0.0206
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0087 0.0089
Echinococcus granulosus GPCR family 2 0.0018 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Echinococcus granulosus heat shock protein 90 0.005 0.0423 0.0423
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0083 0.0083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0052 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0005
Trichomonas vaginalis heat shock protein, putative 0.005 0.0423 0.0417
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0693 0.0693
Trypanosoma cruzi Heat shock protein 83, putative 0.0063 0.057 0.5324
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.1007 0.1007
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.005 0.0423 0.0423
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0693 0.6876
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1473 0.1473
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Brugia malayi Fli-1 protein 0.0247 0.2668 0.2723
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Brugia malayi hypothetical protein 0.0021 0.0083 0.0085
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.057 0.5324
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Echinococcus granulosus endoplasmin 0.005 0.0423 0.0423
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0074 0.0074
Echinococcus multilocularis heat shock protein 90 0.0063 0.057 0.057
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.005 0.0423 0.3746
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0147 0.143
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0422 0.0415
Schistosoma mansoni chromobox protein 0.0071 0.0664 0.0664
Brugia malayi Ets-domain containing protein 0.0081 0.0777 0.0793
Giardia lamblia PHD finger protein 15 0.0031 0.0206 0.1412
Schistosoma mansoni hypothetical protein 0.0088 0.0856 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0893 0.0897
Echinococcus multilocularis expressed protein 0.04 0.4426 0.4426
Mycobacterium ulcerans glutaminase 0.087 0.9798 1
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0777 0.0777
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0064 0.0065
Schistosoma mansoni endoplasmin 0.0063 0.057 0.057
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0074 0.006
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0083 0.0083
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1007 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0299 0.0299
Treponema pallidum heat shock protein 90 0.005 0.0423 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1594 0.1594
Plasmodium vivax heat shock protein 86, putative 0.0063 0.057 0.7763
Brugia malayi CXXC zinc finger family protein 0.0028 0.0171 0.0175
Echinococcus granulosus heat shock protein 0.0063 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.0295
Mycobacterium ulcerans hypothetical protein 0.0074 0.0693 0.0637
Trypanosoma brucei heat shock protein 90, putative 0.0063 0.057 0.5651
Entamoeba histolytica heat shock protein 90, putative 0.0063 0.057 0.2247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0147 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1594 0.1594
Echinococcus multilocularis Niemann Pick C1 protein 0.0304 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0083 0.0083
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0083 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0083 0.0083
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0693 0.0817
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0322 0.317
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0083 0.0083
Schistosoma mansoni ap endonuclease 0.0041 0.0322 0.0322
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0693 0.0693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1594 0.1594
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.1473 0.1503
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0147 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.5248 0.6823
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0147 0.0147
Trypanosoma brucei polo-like protein kinase 0.0101 0.1007 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1594 0.1594
Onchocerca volvulus 0.0074 0.0693 0.6368
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0428 0.6667
Brugia malayi PHD-finger family protein 0.0031 0.0206 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0693 0.6641
Schistosoma mansoni ets-related 0.0247 0.2668 0.2668
Brugia malayi CHE-14 protein 0.0091 0.0893 0.0912
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.1473 0.1503
Echinococcus granulosus sterol regulatory element binding protein 0.0091 0.0893 0.0893
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0021 0.0005
Echinococcus granulosus peregrin 0.0031 0.0206 0.0206
Echinococcus multilocularis sterol regulatory element binding protein 0.0091 0.0893 0.0893
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0299 0.0306
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0281 0.0281
Echinococcus multilocularis endoplasmin 0.005 0.0423 0.0423
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0693 0.0817
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0083 0.0083
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0083 0.0083
Schistosoma mansoni cpg binding protein 0.0028 0.0171 0.0171
Brugia malayi PXA domain containing protein 0.0021 0.0083 0.0085
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Trichomonas vaginalis heat shock protein, putative 0.005 0.0423 0.0417
Onchocerca volvulus 0.0028 0.0171 0.0316
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0052 0.0052
Mycobacterium leprae Probable lipase LipE 0.0074 0.0693 0.0824
Brugia malayi TAR-binding protein 0.0142 0.1473 0.1503
Schistosoma mansoni hypothetical protein 0.0031 0.0206 0.0206
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.0817
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0091 0.0893 0.0912
Mycobacterium ulcerans heat shock protein 90 0.005 0.0423 0.0359
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0664
Echinococcus granulosus heat shock protein 90 0.0063 0.057 0.057
Trypanosoma brucei Heat shock protein 83, putative 0.0063 0.057 0.5651
Brugia malayi Bromodomain containing protein 0.0031 0.0206 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0206 0.1121
Brugia malayi hypothetical protein 0.0051 0.0428 0.0437
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0083 0.0083
Schistosoma mansoni kinase 0.0051 0.0437 0.0437
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0171 0.0175
Toxoplasma gondii exonuclease III APE 0.0041 0.0322 0.3233
Onchocerca volvulus 0.0074 0.0693 0.6368
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0083 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0206 0.1121
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0693 0.0693
Echinococcus granulosus Protein patched homolog 1 0.0091 0.0893 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Schistosoma mansoni DNA polymerase eta 0.002 0.0074 0.0074
Giardia lamblia Grp94/Hsp90 0.005 0.0423 0.3746
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0144 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Schistosoma mansoni endoplasmin 0.0063 0.057 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.005 0.0423 0.0461
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0144 0.0147
Trichomonas vaginalis heat shock protein, putative 0.0063 0.057 0.0567
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0322 0.0327
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0052 0.0053
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0083 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0428 0.4233
Trypanosoma brucei heat shock protein 90, putative 0.0063 0.057 0.5651
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0083 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0074 0.0699
Trypanosoma brucei unspecified product 0.002 0.0074 0.0699
Echinococcus granulosus expressed conserved protein 0.02 0.2136 0.2136
Loa Loa (eye worm) glutaminase 2 0.087 0.9798 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.1007 0.1027
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0147 0.0785
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0074 0.0074
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0147 0.0073
Trypanosoma cruzi heat shock protein 90, putative 0.0063 0.057 0.5324
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0087 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0322 0.2656
Brugia malayi beta-lactamase family protein 0.0074 0.0693 0.0708
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.034 0.227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0053
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0423 0.3746
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0147 0.0147
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0083 0.0083
Echinococcus multilocularis heat shock protein 0.0063 0.057 0.057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0693 0.0708
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4452 0.4452
Plasmodium falciparum phd finger protein, putative 0.0031 0.0206 0.1444
Schistosoma mansoni cpg binding protein 0.003 0.019 0.019
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0083 0.0083
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0083 0.0069
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0083 0.0085
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0074 0.0076
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0083 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Schistosoma mansoni gabp alpha 0.0081 0.0777 0.0777
Mycobacterium ulcerans lipase LipD 0.0074 0.0693 0.0637
Brugia malayi MH2 domain containing protein 0.0121 0.1235 0.126
Echinococcus multilocularis dna polymerase kappa 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0693 0.6641
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0664 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0147 0.0785
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0778 0.0778
Echinococcus multilocularis cpg binding protein 0.003 0.019 0.019
Entamoeba histolytica hypothetical protein 0.0021 0.0083 0.0042
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0083 0.0083
Echinococcus granulosus Niemann Pick C1 protein 0.0213 0.2284 0.2284
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Trypanosoma brucei heat shock protein, putative 0.0063 0.057 0.5651
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0664
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0074 0.0699
Plasmodium falciparum endoplasmin, putative 0.0039 0.0291 0.345
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0693
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0074 0.006
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0147 0.0147
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0693 0.0693
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0147 0.0135
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.0683 0.7658 0.78
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0087 0.0089
Echinococcus granulosus dna polymerase eta 0.002 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Trichomonas vaginalis glutaminase, putative 0.087 0.9798 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0428 0.0437
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0428 0.5175
Onchocerca volvulus 0.0031 0.0206 0.0723
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0144 0.1398
Brugia malayi hypothetical protein 0.0021 0.0083 0.0085
Schistosoma mansoni glutaminase 0.087 0.9798 0.9798
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0087 0.0087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.1594 0.1627
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Echinococcus granulosus chromobox protein 1 0.0071 0.0664 0.0664
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0305 0.1868
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0074 0.0074
Echinococcus multilocularis protein dispatched 1 0.0104 0.1041 0.1041
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0083 0.0085
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0147 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.0708
Echinococcus granulosus Niemann Pick C1 protein 0.0304 0.3329 0.3329
Brugia malayi Ets-domain containing protein 0.0081 0.0777 0.0793
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0274 0.215
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0083 0.0083
Trichomonas vaginalis heat shock protein, putative 0.005 0.0423 0.0417
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0108 0.0108
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1019 0.1019
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.057 0.5324
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0052
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0213 0.2284 1
Leishmania major heat shock protein 83-1 0.0063 0.057 0.5324
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0693 0.0817
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.1007 0.1027
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0074 0.0076
Toxoplasma gondii heat shock protein 90, putative 0.0063 0.057 0.7763
Onchocerca volvulus 0.0074 0.0693 0.6368
Loa Loa (eye worm) fli-1 protein 0.0247 0.2668 0.2723
Schistosoma mansoni hypothetical protein 0.0039 0.0289 0.0289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0206 0.021
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0144 0.0317
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.057 0.5324
Brugia malayi Heterochromatin protein 1 0.0071 0.0664 0.0677
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0147 0.0785
Trichomonas vaginalis chromobox protein, putative 0.0043 0.034 0.0332
Schistosoma mansoni hypothetical protein 0.0023 0.0108 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0206 0.1121
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0074 0.0076
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0144 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.1594 0.1627
Onchocerca volvulus Alhambra homolog 0.0031 0.0206 0.0714
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1007 0.1013
Echinococcus multilocularis chromobox protein 1 0.0071 0.0664 0.0664
Echinococcus granulosus expressed protein 0.04 0.4426 0.4426
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.005 0.0423 1
Plasmodium vivax endoplasmin, putative 0.0063 0.057 0.7763
Brugia malayi Niemann-Pick C1 protein precursor 0.0213 0.2284 0.2331
Brugia malayi jmjC domain containing protein 0.0039 0.0299 0.0306
Loa Loa (eye worm) hypothetical protein 0.004 0.0305 0.0311
Giardia lamblia Kinase, PLK 0.0101 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.2284 0.2331
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0322 0.0328
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0423 0.3746
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.0817
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0069
Echinococcus granulosus dna polymerase kappa 0.002 0.0074 0.0074
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.1007 0.1007
Echinococcus multilocularis dna polymerase eta 0.002 0.0074 0.0074
Brugia malayi RNA binding protein 0.0142 0.1473 0.1503
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0322 0.0328
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0664 0.0662
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1235 0.126
Brugia malayi PXA domain containing protein 0.0021 0.0083 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0142 0.1473 0.1473
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0052 0.0053
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0322 0.0313
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0206 0.0206
Echinococcus multilocularis expressed conserved protein 0.02 0.2136 0.2136
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0693 0.0637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0074 0.0699
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0055 0.004
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0083 0.0083
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0322 0.1121
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0693 0.0637
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0428 0.5175
Schistosoma mansoni heat shock protein 0.0026 0.0144 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1007 0.1007
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0087 0.0089
Giardia lamblia Heat shock protein HSP 90-alpha 0.0063 0.057 0.5324
Loa Loa (eye worm) endoplasmin 0.0063 0.057 0.0582
Schistosoma mansoni ap endonuclease 0.0041 0.0322 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0586 0.0598
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0083 0.0085
Brugia malayi heat shock protein 90 0.0063 0.057 0.0582
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0074 0.0699
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0052 0.0052
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0083 0.0083
Brugia malayi beta-lactamase family protein 0.0074 0.0693 0.0708
Echinococcus multilocularis protein patched 0.0091 0.0893 0.0893

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.96 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
IC50 (binding) = 0.96 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.27 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.27 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Kis (binding) = 1.14 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980
Kis (binding) = 1.14 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.