Detailed information for compound 1105698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.357 | Formula: C16H21N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1c1ccnc(n1)CCN(C)C)OC
  • InChi: 1S/C16H21N3O2/c1-19(2)11-9-15-17-10-8-12(18-15)16-13(20-3)6-5-7-14(16)21-4/h5-8,10H,9,11H2,1-4H3
  • InChiKey: ZOGZUNFJVUUUTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major protein kinase, putative 0.0032 0.0389 0.0599
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.003 0.003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0336 0.0349
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.1592 0.2453
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0336 0.0517
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0393 0.8539 0.8539
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.4369 0.5117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0389 0.0455
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0491 0.0757
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0389 0.0455
Entamoeba histolytica hypothetical protein 0.0023 0.0198 0.02
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0198 0.0436
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0433 0.0433
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0389 0.0404
Mycobacterium ulcerans hypothetical protein 0.0024 0.0223 0.0684
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0336 0.0517
Schistosoma mansoni hypothetical protein 0.0075 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.0075 0.1369 0.1604
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0194 0.4054 0.8923
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0619 0.1233
Echinococcus granulosus GPCR family 2 0.0075 0.1369 0.1369
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0374 0.0374
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0374 0.0374
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0389 0.0455
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0375 0.813 0.9522
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0389 0.0404
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0344 0.0344
Brugia malayi TAR-binding protein 0.0375 0.813 0.9522
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0198 0.0187
Loa Loa (eye worm) glutathione reductase 0.0085 0.1592 0.1864
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Mycobacterium ulcerans hypothetical protein 0.0024 0.0223 0.0684
Echinococcus multilocularis General substrate transporter 0.0089 0.1688 0.1688
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0198 0.0305
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0344 0.0344
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.6489 1
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0336 0.0669
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0433 0.0508
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0433 0.0433
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.003 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0073 0.0073
Toxoplasma gondii hypothetical protein 0.0049 0.077 0.1221
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0336 0.0336
Schistosoma mansoni protein kinase 0.0032 0.0389 0.0389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0238 0.5042 0.5904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0086
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0374 0.0438
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.2897 0.4465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0238 0.5042 0.5904
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.003 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0075 0.1369 0.1369
Plasmodium falciparum glutathione reductase 0.0085 0.1592 0.1652
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Plasmodium falciparum thioredoxin reductase 0.0085 0.1592 0.1652
Leishmania major trypanothione reductase 0.0085 0.1592 0.2453
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0223 0.0344
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1547 0.1547
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0168 0.3464 0.3595
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0129 0.0258
Brugia malayi Pre-SET motif family protein 0.003 0.0344 0.0403
Mycobacterium tuberculosis Probable dehydrogenase 0.0194 0.4054 0.8923
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0393 0.8539 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0457 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.003 0.003
Mycobacterium tuberculosis Probable reductase 0.0194 0.4054 0.8923
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0433 0.0433
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0344 0.0545
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0433 0.0864
Schistosoma mansoni nuclear hormone receptor 0.0016 0.003 0.003
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0374 0.0746
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.0793
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0433 0.0433
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0216 0.4543 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0374 1
Brugia malayi MH2 domain containing protein 0.0119 0.2366 0.277
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.4473 0.6893
Brugia malayi RNA recognition motif domain containing protein 0.0375 0.813 0.9522
Brugia malayi RNA binding protein 0.0375 0.813 0.9522
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0398 0.0793
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0336 0.0517
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0336 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0433 0.0508
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0389 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0896 0.1049
Plasmodium falciparum thioredoxin reductase 0.0029 0.0336 0.0349
Onchocerca volvulus 0.0237 0.5018 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0344 0.0403
Entamoeba histolytica protein kinase, putative 0.0032 0.0389 1
Brugia malayi nuclear receptor RXR 0.0018 0.0073 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0433 0.0433
Brugia malayi Nuclear hormone receptor E75 0.0016 0.003 0.0035
Brugia malayi nuclear receptor NHR-67 0.0016 0.003 0.0035
Brugia malayi hypothetical protein 0.0016 0.003 0.0035
Echinococcus granulosus tar DNA binding protein 0.0375 0.813 0.813
Onchocerca volvulus 0.0083 0.1547 0.3083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2897 0.4465
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0336 0.0336
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0194 0.0227
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0198 0.0305
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0629 0.0969
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0389 0.0404
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0223 0.0444
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.1592 0.3504
Brugia malayi hypothetical protein 0.0018 0.0073 0.0086
Mycobacterium ulcerans hypothetical protein 0.0159 0.3262 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0223 0.0491
Brugia malayi ecdysone receptor 0.0016 0.003 0.0035
Schistosoma mansoni chromobox protein 0.007 0.1243 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0433 0.0508
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0433 0.0433
Schistosoma mansoni glucose transport protein 0.0104 0.2018 0.2018
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0194 0.0595
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0159 0.0186
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.003 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0838 0.1292
Schistosoma mansoni tar DNA-binding protein 0.0375 0.813 0.813
Schistosoma mansoni hypothetical protein 0.0075 0.1369 0.1369
Brugia malayi mbt repeat family protein 0.0048 0.0747 0.0875
Brugia malayi nuclear hormone receptor 0.0034 0.0433 0.0508
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Brugia malayi mbt repeat family protein 0.0048 0.0747 0.0875
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0194 0.0299
Plasmodium falciparum hexose transporter 0.0104 0.2018 0.2094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0344 0.0344
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0194 0.5182
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.003 0.003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Schistosoma mansoni tar DNA-binding protein 0.0375 0.813 0.813
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2366 0.277
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1547 0.1547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0433 0.0508
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.0613
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0115 0.0253
Trypanosoma brucei glucose transporter 2A 0.0032 0.0398 0.0613
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0896 0.0896
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0374 0.9253
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0896 0.0896
Schistosoma mansoni hypothetical protein 0.0075 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0086
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0336 0.0517
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0068 0.0105
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0344 0.0344
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0194 0.0299
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0223 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1547 0.1547
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0194 0.0194
Plasmodium vivax glutathione reductase, putative 0.0085 0.1592 0.1652
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0433 0.0433
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0198 0.0274
Schistosoma mansoni nuclear receptor 0.0016 0.003 0.003
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0896 0.0896
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0075 0.1369 0.1369
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0198 0.0607
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Plasmodium vivax hexose transporter 0.0104 0.2018 0.2094
Brugia malayi tailless protein 0.0016 0.003 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0375 0.813 0.813
Schistosoma mansoni glucose transport protein 0.0104 0.2018 0.2018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0433 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0629 0.0969
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0747 0.0747
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.003 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0433 0.0433
Brugia malayi ecdysteroid receptor 0.0034 0.0433 0.0508
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0194 0.0201
Schistosoma mansoni zinc finger protein 0.0016 0.003 0.003
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1547 0.1812
Leishmania major glucose transporter, lmgt2 0.0032 0.0398 0.0613
Brugia malayi nuclear receptor RXR 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.0793
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0194 0.0178
Trypanosoma brucei trypanothione reductase 0.0085 0.1592 0.2453
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.003 0.003
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0223 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0433 0.0508
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0433 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0552 0.1099
Brugia malayi Pre-SET motif family protein 0.0208 0.4369 0.5117
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0398 0.0793
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0344 0.0344
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0374 0.0438
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0747 0.0747
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2897 0.4465
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0194 0.0299
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0433 0.0508
Trichomonas vaginalis set domain proteins, putative 0.0237 0.5018 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0398 0.0793
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0344 0.0344
Trichomonas vaginalis chromobox protein, putative 0.007 0.1243 0.2477
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0389 0.0404
Brugia malayi Heterochromatin protein 1 0.007 0.1243 0.1456
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0374 0.0374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Onchocerca volvulus 0.0016 0.003 0.006
Loa Loa (eye worm) sugar transporter 0.0104 0.2018 0.2363
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0433 0.0433
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.3262 0.718
Echinococcus multilocularis GPCR, family 2 0.0075 0.1369 0.1369
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0194 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0073 0.0086
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0433 0.0508
Schistosoma mansoni protein kinase 0.0032 0.0389 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.4473 0.6893
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0075 0.1369 0.1369
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0433 0.0433
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0433 0.0433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0344 0.0344
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0075 0.1369 0.1369
Trypanosoma brucei glucose transporter 1E 0.0032 0.0398 0.0613
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.3914 0.3914
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0194 0.4054 0.8923
Plasmodium falciparum glutathione reductase 0.0029 0.0336 0.0349
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.6489 1
Trypanosoma brucei hypothetical protein, conserved 0.0213 0.4473 0.6893
Loa Loa (eye worm) hypothetical protein 0.0054 0.0896 0.1049
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0747 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0433 0.0508
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0552 0.1099
Onchocerca volvulus 0.0041 0.0601 0.1198
Brugia malayi Nuclear hormone receptor E75 0.0016 0.003 0.0035
Plasmodium vivax SET domain protein, putative 0.003 0.0344 0.0357
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0433 0.0433
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.003 0.006
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.3914 0.3914
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0398 0.0793
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0389 0.0617
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.003 0.0035
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0389 0.0599
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0491 0.0757
Schistosoma mansoni nuclear hormone receptor 0.0016 0.003 0.003
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0398 0.0613
Echinococcus multilocularis chromobox protein 1 0.007 0.1243 0.1243
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0433 0.0433
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Brugia malayi conserved hypotetical protein 0.0016 0.003 0.0035
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.0613
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.003 0.003
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0198 0.0205
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.0613
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0168 0.3464 0.5495
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0433 0.0433
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0491 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0336 0.103
Loa Loa (eye worm) hypothetical protein 0.0048 0.0747 0.0875
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0336 0.0517
Leishmania major glucose transporter, lmgt1 0.0032 0.0398 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0375 0.813 0.813
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0433 0.0508
Brugia malayi nuclear hormone receptor 0.0016 0.003 0.0035
Entamoeba histolytica protein kinase, putative 0.0032 0.0389 1
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0336 0.0533
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0086
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0491 0.0779
Brugia malayi Sugar transporter family protein 0.0104 0.2018 0.2363
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0223 0.0344
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0389 0.0617
Loa Loa (eye worm) MBCTL1 0.0054 0.0896 0.1049
Leishmania major hypothetical protein, conserved 0.0213 0.4473 0.6893
Schistosoma mansoni hypothetical protein 0.0104 0.2018 0.2018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0194 0.4054 0.8923
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0433 0.0433
Plasmodium vivax CDK-related protein kinase 6, putative 0.0441 0.9636 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0629 0.0969
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0336 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0433 0.0508
Loa Loa (eye worm) hypothetical protein 0.0039 0.0552 0.0646
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0086
Brugia malayi Calcitonin receptor-like protein seb-1 0.0238 0.5042 0.5904
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0389 0.0455
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0389 0.0404
Mycobacterium tuberculosis Conserved protein 0.0024 0.0223 0.0491
Treponema pallidum NADH oxidase 0.0029 0.0336 1
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.1592 0.1652
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0344 0.0344
Echinococcus multilocularis chromobox protein 1 0.007 0.1243 0.1243
Schistosoma mansoni hypothetical protein 0.0075 0.1369 0.1369
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0336 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0198 0.0314
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1243 0.1456
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0216 0.4543 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Mycobacterium tuberculosis Probable oxidoreductase 0.0216 0.4543 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Schistosoma mansoni hypothetical protein 0.0163 0.3342 0.3342
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0433 0.0508
Toxoplasma gondii thioredoxin reductase 0.0085 0.1592 0.2525
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2018 0.2018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0393 0.8539 0.8539
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0238 0.5042 0.5904
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0375 0.813 0.813
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0433 0.0433
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.6489 1
Onchocerca volvulus 0.0048 0.0747 0.1488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0374 0.0438
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0619 0.1233
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0433 0.0433
Echinococcus granulosus chromobox protein 1 0.007 0.1243 0.1243
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0194 0.0595
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0194 0.0201
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0747 0.0747
Schistosoma mansoni chromobox protein 0.007 0.1243 0.1243
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0433 0.0508
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0194 0.0194
Leishmania major glucose transporter, lmgt3 0.0032 0.0398 0.0613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0242 0.0284
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0433 0.0508
Echinococcus multilocularis tar DNA binding protein 0.0375 0.813 0.813
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0336 0.0739
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0747 0.0747
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0336 0.0517
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0336 0.103
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0374 0.0586
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Schistosoma mansoni glucose transport protein 0.0104 0.2018 0.2018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0336 0.0336
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0398 0.0793
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0491 0.0757
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0223 0.0684
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0073 0.0073
Brugia malayi Cam kinase protein 1 0.0032 0.0389 0.0455
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0747 0.1488
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.003 0.006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0216 0.4543 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0336 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2018 0.4021
Plasmodium falciparum protein kinase 6 0.0441 0.9636 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0336 0.0393
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0389 0.0617
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0433 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0433 0.0508
Brugia malayi chromobox protein homolog 3 0.0039 0.0552 0.0646
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.003 0.003
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0336 0.0349
Brugia malayi Thioredoxin reductase 0.0085 0.1592 0.1864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0433 0.0508
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0433 0.0433
Plasmodium falciparum protein kinase 7 0.0294 0.6304 0.6542
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0398 0.0613
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0073 0.0086
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0194 0.0308
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0896 0.0896
Toxoplasma gondii protein kinase, putative 0.0294 0.6304 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0159 0.0186
Schistosoma mansoni nuclear receptor 0.0016 0.003 0.003
Brugia malayi glutathione reductase 0.0085 0.1592 0.1864
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0433 0.0864
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.1603 0.1603
Echinococcus granulosus General substrate transporter 0.0089 0.1688 0.1688
Loa Loa (eye worm) latrophilin receptor protein 2 0.0075 0.1369 0.1604
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0194 0.0227
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0491 0.051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0389 0.0389
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0223 0.0223
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.1603 0.1603
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0075 0.1369 0.1604
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2366 0.277
Echinococcus granulosus chromobox protein 1 0.007 0.1243 0.1243
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0115 0.0253
Brugia malayi hypothetical protein 0.0018 0.0073 0.0086
Loa Loa (eye worm) DR-78 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0433 0.0433
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0491 0.0757
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0198 0.0205
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0194 0.4054 0.8923
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0552 0.1099
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0194 0.4054 0.8895
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0398 0.0613
Schistosoma mansoni protein kinase 0.0032 0.0389 0.0389
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0433 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0294 0.0586
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0433 0.0433
Brugia malayi latrophilin 2 splice variant baaae 0.0163 0.3342 0.3914
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0747 0.0747
Schistosoma mansoni coup transcription factor 0.0034 0.0433 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0075 0.1369 0.1604
Brugia malayi steroid hormone receptor 0.0034 0.0433 0.0508
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0336 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0336 0.0517
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0336 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0073 0.0086
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0194 0.0386
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0896 0.0896
Loa Loa (eye worm) RNA binding protein 0.0375 0.813 0.9522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0336 0.103
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0389 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0389 0.0775
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0433 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0433 0.0508
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0319 0.0319
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.003 0.003
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0389 0.0404
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0223 0.0223
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.003 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0083 0.1547 0.1812
Trichomonas vaginalis chromobox protein, putative 0.007 0.1243 0.2477
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0198 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0433 0.0508
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0375 0.8135 0.8135
Brugia malayi nuclear receptor NHR-88 0.0016 0.003 0.0035
Trypanosoma cruzi hexose transporter 0.0032 0.0398 0.0613
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0491 0.0757
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0457 1 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0198 0.0607
Schistosoma mansoni hypothetical protein 0.029 0.6217 0.6217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0433 0.0433
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0433 0.0433
Brugia malayi hypothetical protein 0.0016 0.003 0.0035
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0223 0.0344
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0433 0.0864
Plasmodium falciparum mitogen-activated protein kinase 2 0.0168 0.3464 0.3595
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.6489 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2018 0.3201
Trypanosoma brucei glucose transporter, putative 0.0032 0.0398 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0601 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0294 0.0586
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0198 0.5892
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0433 0.0508
Loa Loa (eye worm) hypothetical protein 0.0163 0.3342 0.3914
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0389 0.0404
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.1592 0.1864
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2018 0.2018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0336 0.0517
Loa Loa (eye worm) TAR-binding protein 0.0375 0.813 0.9522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0361 0.0423
Loa Loa (eye worm) hypothetical protein 0.0031 0.0374 0.0438
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0433 0.0433
Brugia malayi nuclear receptor NHR-88 0.0034 0.0433 0.0508
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0336 0.0669
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0336 0.0533
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0336 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0433 0.0508
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0194 0.0194
Onchocerca volvulus 0.0034 0.0433 0.0864
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0073 0.0073
Onchocerca volvulus 0.0031 0.0361 0.072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0619 0.1233
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0629 0.0969
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0433 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0393 0.8539 1
Onchocerca volvulus 0.0016 0.003 0.006
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0336 0.8972
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.003 0.003
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0747 0.0747
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.003 0.0035

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1485 nM Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells ChEMBL. 20138771

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.