Detailed information for compound 1066331

Basic information

Technical information
  • TDR Targets ID: 1066331
  • Name: 4-[2-[(6-aminoquinazolin-4-yl)amino]ethyl]ben zamide
  • MW: 307.35 | Formula: C17H17N5O
  • H donors: 3 H acceptors: 3 LogP: 2.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)c(NCCc1ccc(cc1)C(=O)N)ncn2
  • InChi: 1S/C17H17N5O/c18-13-5-6-15-14(9-13)17(22-10-21-15)20-8-7-11-1-3-12(4-2-11)16(19)23/h1-6,9-10H,7-8,18H2,(H2,19,23)(H,20,21,22)
  • InChiKey: HYKGTENANDWVQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[2-[(6-amino-4-quinazolinyl)amino]ethyl]benzamide
  • AIDS-181294
  • AIDS181294
  • Benzamide, 4-[2-[(6-amino-4-quinazolinyl)amino]ethyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.1295 1
Brugia malayi intermediate filament protein 0.0026 0.0452 0.0723
Echinococcus granulosus cyclins 0.0017 0.0225 0.0221
Trypanosoma brucei mitotic cyclin 6 0.0017 0.0225 0.0032
Schistosoma mansoni cyclin B 0.0017 0.0225 0.005
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1059 0.1388
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Trypanosoma cruzi CYC2-like cyclin, putative 0.0017 0.0225 0.0032
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0225 0.0361
Schistosoma mansoni lamin 0.0026 0.0452 0.028
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0701 0.0533
Loa Loa (eye worm) hypothetical protein 0.0058 0.1272 0.2041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1028 0.1647
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.4455 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1059 0.78
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1059 0.78
Brugia malayi cytochrome P450 0.0017 0.0222 0.0353
Mycobacterium leprae putative cytochrome p450 0.0017 0.0222 0.5
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0701 0.0696
Echinococcus granulosus lamin dm0 0.0026 0.0452 0.0448
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.4015 0.8961
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.4455 0.704
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0701 0.4461
Echinococcus granulosus cyclin B 0.0017 0.0225 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0701 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.1295 0.1139
Loa Loa (eye worm) hypothetical protein 0.0049 0.1028 0.1649
Echinococcus granulosus RUN 0.0019 0.0272 0.0268
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0222 0.0879
Onchocerca volvulus 0.0026 0.0452 0.0536
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0182 0.4455 1
Trypanosoma cruzi cyclin, putative 0.0017 0.0225 0.0032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0141 0.0226
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1059 0.7993
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0701 0.0791
Echinococcus granulosus intermediate filament protein 0.0026 0.0452 0.0448
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1059 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0272 0.0268
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.1295 1
Echinococcus granulosus cyclin b3 0.0017 0.0225 0.0221
Trypanosoma brucei protein kinase, putative 0.005 0.1059 0.78
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0439 0.0514
Schistosoma mansoni lipoxygenase 0.008 0.1829 0.1683
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0701 0.0533
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.05 0.0802
Echinococcus granulosus lamin 0.0026 0.0452 0.0448
Echinococcus multilocularis RUN 0.0019 0.0272 0.0268
Schistosoma mansoni cpg binding protein 0.003 0.0541 0.0371
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0701 0.0791
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.4455 0.704
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0439 0.2027
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0225 0.0359
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0701 0.0696
Echinococcus multilocularis lamin 0.0026 0.0452 0.0448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1028 0.1647
Brugia malayi hypothetical protein 0.0019 0.0272 0.0434
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0701 0.4461
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1059 0.78
Loa Loa (eye worm) hypothetical protein 0.0026 0.0452 0.0725
Plasmodium vivax serine/threonine kinase-1, putative 0.0059 0.1295 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0225 0.0359
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1059 0.1971
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0225 0.0361
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0225 0.0221
Giardia lamblia Kinase, CMGC CLK 0.0059 0.1295 0.2529
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1059 0.1388
Plasmodium falciparum protein serine/threonine kinase-1 0.0059 0.1295 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0701 0.0791
Brugia malayi Cytochrome P450 family protein 0.0026 0.0439 0.0702
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1059 0.78
Echinococcus granulosus GPCR family 2 0.0015 0.0177 0.0172
Schistosoma mansoni cytochrome P450 0.0017 0.0222 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0439 0.0705
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0177 0.0172
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0439 0.0705
Leishmania major protein kinase, putative 0.0059 0.1295 1
Echinococcus multilocularis 0.0017 0.0222 0.0217
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0177 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1
Echinococcus granulosus cyclins 0.0017 0.0225 0.0221
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0701 0.1121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0177 0.0172
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0222 0.5
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0701 0.1124
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.4455 0.704
Schistosoma mansoni rab6-interacting 0.0019 0.0272 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Echinococcus granulosus cyclins 0.0017 0.0225 0.0221
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0701 0.4461
Echinococcus multilocularis cyclin B 0.0017 0.0225 0.0221
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.4455 0.704
Schistosoma mansoni lamin 0.0026 0.0452 0.028
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0701 0.4461
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0059 0.1295 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1059 0.1388
Schistosoma mansoni polycystin 1-related 0.0019 0.0272 0.0097
Echinococcus multilocularis musashi 0.0026 0.0452 0.0448
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.1295 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0701 0.0696
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0017 0.0225 0.0032
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0452 0.0725
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1059 0.1388
Loa Loa (eye worm) hypothetical protein 0.0017 0.0225 0.0361
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0439 0.2027
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0439 0.0705
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1142 0.8696
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.271 0.2707
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0272 0.0436
Brugia malayi hypothetical protein 0.0019 0.0272 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1059 0.0898
Leishmania major cyclin 0.0017 0.0225 0.0032
Brugia malayi Cytochrome P450 family protein 0.0017 0.0222 0.0353
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1059 0.1699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0701 0.1124
Brugia malayi Protein kinase domain containing protein 0.0059 0.1295 0.2075
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1059 0.78
Schistosoma mansoni hypothetical protein 0.0033 0.0634 0.0465
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0177 0.0172
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0634 0.1014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0177 0.0283
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0126 0.3015 1
Schistosoma mansoni cpg binding protein 0.003 0.0541 0.0371
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0701 0.0696
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0452 0.0725
Loa Loa (eye worm) hypothetical protein 0.0015 0.0177 0.0283
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Onchocerca volvulus 0.0019 0.0272 0.0111
Onchocerca volvulus 0.0028 0.05 0.0649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0093 0.015
Echinococcus multilocularis GPCR, family 2 0.0015 0.0177 0.0172
Brugia malayi Cytochrome P450 family protein 0.0054 0.1169 0.1873
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0106 0.0101
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1059 0.1055
Echinococcus multilocularis dual specificity protein kinase clk2 0.0059 0.1295 0.1291
Loa Loa (eye worm) cytochrome P450 0.0017 0.0222 0.0356
Echinococcus granulosus hypothetical protein 0.0058 0.1272 0.1268
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.1223 0.9327
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.1223 0.9327
Schistosoma mansoni cpg binding protein 0.0028 0.05 0.0329
Echinococcus multilocularis cyclin b3 0.0017 0.0225 0.0221
Echinococcus multilocularis lamin dm0 0.0026 0.0452 0.0448
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0272 0.0268
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.6234 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0093 0.015
Onchocerca volvulus 0.0026 0.0452 0.0536
Brugia malayi Cytochrome P450 family protein 0.0026 0.0439 0.0702
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.1295 0.1139
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.4455 0.704
Schistosoma mansoni intermediate filament proteins 0.0026 0.0452 0.028
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0182 0.4455 0.7147
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.1223 0.166
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0177 0.0281
Echinococcus granulosus dual specificity protein kinase clk2 0.0059 0.1295 0.1291
Echinococcus multilocularis dnaJ subfamily B 0.0398 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0272 0.0268
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.1295 1
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0222 0.0217
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.4455 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.044 0.0705
Brugia malayi Doublecortin family protein 0.0019 0.0272 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1304 0.1148
Leishmania major protein kinase, putative 0.0059 0.1295 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.1169 0.1875
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0182 0.4455 0.7146
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0056 0.1223 0.9327
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0177 0.0172
Onchocerca volvulus 0.0182 0.4455 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0272 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0106 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Schistosoma mansoni hypothetical protein 0.0017 0.0222 0.0046
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0452 0.0723
Leishmania major cytochrome p450-like protein 0.0026 0.0439 0.2027
Brugia malayi MAP kinase sur-1 0.005 0.1059 0.1697
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0059 0.1295 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0182 0.4455 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0272 0.0437
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1059 0.78
Schistosoma mansoni cyclin B3 0.0017 0.0225 0.005
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0225 0.0359
Brugia malayi CXXC zinc finger family protein 0.0028 0.05 0.08
Echinococcus multilocularis cpg binding protein 0.003 0.0541 0.0537
Schistosoma mansoni loxhd1 0.0019 0.0272 0.0097
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Echinococcus granulosus cyclins 0.0017 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.0013 0.0106 0.0169
Echinococcus multilocularis cyclins 0.0017 0.0225 0.0221
Echinococcus multilocularis cyclin B3 1 0.0017 0.0225 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1028 0.1649
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.4243 0.6687
Trypanosoma cruzi cyclin 6, putative 0.0017 0.0225 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0436
Schistosoma mansoni cyclins 0.0017 0.0225 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1295 0.1781
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.4455 0.704
Schistosoma mansoni hypothetical protein 0.0019 0.0272 0.0097
Echinococcus granulosus cyclin B3 1 0.0017 0.0225 0.0221
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0701 0.0696
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.6234 1
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0439 0.2027
Echinococcus granulosus cpg binding protein 0.003 0.0541 0.0537
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0272 0.0268
Loa Loa (eye worm) hypothetical protein 0.0033 0.0634 0.1017
Echinococcus granulosus cyclins 0.0017 0.0225 0.0221
Schistosoma mansoni rab6-interacting 0.0019 0.0272 0.0097
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.1223 0.166
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0225 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1
Schistosoma mansoni hypothetical protein 0.0398 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0059 0.1295 0.2078
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.4243 0.6687
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.271 0.2707
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1059 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1059 0.1055
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.4015 0.6308
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0272 0.0268
Onchocerca volvulus 0.0019 0.0272 0.0111
Echinococcus multilocularis 0.0058 0.1272 0.1268
Leishmania major hypothetical protein, conserved 0.0056 0.1223 0.9327
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0141 0.0224
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0701 0.1124
Trypanosoma cruzi cyclin, putative 0.0017 0.0225 0.0032
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1059 0.78
Schistosoma mansoni lipoxygenase 0.0114 0.271 0.2579
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0059 0.1295 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.6234 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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