Detailed information for compound 107554

Basic information

Technical information
  • TDR Targets ID: 107554
  • Name: 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl ]sulfonylamino]-3-phenylpropanoic acid
  • MW: 462.521 | Formula: C24H22N4O4S
  • H donors: 4 H acceptors: 5 LogP: 3.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC(c1ccccc1)NS(=O)(=O)c1cccc(c1)c1cccc(c1)Nc1[nH]ccn1
  • InChi: 1S/C24H22N4O4S/c29-23(30)16-22(17-6-2-1-3-7-17)28-33(31,32)21-11-5-9-19(15-21)18-8-4-10-20(14-18)27-24-25-12-13-26-24/h1-15,22,28H,16H2,(H,29,30)(H2,25,26,27)
  • InChiKey: ZYHLKGSZXSXNIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl]sulfonylamino]-3-phenyl-propanoic acid
  • 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl]sulfonylamino]-3-phenyl-propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0644 0.3441 0.3635
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Plasmodium falciparum serine repeat antigen 3 0.0152 0.0743 0.3207
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0152 0.0743 0.3229
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0436 0.23 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Brugia malayi beta-lactamase 0.0071 0.03 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.0179
Plasmodium falciparum serine repeat antigen 4 0.0152 0.0743 0.3207
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0016 0.0017
Giardia lamblia Encystation-specific protease 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0822 0.236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Mycobacterium ulcerans lipase LipD 0.0071 0.03 1
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Entamoeba histolytica Ran family GTPase 0.0021 0.0025 0.0052
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Plasmodium vivax unspecified product 0.0152 0.0743 0.3229
Brugia malayi fibroinase precursor 0.0152 0.0743 0.0743
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.03 0.1242
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0027
Echinococcus multilocularis cysteine protease 0.0436 0.23 0.243
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Brugia malayi cathepsin F-like cysteine proteinase 0.0152 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Echinococcus multilocularis cathepsin b 0.1744 0.9466 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Schistosoma mansoni cathepsin B (C01 family) 0.0152 0.0743 0.0785
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.03 0.0317
Echinococcus multilocularis snurportin 1 0.0303 0.1574 0.1662
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Mycobacterium leprae PROBABLE HYDROLASE 0.0051 0.0192 0.5838
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.03 0.1242
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0152 0.0743 0.2128
Trypanosoma cruzi cysteine protease, putative 0.0166 0.0822 0.0869
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Onchocerca volvulus 0.0071 0.03 0.115
Trypanosoma cruzi cysteine proteinase, putative 0.0166 0.0822 0.0869
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1744 0.9466 1
Onchocerca volvulus 0.0042 0.0142 0.0448
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus granulosus cathepsin L 0.0166 0.0822 0.0869
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Leishmania major hypothetical protein, conserved 0.0071 0.03 0.0873
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0045 0.0158 0.0167
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.03 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0041 0.1123
Loa Loa (eye worm) fibroinase 0.0436 0.23 0.23
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0152 0.0743 0.3229
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.03 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0013 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1744 0.9466 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.03 0.0317
Loa Loa (eye worm) hypothetical protein 0.0049 0.0182 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0403 0.0425
Plasmodium vivax unspecified product 0.0166 0.0822 0.3576
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0042 0.0142 0.015
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.03 0.1242
Leishmania major hypothetical protein, conserved 0.0025 0.0049 0.0142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0069
Entamoeba histolytica cysteine proteinase, putative 0.0421 0.222 0.9652
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0743 0.0785
Onchocerca volvulus 0.0152 0.0743 0.3108
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.03 0.0317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Echinococcus granulosus dna polymerase eta 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0436 0.23 0.23
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Plasmodium vivax serine-repeat antigen (SERA) 0.0152 0.0743 0.3229
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0153 0.0752 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Onchocerca volvulus 0.0436 0.23 1
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.23 0.243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0822 0.236
Giardia lamblia Hypothetical protein 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Echinococcus multilocularis cathepsin L 0.0152 0.0743 0.0785
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Mycobacterium ulcerans beta-lactamase 0.0071 0.03 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0097 0.0097
Giardia lamblia Hypothetical protein 0.0152 0.0743 0.2128
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0421 0.222 0.2346
Brugia malayi Cathepsin L-like precursor 0.0421 0.222 0.222
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0027
Echinococcus granulosus integrin beta 2 0.1351 0.7316 0.7728
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0049 0.0069
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Loa Loa (eye worm) integrin beta-2 0.1841 1 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.03 0.1242
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0152 0.0743 0.0785
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Echinococcus granulosus importin subunit beta 1 0.0028 0.0066 0.007
Brugia malayi calpain family protein 1 0.0043 0.0148 0.0148
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0025 0.0027
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Brugia malayi hypothetical protein 0.0287 0.1484 0.1484
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.03 0.1242
Schistosoma mansoni hypothetical protein 0.0333 0.1733 0.1831
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0152 0.0743 0.3229
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0287 0.1484 0.1484
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0421 0.222 0.6439
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0025 0.0027
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Schistosoma mansoni ran 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.03 0.03
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.0822 0.0822
Plasmodium falciparum importin beta, putative 0.0028 0.0066 0.0256
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Toxoplasma gondii cathepsin CPC2 0.0152 0.0743 0.2101
Echinococcus granulosus cathepsin L cysteine protease 0.0166 0.0822 0.0869
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus multilocularis geminin 0.0333 0.1733 0.1831
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Onchocerca volvulus 0.0421 0.222 0.9647
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0119
Entamoeba histolytica hypothetical protein 0.0023 0.0037 0.0103
Loa Loa (eye worm) matrixin family protein 0.0094 0.0424 0.0424
Onchocerca volvulus 0.0071 0.03 0.115
Trypanosoma brucei cysteine peptidase C (CPC) 0.0644 0.3441 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0403 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0152 0.0743 0.2128
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus granulosus cathepsin b 0.1744 0.9466 1
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.23 0.243
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.03 0.0317
Onchocerca volvulus 0.0071 0.03 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0303 0.1574 0.1662
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0008 0.5
Schistosoma mansoni hypothetical protein 0.006 0.0239 0.0252
Leishmania major DNA polymerase eta, putative 0.0019 0.0013 0.0039
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0014
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0052
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0066 0.007
Plasmodium vivax vivapain-3 0.0166 0.0822 0.3576
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.03 0.0838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) calpain family protein 1 0.0032 0.0085 0.0085
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0152 0.0743 0.3229
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0436 0.23 0.23
Brugia malayi cathepsin L-like cysteine proteinase 0.0152 0.0743 0.0743
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0148 0.0148
Plasmodium falciparum serine repeat antigen 5 0.0152 0.0743 0.3207
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0076
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Onchocerca volvulus Cathepsin L homolog 0.0152 0.0743 0.3108
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0041 0.1123
Mycobacterium ulcerans hypothetical protein 0.0071 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0152 0.0743 0.3229
Toxoplasma gondii cathepsin CPC1 0.0152 0.0743 0.2101
Plasmodium falciparum serine repeat antigen 1 0.0152 0.0743 0.3207
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Brugia malayi beta-lactamase family protein 0.0071 0.03 0.03
Plasmodium falciparum serine repeat antigen 2 0.0152 0.0743 0.3207
Loa Loa (eye worm) hypothetical protein 0.0043 0.0148 0.0148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.03 0.03
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0558 0.0558
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0193
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0025 0.011
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0049 0.0212
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.03 0.1242
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0041 0.1123
Trichomonas vaginalis esterase, putative 0.0071 0.03 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0153 0.0752 0.0794
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0152 0.0743 0.319
Brugia malayi Matrixin family protein 0.0102 0.047 0.047
Toxoplasma gondii cathepsin B 0.0644 0.3441 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0166 0.0822 0.3538
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0152 0.0743 0.319
Mycobacterium leprae conserved hypothetical protein 0.0071 0.03 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0403 0.0403
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0152 0.0743 0.3229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0021 0.0025 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Echinococcus granulosus snurportin 1 0.0303 0.1574 0.1662
Plasmodium falciparum serine repeat antigen 8 0.0152 0.0743 0.3207
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Mycobacterium leprae Probable lipase LipE 0.0071 0.03 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.2402 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0152 0.0743 0.3207
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0182 0.0192
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0049 0.0142
Loa Loa (eye worm) hypothetical protein 0.1744 0.9466 0.9466
Schistosoma mansoni importin beta-1 0.0028 0.0066 0.007
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Brugia malayi Cathepsin L-like cysteine proteinase 0.0421 0.222 0.222
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi RNA, U transporter 1 0.0081 0.0354 0.0354
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0008 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Echinococcus multilocularis cysteine protease 0.0436 0.23 0.243
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Schistosoma mansoni ran 0.0021 0.0025 0.0027
Toxoplasma gondii ABC1 family protein 0.0071 0.03 0.0806
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Leishmania major GTP-binding protein, putative 0.0021 0.0025 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.23 1
Schistosoma mansoni cathepsin S (C01 family) 0.0152 0.0743 0.0785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0041 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus granulosus cathepsin b 0.1744 0.9466 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0152 0.0743 0.2128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Loa Loa (eye worm) ctsf protein 0.0436 0.23 0.23
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0041 0.1123
Echinococcus granulosus calpain A 0.0045 0.0158 0.0167
Echinococcus multilocularis tumor protein p63 0.0338 0.1763 0.1863
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Plasmodium vivax vivapain-2 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0152 0.0743 0.0785
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0152 0.0743 0.2128
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Brugia malayi Hemopexin family protein 0.006 0.0239 0.0239
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Echinococcus granulosus cathepsin l1 0.0421 0.222 0.2346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Plasmodium vivax vivapain-1 0.0166 0.0822 0.3576
Onchocerca volvulus Cathepsin F homolog 0.0436 0.23 1
Echinococcus granulosus cysteine protease 0.0166 0.0822 0.0869
Onchocerca volvulus 0.0436 0.23 1
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0152 0.0743 0.3229
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Onchocerca volvulus 0.0027 0.0058 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0013 0.0046
Leishmania major cysteine peptidase A (CPA) 0.0436 0.23 0.6685
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.23 0.243
Toxoplasma gondii preprocathepsin c precursor, putative 0.0152 0.0743 0.2101
Echinococcus multilocularis cathepsin b 0.1744 0.9466 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0049
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0016 0.0017
Loa Loa (eye worm) matrix metalloproteinase 0.0042 0.0142 0.0142
Echinococcus granulosus cathepsin l1 0.0436 0.23 0.243
Plasmodium falciparum cysteine proteinase falcipain 1 0.0166 0.0822 0.3554
Schistosoma mansoni DNA polymerase eta 0.0019 0.0013 0.0014
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.0743 0.2128
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0644 0.3441 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0014
Loa Loa (eye worm) cysteine protease 0.0436 0.23 0.23
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0008 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) beta-lactamase 0.0071 0.03 0.03
Entamoeba histolytica hypothetical protein 0.0152 0.0743 0.319
Plasmodium falciparum serine repeat antigen 6 0.0152 0.0743 0.3207
Echinococcus granulosus tumor protein p63 0.0338 0.1763 0.1863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Brugia malayi cathepsin Z-like cysteine proteinase 0.0152 0.0743 0.0743
Onchocerca volvulus 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0166 0.0822 0.239
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1574 0.1574
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0152 0.0743 0.0785
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Plasmodium vivax importin-beta 2, putative 0.0028 0.0066 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0403 0.0425
Plasmodium vivax vivapain-2 0.0436 0.23 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Mycobacterium ulcerans hypothetical protein 0.0024 0.0041 0.1123
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Onchocerca volvulus 0.0436 0.23 1
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Schistosoma mansoni cathepsin F (C01 family) 0.0421 0.222 0.2346
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Echinococcus multilocularis cathepsin L 0.0166 0.0822 0.0869
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Schistosoma mansoni cathepsin C 0.0152 0.0743 0.0785
Echinococcus multilocularis dna polymerase eta 0.0019 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.23 0.243
Brugia malayi Papain family cysteine protease containing protein 0.0436 0.23 0.23
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.03 0.0317
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.03 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Giardia lamblia Cathepsin L-like protease 0.0152 0.0743 0.2128
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.0436 0.23 0.243
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.23 1
Entamoeba histolytica cysteine protease, putative 0.0436 0.23 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Onchocerca volvulus 0.0436 0.23 1
Onchocerca volvulus 0.0049 0.0182 0.0625
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0037 0.0039
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.0822 0.0822
Brugia malayi cathepsin L-like precursor 0.0421 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0287 0.1484 0.1484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0121
Brugia malayi cathepsin L precursor 0.0152 0.0743 0.0743
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0192 0.0192
Entamoeba histolytica cysteine proteinase 2 0.0166 0.0822 0.3538
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0041 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Brugia malayi Kelch motif family protein 0.0287 0.1484 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Leishmania major importin beta-1 subunit, putative 0.0023 0.0037 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0558 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi Importin beta-1 subunit 0.0028 0.0066 0.0066
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0184 0.0184
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0025
Trypanosoma cruzi cysteine proteinase, putative 0.0166 0.0822 0.0869
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0152 0.0743 0.0785
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.03 0.0838
Echinococcus multilocularis integrin beta 2 0.1351 0.7316 0.7728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0436 0.23 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.005 0.0184 0.0184
Trypanosoma cruzi cysteine peptidase, putative 0.0166 0.0822 0.0869
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Brugia malayi calpain family protein 1 0.0043 0.0148 0.0148
Plasmodium falciparum serine repeat antigen 7 0.0152 0.0743 0.3207
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0152 0.0743 0.3229
Plasmodium vivax hypothetical protein, conserved 0.0071 0.03 0.1307
Brugia malayi hypothetical protein 0.0025 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Brugia malayi beta-lactamase family protein 0.0071 0.03 0.03
Loa Loa (eye worm) cathepsin B 0.0644 0.3441 0.3441
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0436 0.23 0.23
Onchocerca volvulus Cathepsin L homolog 0.0436 0.23 1
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Echinococcus granulosus cathepsin L 0.0152 0.0743 0.0785
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0051 0.0192 0.0192
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0051 0.0192 0.0792
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0403 0.0425
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0152 0.0743 0.3229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0043 0.0148 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi cathepsin B-like cysteine proteinase 0.1744 0.9466 0.9466
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.03 0.1242
Plasmodium falciparum serine repeat antigen 9 0.0152 0.0743 0.3207
Brugia malayi cathepsin Z-like cysteine proteinase 0.0152 0.0743 0.0743
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0103
Onchocerca volvulus Cathepsin L homolog 0.0436 0.23 1
Giardia lamblia Cathepsin L-like protease 0.0152 0.0743 0.2128
Mycobacterium ulcerans hydrolase 0.0051 0.0192 0.6306
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0152 0.0743 0.0743
Plasmodium falciparum cysteine proteinase falcipain 3 0.0436 0.23 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0403 0.0425
Echinococcus granulosus cathepsin L cysteine proteinase 0.0436 0.23 0.243
Echinococcus granulosus geminin 0.0333 0.1733 0.1831
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0194
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0152 0.0743 0.3207
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0184 0.0184
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.23 0.243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0421 0.222 0.6439
Echinococcus multilocularis calpain A 0.0045 0.0158 0.0167
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Brugia malayi Cathepsin L-like precursor 0.0421 0.222 0.222
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0743 0.0785
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Onchocerca volvulus 0.006 0.0239 0.0876
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0013 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.03 0.0317
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Onchocerca volvulus 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Toxoplasma gondii cathepsin CPL 0.0436 0.23 0.666
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Onchocerca volvulus Matrilysin homolog 0.0042 0.0142 0.0448
Onchocerca volvulus 0.0436 0.23 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0066 0.012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.23 0.243
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0644 0.3441 0.3635
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Schistosoma mansoni integrin beta subunit 0.1064 0.5742 0.6066
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.0743 0.2128
Trypanosoma cruzi cruzipain precursor, putative 0.0436 0.23 0.243
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0152 0.0743 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0166 0.0822 0.239
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0644 0.3441 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Onchocerca volvulus Matrix metalloproteinase homolog 0.0094 0.0424 0.1695
Echinococcus multilocularis calpain family protein 1, d 0.0032 0.0085 0.009
Plasmodium vivax serine-repeat antigen (SERA) 0.0152 0.0743 0.3229
Schistosoma mansoni hypothetical protein 0.0333 0.1733 0.1831
Onchocerca volvulus Matrilysin homolog 0.0094 0.0424 0.1695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Loa Loa (eye worm) matrixin family protein 0.0102 0.047 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0166 0.0822 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Trypanosoma brucei unspecified product 0.0019 0.0013 0.0039
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0152 0.0743 0.3207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi MH2 domain containing protein 0.0118 0.0558 0.0558
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0037 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0152 0.0743 0.3229

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 180 nM In vitro activity in an vitronectin receptor (alpha v beta3) scintillation bead assay using 125-I labelled echistatin as a radioligand ChEMBL. 11755355
Ki (binding) = 180 nM In vitro activity in an vitronectin receptor (alpha v beta3) scintillation bead assay using 125-I labelled echistatin as a radioligand ChEMBL. 11755355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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