Detailed information for compound 103659

Basic information

Technical information
  • TDR Targets ID: 103659
  • Name: (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4 -hydroxy-4-oxobutanoyl]amino]-5-hydroxy-5-oxo pentanoyl]amino]-4-methylsulfanylbutanoyl]ami no]-5-[[(2S)-5-hydroxy-1-[[(2R)-1-hydroxy-1-o xo-3-sulfanylpropan-2-yl]amino]-1,5-dioxopent an-2-yl]amino]-5-oxopentanoic acid
  • MW: 796.82 | Formula: C29H44N6O16S2
  • H donors: 11 H acceptors: 16 LogP: -3.57 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CS)CCC(=O)O)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O
  • InChi: 1S/C29H44N6O16S2/c1-13(36)30-18(11-23(43)44)28(49)33-15(4-7-21(39)40)25(46)34-17(9-10-53-2)27(48)32-14(3-6-20(37)38)24(45)31-16(5-8-22(41)42)26(47)35-19(12-52)29(50)51/h14-19,52H,3-12H2,1-2H3,(H,30,36)(H,31,45)(H,32,48)(H,33,49)(H,34,46)(H,35,47)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,50,51)/t14-,15-,16-,17-,18-,19-/m0/s1
  • InChiKey: VGFHUYLCQHZNFZ-DYKIIFRCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-hydroxy-5-oxo-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-5-[[(1S)-4-hydroxy-1-[[(1R)-2-hydroxy-2-oxo-1-(sulfanylmethyl)ethyl]carbamoyl]-4-oxo-butyl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-1,4-dioxobutyl]amino]-5-hydroxy-1,5-dioxopentyl]amino]-4-(methylthio)-1-oxobutyl]amino]-5-[[(1S)-4-hydroxy-1-[[[(1R)-2-hydroxy-1-(mercaptomethyl)-2-oxoethyl]amino]-oxomethyl]-4-oxobutyl]amino]-5-oxopentanoic acid
  • (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-hydroxy-5-oxo-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-5-[[(2S)-5-hydroxy-1-[[(2R)-1-hydroxy-1-oxo-3-sulfanyl-propan-2-yl]amino]-1,5-dioxo-pentan-2-yl]amino]-5-oxo-pentanoic acid
  • (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-4-keto-butanoyl]amino]-5-hydroxy-5-keto-pentanoyl]amino]-4-(methylthio)butanoyl]amino]-5-[[(1S)-4-hydroxy-1-[[(1R)-2-hydroxy-2-keto-1-(mercaptomethyl)ethyl]carbamoyl]-4-keto-butyl]amino]-5-keto-valeric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human rhinovirus sp. Human rhinovirus A protease Starlite/ChEMBL References
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PAN domain-containing protein 0.0156 0.0232 0.0379
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0262 0.0469 0.0699
Schistosoma mansoni heat shock protein 0.0141 0.0199 0.0178
Onchocerca volvulus 0.0156 0.0232 0.1231
Echinococcus multilocularis SWI:SNF matrix associated 0.0187 0.0302 0.045
Schistosoma mansoni ephrin receptor 0.0063 0.0027 0.0005
Echinococcus multilocularis jun protein 0.0092 0.009 0.0134
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0262 0.0469 0.0699
Brugia malayi G protein-coupled receptor F59B2.13 0.0262 0.0469 0.0684
Toxoplasma gondii heat shock protein HSP90 0.0141 0.0199 0.0316
Echinococcus granulosus glutamate NMDA receptor subunit 0.0269 0.0483 0.0722
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) neuropeptide F receptor 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0019
Onchocerca volvulus 0.0262 0.0469 0.2611
Schistosoma mansoni hypothetical protein 0.0328 0.0614 0.0593
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Echinococcus granulosus fmrfamide receptor 0.0262 0.0469 0.0699
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0019
Trichomonas vaginalis heat shock protein, putative 0.0128 0.017 0.2812
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0328 0.0614 0.0906
Echinococcus multilocularis g-protein coupled receptor 0.0262 0.0469 0.0699
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0022 0.0032
Onchocerca volvulus 0.0262 0.0469 0.2611
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0262 0.0469 0.0684
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3069 0.6699 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0022 0.0032
Brugia malayi neuropeptide F receptor 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0156 0.0232 0.1231
Schistosoma mansoni fusion 0.0067 0.0034 0.0012
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Echinococcus multilocularis SWI:SNF matrix associated 0.0187 0.0302 0.045
Loa Loa (eye worm) PAN domain-containing protein 0.0156 0.0232 0.0323
Schistosoma mansoni amine GPCR 0.0262 0.0469 0.0448
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0187 0.0302 0.0428
Onchocerca volvulus 0.0262 0.0469 0.2611
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Schistosoma mansoni opsin-like receptor 0.0262 0.0469 0.0448
Schistosoma mansoni amine GPCR 0.0262 0.0469 0.0448
Echinococcus granulosus heat shock protein 0.0141 0.0199 0.0297
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0262 0.0469 0.0699
Giardia lamblia Grp94/Hsp90 0.0128 0.017 0.813
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.016 0.0242 0.0361
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0115 0.0141 0.1472
Onchocerca volvulus 0.0262 0.0469 0.2611
Brugia malayi hypothetical protein 0.1788 0.3855 0.5869
Echinococcus granulosus neuropeptides capa receptor 0.0262 0.0469 0.0699
Schistosoma mansoni histamine h1 receptor 0.0262 0.0469 0.0448
Echinococcus granulosus 7TM GPCR rhodopsin 0.0262 0.0469 0.0699
Onchocerca volvulus 0.007 0.0041 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Echinococcus multilocularis orexin receptor type 2 0.0262 0.0469 0.0699
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1426 0.3052 0.4556
Schistosoma mansoni jun-related protein 0.0074 0.0051 0.003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0262 0.0469 0.0684
Echinococcus multilocularis heat shock protein 90 0.0128 0.017 0.0253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0022 0.0032
Toxoplasma gondii PAN domain-containing protein 0.2423 0.5265 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0019
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0187 0.0302 0.0512
Brugia malayi Dopamine receptor protein 1 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0262 0.0469 0.2611
Echinococcus granulosus neuropeptide Y receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0262 0.0469 0.0699
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0262 0.0469 0.0699
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.016 0.0242 0.0361
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0067 0.0034 0.0051
Echinococcus granulosus SWI:SNF matrix associated 0.0187 0.0302 0.045
Onchocerca volvulus 0.0156 0.0232 0.1231
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1426 0.3052 0.4556
Echinococcus granulosus alpha 1A adrenergic receptor 0.0262 0.0469 0.0699
Schistosoma mansoni hypothetical protein 0.0262 0.0469 0.0448
Plasmodium falciparum heat shock protein 90 0.0141 0.0199 0.6178
Brugia malayi follicle stimulating hormone receptor 0.0262 0.0469 0.0684
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) bone morphogenic protein 6 0.0132 0.0178 0.0239
Echinococcus multilocularis GPCR, family 2 0.0765 0.1584 0.2364
Echinococcus multilocularis neuropeptide FF receptor 2 0.0721 0.1488 0.2221
Echinococcus granulosus sodium channel protein 0.0553 0.1113 0.1662
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus tachykinin peptides receptor 99D 0.0262 0.0469 0.0699
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus neuropeptides capa receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis neuropeptides capa receptor 0.0262 0.0469 0.0699
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0156 0.0232 0.0379
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.016 0.0242 0.0361
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0022 0.0032
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0067 0.0034 0.0071
Schistosoma mansoni biogenic amine receptor 0.0262 0.0469 0.0448
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.0498 0.0729
Echinococcus multilocularis G protein coupled receptor 139 0.0414 0.0804 0.1201
Brugia malayi Thioredoxin family protein 0.007 0.0041 0.003
Trichomonas vaginalis heat shock protein, putative 0.0128 0.017 0.2812
Onchocerca volvulus Neuropeptide F receptor homolog 0.0262 0.0469 0.2611
Onchocerca volvulus 0.0187 0.0302 0.1635
Onchocerca volvulus 0.0067 0.0034 0.0071
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) PAN domain-containing protein 0.0156 0.0232 0.0323
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0138 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.0302 0.5697
Loa Loa (eye worm) voltage-dependent calcium channel 0.016 0.0242 0.0337
Schistosoma mansoni hypothetical protein 0.0328 0.0614 0.0593
Brugia malayi Dopamine receptor protein 2 0.0262 0.0469 0.0684
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0138 0.0207
Echinococcus granulosus neuropeptide s receptor 0.076 0.1573 0.2348
Schistosoma mansoni RNA binding protein 0.0067 0.0034 0.0012
Onchocerca volvulus 0.0156 0.0232 0.1231
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi Dopamine receptor 0.0262 0.0469 0.0684
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0022 0.0032
Echinococcus granulosus serotonin receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis heat shock protein 0.0141 0.0199 0.0297
Echinococcus multilocularis endoplasmin 0.0128 0.017 0.0253
Toxoplasma gondii microneme protein MIC17C 0.0156 0.0232 0.0379
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Toxoplasma gondii transporter, cation channel family protein 0.016 0.0242 0.0397
Toxoplasma gondii subtilisin SUB12 0.0156 0.0232 0.0379
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0022 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis dro:myosuppressin receptor 0.0262 0.0469 0.0699
Echinococcus granulosus tm gpcr rhodopsin 0.2875 0.6268 0.9357
Trypanosoma brucei C-8 sterol isomerase, putative 0.0393 0.0759 1
Echinococcus granulosus G protein coupled receptor 139 0.0262 0.0469 0.0699
Toxoplasma gondii PAN domain-containing protein 0.0156 0.0232 0.0379
Echinococcus granulosus jun protein 0.0092 0.009 0.0134
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.0199 0.2281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0022 0.0032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Schistosoma mansoni amine GPCR 0.0262 0.0469 0.0448
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0135 0.2057
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0187 0.0302 0.045
Echinococcus granulosus g protein coupled receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0262 0.0469 0.0684
Echinococcus granulosus hypothetical protein 0.0262 0.0469 0.0699
Echinococcus multilocularis zinc finger protein Ran binding 0.0067 0.0034 0.0051
Schistosoma mansoni amine GPCR 0.0262 0.0469 0.0448
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0187 0.0302 0.045
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0187 0.0302 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0262 0.0469 0.0448
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0067 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0832 0.1733 0.1715
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0133 0.0182 0.0272
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.016 0.0242 0.0361
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0262 0.0469 0.0684
Echinococcus granulosus adenylate cyclase 9 0.0064 0.0028 0.0041
Schistosoma mansoni brg-1 associated factor 0.0187 0.0302 0.028
Schistosoma mansoni zinc finger protein 0.0067 0.0034 0.0012
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Trypanosoma cruzi Heat shock protein 83, putative 0.0141 0.0199 0.2281
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0262 0.0469 0.0699
Schistosoma mansoni neuropeptide receptor 0.0262 0.0469 0.0448
Echinococcus granulosus Zinc finger RanBP2 type 0.0067 0.0034 0.0051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0022 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0135 0.0114
Schistosoma mansoni hypothetical protein 0.0262 0.0469 0.0448
Onchocerca volvulus 0.0262 0.0469 0.2611
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0135 0.2057
Schistosoma mansoni hypothetical protein 0.0074 0.0051 0.003
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0112 0.0135 0.0202
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0199 0.2281
Giardia lamblia Heat shock protein HSP 90-alpha 0.0141 0.0199 1
Onchocerca volvulus 0.0262 0.0469 0.2611
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0135 0.2057
Schistosoma mansoni hypothetical protein 0.0765 0.1584 0.1565
Brugia malayi putative neuropeptide receptor NPR1 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0064 0.0028 0.0009
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.0199 1
Schistosoma mansoni hypothetical protein 0.0765 0.1584 0.1565
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus multilocularis somatostatin receptor 0.0262 0.0469 0.0699
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0128 0.017 0.0253
Echinococcus multilocularis serotonin receptor 0.0262 0.0469 0.0699
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Toxoplasma gondii microneme protein, putative 0.0156 0.0232 0.0379
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0201 0.0332 0.0475
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni protein kinase 0.0133 0.0182 0.0161
Schistosoma mansoni neuropeptide receptor 0.0262 0.0469 0.0448
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0067 0.0034 0.0019
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0116 0.0144 0.0187
Loa Loa (eye worm) apoptosis regulator protein 0.0328 0.0614 0.0906
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Onchocerca volvulus 0.0156 0.0232 0.1231
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0262 0.0469 0.0699
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0262 0.0469 0.0448
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Onchocerca volvulus 0.0262 0.0469 0.2611
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.0614 0.0906
Schistosoma mansoni adenoreceptor 0.0262 0.0469 0.0448
Brugia malayi G-protein coupled receptor 0.0262 0.0469 0.0684
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.009 0.0134
Trypanosoma cruzi heat shock protein 90, putative 0.0114 0.014 0.146
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2342 0.5085 0.7752
Onchocerca volvulus 0.0067 0.0034 0.0071
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Brugia malayi Latrophilin receptor protein 2 0.0765 0.1584 0.2391
Schistosoma mansoni hypothetical protein 0.0765 0.1584 0.1565
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0089 0.0084 0.0095
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0072 0.0046 0.0142
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0177 0.0279 0.1501
Loa Loa (eye worm) hypothetical protein 0.0832 0.1733 0.262
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0141 0.1472
Echinococcus multilocularis neuropeptides capa receptor 0.0262 0.0469 0.0699
Brugia malayi RE15519p 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0156 0.0232 0.1231
Echinococcus granulosus neuropeptide Y receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0022 0.0032
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Onchocerca volvulus 0.0156 0.0232 0.1231
Echinococcus granulosus orexin receptor type 2 0.0262 0.0469 0.0699
Echinococcus multilocularis fmrfamide receptor 0.0262 0.0469 0.0699
Trypanosoma brucei hypothetical protein 0.0115 0.0141 0.1472
Loa Loa (eye worm) hypothetical protein 0.0393 0.0759 0.1128
Brugia malayi YY1-associated factor 2 0.0067 0.0034 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Mycobacterium ulcerans heat shock protein 90 0.0128 0.017 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0328 0.0614 0.0593
Giardia lamblia Heat shock protein HSP 90-alpha 0.0128 0.017 0.813
Onchocerca volvulus 0.0067 0.0034 0.0071
Onchocerca volvulus 0.0067 0.0034 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0765 0.1584 0.2391
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0022 0.0032
Schistosoma mansoni neuropeptide receptor 0.0414 0.0804 0.0784
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0141 0.0989
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus multilocularis neuropeptide receptor 0.0414 0.0804 0.1201
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0116 0.0144 0.0187
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0328 0.0614 0.0916
Echinococcus granulosus endoplasmin 0.0128 0.017 0.0253
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0262 0.0469 0.2611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0765 0.1584 0.2364
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0019
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0393 0.0759 0.1128
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Brugia malayi Serotonin receptor 0.0262 0.0469 0.0684
Toxoplasma gondii hypothetical protein 0.0156 0.0232 0.0379
Loa Loa (eye worm) hypothetical protein 0.016 0.0242 0.0337
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.3069 0.6699 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0067 0.0034 0.0051
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0262 0.0469 0.0684
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0199 0.2281
Echinococcus granulosus ephrin type A receptor 4 A 0.0063 0.0027 0.004
Brugia malayi Serotonin receptor 0.0262 0.0469 0.0684
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0553 0.1113 1
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.0288 0.1555
Echinococcus multilocularis G-protein coupled receptor, putative 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0262 0.0469 0.2611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0068 0.2064
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0721 0.1488 0.2244
Echinococcus multilocularis g protein coupled receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0269 0.0483 0.0722
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0022 0.0032
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0174 0.0272 0.0384
Onchocerca volvulus 0.0156 0.0232 0.1231
Brugia malayi neuropeptide F receptor 0.0262 0.0469 0.0684
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Loa Loa (eye worm) TK/EPH protein kinase 0.008 0.0065 0.0066
Chlamydia trachomatis DNA topoisomerase I 0.0187 0.0302 1
Echinococcus multilocularis serotonin receptor 0.0262 0.0469 0.0699
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0132 0.0178 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0022 0.0032
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Echinococcus granulosus heat shock protein 90 0.0128 0.017 0.0253
Schistosoma mansoni biogenic amine (5HT) receptor 0.0262 0.0469 0.0448
Toxoplasma gondii hypothetical protein 0.011 0.0131 0.0186
Loa Loa (eye worm) PAN domain-containing protein 0.0156 0.0232 0.0323
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0187 0.0302 0.0512
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.016 0.0242 0.2868
Echinococcus granulosus heat shock protein 90 0.0141 0.0199 0.0297
Toxoplasma gondii PAN domain-containing protein 0.2423 0.5265 1
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Onchocerca volvulus 0.0262 0.0469 0.2611
Schistosoma mansoni neuropeptide F-like receptor 0.0262 0.0469 0.0448
Brugia malayi Caveolin-1 0.0521 0.1042 0.1562
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.0199 0.2281
Echinococcus granulosus biogenic amine 5HT receptor 0.0262 0.0469 0.0699
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.0199 0.2281
Schistosoma mansoni apoptosis regulator bax 0.0328 0.0614 0.0593
Schistosoma mansoni hypothetical protein 0.0067 0.0034 0.0012
Brugia malayi sulfakinin receptor protein 0.1788 0.3855 0.5869
Echinococcus granulosus neuropeptide receptor 0.0262 0.0469 0.0699
Echinococcus granulosus g protein coupled receptor 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0063 0.0025 0.0005
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0132 0.0178 0.0266
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Loa Loa (eye worm) brahma associated protein 0.0187 0.0302 0.0428
Toxoplasma gondii PAN domain-containing protein 0.0156 0.0232 0.0379
Brugia malayi brahma associated protein 60 kDa 0.0187 0.0302 0.0428
Schistosoma mansoni hypothetical protein 0.007 0.0041 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0131 0.0167
Echinococcus granulosus GPCR family 2 0.0765 0.1584 0.2364
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0553 0.1113 0.1662
Toxoplasma gondii heat shock protein 90, putative 0.0141 0.0199 0.0316
Loa Loa (eye worm) hypothetical protein 0.0521 0.1042 0.1562
Echinococcus granulosus somatostatin receptor 0.0262 0.0469 0.0699
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Schistosoma mansoni endoplasmin 0.0141 0.0199 0.0178
Loa Loa (eye worm) PAN domain-containing protein 0.0156 0.0232 0.0323
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0128 0.017 1
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0309 0.5868
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Schistosoma mansoni opsin-like receptor 0.0262 0.0469 0.0448
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0141 0.0989
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0288 0.5395
Echinococcus multilocularis fmrfamide receptor 0.0262 0.0469 0.0699
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.016 0.0242 0.0361
Loa Loa (eye worm) endoplasmin 0.0141 0.0199 0.0272
Loa Loa (eye worm) hypothetical protein 0.1788 0.3855 0.5869
Trypanosoma cruzi heat shock protein 85, putative 0.0128 0.017 0.1873
Schistosoma mansoni hypothetical protein 0.0262 0.0469 0.0448
Brugia malayi Endoplasmin precursor 0.0141 0.0199 0.0272
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.0199 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Toxoplasma gondii microneme protein MIC4 0.0156 0.0232 0.0379
Schistosoma mansoni hypothetical protein 0.0765 0.1584 0.1565
Echinococcus multilocularis Transglutaminase 0.007 0.0041 0.0061
Schistosoma mansoni myosin xvIII 0.0262 0.0469 0.0448
Schistosoma mansoni biogenic amine receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Schistosoma mansoni biogenic amine (5HT) receptor 0.0262 0.0469 0.0448
Onchocerca volvulus 0.0262 0.0469 0.2611
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Schistosoma mansoni hypothetical protein 0.0187 0.0302 0.028
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Schistosoma mansoni neuropeptide F-like receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) hypothetical protein 0.1577 0.3388 0.5153
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus granulosus 7tm_1 domain containing protein 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Echinococcus granulosus dro:myosuppressin receptor 0.0262 0.0469 0.0699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Loa Loa (eye worm) hypothetical protein 0.011 0.0131 0.0167
Echinococcus multilocularis adenylate cyclase type IX 0.009 0.0085 0.0127
Onchocerca volvulus 0.0262 0.0469 0.2611
Echinococcus granulosus neuropeptide receptor A26 0.076 0.1573 0.2348
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0187 0.0302 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.016 0.0242 0.0337
Loa Loa (eye worm) PAN domain-containing protein 0.0156 0.0232 0.0323
Echinococcus multilocularis neuropeptide receptor A26 0.076 0.1573 0.2348
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Trypanosoma brucei calpain, putative 0.0115 0.0141 0.1472
Toxoplasma gondii hypothetical protein 0.0156 0.0232 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0309 0.5868
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0328 0.0614 0.0916
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0128 0.017 0.1258
Schistosoma mansoni growth hormone secretagogue receptor 0.0262 0.0469 0.0448
Trichomonas vaginalis heat shock protein, putative 0.0141 0.0199 0.3459
Schistosoma mansoni neuropeptide f receptor 76f 0.0262 0.0469 0.0448
Brugia malayi putative neuropeptide receptor 0.0262 0.0469 0.0684
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0262 0.0469 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Onchocerca volvulus 0.0156 0.0232 0.1231
Schistosoma mansoni hypothetical protein 0.0328 0.0614 0.0593
Brugia malayi phosphoinositide-dependent protein kinase I 0.0112 0.0135 0.0174
Echinococcus granulosus neuropeptide receptor 0.0414 0.0804 0.1201
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0483 0.0463
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.016 0.0242 0.0361
Loa Loa (eye worm) hypothetical protein 0.3003 0.6554 1
Schistosoma mansoni TRABID protein (C64 family) 0.0067 0.0034 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Echinococcus granulosus ring and YY1 binding protein 0.0067 0.0034 0.0051
Onchocerca volvulus 0.0156 0.0232 0.1231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Brugia malayi G protein-coupled receptor 0.0262 0.0469 0.0684
Echinococcus multilocularis neuropeptide Y receptor 0.0262 0.0469 0.0699
Brugia malayi ORL1-like opioid receptor 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Trypanosoma brucei Heat shock protein 83, putative 0.0141 0.0199 0.2281
Echinococcus granulosus g protein coupled receptor 0.0262 0.0469 0.0699
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0262 0.0469 0.0448
Treponema pallidum heat shock protein 90 0.0128 0.017 1
Schistosoma mansoni hypothetical protein 0.0312 0.058 0.0559
Echinococcus granulosus tm gpcr rhodopsin 0.0262 0.0469 0.0699
Onchocerca volvulus 0.0064 0.0028 0.0035
Brugia malayi Melatonin receptor type 1A 0.0262 0.0469 0.0684
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.0498 0.0729
Brugia malayi GnHR receptor homolog 0.0262 0.0469 0.0684
Schistosoma mansoni hypothetical protein 0.0187 0.0302 0.028
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.016 0.0242 0.0361
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0262 0.0469 0.0684
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0128 0.017 1
Brugia malayi latrophilin 2 splice variant baaae 0.1577 0.3388 0.5153
Loa Loa (eye worm) G-protein coupled receptor 0.0262 0.0469 0.0684
Echinococcus granulosus voltage dependent calcium channel 0.016 0.0242 0.0361
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0022 0.0032
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0262 0.0469 0.0699
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0133 0.0182 0.0272
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0262 0.0469 0.0699
Onchocerca volvulus 0.0262 0.0469 0.2611
Chlamydia trachomatis SWIB complex protein 0.0187 0.0302 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0115 0.0141 0.1472
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0262 0.0469 0.0699
Echinococcus granulosus neuropeptide FF receptor 2 0.0721 0.1488 0.2221
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0262 0.0469 0.0699
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0765 0.1584 0.2391
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0498 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Echinococcus multilocularis voltage dependent calcium channel 0.016 0.0242 0.0361
Onchocerca volvulus 0.0832 0.1733 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Echinococcus multilocularis sex peptide receptor 0.0262 0.0469 0.0699
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0067 0.0034 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0765 0.1584 0.2364
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0393 0.0759 1
Echinococcus granulosus zinc finger protein Ran binding 0.0067 0.0034 0.0051
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0187 0.0302 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi Tachykinin-like peptides receptor 99D 0.0721 0.1488 0.2244
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0262 0.0469 0.0448
Echinococcus multilocularis sodium channel protein 0.0553 0.1113 0.1662
Trypanosoma brucei RNA helicase, putative 0.0312 0.058 0.7528
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Schistosoma mansoni voltage-gated cation channel 0.016 0.0242 0.0221
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.0469 0.0684
Echinococcus multilocularis ring and YY1 binding protein 0.0067 0.0034 0.0051
Echinococcus multilocularis g protein coupled receptor 0.0262 0.0469 0.0699
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0022 0.0032
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0064 0.0028 0.0035
Schistosoma mansoni alpha-1 adrenergic receptor 0.0262 0.0469 0.0448
Brugia malayi brahma associated protein 60 kDa 0.0187 0.0302 0.0428
Onchocerca volvulus 0.0061 0.0022 0.0000063448
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Schistosoma mansoni endoplasmin 0.0141 0.0199 0.0178
Brugia malayi G-protein coupled receptor 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi Adenylyl cyclase protein 0.0064 0.0028 0.0009
Trypanosoma brucei calpain-like protein, putative 0.0115 0.0141 0.1472
Loa Loa (eye worm) hypothetical protein 0.0765 0.1584 0.2391
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0068 0.2064
Schistosoma mansoni hypothetical protein 0.0187 0.0302 0.028
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi larval opioid receptor 0.0262 0.0469 0.0684
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0141 0.1472
Brugia malayi Transforming growth factor beta like domain containing protein 0.0132 0.0178 0.0239
Echinococcus granulosus g-protein coupled receptor 0.0262 0.0469 0.0699
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0262 0.0469 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Brugia malayi Calcitonin receptor-like protein seb-1 0.2342 0.5085 0.7752
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.016 0.0242 0.2868
Onchocerca volvulus 0.0262 0.0469 0.2611
Schistosoma mansoni heat shock protein 0.0141 0.0199 0.0178
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) hypothetical protein 0.016 0.0242 0.0337
Plasmodium vivax hypothetical protein, conserved 0.0187 0.0302 1
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0138 0.0207
Brugia malayi hypothetical protein 0.0072 0.0046 0.0037
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.016 0.0242 0.0221
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Loa Loa (eye worm) G-protein coupled receptor 0.0262 0.0469 0.0684
Brugia malayi heat shock protein 90 0.0141 0.0199 0.0272
Trichomonas vaginalis heat shock protein, putative 0.0128 0.017 0.2812
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0128 0.017 0.5
Toxoplasma gondii PAN domain-containing protein 0.0156 0.0232 0.0379
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.009 0.0134
Echinococcus multilocularis voltage dependent calcium channel 0.016 0.0242 0.0361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0022 0.0032
Loa Loa (eye worm) melatonin receptor type 1A 0.0262 0.0469 0.0684
Toxoplasma gondii PAN/Apple domain-containing protein 0.0156 0.0232 0.0379
Echinococcus granulosus allatostatin A receptor 0.0832 0.1733 0.2587
Onchocerca volvulus 0.0262 0.0469 0.2611
Echinococcus multilocularis neuropeptide receptor 0.0262 0.0469 0.0699
Echinococcus granulosus sex peptide receptor 0.0262 0.0469 0.0699
Echinococcus granulosus adenylate cyclase type IX 0.009 0.0085 0.0127
Echinococcus granulosus Transglutaminase 0.007 0.0041 0.0061
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0067 0.0034 0.0019
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Schistosoma mansoni amine GPCR 0.0262 0.0469 0.0448
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0262 0.0469 0.0699
Brugia malayi SWIB/MDM2 domain containing protein 0.0187 0.0302 0.0428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Trypanosoma brucei heat shock protein, putative 0.0141 0.0199 0.2281
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0141 0.0989
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0262 0.0469 0.0448
Schistosoma mansoni serine-type protease inhibitor 0.4556 1 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Schistosoma mansoni hypothetical protein 0.0262 0.0469 0.0448
Echinococcus granulosus peptide allatostatin:somatostatin 0.0262 0.0469 0.0699
Schistosoma mansoni neuropeptide receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) calcium channel 0.016 0.0242 0.0337
Echinococcus multilocularis adenylate cyclase 9 0.0064 0.0028 0.0041
Trypanosoma cruzi heat shock protein 90, putative 0.0128 0.017 0.1873
Loa Loa (eye worm) adenylyl cyclase 3 0.0151 0.0221 0.0305
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.016 0.0242 0.0221
Schistosoma mansoni hypothetical protein 0.1577 0.3388 0.3373
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0135 0.0174
Echinococcus multilocularis neuropeptide s receptor 0.076 0.1573 0.2348
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0262 0.0469 0.0699
Toxoplasma gondii microneme protein MIC17B 0.0156 0.0232 0.0379
Brugia malayi hypothetical protein 0.0262 0.0469 0.0684
Brugia malayi Protein kinase domain containing protein 0.0112 0.0135 0.0174
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0067 0.0034 0.0019
Schistosoma mansoni biogenic amine receptor 0.0262 0.0469 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0262 0.0469 0.0448
Onchocerca volvulus 0.0156 0.0232 0.1231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Loa Loa (eye worm) hypothetical protein 0.0262 0.0469 0.0684
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0187 0.0302 0.045
Echinococcus multilocularis neuropeptide Y receptor 0.0262 0.0469 0.0699
Schistosoma mansoni opsin-like receptor 0.0262 0.0469 0.0448
Loa Loa (eye worm) neuropeptide F receptor 0.0262 0.0469 0.0684
Brugia malayi bZIP transcription factor family protein 0.0092 0.009 0.0104
Onchocerca volvulus 0.0063 0.0025 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0262 0.0469 0.0448
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.0199 0.2281
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0022 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2875 0.6268 0.9357
Echinococcus granulosus rhodopsin orphan GPCR 0.0262 0.0469 0.0699
Leishmania major heat shock protein 83-1 0.0141 0.0199 0.1532
Schistosoma mansoni protein kinase 0.0133 0.0182 0.0161
Loa Loa (eye worm) hypothetical protein 0.0156 0.0232 0.0323
Echinococcus multilocularis ephrin type A receptor 4 A 0.0063 0.0027 0.004
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0262 0.0469 0.0448
Brugia malayi PAN domain containing protein 0.0156 0.0232 0.0323
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0022 0.0032
Schistosoma mansoni protein kinase 0.0133 0.0182 0.0161
Loa Loa (eye worm) heat shock protein 90 0.0141 0.0199 0.0272
Echinococcus granulosus voltage dependent calcium channel 0.016 0.0242 0.0361
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0262 0.0469 0.0448
Echinococcus granulosus tm gpcr rhodopsin 0.0262 0.0469 0.0699
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0262 0.0469 0.0699
Echinococcus multilocularis allatostatin A receptor 0.0832 0.1733 0.2587
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0141 0.1472
Toxoplasma gondii microneme protein MIC17A 0.0156 0.0232 0.0379
Echinococcus multilocularis heat shock protein 90 0.0141 0.0199 0.0297
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3003 0.6554 1
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0112 0.0135 0.0202
Onchocerca volvulus 0.0262 0.0469 0.2611
Echinococcus granulosus biogenic amine 5HT receptor 0.0262 0.0469 0.0699
Leishmania major C-8 sterol isomerase-like protein 0.0393 0.0759 0.6716
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0135 0.0174
Brugia malayi AKH receptor 0.0262 0.0469 0.0684

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.36 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length) ChEMBL. 11206459
Ki (binding) = 0.36 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length) ChEMBL. 11206459
Ki (binding) = 0.5 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain) ChEMBL. 11206459
Ki (binding) = 0.5 uM Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain) ChEMBL. 11206459
Ki (binding) = 0.6 uM Binding affinity against Protease ChEMBL. 10669559
Ki (binding) = 0.6 uM Inhibitory constant of the compound against hepatitis C virus NS3 protease ChEMBL. 15633995
Ki (binding) = 0.6 uM Binding affinity against Protease ChEMBL. 10669559
Ki (binding) = 0.6 uM Inhibitory constant of the compound against hepatitis C virus NS3 protease ChEMBL. 15633995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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