TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 758.45 | Formula: C41H60ClN3O6S
H donors: 5 H acceptors: 5 LogP: 7.88 Rotable bonds: 25
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NCc1cccc(c1O)OC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)Cc1ccccc1.Cl
InChi: 1S/C41H59N3O6S.ClH/c1-28(2)14-11-15-30(5)16-12-17-31(6)22-24-50-36-21-13-20-33(38(36)45)27-42-37(29(3)4)40(47)44-35(26-32-18-9-8-10-19-32)39(46)43-34(41(48)49)23-25-51-7;/h8-10,13-14,16,18-22,29,34-35,37,42,45H,11-12,15,17,23-27H2,1-7H3,(H,43,46)(H,44,47)(H,48,49);1H/b30-16+,31-22+;/t34-,35-,37-;/m0./s1
InChiKey: WOAQVRXUMARCJT-LIUDSTGRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Loa Loa (eye worm)	MH2 domain-containing protein	0.0367	0.4179	0.5582
Echinococcus granulosus	lamin	0.0054	0.0408	0.106
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0216	0.0216
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0377	0.1377
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0229	0.2524	1
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0216	0.236	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Onchocerca volvulus	Glutamate dehydrogenase, mitochondrial homolog	0.0023	0.0034	0.0039
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0206	0.0202
Schistosoma mansoni	hypothetical protein	0.0339	0.385	1
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.2077
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0206	0.0534
Toxoplasma gondii	melibiase subfamily protein	0.0103	0.1	0.3878
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0206	0.0275
Brugia malayi	Pre-SET motif family protein	0.0641	0.7486	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0551	0.1432
Echinococcus multilocularis	geminin	0.0339	0.385	0.385
Echinococcus multilocularis	lamin dm0	0.0054	0.0408	0.0408
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.1266	0.1691
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Onchocerca volvulus		0.0037	0.0206	0.024
Onchocerca volvulus		0.0092	0.0865	0.1011
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0967	0.0967
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0229	0.2524	1
Loa Loa (eye worm)	RNA binding protein	0.0125	0.1266	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0396	0.0529
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0057	0.0077
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0967	0.1292
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0493	0.0493
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0377	0.1377
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.149
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Loa Loa (eye worm)	transcription factor SMAD2	0.0367	0.4179	0.5582
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0551	0.1432
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0095	0.0907	0.1211
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.012	0.121	0.4144
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0057	0.0149
Plasmodium vivax	glutamate dehydrogenase (NADP+), putative	0.0023	0.0034	0.0143
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0585	0.152
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0216	0.0562
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0057	0.0077
Onchocerca volvulus	Glutamate dehydrogenase, mitochondrial homolog	0.0023	0.0034	0.0039
Brugia malayi	Pre-SET motif family protein	0.0092	0.0865	0.1155
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0229	0.2524	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0057	0.0057
Schistosoma mansoni	smad	0.0025	0.0057	0.0149
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0206	0.0534
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0105	0.0141
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.2628	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0865	0.1155
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.0439	0.114
Leishmania major	hypothetical protein, conserved	0.0037	0.0206	0.069
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0206	0.0275
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Brugia malayi	beta-lactamase family protein	0.0037	0.0206	0.0275
Brugia malayi	RNA binding protein	0.0125	0.1266	0.1691
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0493	0.1281
Onchocerca volvulus	Putative GMP reductase	0.0095	0.0907	0.106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Echinococcus multilocularis	lamin	0.0054	0.0408	0.0408
Giardia lamblia	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0493	0.1845
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0229	0.2524	0.9571
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0408	0.0545
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Echinococcus granulosus	Glutamate dehydrogenase mitochondrial	0.0023	0.0034	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0493	0.1187
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0206	0.0871
Echinococcus multilocularis	glutamate dehydrogenase	0.0023	0.0034	0.0034
Plasmodium falciparum	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.0143
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0229	0.2524	0.3372
Onchocerca volvulus		0.0037	0.0206	0.024
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0229	0.2524	0.3372
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Schistosoma mansoni	lamin	0.0054	0.0408	0.106
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0206	0.0534
Echinococcus granulosus	tar DNA binding protein	0.0125	0.1266	0.3288
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0493	0.1845
Echinococcus granulosus	geminin	0.0339	0.385	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0408	0.0545
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0077
Echinococcus multilocularis	Smad4	0.0025	0.0057	0.0057
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0967	0.1292
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0551	0.2077
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0103	0.1	0.1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0585	0.0782
Schistosoma mansoni	hypothetical protein	0.0339	0.385	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Toxoplasma gondii	ABC1 family protein	0.0037	0.0206	0.069
Brugia malayi	Muscleblind-like protein	0.0149	0.1555	0.2077
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.1555	0.1555
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Loa Loa (eye worm)	Smad1	0.0025	0.0057	0.0077
Onchocerca volvulus		0.0729	0.8554	1
Echinococcus multilocularis	Glutamate dehydrogenase, mitochondrial	0.0023	0.0034	0.0034
Loa Loa (eye worm)	GMP reductase	0.0095	0.0907	0.1211
Echinococcus granulosus	histone lysine methyltransferase setb	0.0092	0.0865	0.2247
Brugia malayi	Smad1	0.0025	0.0057	0.0077
Brugia malayi	hypothetical protein	0.0051	0.0377	0.0503
Trichomonas vaginalis	set domain proteins, putative	0.0729	0.8554	1
Echinococcus granulosus	glutamate dehydrogenase	0.0023	0.0034	0.0088
Onchocerca volvulus		0.0054	0.0408	0.0477
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0206	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0229	0.2524	0.6557
Trypanosoma brucei	GMP reductase	0.0229	0.2524	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0551	0.0551
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0377	0.0738
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0206	0.0206
Leishmania major	hypothetical protein, conserved	0.0051	0.0377	0.1377
Brugia malayi	TAR-binding protein	0.0125	0.1266	0.1691
Trypanosoma cruzi	GMP reductase	0.0229	0.2524	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0585	0.152
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0408	0.106
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1555	0.2077
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0071	0.0071
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0493	0.1281
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0377	0.0503
Brugia malayi	MH2 domain containing protein	0.0367	0.4179	0.5582
Echinococcus granulosus	intermediate filament protein	0.0054	0.0408	0.106
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0641	0.7486	1
Toxoplasma gondii	IMP dehydrogenas	0.0229	0.2524	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0408	0.0545
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0377	0.1377
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0092	0.0865	0.2247
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0059	0.0079
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0206	0.0275
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0103	0.1	0.2596
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0071	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0071	0.0095
Schistosoma mansoni	lamin	0.0054	0.0408	0.106
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0089	0.0824	0.2141
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1555	0.2077
Echinococcus granulosus	Smad4	0.0025	0.0057	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0206	0.069
Onchocerca volvulus		0.0037	0.0206	0.024
Leishmania major	guanosine monophosphate reductase	0.0229	0.2524	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Schistosoma mansoni	hypothetical protein	0.0023	0.0034	0.009
Plasmodium vivax	SET domain protein, putative	0.0092	0.0865	0.3665
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0092	0.0865	0.0865
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0493	0.1281
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0109	0.1071	0.3732
Schistosoma mansoni	lipoxygenase	0.0057	0.0439	0.114
Echinococcus granulosus	lamin dm0	0.0054	0.0408	0.106
Brugia malayi	glutamate dehydrogenase, mitochondrial precursor, putative	0.0023	0.0034	0.0045
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0216	0.236	0.9291
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0551	0.0736
Brugia malayi	GMP reductase	0.0095	0.0907	0.1211
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0408	0.0545
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0967	0.2512
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0229	0.2524	1
Plasmodium falciparum	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.0143
Schistosoma mansoni	Smad4	0.0025	0.0057	0.0149
Trypanosoma cruzi	GMP reductase	0.0229	0.2524	1
Brugia malayi	hypothetical protein	0.0033	0.0157	0.0209
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0092	0.0865	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0059	0.0079
Echinococcus multilocularis	muscleblind protein	0.0149	0.1555	0.1555
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.1266	0.1266
Echinococcus granulosus	muscleblind protein	0.0149	0.1555	0.404
Echinococcus multilocularis	smad	0.0025	0.0057	0.0057
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0206	0.069
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.1266	0.1691
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.2077
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0967	0.2512
Brugia malayi	Melibiase family protein	0.0069	0.0585	0.0782
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0103	0.1	0.1
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0077
Echinococcus granulosus	smad	0.0025	0.0057	0.0149
Brugia malayi	intermediate filament protein	0.0054	0.0408	0.0545
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0551	0.0736
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0095	0.0907	0.1211
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0069	0.0585	0.0647
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0057	0.0149
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0057	0.0149
Brugia malayi	beta-lactamase	0.0037	0.0206	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Brugia malayi	beta-lactamase family protein	0.0037	0.0206	0.0275
Schistosoma mansoni	glutamate dehydrogenase	0.0023	0.0034	0.0088
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.0439	0.0439
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.1266	0.1691
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0229	0.2524	0.2524
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0057	0.0057
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0034	0.0034
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0034	0.009
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0105	0.0141
Brugia malayi	glutamate dehydrogenase, mitochondrial precursor, putative	0.0023	0.0034	0.0045
Echinococcus multilocularis	musashi	0.0054	0.0408	0.0408
Onchocerca volvulus		0.0054	0.0408	0.0477
Trichomonas vaginalis	esterase, putative	0.0037	0.0206	0.0202
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0077
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0109	0.1071	0.3732
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0229	0.2524	0.6557
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0551	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0967	0.0967
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.012	0.121	0.433
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0216	0.236	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0092	0.0865	0.3337
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0229	0.2524	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 70 uM	Inhibition of farnesyl transferase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL544567

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1036259