Detailed information for compound 1039570

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 279.336 | Formula: C17H17N3O
  • H donors: 1 H acceptors: 2 LogP: 2.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)c1occ(n1)CNCc1cccnc1
  • InChi: 1S/C17H17N3O/c1-13-4-2-6-15(8-13)17-20-16(12-21-17)11-19-10-14-5-3-7-18-9-14/h2-9,12,19H,10-11H2,1H3
  • InChiKey: XNPBYNWUZPXKCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0046 0.0093 0.0463
Leishmania major telomerase reverse transcriptase, putative 0.0694 0.2667 1
Plasmodium falciparum telomerase reverse transcriptase 0.0694 0.2667 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0015 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0146 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Brugia malayi Bromodomain containing protein 0.0043 0.008 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Schistosoma mansoni hypothetical protein 0.0164 0.0562 0.5849
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0093 0.0272
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1034 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0195 0.117
Onchocerca volvulus 0.0108 0.0339 0.0293
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0048 0.0066
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0129 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0048 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0048 0.0497
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0055 0.0129 0.0482
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0048 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0037 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0048 0.0238
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.3026 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0048 0.0184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0048 0.0122
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0212 0.0795
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0046 0.0093 0.0272
Brugia malayi Telomerase reverse transcriptase 0.1848 0.7244 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0212 0.1056
Trypanosoma cruzi DNA polymerase eta, putative 0.0076 0.0213 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0048 0.0184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0213 0.106
Echinococcus multilocularis GA binding protein alpha chain 0.0086 0.0251 0.0798
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0137 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0048 0.0238
Echinococcus multilocularis geminin 0.0164 0.0562 0.1829
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0088 0.0329
Loa Loa (eye worm) glutaminase 2 0.0265 0.0962 0.4789
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0093 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.007 0.0196
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0048 0.0497
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0086 0.0251 0.1252
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0048 0.0238
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0108 0.2099
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0195 0.073
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0339 0.0468
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0055 0.0129 0.0971
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Trypanosoma brucei DNA polymerase eta, putative 0.0076 0.0213 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0046 0.0093 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0048 0.0066
Echinococcus granulosus dna polymerase kappa 0.0046 0.0093 0.041
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0195 0.0609
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0212 0.0795
Schistosoma mansoni hypothetical protein 0.0108 0.0339 0.3527
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0195 0.2023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0048 0.0238
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0048 0.0184
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0077 0.0217 0.338
Schistosoma mansoni bromodomain containing protein 0.007 0.0191 0.1982
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0212 0.1006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0093 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0202 0.1007
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.046 1
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0048 0.0066
Schistosoma mansoni hypothetical protein 0.0164 0.0562 0.5849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0332 0.1608
Schistosoma mansoni glutaminase 0.0265 0.0962 1
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0027
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0108 0.0323
Mycobacterium ulcerans DNA polymerase I 0.0077 0.0217 0.1428
Brugia malayi ecdysteroid receptor 0.0034 0.0048 0.0066
Trichomonas vaginalis glutaminase, putative 0.0265 0.0962 0.9298
Schistosoma mansoni coup transcription factor 0.0034 0.0048 0.0497
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0048 0.0184
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0129 0.0482
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0108 0.0423
Trypanosoma brucei unspecified product 0.0032 0.0037 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0048 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0195 0.2023
Brugia malayi PHD-finger family protein 0.0028 0.0021 0.003
Mycobacterium ulcerans glutaminase 0.0265 0.0962 1
Schistosoma mansoni DNA polymerase eta 0.0076 0.0213 0.2213
Toxoplasma gondii hypothetical protein 0.0026 0.0015 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0048 0.0238
Brugia malayi jmjC domain containing protein 0.0059 0.0146 0.0201
Brugia malayi glutaminase DH11.1 0.0265 0.0962 0.1327
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0077 0.0217 0.4539
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0212 0.137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0332 0.1065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0212 0.0795
Echinococcus granulosus survival motor neuron protein 1 0.0528 0.2008 1
Loa Loa (eye worm) fli-1 protein 0.026 0.0944 0.4699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0048 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0048 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0108 0.0488
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0048 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0137 0.143
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.046 1
Schistosoma mansoni gabp alpha 0.0086 0.0251 0.2615
Mycobacterium ulcerans 5'-3' exonuclease 0.0055 0.0129 0.041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0048 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0048 0.0497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0332 0.3452
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0195 0.117
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0048 0.0122
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0088 0.0329
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0048 0.0497
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0048 0.0497
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0454
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0046 0.0093 0.041
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0694 0.2667 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Toxoplasma gondii RNA-directed DNA polymerase 0.0694 0.2667 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0195 0.2769
Plasmodium vivax telomerase reverse transcriptase, putative 0.0694 0.2667 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0048 0.0066
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0195 0.073
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0027 0.0018 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0048 0.0122
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0048 0.0497
Schistosoma mansoni terminal deoxycytidyl transferase 0.0046 0.0093 0.0967
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0037 0.0137
Brugia malayi Ets-domain containing protein 0.0086 0.0251 0.0347
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0003 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Loa Loa (eye worm) hypothetical protein 0.0079 0.0223 0.1113
Schistosoma mansoni ets-related 0.026 0.0944 0.9812
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1034 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0048 0.0066
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0055 0.0129 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0048 0.0066
Trypanosoma brucei telomerase reverse transcriptase 0.0694 0.2667 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0048 0.0238
Echinococcus granulosus GA binding protein alpha chain 0.0086 0.0251 0.1204
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0093 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0048 0.0066
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0195 0.0919
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Loa Loa (eye worm) glutaminase 0.0265 0.0962 0.4789
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0048 0.0122
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0694 0.2667 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0212 0.1932
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0175 0.0543
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.0332 0.1653
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0048 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0048 0.0066
Brugia malayi nuclear hormone receptor 0.0034 0.0048 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0093 0.0348
Schistosoma mansoni survival motor neuron protein 0.0108 0.0339 0.3527
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0048 0.0122
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0093 0.0348
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0137 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0037 0.0137
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0212 0.0795
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0048 0.0497
Chlamydia trachomatis DNA polymerase I 0.0077 0.0217 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0146 0.1517
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0048 0.0122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0081 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0332 0.3452
Echinococcus multilocularis dna polymerase eta 0.0076 0.0213 0.0669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0332 0.3452
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0015 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0213 0.0294
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0048 0.0497
Trypanosoma brucei unspecified product 0.0032 0.0037 0.0137
Treponema pallidum DNA polymerase I (polA) 0.0077 0.0217 0.1982
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0048 0.0184
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0048 0.0184
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0146 0.0676
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0212 0.0666
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0129 0.0482
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0048 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0212 0.2204
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0146 0.1517
Leishmania major DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Trypanosoma brucei unspecified product 0.0046 0.0093 0.0348
Loa Loa (eye worm) hypothetical protein 0.0528 0.2008 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0088 0.0329
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0129 0.0482
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0048 0.0184
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0048 0.0497
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0046 0.0093 0.0348
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0332 0.1608
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1034 0.3657
Brugia malayi nuclear receptor NHR-88 0.0034 0.0048 0.0066
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0212 0.137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0048 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0048 0.0122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.007 0.0296
Echinococcus multilocularis survival motor neuron protein 1 0.0528 0.2008 0.6622
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0212 0.4425
Brugia malayi steroid hormone receptor 0.0034 0.0048 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0093 0.0348
Giardia lamblia Telomerase catalytic subunit 0.0694 0.2667 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Brugia malayi Fli-1 protein 0.026 0.0944 0.1302
Echinococcus granulosus geminin 0.0164 0.0562 0.2762
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0048 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0175 0.0821
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0238
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0077 0.0217 1
Echinococcus granulosus dna polymerase eta 0.0076 0.0213 0.1011
Leishmania major DNA polymerase eta, putative 0.0076 0.0213 0.0798
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0048 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0048 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0195 0.117
Brugia malayi Ets-domain containing protein 0.0086 0.0251 0.0347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0332 0.1065
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.046 0.4225
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.0332 0.0458
Brugia malayi jmjC domain containing protein 0.0057 0.0137 0.019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0046 0.0093 0.0899
Brugia malayi hypothetical protein 0.0528 0.2008 0.2772
Brugia malayi Probable ClpP-like protease 0.0076 0.0212 0.0293
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1034 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0011 0.0114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0137 0.042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0108 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0048 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0048 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1034 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0093 0.0348
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0496
Brugia malayi Bromodomain containing protein 0.0083 0.0242 0.0334

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -15 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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