Detailed information for compound 1067151

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 542.544 | Formula: C31H22N6O4
  • H donors: 1 H acceptors: 6 LogP: 3.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1)nccc2Oc1ccc(nc1)NC(=O)c1cc(cn(c1=O)c1ccccc1)c1cnccn1
  • InChi: 1S/C31H22N6O4/c1-40-22-7-9-24-26(16-22)33-12-11-28(24)41-23-8-10-29(35-17-23)36-30(38)25-15-20(27-18-32-13-14-34-27)19-37(31(25)39)21-5-3-2-4-6-21/h2-19H,1H3,(H,35,36,38)
  • InChiKey: KFDHIQVUEANUNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine kinase 2 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Excitatory amino acid transporter 0.0247 0.515 0.803
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0207 0.0323
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0751 0.5147
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0268 0.0501
Entamoeba histolytica hypothetical protein 0.0037 0.0628 0.9308
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Loa Loa (eye worm) acetyltransferase 0.0146 0.2971 0.4576
Echinococcus multilocularis bloom syndrome protein 0.002 0.0268 0.0418
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0251 0.0359
Loa Loa (eye worm) excitatory amino acid transporter 0.0247 0.515 0.7934
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1419 0.2186
Echinococcus granulosus neutral amino acid transporter A 0.0247 0.515 0.803
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0109 0.2186 0.3409
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.515 0.803
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0207 0.1193
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0354 0.1215
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.1012
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.1012
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1419 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1419 0.258
Brugia malayi beta-lactamase 0.0074 0.1419 0.2186
Leishmania major hypothetical protein, conserved 0.0074 0.1419 1
Brugia malayi hypothetical protein 0.0037 0.0628 0.0967
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1419 0.1244
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0052 0.0081
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0268 0.1634
Mycobacterium tuberculosis Conserved protein 0.0074 0.1419 0.1244
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Loa Loa (eye worm) RecQ helicase 0.002 0.0268 0.0413
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Brugia malayi follicle stimulating hormone receptor 0.0239 0.4982 0.7674
Treponema pallidum glutamate transporter 0.0109 0.2186 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1169 0.0989
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0354 0.0546
Echinococcus granulosus excitatory amino acid transporter 2 0.0247 0.515 0.803
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0207 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1169 0.1822
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1419 1
Echinococcus granulosus neutral amino acid transporter 0.0247 0.515 0.803
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.55 0.8472
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0251 0.0386
Brugia malayi hypothetical protein 0.0017 0.0184 0.0284
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0251 0.0391
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.55 0.8472
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1419 0.2213
Trichomonas vaginalis esterase, putative 0.0074 0.1419 0.258
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0674 1
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0354 0.1215
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0268 0.0413
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0109 0.2186 0.3409
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0251 0.0391
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0354 0.5258
Echinococcus multilocularis Excitatory amino acid transporter 0.0247 0.515 0.803
Entamoeba histolytica recQ family helicase, putative 0.002 0.0268 0.3974
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0354 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Loa Loa (eye worm) hypothetical protein 0.0024 0.0354 0.0546
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0251 0.1012
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0251 0.1456
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0268 0.1634
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0251 0.0359
Echinococcus multilocularis excitatory amino acid transporter 2 0.0247 0.515 0.803
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1419 0.1244
Entamoeba histolytica recQ family helicase, putative 0.001 0.0043 0.0639
Echinococcus multilocularis dna polymerase eta 0.002 0.0251 0.0391
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.2971 0.4576
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0381 0.201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.3859 0.6017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1419 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.375 0.6817
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0268 0.0418
Treponema pallidum glutamate/aspartate transporter 0.0109 0.2186 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0268 0.13
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0207 0.0677
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0268 0.13
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0751 0.5147
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0251 0.3719
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Mycobacterium ulcerans lipase LipD 0.0074 0.1419 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0251 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.3859 0.6017
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0247 0.515 0.5052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Entamoeba histolytica recQ family DNA helicase 0.001 0.0052 0.0766
Brugia malayi beta-lactamase family protein 0.0074 0.1419 0.2186
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0207 0.0377
Schistosoma mansoni ap endonuclease 0.0018 0.0207 0.0323
Echinococcus multilocularis Excitatory amino acid transporter 0.0247 0.515 0.803
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.375 0.6817
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Echinococcus granulosus excitatory amino acid transporter 2 0.0247 0.515 0.803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0221 0.0341
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0381 0.371
Leishmania major DNA polymerase eta, putative 0.002 0.0251 0.0359
Mycobacterium tuberculosis Conserved protein 0.0074 0.1419 0.1244
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0268 0.0418
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0052 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.1456
Chlamydia trachomatis glutamate symporter 0.0247 0.515 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0251 0.0391
Mycobacterium tuberculosis Conserved protein 0.0074 0.1419 0.1244
Loa Loa (eye worm) hypothetical protein 0.0024 0.0354 0.0546
Echinococcus granulosus Excitatory amino acid transporter 0.0247 0.515 0.803
Schistosoma mansoni DNA polymerase eta 0.002 0.0251 0.0391
Echinococcus multilocularis excitatory amino acid transporter 2 0.0247 0.515 0.803
Echinococcus granulosus protein tyrosine kinase 0.0305 0.6414 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0247 0.515 0.803
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0251 0.0359
Brugia malayi hypothetical protein 0.0026 0.0381 0.0586
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0075 0.0117
Schistosoma mansoni DNA helicase recq1 0.002 0.0268 0.0418
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0268 0.0413
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0247 0.515 0.803
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1419 0.1244
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0251 0.0456
Brugia malayi Excitatory amino acid transporter 0.0247 0.515 0.7934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0354 0.0158
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1419 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1419 0.2213
Mycobacterium ulcerans hypothetical protein 0.0074 0.1419 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0309 0.6492 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1419 0.258
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1419 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0354 0.1215
Schistosoma mansoni hypothetical protein 0.0037 0.0628 0.0978
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0207 0.1138
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1419 0.1244
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0354 0.1215
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0221 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1419 0.258
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1419 1
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0247 0.515 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1169 0.1822
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Entamoeba histolytica hypothetical protein 0.0037 0.0628 0.9308
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0221 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2882 0.4494
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.3859 0.5945
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0075 0.0117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1169 0.7932
Loa Loa (eye worm) hypothetical protein 0.0018 0.0221 0.0341
Echinococcus granulosus excitatory amino acid transporter 3 0.0247 0.515 0.803
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0221 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.515 0.803
Echinococcus granulosus dna polymerase kappa 0.002 0.0251 0.0391
Schistosoma mansoni DNA helicase recq5 0.002 0.0268 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.3859 0.6017
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1419 0.1244
Mycobacterium ulcerans hypothetical protein 0.0024 0.0354 0.1215
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0268 0.13
Onchocerca volvulus 0.0074 0.1419 0.2755
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1419 0.258
Entamoeba histolytica hypothetical protein 0.0037 0.0628 0.9308
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Loa Loa (eye worm) beta-lactamase 0.0074 0.1419 0.2186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1169 0.7932
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0674 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0628 0.0978
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.1456
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0251 0.0391
Loa Loa (eye worm) hypothetical protein 0.0074 0.1419 0.2186
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.1012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0207 0.3073
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1169 0.7932
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0251 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1419 0.258
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0674 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0268 0.0413
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.3859 0.5945
Giardia lamblia DINP protein human, muc B family 0.002 0.0251 0.0932
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.3549 0.6891
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0247 0.515 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0381 0.2452
Onchocerca volvulus 0.0074 0.1419 0.2755
Mycobacterium ulcerans beta-lactamase 0.0074 0.1419 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.4982 0.7674
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0207 0.0377
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0251 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0386
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0207 0.0729
Leishmania major hypothetical protein, conserved 0.0026 0.0381 0.143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0354 0.5258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0628 0.0978
Loa Loa (eye worm) hypothetical protein 0.0018 0.0221 0.0341
Schistosoma mansoni ap endonuclease 0.0018 0.0207 0.0323
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0751 0.1366
Toxoplasma gondii ABC1 family protein 0.0074 0.1419 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.1012
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0268 0.0487
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0381 0.2405
Trypanosoma brucei unspecified product 0.002 0.0251 0.1012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.2971 0.4632
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0268 0.0487
Mycobacterium leprae Probable lipase LipE 0.0074 0.1419 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0268 0.1144
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1169 0.1822
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1169 0.1822
Echinococcus granulosus sodium:dicarboxylate symporter 0.0247 0.515 0.803
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.2971 0.4632
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0043 0.0067
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0247 0.515 0.803
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0751 0.5147
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1169 0.8179
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0354 0.1215
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.3859 0.6017
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0354 0.1215
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0251 0.0391
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.1456
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.515 0.803
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0354 0.0546
Loa Loa (eye worm) hypothetical protein 0.0018 0.0221 0.0341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1419 0.2213
Brugia malayi Protein kinase domain containing protein 0.0309 0.6492 1
Chlamydia trachomatis neutral amino acid transporter 0.0109 0.2186 0.3987
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0268 0.0487
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1419 0.2186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0381 0.0586
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0052 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.3859 0.6017
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0268 0.0418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1419 0.2213
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0207 0.1138
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.55 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0221 0.0341
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0207 0.0319
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1419 0.1244
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0268 0.0413
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0751 0.1366
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0381 0.2405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1169 0.7932
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0381 0.2452
Brugia malayi beta-lactamase family protein 0.0074 0.1419 0.2186
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.1456
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0251 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0354 0.0546
Leishmania major DNA polymerase kappa, putative 0.002 0.0251 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0354 0.1215
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0221 0.1294
Echinococcus granulosus neutral amino acid transporter A 0.0247 0.515 0.803
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0207 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.3859 0.6017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0207 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1419 1
Entamoeba histolytica hypothetical protein 0.0037 0.0628 0.9308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0354 0.1215
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0251 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0268 0.0413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0354 0.5258
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0751 0.1171
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0354 0.1215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.3859 0.6017
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0247 0.515 0.803
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0268 0.1582
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.2186 0.3409
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0354 0.1215
Onchocerca volvulus 0.0074 0.1419 0.2755
Onchocerca volvulus 0.0024 0.0354 0.0688
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0381 0.371
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0268 0.0418
Echinococcus granulosus dna polymerase eta 0.002 0.0251 0.0391
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0628 0.0978
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.2186 0.3409
Schistosoma mansoni tyrosine kinase 0.0305 0.6414 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0354 0.0546
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3549 0.6453
Echinococcus granulosus bloom syndrome protein 0.002 0.0268 0.0418
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1419 0.1244
Toxoplasma gondii exonuclease III APE 0.0018 0.0207 0.1193
Echinococcus multilocularis protein tyrosine kinase 0.0305 0.6414 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM Inhibition of human Pyk2 by HTRF assay ChEMBL. 19648005
IC50 (binding) > 125 uM Inhibition of human FAK by HTRF assay ChEMBL. 19648005

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.