Detailed information for compound 1030349

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.797 | Formula: C16H19ClF2N4O3
  • H donors: 3 H acceptors: 3 LogP: -0.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(C(=O)O)c(=O)c2c1c(F)c(N1C[C@H]([C@@H](C1)N)N)c(c2)F.Cl
  • InChi: 1S/C16H18F2N4O3.ClH/c1-2-21-4-8(16(24)25)15(23)7-3-9(17)14(12(18)13(7)21)22-5-10(19)11(20)6-22;/h3-4,10-11H,2,5-6,19-20H2,1H3,(H,24,25);1H/t10-,11-;/m1./s1
  • InChiKey: BFIQTUDFWPIXFM-NDXYWBNTSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0014 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni neuropeptide receptor 0.0176 0.1814 0.4375
Echinococcus granulosus g protein coupled receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Brugia malayi Melatonin receptor type 1A 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0176 0.1814 0.6429
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0714 0.0714
Schistosoma mansoni alpha-glucosidase 0.0155 0.1585 0.3822
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0159
Loa Loa (eye worm) G-protein coupled receptor 0.0176 0.1814 0.6429
Brugia malayi Bromodomain containing protein 0.0016 0.0045 0.0161
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0176 0.1814 0.1814
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus PHD finger protein rhinoceros 0.0016 0.0045 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0563 0.5538
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0176 0.1814 0.1814
Schistosoma mansoni patched 1 0.0048 0.0393 0.0947
Echinococcus granulosus tm gpcr rhodopsin 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0019 0.008 0.0192
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.029 0.1144
Echinococcus granulosus neuropeptide receptor 0.0176 0.1814 0.4375
Brugia malayi MH2 domain containing protein 0.0018 0.0066 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0033 0.1085
Onchocerca volvulus 0.0019 0.008 0.02
Echinococcus multilocularis muscleblind protein 1 0.0247 0.2602 0.2602
Echinococcus granulosus glycogen phosphorylase 0.024 0.2531 0.6106
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0308 0.1216
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0176 0.1814 0.1814
Schistosoma mansoni amine GPCR 0.0176 0.1814 0.4375
Echinococcus granulosus neuropeptide s receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis allatostatin A receptor 0.0176 0.1814 0.1814
Schistosoma mansoni lamin 0.006 0.0532 0.1284
Echinococcus multilocularis serotonin receptor 0.0176 0.1814 0.1814
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Echinococcus multilocularis neuropeptide FF receptor 2 0.0176 0.1814 0.1814
Echinococcus multilocularis neuropeptide receptor 0.0176 0.1814 0.1814
Echinococcus granulosus neuropeptide Y receptor 0.0176 0.1814 0.4375
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni amine GPCR 0.0176 0.1814 0.4375
Brugia malayi RNA binding protein 0.0096 0.0928 0.3288
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0176 0.1814 0.4375
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0393 0.1551
Echinococcus granulosus Smad4 0.0018 0.0066 0.0159
Echinococcus multilocularis g protein coupled receptor 0.0176 0.1814 0.1814
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0308 0.5464
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0176 0.1814 0.6429
Echinococcus multilocularis peregrin 0.0016 0.0045 0.0045
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0062 0.1099
Echinococcus multilocularis microtubule associated protein 2 0.0386 0.4145 0.4145
Echinococcus granulosus tar DNA binding protein 0.0096 0.0928 0.2237
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.003 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Schistosoma mansoni microtubule-associated protein tau 0.0386 0.4145 1
Echinococcus multilocularis neuropeptide receptor A26 0.0176 0.1814 0.1814
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0062 0.0062
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0096 0.0928 0.3288
Onchocerca volvulus Glycogen phosphorylase homolog 0.024 0.2531 1
Schistosoma mansoni adenoreceptor 0.0176 0.1814 0.4375
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0062 1
Giardia lamblia DINP protein human, muc B family 0.0015 0.0033 0.0132
Echinococcus granulosus Glycosyl transferase family 35 0.024 0.2531 0.6106
Echinococcus granulosus neuropeptide Y receptor 0.0176 0.1814 0.4375
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0033 0.0118
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi ORL1-like opioid receptor 0.0176 0.1814 0.6429
Echinococcus granulosus neuropeptide receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis musashi 0.006 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.006 0.0532 0.1887
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0176 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.1001
Brugia malayi Dopamine receptor protein 2 0.0176 0.1814 0.6429
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0062 0.022
Echinococcus granulosus neuropeptides capa receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni glycogen phosphorylase 0.024 0.2531 0.6106
Brugia malayi PHD-finger family protein 0.0016 0.0045 0.0161
Echinococcus granulosus jumonji domain containing protein 0.0023 0.0116 0.028
Brugia malayi Dopamine receptor protein 1 0.0176 0.1814 0.6429
Echinococcus multilocularis G protein coupled receptor 139 0.0176 0.1814 0.1814
Brugia malayi MH1 domain containing protein 0.0018 0.0066 0.0234
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0176 0.1814 0.1814
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.1863 0.6603
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0096 0.0928 0.2237
Brugia malayi Serotonin receptor 0.0176 0.1814 0.6429
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0033 0.1085
Brugia malayi Dopamine receptor 0.0176 0.1814 0.6429
Schistosoma mansoni neuropeptide F-like receptor 0.0176 0.1814 0.4375
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0066 0.0159
Echinococcus granulosus peptide allatostatin:somatostatin 0.0176 0.1814 0.4375
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0066 0.0066
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0016 0.0045 0.0109
Schistosoma mansoni hypothetical protein 0.0176 0.1814 0.4375
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.003 0.0962
Brugia malayi G-protein coupled receptor 0.0176 0.1814 0.6429
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0112 0.1112 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0963 0.2323
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.2821 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0308 0.1216
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0058 0.0205
Echinococcus multilocularis somatostatin receptor 0.0176 0.1814 0.1814
Onchocerca volvulus 0.0176 0.1814 0.7132
Echinococcus multilocularis neuropeptides capa receptor 0.0176 0.1814 0.1814
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0176 0.1814 0.1814
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0963 0.2323
Brugia malayi RNA recognition motif domain containing protein 0.0096 0.0928 0.3288
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.0021 0.037
Brugia malayi putative neuropeptide receptor NPR1 0.0176 0.1814 0.6429
Echinococcus granulosus neuropeptide receptor A26 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0059 0.052 0.1844
Schistosoma mansoni amine GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0033 0.0081
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.1623 0.3915
Echinococcus granulosus allatostatin A receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) TAR-binding protein 0.0096 0.0928 0.3288
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni hypothetical protein 0.0351 0.3754 0.9057
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0176 0.1814 0.4375
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0021 0.3364
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0963 0.2323
Loa Loa (eye worm) inositol-1 0.0038 0.029 0.1027
Echinococcus granulosus g-protein coupled receptor 0.0176 0.1814 0.4375
Echinococcus granulosus glycogen phosphorylase 0.024 0.2531 0.6106
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0308 0.1216
Loa Loa (eye worm) neuropeptide F receptor 0.0176 0.1814 0.6429
Schistosoma mansoni hypothetical protein 0.0351 0.3754 0.9057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0563 0.1359
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0053 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0176 0.1814 0.4375
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.003 0.0962
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0104 0.1017 1
Leishmania major DNA polymerase kappa, putative 0.0015 0.0033 0.03
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.003 0.0117
Brugia malayi Serotonin receptor 0.0176 0.1814 0.6429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni lamin 0.006 0.0532 0.1284
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0062 0.0062
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0176 0.1814 0.4375
Echinococcus granulosus lamin dm0 0.006 0.0532 0.1284
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0662
Schistosoma mansoni amine GPCR 0.0176 0.1814 0.4375
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0033 0.0328
Brugia malayi intermediate filament protein 0.006 0.0532 0.1887
Echinococcus granulosus fmrfamide receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0619
Schistosoma mansoni hypothetical protein 0.0077 0.0714 0.1721
Brugia malayi Smad1 0.0018 0.0066 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0019 0.008 0.008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.029 0.9408
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.029 0.0699
Echinococcus granulosus sodium channel protein 0.0112 0.1112 0.2682
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0062 0.2012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.008 0.0192
Schistosoma mansoni intermediate filament proteins 0.006 0.0532 0.1284
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0033 0.0328
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0117
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1095 0.2642
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0033 0.03
Entamoeba histolytica hypothetical protein 0.0077 0.0714 0.2819
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0176 0.1814 0.6429
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Schistosoma mansoni hypothetical protein 0.0046 0.0374 0.0901
Schistosoma mansoni tar DNA-binding protein 0.0096 0.0928 0.2237
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0033 0.0328
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Plasmodium vivax SET domain protein, putative 0.0019 0.008 1
Schistosoma mansoni hypothetical protein 0.0017 0.0058 0.014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0963 0.3413
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0033 0.1085
Brugia malayi neuropeptide F receptor 0.0176 0.1814 0.6429
Onchocerca volvulus Alhambra homolog 0.0016 0.0045 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0714 0.1721
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0176 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0104 0.1017 1
Loa Loa (eye worm) glycogen phosphorylase 0.024 0.2531 0.8973
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0045 0.0161
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.003 0.0117
Brugia malayi G-protein coupled receptor 0.0176 0.1814 0.6429
Trypanosoma brucei unspecified product 0.0015 0.0033 0.1085
Onchocerca volvulus 0.0176 0.1814 0.7132
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Echinococcus multilocularis g protein coupled receptor 0.0176 0.1814 0.1814
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.003 0.0117
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0308 0.1216
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.029 0.1144
Echinococcus granulosus microtubule associated protein 2 0.0386 0.4145 1
Echinococcus granulosus hypothetical protein 0.0176 0.1814 0.4375
Echinococcus multilocularis protein patched 0.0048 0.0393 0.0393
Brugia malayi carbohydrate phosphorylase 0.024 0.2531 0.8973
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0176 0.1814 0.4375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0135 0.1364 0.4836
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0245 0.5
Brugia malayi hypothetical protein 0.0077 0.0714 0.253
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0109
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0021 0.0677
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.0021 0.2617
Loa Loa (eye worm) TYRA-2 protein 0.0176 0.1814 0.6429
Echinococcus multilocularis serotonin receptor 0.0176 0.1814 0.1814
Brugia malayi AKH receptor 0.0176 0.1814 0.6429
Echinococcus granulosus g protein coupled receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.1623 0.1623
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0238 0.0843
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0062 0.0062
Brugia malayi isocitrate dehydrogenase 0.0018 0.0062 0.022
Echinococcus granulosus dro:myosuppressin receptor 0.0176 0.1814 0.4375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0563 0.5538
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0176 0.1814 0.1814
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0033 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0033 0.0118
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0176 0.1814 0.6429
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0062 0.2012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0176 0.1814 0.6429
Schistosoma mansoni neuropeptide receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0963 0.0963
Brugia malayi MH1 domain containing protein 0.0018 0.0066 0.0234
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0058 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis smad 0.0018 0.0066 0.0066
Echinococcus granulosus serotonin receptor 0.0176 0.1814 0.4375
Echinococcus granulosus G protein coupled receptor 139 0.0176 0.1814 0.4375
Entamoeba histolytica glycogenphosphorylase, putative 0.0104 0.1017 0.402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.008 0.0192
Echinococcus multilocularis jumonji domain containing protein 0.0023 0.0116 0.0116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.1814 0.4375
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0083 0.0296
Schistosoma mansoni hypothetical protein 0.0176 0.1814 0.4375
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0176 0.1814 0.1814
Echinococcus granulosus GPCR family 2 0.0017 0.0058 0.014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0176 0.1814 0.1814
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.1017 0.402
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0282 0.1001
Onchocerca volvulus 0.0176 0.1814 0.7132
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0066 0.0159
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0308 0.1216
Echinococcus granulosus intermediate filament protein 0.006 0.0532 0.1284
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0205
Brugia malayi neuropeptide F receptor 0.0176 0.1814 0.6429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Brugia malayi Cytochrome P450 family protein 0.0017 0.0053 0.0187
Onchocerca volvulus 0.006 0.0532 0.2009
Echinococcus multilocularis protein dispatched 1 0.0054 0.0467 0.0467
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0033 0.1085
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0308 0.0743
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0563 0.0563
Echinococcus multilocularis PHD finger protein rhinoceros 0.0016 0.0045 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0563 0.1359
Loa Loa (eye worm) RNA binding protein 0.0096 0.0928 0.3288
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0176 0.1814 0.4375
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0021 0.0677
Echinococcus granulosus orexin receptor type 2 0.0176 0.1814 0.4375
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.029 0.1144
Schistosoma mansoni biogenic amine receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis muscleblind protein 0.0247 0.2602 0.2602
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis fmrfamide receptor 0.0176 0.1814 0.1814
Echinococcus multilocularis sex peptide receptor 0.0176 0.1814 0.1814
Entamoeba histolytica hypothetical protein 0.0077 0.0714 0.2819
Entamoeba histolytica glycogen phosphorylase, putative 0.024 0.2531 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0963 0.3413
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0033 0.0132
Entamoeba histolytica hypothetical protein 0.0077 0.0714 0.2819
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0308 0.1216
Schistosoma mansoni hypothetical protein 0.0017 0.0058 0.014
Echinococcus multilocularis tar DNA binding protein 0.0096 0.0928 0.0928
Leishmania major glycosyl hydrolase-like protein 0.0015 0.003 0.0266
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.029 0.029
Schistosoma mansoni amine GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni tar DNA-binding protein 0.0096 0.0928 0.2237
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0021 0.3364
Schistosoma mansoni inositol monophosphatase 0.0038 0.029 0.0699
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.1863 0.4494
Schistosoma mansoni smad 0.0018 0.0066 0.0159
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0159
Echinococcus multilocularis dna polymerase eta 0.0015 0.0033 0.0033
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0176 0.1814 0.1814
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.1095 0.3882
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) intermediate filament protein 0.006 0.0532 0.1887
Schistosoma mansoni growth hormone secretagogue receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0619
Trypanosoma brucei glucosidase, putative 0.004 0.0308 1
Onchocerca volvulus 0.0176 0.1814 0.7132
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0033 0.0081
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.1814 0.4375
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0072 0.0173
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus multilocularis g protein coupled receptor 0.0176 0.1814 0.1814
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0176 0.1814 0.4375
Schistosoma mansoni hypothetical protein 0.0046 0.0374 0.0901
Echinococcus multilocularis fmrfamide receptor 0.0176 0.1814 0.1814
Onchocerca volvulus 0.0176 0.1814 0.7132
Brugia malayi sulfakinin receptor protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Onchocerca volvulus 0.0176 0.1814 0.7132
Schistosoma mansoni myosin xvIII 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Plasmodium falciparum phd finger protein, putative 0.0016 0.0045 0.7318
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0058 0.014
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi jmjC domain containing protein 0.002 0.0083 0.0296
Chlamydia trachomatis glycogen phosphorylase 0.024 0.2531 0.5
Brugia malayi putative neuropeptide receptor 0.0176 0.1814 0.6429
Echinococcus multilocularis sodium channel protein 0.0112 0.1112 0.1112
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0308 1
Echinococcus granulosus somatostatin receptor 0.0176 0.1814 0.4375
Brugia malayi Tachykinin-like peptides receptor 99D 0.0176 0.1814 0.6429
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0563 0.1359
Echinococcus multilocularis orexin receptor type 2 0.0176 0.1814 0.1814
Echinococcus granulosus g protein coupled receptor 0.0176 0.1814 0.4375
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0563 0.5068
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) melatonin receptor type 1A 0.0176 0.1814 0.6429
Echinococcus granulosus lysine specific demethylase 5A 0.002 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0066 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0033 0.0118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0062 0.0149
Echinococcus multilocularis dro:myosuppressin receptor 0.0176 0.1814 0.1814
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0176 0.1814 0.7132
Loa Loa (eye worm) hypothetical protein 0.0048 0.0393 0.1392
Echinococcus granulosus tm gpcr rhodopsin 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni jumonji/arid domain-containing protein 0.002 0.0083 0.0201
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.003 0.0117
Brugia malayi TAR-binding protein 0.0096 0.0928 0.3288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0062 0.0062
Echinococcus multilocularis neuropeptide s receptor 0.0176 0.1814 0.1814
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0563 1
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0222 0.0788
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0062 0.2012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0176 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0055 0.0476 0.1687
Loa Loa (eye worm) Smad1 0.0018 0.0066 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.1814 0.4375
Echinococcus granulosus 7tm_1 domain containing protein 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.003 0.0962
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0308 0.1091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.008 0.0192
Echinococcus multilocularis neuropeptide Y receptor 0.0176 0.1814 0.1814
Leishmania major hypothetical protein, conserved 0.0014 0.0021 0.0187
Brugia malayi CHE-14 protein 0.0048 0.0393 0.1392
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0176 0.1814 0.4375
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0033 0.0132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.003 0.0117
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0176 0.1814 0.4375
Brugia malayi jmjC domain containing protein 0.0053 0.0457 0.1619
Schistosoma mansoni biogenic amine receptor 0.0176 0.1814 0.4375
Brugia malayi Inositol-1 0.0038 0.029 0.1027
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Toxoplasma gondii PHD-finger domain-containing protein 0.0016 0.0045 0.0804
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0053 0.0187
Onchocerca volvulus 0.0176 0.1814 0.7132
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.1095 0.4326
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0308 0.1216
Brugia malayi Pre-SET motif family protein 0.0019 0.008 0.0282
Echinococcus granulosus dna polymerase kappa 0.0015 0.0033 0.0081
Echinococcus granulosus sex peptide receptor 0.0176 0.1814 0.4375
Onchocerca volvulus 0.0176 0.1814 0.7132
Trichomonas vaginalis set domain proteins, putative 0.0154 0.1572 0.6209
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0176 0.1814 0.4375
Onchocerca volvulus 0.0176 0.1814 0.7132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0963 0.2323
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0187 0.0187
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0393 0.0947
Schistosoma mansoni histamine h1 receptor 0.0176 0.1814 0.4375
Schistosoma mansoni smad1 5 8 and 0.0018 0.0066 0.0159
Brugia malayi MH2 domain containing protein 0.0018 0.0066 0.0234
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0176 0.1814 0.6429
Echinococcus multilocularis g-protein coupled receptor 0.0176 0.1814 0.1814
Schistosoma mansoni neuropeptide F-like receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0247 0.2602 0.9225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Brugia malayi MH2 domain containing protein 0.0267 0.2821 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.029 0.9408
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0062 0.1099
Schistosoma mansoni alpha glucosidase 0.004 0.0308 0.0743
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1863 0.1863
Brugia malayi GnHR receptor homolog 0.0176 0.1814 0.6429
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0062 0.2012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0176 0.1814 0.6429
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus tachykinin peptides receptor 99D 0.0176 0.1814 0.4375
Echinococcus multilocularis G-protein coupled receptor, putative 0.0176 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi larval opioid receptor 0.0176 0.1814 0.6429
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.029 0.2847
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0176 0.1814 0.6429
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0062 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Echinococcus multilocularis neuropeptides capa receptor 0.0176 0.1814 0.1814
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0066 0.0234
Brugia malayi Muscleblind-like protein 0.0247 0.2602 0.9225
Onchocerca volvulus 0.006 0.0532 0.2009
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni hypothetical protein 0.0176 0.1814 0.4375
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0111 0.1095 0.3882
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0176 0.1814 0.4375
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.2821 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0016 0.0045 0.0804
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0062 0.0149
Echinococcus multilocularis lamin 0.006 0.0532 0.0532
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0058 0.0205
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Leishmania major DNA polymerase eta, putative 0.0015 0.0033 0.03
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) neuropeptide F receptor 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0118
Echinococcus multilocularis glycogen phosphorylase 0.024 0.2531 0.2531
Schistosoma mansoni Smad4 0.0018 0.0066 0.0159
Onchocerca volvulus Neuropeptide F receptor homolog 0.0176 0.1814 0.7132
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0066 0.0234
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0176 0.1814 0.6429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Schistosoma mansoni hypothetical protein 0.0017 0.0058 0.014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0176 0.1814 0.4375
Echinococcus granulosus neuropeptides capa receptor 0.0176 0.1814 0.4375
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Echinococcus granulosus dna polymerase eta 0.0015 0.0033 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Echinococcus granulosus tm gpcr rhodopsin 0.0176 0.1814 0.4375
Schistosoma mansoni tar DNA-binding protein 0.0096 0.0928 0.2237
Schistosoma mansoni jumonji/arid domain-containing protein 0.002 0.0083 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0245 0.2409
Schistosoma mansoni hypothetical protein 0.0038 0.0282 0.0681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0963 0.2323
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Schistosoma mansoni neuropeptide receptor 0.0176 0.1814 0.4375
Trichomonas vaginalis glycogen phosphorylase, putative 0.024 0.2531 1
Onchocerca volvulus 0.0176 0.1814 0.7132
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0308 0.2769
Echinococcus multilocularis neuropeptide receptor 0.0176 0.1814 0.1814
Schistosoma mansoni opsin-like receptor 0.0176 0.1814 0.4375
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0112 0.1112 0.2682
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0033 0.0328
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0045 0.5694
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni neuropeptide f receptor 76f 0.0176 0.1814 0.4375
Brugia malayi follicle stimulating hormone receptor 0.0176 0.1814 0.6429
Onchocerca volvulus 0.0176 0.1814 0.7132
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0176 0.1814 0.6429
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0393 0.1392
Echinococcus multilocularis glycogen phosphorylase 0.024 0.2531 0.2531
Echinococcus granulosus 7TM GPCR rhodopsin 0.0176 0.1814 0.4375
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.008 0.008
Onchocerca volvulus 0.0176 0.1814 0.7132
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0308 0.1216
Loa Loa (eye worm) G-protein coupled receptor 0.0176 0.1814 0.6429
Giardia lamblia Glycogen phosphorylase 0.024 0.2531 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0053 0.0457 0.1102
Trichomonas vaginalis glycogen phosphorylase, putative 0.024 0.2531 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.029 0.9408
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0187 0.0451
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0308 0.1216
Schistosoma mansoni alpha-glucosidase 0.0155 0.1585 0.3822
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Echinococcus multilocularis neuropeptide Y receptor 0.0176 0.1814 0.1814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Schistosoma mansoni biogenic amine receptor 0.0176 0.1814 0.4375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0033 0.1085
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0532 0.1887
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0074
Echinococcus multilocularis Smad4 0.0018 0.0066 0.0066
Echinococcus multilocularis lysine specific demethylase 5A 0.002 0.0083 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0714 0.1721
Echinococcus granulosus lamin 0.006 0.0532 0.1284
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0062 0.0557
Onchocerca volvulus 0.0104 0.102 0.396
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0033 0.0081
Giardia lamblia PHD finger protein 15 0.0016 0.0045 0.0179
Echinococcus granulosus geminin 0.0351 0.3754 0.9057
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0308 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni opsin-like receptor 0.0176 0.1814 0.4375
Echinococcus multilocularis Glycosyl transferase, family 35 0.024 0.2531 0.2531
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.1017 0.402
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0222 0.0788
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1863 0.1863
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0176 0.1814 0.1814
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.1814 0.4375
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Echinococcus granulosus neuropeptide FF receptor 2 0.0176 0.1814 0.4375
Echinococcus granulosus muscleblind protein 0.0247 0.2602 0.6278
Entamoeba histolytica glycogen phosphorylase, putative 0.024 0.2531 1
Onchocerca volvulus 0.0176 0.1814 0.7132
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.029 0.1144
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni opsin-like receptor 0.0176 0.1814 0.4375
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0176 0.1814 0.1814
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.1863 0.6603
Schistosoma mansoni DNA polymerase eta 0.0015 0.0033 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1095 0.1095
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0019 0.008 0.1413
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.029 0.2605
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0058 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.1814 0.1814
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0619
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus expressed conserved protein 0.0104 0.102 0.2462
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0062 0.7781
Echinococcus multilocularis expressed conserved protein 0.0104 0.102 0.102
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi RE15519p 0.0176 0.1814 0.6429
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0308 0.1216
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0062 0.0609
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.029 0.5141
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0033 0.1085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0476 0.1687
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0176 0.1814 0.4375
Loa Loa (eye worm) hypothetical protein 0.0247 0.2602 0.9225
Entamoeba histolytica hypothetical protein 0.0077 0.0714 0.2819
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Brugia malayi G protein-coupled receptor 0.0176 0.1814 0.6429
Echinococcus granulosus smad 0.0018 0.0066 0.0159
Brugia malayi hypothetical protein 0.0176 0.1814 0.6429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0476 0.1687
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0033 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Echinococcus granulosus peregrin 0.0016 0.0045 0.0109
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0308 0.1091
Onchocerca volvulus 0.0176 0.1814 0.7132
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0033 0.0132
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0335 0.0808
Echinococcus multilocularis lamin dm0 0.006 0.0532 0.0532
Schistosoma mansoni glycogen phosphorylase 0.024 0.2531 0.6106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.1814 0.4375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0563 0.5538
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Schistosoma mansoni inositol monophosphatase 0.0038 0.029 0.0699
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0532 0.1887
Schistosoma mansoni hypothetical protein 0.0046 0.0374 0.0901
Onchocerca volvulus 0.0154 0.1572 0.6164
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0393 0.0947
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0062 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0096 0.0928 0.2237
Echinococcus multilocularis geminin 0.0351 0.3754 0.3754
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0563 0.5538
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.1814 0.4375
Schistosoma mansoni hypothetical protein 0.0046 0.0374 0.0901
Loa Loa (eye worm) hypothetical protein 0.0176 0.1814 0.6429
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0058 0.014
Schistosoma mansoni hypothetical protein 0.0017 0.0058 0.014
Schistosoma mansoni glycogen phosphorylase 0.0104 0.1017 0.2454
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0476 0.1687
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.0021 0.0677
Echinococcus multilocularis GPCR, family 2 0.0017 0.0058 0.0058
Onchocerca volvulus 0.0176 0.1814 0.7132
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0066 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0963 0.0963
Schistosoma mansoni neuropeptide receptor 0.0176 0.1814 0.4375
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0176 0.1814 0.4375
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0308 0.1216
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0308 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.1814 0.4375
Onchocerca volvulus 0.0176 0.1814 0.7132
Loa Loa (eye worm) hypothetical protein 0.0058 0.0511 0.1813
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.1114 0.2687
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0176 0.1814 0.4375
Brugia malayi G protein-coupled receptor F59B2.13 0.0176 0.1814 0.6429
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.008 0.0192
Onchocerca volvulus 0.0176 0.1814 0.7132
Brugia malayi Pre-SET motif family protein 0.0135 0.1364 0.4836
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0161

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 ug ml-1 Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain ATCC 25922 ChEMBL. 9871611
MIC (functional) = 1 ug ml-1 Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain ATCC 35218 ChEMBL. 9871611
MIC (functional) > 8 ug ml-1 Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 091 ChEMBL. 9871611
MIC (functional) > 8 ug ml-1 Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 133 ChEMBL. 9871611
MIC (functional) > 8 ug ml-1 Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 134 ChEMBL. 9871611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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