TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 222.264 | Formula: C10H10N2O2S
H donors: 3 H acceptors: 2 LogP: 0.71 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1O)Cn1cc[nH]c1=S
InChi: 1S/C10H10N2O2S/c13-8-2-1-7(5-9(8)14)6-12-4-3-11-10(12)15/h1-5,13-14H,6H2,(H,11,15)
InChiKey: HODJWVPARHDNHO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Starlite/ChEMBL	References
Bos taurus	Dopamine beta-hydroxylase	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine beta-hydroxylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	dopamine-beta-monooxygenase	Get druggable targets OG5_129281	All targets in OG5_129281
Schistosoma japonicum	ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative	Get druggable targets OG5_129281	All targets in OG5_129281

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase	0.0164	0.0097	0.0097
Brugia malayi	cathepsin L-like precursor	0.0181	0.0164	0.0164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	Cathepsin L-like precursor	0.0181	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Schistosoma mansoni	protein tyrosine phosphatase	0.0164	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Echinococcus multilocularis	hypothetical protein	0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Brugia malayi	hypothetical protein	0.0164	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Onchocerca volvulus		0.0181	0.0164	0.1271
Brugia malayi	hypothetical protein	0.0164	0.0097	0.0097
Echinococcus granulosus	cathepsin l cysteine peptidase	0.027	0.0515	0.0515
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Entamoeba histolytica	cysteine protease, putative	0.027	0.0515	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.019	0.0201	0.0201
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0323	0.0725	0.0725
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.019	0.0201	0.0201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.0164	0.3182
Onchocerca volvulus		0.027	0.0515	0.7975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0345	0.0811	0.0811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0345	0.0811	0.0811
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0181	0.0164	0.0164
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.037	0.0911	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Echinococcus multilocularis	cysteine protease	0.027	0.0515	0.0515
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0297	0.0621	0.6815
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Echinococcus granulosus	cathepsin l1	0.0181	0.0164	0.0164
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0345	0.0811	0.0811
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.019	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Toxoplasma gondii	fructose-bisphospatase II	0.037	0.0911	1
Brugia malayi	Papain family cysteine protease containing protein	0.027	0.0515	0.0515
Leishmania major		0.037	0.0911	1
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Schistosoma mansoni	cathepsin F (C01 family)	0.027	0.0515	0.0515
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.0164	0.3182
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Onchocerca volvulus	Cathepsin L homolog	0.027	0.0515	0.7975
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0323	0.0725	0.0725
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.268	1	1
Loa Loa (eye worm)	hypothetical protein	0.0448	0.1215	0.116
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0164	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Plasmodium vivax	vivapain-2	0.027	0.0515	1
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0448	0.1215	0.1215
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0345	0.0811	0.0811
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Brugia malayi	Cathepsin L-like precursor	0.0181	0.0164	0.0164
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0164	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Echinococcus multilocularis	cathepsin L cysteine protease	0.027	0.0515	0.0515
Onchocerca volvulus		0.027	0.0515	0.7975
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0164	0.0102
Onchocerca volvulus	Cathepsin F homolog	0.027	0.0515	0.7975
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.019	0.0201	0.0201
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0448	0.1215	0.1215
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0848	0.279	0.279
Echinococcus multilocularis	cysteine protease	0.027	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Trypanosoma cruzi	cysteine peptidase, putative	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0323	0.0725	0.0666
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.027	0.0515	0.0515
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0164	0.0097	0.1067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Trypanosoma cruzi	cysteine peptidase, putative	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0164	0.0097	0.0097
Schistosoma mansoni	protein tyrosine phosphatase	0.0164	0.0097	0.0097
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0164	0.0097	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0164	0.0097	0.0097
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0164	0.0097	0.0035
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0164	0.0102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0164	0.0097	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Schistosoma mansoni	cathepsin F (C01 family)	0.027	0.0515	0.0515
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.027	0.0515	0.0455
Leishmania major	cysteine peptidase A (CPA)	0.027	0.0515	0.5132
Onchocerca volvulus		0.0297	0.0621	1
Trypanosoma cruzi	cysteine peptidase, putative	0.027	0.0515	0.5651
Schistosoma mansoni	pcd6 interacting protein-related	0.0164	0.0097	0.0097
Plasmodium falciparum	cysteine proteinase falcipain 3	0.027	0.0515	1
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.037	0.0911	0.0911
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0164	0.0097	0.0097
Trichomonas vaginalis	pten, drome, putative	0.0164	0.0097	0.1889
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.027	0.0515	1
Schistosoma mansoni	peptidylglycine monooxygenase	0.0448	0.1215	0.1215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0297	0.0621	0.0621
Loa Loa (eye worm)	fibroinase	0.027	0.0515	0.0455
Loa Loa (eye worm)	hypothetical protein	0.027	0.0515	0.0455
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0297	0.0621	0.6815
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.037	0.0911	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0227	0.0347	0.0347
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0164	0.0097	0.1889
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0164	0.0097	0.0097
Leishmania major	tyrosine specific protein phosphatase, putative	0.0297	0.0621	0.6435
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.027	0.0515	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Echinococcus multilocularis		0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	ctsf protein	0.027	0.0515	0.0455
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	fructose-1,6-bisphosphatase	0.037	0.0911	0.0911
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0448	0.1215	0.1215
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0164	0.0097	0.0097
Onchocerca volvulus		0.027	0.0515	0.7975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.037	0.0911	0.0911
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0164	0.0097	0.0097
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Schistosoma mansoni	cathepsin F (C01 family)	0.0181	0.0164	0.0164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.027	0.0515	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.027	0.0515	0.0455
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0297	0.0621	0.0621
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.019	0.0201	0.0201
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Trypanosoma cruzi	cysteine peptidase, putative	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0345	0.0811	0.0811
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0221	0.0321	0.0321
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0448	0.1215	0.1215
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0297	0.0621	0.0621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0164	0.0097	0.1889
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Brugia malayi	Protein-tyrosine phosphatase 1	0.0164	0.0097	0.0097
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0181	0.0164	0.1798
Brugia malayi	hypothetical protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0164	0.0097	0.0097
Schistosoma mansoni	protein tyrosine phosphatase	0.019	0.0201	0.0201
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0164	0.0097	0.0035
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0345	0.0811	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0164	0.0097	0.1889
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.027	0.0515	0.0515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0164	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.268	1	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus granulosus	cathepsin l1	0.027	0.0515	0.0515
Echinococcus multilocularis	cathepsin L cysteine protease	0.027	0.0515	0.0515
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0164	0.0097	0.0097
Onchocerca volvulus		0.027	0.0515	0.7975
Giardia lamblia	Protein tyrosine phosphatase	0.0164	0.0097	0.5
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0448	0.1215	0.1215
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0323	0.0725	0.0725
Entamoeba histolytica	cysteine proteinase, putative	0.027	0.0515	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.0164	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Plasmodium vivax	vivapain-2	0.027	0.0515	1
Brugia malayi	hypothetical protein	0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.268	1	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0323	0.0725	0.0725
Onchocerca volvulus		0.027	0.0515	0.7975
Brugia malayi	hypothetical protein	0.0164	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.016	0.0081	0.0018
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0297	0.0621	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0164	0.0097	0.0097
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0164	0.0097	0.0097
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0164	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.027	0.0515	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Onchocerca volvulus	Cathepsin L homolog	0.027	0.0515	0.7975
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.027	0.0515	0.5651
Brugia malayi	Cathepsin L-like precursor	0.027	0.0515	0.0515
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.037	0.0911	0.0911
Brugia malayi	Protein-tyrosine phosphatase	0.019	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0097	0.0035
Entamoeba histolytica	cysteine proteinase, putative	0.027	0.0515	1
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Trypanosoma cruzi	cruzipain precursor, putative	0.027	0.0515	0.5651
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.037	0.0911	0.0853
Leishmania major	cathepsin L-like protease	0.027	0.0515	0.5132
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Onchocerca volvulus		0.027	0.0515	0.7975
Echinococcus granulosus	cathepsin L cysteine proteinase	0.027	0.0515	0.0515
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0164	0.0097	0.1067
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0164	0.0097	0.0035
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0164	0.0097	0.0097
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.037	0.0911	1
Loa Loa (eye worm)	hypothetical protein	0.0448	0.1215	0.116
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0164	0.0097	0.0097
Loa Loa (eye worm)	cysteine protease	0.027	0.0515	0.0455
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0164	0.0097	0.0097
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0164	0.0097	0.0097
Onchocerca volvulus		0.027	0.0515	0.7975
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.268	1	1
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0164	0.0097	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0164	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.0515	1

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log IC50 (binding)	= 5.66	Inhibition of dopamine beta hydroxylase	ChEMBL.	7783140
-Log IC50 (binding)	= 5.66	Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally	ChEMBL.	2296023
IC50 (binding)	= 5.66	Inhibition of dopamine beta hydroxylase	ChEMBL.	7783140
IC50 (binding)	= 5.66	Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally	ChEMBL.	2296023
IC50 (binding)	= 5.66	Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme	ChEMBL.	9435905
IC50 (binding)	= 2.2 uM	Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.1-3.8).	ChEMBL.	3820219
IC50 (binding)	= 2.2 uM	Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.1-3.8).	ChEMBL.	3820219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL67369

Bibliographic References

4 literature references were collected for this gene.

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Detailed information for compound 107376