Detailed information for compound 1051755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.409 | Formula: C20H28Cl2N10
  • H donors: 4 H acceptors: 0 LogP: 1.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1=NC(N(C(=N1)N)c1cccc2c1cccc2N1C(=NC(=NC1(C)C)N)N)(C)C.Cl.Cl
  • InChi: 1S/C20H26N10.2ClH/c1-19(2)27-15(21)25-17(23)29(19)13-9-5-8-12-11(13)7-6-10-14(12)30-18(24)26-16(22)28-20(30,3)4;;/h5-10H,1-4H3,(H4,21,23,25,27)(H4,22,24,26,28);2*1H
  • InChiKey: DCABCCOTZBDKFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0161 0.0397
Echinococcus granulosus caspase 2 0.0027 0.0098 0.0483
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.001 0.001 0.0012
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0534 0.2699 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0077 0.028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.028 0.069
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0152 0.3323
Brugia malayi Heterochromatin protein 1 0.0141 0.0681 0.0937
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0098 0.0359
Mycobacterium ulcerans hypothetical protein 0.0012 0.0022 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Echinococcus granulosus snurportin 1 0.03 0.1501 0.7498
Echinococcus granulosus geminin 0.0333 0.1666 0.8322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Schistosoma mansoni cpg binding protein 0.0059 0.0263 0.1316
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.104
Leishmania major DNA damage repair protein, putative 0.0012 0.0022 0.0075
Loa Loa (eye worm) glutaminase 0.028 0.1395 0.9289
Brugia malayi chromobox protein homolog 3 0.0079 0.0363 0.05
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trypanosoma brucei unspecified product 0.0039 0.0161 0.0593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.0542
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Brugia malayi Muscleblind-like protein 0.0149 0.0722 0.0994
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.001 0.0012
Toxoplasma gondii exonuclease III APE 0.0038 0.0152 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0016 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0363 0.2598
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Onchocerca volvulus 0.0056 0.0247 0.0246
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0161 0.1048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0146 0.0949
Trichomonas vaginalis glutaminase, putative 0.028 0.1395 1
Echinococcus granulosus cpg binding protein 0.0059 0.0263 0.131
Giardia lamblia Ribonuclease H 0.0022 0.007 0.0256
Loa Loa (eye worm) hypothetical protein 0.0149 0.0722 0.4806
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0098 0.0483
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Echinococcus granulosus carboxylesterase 5A 0.0066 0.03 0.1492
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Mycobacterium ulcerans epoxide hydrolase EphA 0.0158 0.077 0.5029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.057 0.2848
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0093 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0022 0.0075
Entamoeba histolytica Ran family GTPase 0.0021 0.0065 0.1403
Leishmania major DNA polymerase eta, putative 0.0038 0.0155 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.028 0.1033
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.001 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0077 0.028
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Onchocerca volvulus 0.0011 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0534 0.2699 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.0542
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Leishmania major GTP-binding protein, putative 0.0021 0.0065 0.0236
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0295 0.109
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0077 0.1664
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.001 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.001 0.0045
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0146 0.9617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.001 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.001 0.0052
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.008 0.0291
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.007 0.0256
Leishmania major DNA polymerase eta, putative 0.0066 0.0295 0.109
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.0024 0.0146
Trypanosoma brucei polo-like protein kinase 0.0097 0.0455 0.1681
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.003 0.0151
Loa Loa (eye worm) inositol-1 0.0037 0.0146 0.0966
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0161 0.0593
Echinococcus granulosus chromobox protein 1 0.0141 0.0681 0.3396
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0077 0.0104
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.008 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.001 0.0012
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0731
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni acetylcholinesterase 0.0011 0.0016 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0135
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0559
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2002 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.028 0.1398
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0394 0.2819
Trypanosoma brucei metacaspase MCA2 0.0027 0.0098 0.0359
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.028 0.1033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0559
Onchocerca volvulus 0.0011 0.0016 0.0015
Echinococcus granulosus dna polymerase kappa 0.0039 0.0161 0.08
Schistosoma mansoni phosphoglucomutase 0.0022 0.007 0.0352
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0001 0.0007
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0363 0.0362
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0047 0.0063
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0146 0.104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0045
Brugia malayi glutaminase DH11.1 0.028 0.1395 0.1922
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0065 0.0318
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0077 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.065 0.324
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis ran, putative 0.0021 0.0065 0.0457
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0236
Onchocerca volvulus 0.0024 0.0083 0.0082
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0077 0.028
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0022 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0076 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0022
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0022 0.0075
Trypanosoma brucei metacaspase 0.0027 0.0098 0.0359
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.003 0.0144
Schistosoma mansoni cpg binding protein 0.0056 0.0247 0.1234
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Onchocerca volvulus 0.0011 0.0016 0.0015
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0152 0.0987
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0016 0.0037
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0363 0.2598
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0455 0.0454
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Toxoplasma gondii ribonuclease HI protein 0.0022 0.007 0.0256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.065 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.001 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.001 0.0059
Trypanosoma brucei RNA helicase, putative 0.0082 0.0378 0.1396
Echinococcus granulosus ribonuclease H1 0.0022 0.007 0.0345
Schistosoma mansoni hypothetical protein 0.0023 0.0077 0.0384
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0146 0.0725
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0024 0.0146
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0016 0.0037
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0155 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0455 0.2272
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.065 0.324
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0681 0.4876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.001 0.0059
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Schistosoma mansoni DNA polymerase eta 0.0066 0.0295 0.1475
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0158 0.077 0.5029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0152 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0016 0.0098
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0098 0.024
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0394 0.0393
Schistosoma mansoni importin beta-1 0.0028 0.0103 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Echinococcus granulosus acetylcholinesterase 0.0066 0.03 0.1492
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0077 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Onchocerca volvulus 0.0023 0.0077 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Onchocerca volvulus 0.0062 0.0276 0.0275
Plasmodium falciparum metacaspase 1 0.0027 0.0098 0.0359
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.0052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.065 0.4321
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0016 0.0081
Echinococcus multilocularis chromobox protein 1 0.0141 0.0681 0.1684
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.028 0.1824
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0146 0.0359
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0065 0.0236
Brugia malayi ecdysteroid receptor 0.001 0.001 0.0012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0152 0.0987
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.001 0.0009
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0076 0.0534
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0016 0.0081
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0161 0.1048
Echinococcus multilocularis acetylcholinesterase 0.0066 0.03 0.074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0534
Brugia malayi Cell death protein 3 precursor 0.0027 0.0098 0.0133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0505 0.1867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.001 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.001 0.0012
Echinococcus granulosus Chromobox protein 3 0.0023 0.0077 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0098 0.036
Leishmania major telomerase reverse transcriptase, putative 0.0534 0.2699 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.001 0.0059
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.001 0.0052
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.0377
Schistosoma mansoni hypothetical protein 0.03 0.1501 0.75
Onchocerca volvulus Bile acid receptor homolog 0.001 0.001 0.0009
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0098 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0455 0.1681
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0152 0.0559
Brugia malayi Carboxylesterase family protein 0.0066 0.03 0.0412
Schistosoma mansoni chromobox protein 0.0023 0.0077 0.0384
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0001 0.0007
Brugia malayi steroid hormone receptor 0.001 0.001 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Brugia malayi hypothetical protein 0.0023 0.0077 0.0104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.065 0.1607
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0295 0.109
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0022 0.0075
Giardia lamblia DNA damage repair protein 0.0012 0.0022 0.0075
Schistosoma mansoni gliotactin 0.0011 0.0016 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0083 0.0415
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0161 0.1048
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0103 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.1082
Schistosoma mansoni hypothetical protein 0.0333 0.1666 0.8323
Brugia malayi Inositol-1 0.0037 0.0146 0.02
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0455 0.1124
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0394 0.2819
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.001 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.001 0.0012
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0077 0.0104
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0455 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0107 0.0759
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.008 0.0291
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0204 0.1456
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.001 0.0052
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0016 0.0098
Schistosoma mansoni ran 0.0021 0.0065 0.0325
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0455 0.2267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.001 0.0059
Brugia malayi Carboxylesterase family protein 0.0066 0.03 0.0412
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2002 0.4959
Schistosoma mansoni hypothetical protein 0.0082 0.0378 0.1888
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0142 0.101
Trypanosoma brucei metacaspase MCA3 0.0027 0.0098 0.0359
Echinococcus multilocularis muscleblind protein 0.0149 0.0722 0.1787
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0048 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0022 0.0075
Giardia lamblia Telomerase catalytic subunit 0.0534 0.2699 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.001 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0161 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.03 0.1498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.065 0.1607
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0022 0.0075
Brugia malayi RNA, U transporter 1 0.008 0.037 0.0508
Echinococcus multilocularis dna polymerase eta 0.0066 0.0295 0.0728
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.001 0.0009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0161 0.1048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.001 0.0052
Echinococcus multilocularis ribonuclease H1 0.0022 0.007 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Brugia malayi CXXC zinc finger family protein 0.0056 0.0247 0.0339
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.001 0.0052
Echinococcus multilocularis geminin 0.0333 0.1666 0.4126
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0146 0.0537
Trypanosoma brucei telomerase reverse transcriptase 0.0534 0.2699 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0022 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.008 0.0291
Schistosoma mansoni chromobox protein 0.0141 0.0681 0.3401
Echinococcus granulosus dna polymerase eta 0.0066 0.0295 0.1469
Mycobacterium ulcerans glutaminase 0.028 0.1395 0.9123
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0065 0.0236
Echinococcus multilocularis acetylcholinesterase 0.0066 0.03 0.074
Leishmania major DNA polymerase kappa, putative 0.0012 0.0022 0.0075
Echinococcus multilocularis Chromo domain 0.0023 0.0077 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus multilocularis caspase 2 0.0027 0.0098 0.024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0152 0.0559
Plasmodium vivax importin-beta 2, putative 0.0028 0.0103 0.0377
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.028 0.1398
Brugia malayi hypothetical protein 0.0011 0.0016 0.0021
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0022 0.0075
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.0052
Brugia malayi CHD4 protein 0.0026 0.0093 0.0127
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0001 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0161 0.08
Leishmania major importin beta-1 subunit, putative 0.0023 0.0076 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.001 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Echinococcus multilocularis chromobox protein 1 0.0141 0.0681 0.1684
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.001 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0295 0.0405
Plasmodium falciparum metacaspase-like protein 0.0027 0.0098 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Onchocerca volvulus 0.0011 0.0016 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0152 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Loa Loa (eye worm) hypothetical protein 0.0062 0.0276 0.1831
Echinococcus multilocularis neuroligin 0.0011 0.0016 0.0037
Echinococcus granulosus acetylcholinesterase 0.0066 0.03 0.1492
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0077 0.028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.001 0.0045
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0022 0.0075
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0077 0.0542
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.001 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Loa Loa (eye worm) carboxylesterase 0.0011 0.0016 0.0099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Onchocerca volvulus 0.0023 0.0077 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0016 0.0098
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Brugia malayi Protein cec-1. 0.0023 0.0077 0.0104
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Plasmodium vivax metacaspase 1, putative 0.0027 0.0098 0.0359
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0016 0.0107
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.076
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.0377
Echinococcus multilocularis chromobox protein 2 0.0023 0.0077 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.001 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0306 0.1529 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0012
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0077 0.028
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Leishmania major DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0045
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0152 0.0208
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni ap endonuclease 0.0038 0.0152 0.076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0077 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.001 0.0045
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0077 0.0187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.001 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.001 0.0022
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0001 0.0007
Brugia malayi polk-prov protein 0.0012 0.0022 0.0028
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0722 0.1787
Echinococcus granulosus caspase 0.0027 0.0098 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0359
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0146 0.3196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0048 0.0232
Schistosoma mansoni chromobox protein 0.0023 0.0077 0.0384
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0016 0.0074
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Loa Loa (eye worm) heterochromatin protein 1 0.0141 0.0681 0.4529
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0093 0.0228
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0236
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0016 0.0107
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0016 0.0074
Echinococcus granulosus neuroligin 0.0011 0.0016 0.0074
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0077 0.028
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0161 0.0397
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0247 0.1637
Echinococcus granulosus importin subunit beta 1 0.0028 0.0103 0.0509
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0077 0.0542
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0155 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0012
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0161 0.1149
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0152 0.0374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Brugia malayi RNase H family protein 0.0022 0.007 0.0095
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0048 0.0115
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Trichomonas vaginalis helicase, putative 0.0013 0.0024 0.0162
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.007 0.4583
Trypanosoma brucei ribonuclease H1 0.0022 0.007 0.0256
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0161 0.0806
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Entamoeba histolytica hypothetical protein 0.0023 0.0076 0.1641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.003 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Giardia lamblia Kinase, PLK 0.0097 0.0455 0.1681
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trypanosoma brucei unspecified product 0.0027 0.0098 0.036
Trypanosoma brucei Metacaspase-4 0.0027 0.0098 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0245 0.175
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0022 0.0075
Schistosoma mansoni hypothetical protein 0.0398 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0363 0.2414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Schistosoma mansoni chromobox protein 0.0141 0.0681 0.3401
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Echinococcus multilocularis snurportin 1 0.03 0.1501 0.3718
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0077 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Echinococcus granulosus Chromo domain 0.0023 0.0077 0.0377
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0098 0.0359
Giardia lamblia DINP protein human, muc B family 0.0039 0.0161 0.0593
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0065 0.0158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0152 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.0024 0.1777
Brugia malayi Telomerase reverse transcriptase 0.142 0.725 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0127 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.4036 1
Trichomonas vaginalis hypothetical protein 0.0023 0.0077 0.0542
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0098 0.049
Onchocerca volvulus 0.001 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0793
Loa Loa (eye worm) glutaminase 2 0.028 0.1395 0.9289
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0077 0.0377
Loa Loa (eye worm) carboxylesterase 0.0011 0.0016 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0245 0.175
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.001 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0161 0.0806
Mycobacterium tuberculosis Probable oxidoreductase 0.0306 0.1529 1
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.03 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.1989
Echinococcus granulosus chromobox protein 1 0.0141 0.0681 0.3396
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0455 0.3255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0645
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0152 0.0559
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0681 0.4876
Echinococcus multilocularis caspase 8 0.0027 0.0098 0.024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.001 0.0012
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0142 0.101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0059
Brugia malayi SET domain containing protein 0.0024 0.0083 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.001 0.0052
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0455 0.1681
Echinococcus granulosus chromobox protein 2 0.0023 0.0077 0.0377
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0016 0.0074
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Echinococcus multilocularis cpg binding protein 0.0059 0.0263 0.0649
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0236
Schistosoma mansoni hypothetical protein 0.0333 0.1666 0.8323
Loa Loa (eye worm) hypothetical protein 0.0149 0.0722 0.4806
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.03 0.1989
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0022 0.0075
Echinococcus multilocularis FTZ F1 alpha 0.001 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0503
Echinococcus granulosus caspase 8 0.0027 0.0098 0.0483
Schistosoma mansoni cpg binding protein 0.0059 0.0263 0.1316
Schistosoma mansoni kinase 0.0049 0.0211 0.1053
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.003 0.0072
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0142 0.101
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0127 0.082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0112 0.0793
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0359
Schistosoma mansoni carbonyl reductase 0.0008 0.0001 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0161 0.1149
Loa Loa (eye worm) hypothetical protein 0.0066 0.0295 0.1959
Plasmodium vivax telomerase reverse transcriptase, putative 0.0534 0.2699 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.001 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0424
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma brucei unspecified product 0.0024 0.008 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Trypanosoma brucei unspecified product 0.0027 0.0098 0.036
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0077 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0077 0.0542
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0152 0.0559
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0152 0.0753
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0103 0.0377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.028 0.1392
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0093 0.0613
Loa Loa (eye worm) helicase 0.0023 0.0077 0.0503
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0161 0.3529
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0455 0.0626
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.007 0.0496
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0204 0.1456
Plasmodium falciparum telomerase reverse transcriptase 0.0534 0.2699 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0678
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.003 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.001 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0161 0.0593
Schistosoma mansoni glutaminase 0.028 0.1395 0.6968
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.001 0.0012
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0022 0.0075
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0455 0.1681
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.007 0.0256
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0077 0.0542
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0098 0.0097
Toxoplasma gondii RNA-directed DNA polymerase 0.0534 0.2699 1
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.1664
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0455 0.3023
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.049
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0077 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Schistosoma mansoni coup transcription factor 0.001 0.001 0.0052
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni ran 0.0021 0.0065 0.0325
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.007 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.065 0.3245
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0152 0.1005
Leishmania major ribonuclease H1, putative 0.0022 0.007 0.0256
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.1989
Brugia malayi Importin beta-1 subunit 0.0028 0.0103 0.014
Echinococcus multilocularis caspase 0.0027 0.0098 0.024
Loa Loa (eye worm) carboxylesterase 0.0066 0.03 0.1989
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0537
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0022 0.0075
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0093 0.0466
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.001 0.0052
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0077 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0694
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0152 0.1082
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0161 0.0221
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0016 0.0081
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0098 0.049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1501 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.001 0.0045
Echinococcus granulosus muscleblind protein 0.0149 0.0722 0.3603
Leishmania major metacaspase, putative 0.0027 0.0098 0.0359
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.0052
Plasmodium falciparum importin beta, putative 0.0028 0.0103 0.0377
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0077 0.0187
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0001 0.0007
Onchocerca volvulus 0.0011 0.0016 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.028 0.1824
Brugia malayi Carboxylesterase family protein 0.0011 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0645
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0694
Echinococcus granulosus FTZ F1 alpha 0.001 0.001 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0161 0.0593
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0016 0.0037

Activities

Activity type Activity value Assay description Source Reference
Delta MST (functional) = -0.3 day Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 424 mg/kg,administered subcutaneously ChEMBL. 4067999
Delta MST (functional) = 0 day Anti-trypanosomal activity against Trypanosoma rhodesiense infections in mice, 26 mg/kg administered subcutaneously ChEMBL. 4067999
Delta MST (functional) = 0 day Antitrypanosomal activity against Trypanosoma rhodesiense infections in mice, 106 mg/kg administered subcutaneously ChEMBL. 4067999
Toxic (functional) = 3 Antitrypanosomal activity was evaluated against Trypanosoma rhodesiense infections in mice,at dose 424 mg/kg,administered subcutaneously;Toxic ChEMBL. 4067999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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